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Article: Anti-N-methyl-D-aspartate Receptor Encephalitis in People Living with HIV: Case Report and Literature Review.

Hui, Jiangjin / Wang, Jinhua / Wan, Zhikai / Cao, Qing / Dai, Bohao / Lou, Haiyan / Zhu, Biao

Neurology and therapy

2024

Abstract: With the increase in the number of cases of autoimmune encephalitis (AE), the cerebrospinal fluid (CSF) of people living with HIV (PLWH) showing abnormal behavior, cognitive impairment or abnormal movements should be actively screened for the antibody ... ...

Abstract	With the increase in the number of cases of autoimmune encephalitis (AE), the cerebrospinal fluid (CSF) of people living with HIV (PLWH) showing abnormal behavior, cognitive impairment or abnormal movements should be actively screened for the antibody panel of AE. Early recognition and treatment can prevent severe seizures or coma and markedly improve the prognosis of patients. The first-line immunotherapy for AE includes intravenous methylprednisolone and immunoglobulin. However, whether long-time immunosuppressive maintenance therapy is needed is debated. For PLWH, immunosuppressive therapy and even steroids could be more challenging. Here, we review and summarize the clinical characteristics often reported cases and report one case from our center to improve the diagnosis and treatment of anti-N-methyl-D-aspartate receptor encephalitis in PLWH.
Language	English
Publishing date	2024-03-26
Publishing country	New Zealand
Document type	Journal Article ; Review
ISSN	2193-8253
ISSN	2193-8253
DOI	10.1007/s40120-024-00594-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: HIV-associated dyslipidemia: pathogenesis and its management.

Wan, Zhikai / Dai, Bohao / Zhu, Xueling / Huang, Ying / Zhu, Biao

Chinese medical journal

2023 Volume 136, Issue 22, Page(s) 2732–2734

MeSH term(s)	Humans ; Dyslipidemias ; HIV Infections/complications ; HIV Infections/drug therapy ; Risk Factors
Language	English
Publishing date	2023-10-25
Publishing country	China
Document type	Journal Article
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000002879
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Article ; Online: Research on the bidirectional motion of resonant single-wing bionic piezoelectric motor based on a biasing self-clamping mechanism.

He, Liangguo / Qian, An / Li, Xinyu / Yue, Xukang / Wan, Zhikai / Huang, Liang

The Review of scientific instruments

2023 Volume 94, Issue 12

Abstract: Based on our previous research, this article adds new research content and further refines the previous research on bionic motors. It is in the form of note as a complementary improvement to the previous article. This article proposes a novel approach to ...

Abstract	Based on our previous research, this article adds new research content and further refines the previous research on bionic motors. It is in the form of note as a complementary improvement to the previous article. This article proposes a novel approach to achieving reversal motion in such motors driven by a single harmonic signal, specifically the multimode mode of the vibrator. In contrast to the conventional inertial impact piezoelectric motor, we propose a bidirectional piezoelectric motor that can achieve bidirectional motion only by altering the driving signal characteristics. Compared to other bidirectional piezoelectric motors, this motor features a simpler structure and more convenient control. The COMSOL6.0 finite element analysis software was utilized to optimize the working mode of the piezoelectric motor, and an experimental platform was constructed for testing and verifying the performance of the designed prototype. The final experimental data demonstrate that, with an excitation voltage of 300 Vp-p, a preload of 2 N, and an excitation frequency of 781 Hz, the motor prototype achieves a maximum no-load speed of 12.15 mm/s, a maximum resolution of 15.27 μm, and a maximum load of 14 g. These results confirm the validity of the new working mode.
Language	English
Publishing date	2023-12-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0169842
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Article ; Online: A resonant single-wing bionic piezoelectric motor based on a biasing self-clamping mechanism.

He, Liangguo / Qian, An / Dong, Yuge / Li, Xinyu / Wan, Zhikai / Yue, Xukang

The Review of scientific instruments

2023 Volume 94, Issue 6

Abstract: In this study, a resonant single-wing bionic piezoelectric motor based on a biasing self-clamping mechanism inspired by dragonfly flight was designed, assembled, and tested. The main mechanism of the designed piezoelectric motor includes a mover ( ... ...

Abstract	In this study, a resonant single-wing bionic piezoelectric motor based on a biasing self-clamping mechanism inspired by dragonfly flight was designed, assembled, and tested. The main mechanism of the designed piezoelectric motor includes a mover (including a vibrator, clamping foot, bionic pedestal, etc.), a stator, and other auxiliary components. The clamping foot of the mover contacts the side of the stator to form a biasing self-clamping mechanism, which can achieve a clamping effect within half a cycle of the vibrator's resonant vibration. The piezoelectric plate on the vibrator receives a single harmonic excitation from the signal generator, causing the base plate to bend and distort. The base plate drives the clamping foot to move regularly, causing the mover to perform a linear motion. Moreover, repeated single harmonic excitations can realize the continuous movement of the mover. The structure of the piezoelectric motor was optimized using COMSOL6.0, which is a finite element analysis software. The first-order bending vibration of the vibrator was chosen as the working mode through finite element simulation, and an experimental platform was built. The performance of the prototype piezoelectric motor was tested and verified on the experimental platform. The final experimental data show that under the conditions of 300 Vp-p excitation voltage and 109 Hz driving frequency, the maximum no-load speed of the prototype reaches 6.184 mm/s, and the maximum load of the motor is 4 g.
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0139589
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Article ; Online: Bidirectional motion characteristics of resonant inertial impact rotating piezoelectric motor based on self-clamping structure.

He, Liangguo / Wan, Zhikai / Li, Kun / Huang, Liang / Pan, Chengliang / Ge, Xinfang / Yue, Xukang / Qian, An

The Review of scientific instruments

2023 Volume 94, Issue 8

Abstract: A new working principle for multimodal excitation of a resonant bidirectional rotary inertial impact piezoelectric motor with a self-clamping structure was developed based on previous research on piezoelectric motors. Unlike previous piezoelectric motors ...

Abstract	A new working principle for multimodal excitation of a resonant bidirectional rotary inertial impact piezoelectric motor with a self-clamping structure was developed based on previous research on piezoelectric motors. Unlike previous piezoelectric motors that relied on single harmonic waves for unidirectional rotation, in this motor, we can simply change the driving signal characteristics of the motor without changing the structure of the piezoelectric motor to excite multiple vibration modes, thereby achieving rotation in both directions. Compared with other bidirectional resonant motors, the structure and control signal are simpler. The finite element simulation software COMSOL5.5 was used to simulate the working mode of the motor, and the results were in good agreement with the final experiment. During the experiments, the optimal operating frequency of the motor prototype was 900 Hz. The maximum output speed of the motor prototype was 3.9 rad/s, the maximum output torque was 15 N mm, and the maximum resolution was 0.248° under the conditions of 240 Vp-p voltage, 900 Hz frequency, and 7.8 N mm preload torque.
Language	English
Publishing date	2023-12-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0157465
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Article ; Online: A resonant inertial impact rotary piezoelectric motor based on a self-clamping structure.

He, Liangguo / Wan, Zhikai / Li, Kun / Wang, Yong / Li, Xinyu / Ge, Xinfang / Dou, Haotian / Shan, Zengxiang / Yue, Xukang / Qian, An

The Review of scientific instruments

2023 Volume 94, Issue 4

Abstract: A resonant inertial impact rotary piezoelectric motor based on a self-clamping structure is designed, assembled, and tested. The designed piezoelectric motor mainly includes a rotor (two vibrators, preload mechanism, and intermediate connection mechanism) ...

Abstract	A resonant inertial impact rotary piezoelectric motor based on a self-clamping structure is designed, assembled, and tested. The designed piezoelectric motor mainly includes a rotor (two vibrators, preload mechanism, and intermediate connection mechanism), a clamping mechanism, and another auxiliary mechanism. The piezoelectric ceramic sheet on the rotor drives the vibrator to swing under the excitation of a single harmonic wave. Because there is a clamping mechanism formed by the combination of clamp baffle and fixed clamp ring, thus the half-cycle resonant rotation of the rotor can be effectively completed, and repeated harmonic excitation can realize the unidirectional continuous rotation and swing of the rotor. The whole excitation process of the motor is in a resonance state, which has significant advantages, such as low friction and simple structure, compared with the traditional quasi-static piezoelectric motor. The structure of the piezoelectric motor is designed and analyzed using COMSOL5.5 software and then the motor performance is tested and analyzed by building an experimental platform to verify the feasibility of the motor design. The final experimental results show that the optimal working frequency of the piezoelectric motor is 150 Hz, which is consistent with the characteristic frequency of the simulation. When the motor prototype is under the conditions of optimal operating frequency 150 Hz, voltage 240 Vp-p, and preload torque 7.8 N.mm, the maximum angular speed can reach 2.4 rad/s, the maximum load can reach 27.8 N mm and the maximum resolution of the movement angle can reach 0.941°.
Language	English
Publishing date	2023-12-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0133681
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Safety and efficacy of PD-1 inhibitors in HIV-infected patients with severe comorbidities: a prospective observational cohort study.

Zhu, Xueling / Liu, Xiang / Wan, Zhikai / Hui, Jiangjin / Tao, Ran / Peng, Xiaorong / Su, Junwei / Huang, Ying / Zhu, Biao

Chinese medical journal

2023 Volume 136, Issue 22, Page(s) 2750–2752

MeSH term(s)	Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Prospective Studies ; HIV Infections/drug therapy ; Anti-HIV Agents/therapeutic use ; Comorbidity
Chemical Substances	Immune Checkpoint Inhibitors ; Anti-HIV Agents
Language	English
Publishing date	2023-10-25
Publishing country	China
Document type	Observational Study ; Letter
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000002883
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Efficacy and safety of lenalidomide in HIV-associated cryptococcal meningitis patients with persistent intracranial inflammation: an open-label, single-arm, prospective interventional study.

Wan, Zhikai / Tao, Ran / Hui, Jiangjin / Liu, Xiang / Peng, Xiaorong / Guo, Yongzheng / Zhu, Xueling / Huang, Ying / Zhu, Biao

Journal of neuroinflammation

2023 Volume 20, Issue 1, Page(s) 38

Abstract: Background: Patients with human immunodeficiency virus-associated cryptococcal meningitis (HIV-CM) have persistent intracranial inflammation despite negative cerebrospinal fluid (CSF) fungal cultures after optimal treatment for CM, which could be ... ...

Abstract	Background: Patients with human immunodeficiency virus-associated cryptococcal meningitis (HIV-CM) have persistent intracranial inflammation despite negative cerebrospinal fluid (CSF) fungal cultures after optimal treatment for CM, which could be devastating for the central nervous system. However, a definitive treatment strategy for persistent intracranial inflammation despite optimal antifungal therapies is undefined. Methods: We identified 14 HIV-CM patients with persistent intracranial inflammation and conducted a 24-week, prospective, interventional study. All participants received lenalidomide (25 mg, p.o.) on days 1 to 21 of a 28-day cycle. Follow-up lasted for 24 weeks with visits at baseline and weeks 4, 8, 12, and 24. The primary endpoint was the change in clinical manifestations, routine CSF parameters, and MRI findings after lenalidomide treatment. An exploratory analysis was made on changes in cytokine levels in CSF. Safety and efficacy analyses were undertaken in patients who received at least one dose of lenalidomide. Results: Of 14 participants, 11 patients completed the 24 weeks of follow-up. Rapid clinical remission following lenalidomide therapy was observed. Clinical manifestations (fever, headache, altered mentation) were reversed fully by week-4 and remained stable during follow-up. A significant reduction in white blood cell (WBC) count in CSF was noted occurred at week-4 (P = 0.009). The median protein concentration in CSF decreased from 1.4 (0.7-3.2) g/L at baseline to 0.9 (0.6-1.4) at week-4 (P = 0.004). The median albumin concentration in CSF decreased from 79.2 (48.4-149.8) mg/L at baseline to 55.3 (38.3-89.0) mg/L at week-4 (P = 0.011). The WBC count, protein level, and albumin level in CSF remained stable and approached a normal range through week-24. There was no significant change in immunoglobulin-G, intracranial pressure (ICP), or chloride-ion concentration at each visit. Brain MRI demonstrated multiple lesions to be absorbed post-therapy. Levels of tumor necrosis factor-α granulocyte colony stimulating factor, interleukin (IL)-6, and IL-17A decreased significantly during 24-week follow-up. Two (14.3%) patients had mild skin rash, which resolved spontaneously. Lenalidomide-related serious adverse events were not observed. Conclusion: Lenalidomide could improve persistent intracranial inflammation in HIV-CM patients significantly and was well tolerated without serious adverse events observed. And the additional randomized controlled study is required to further validate the finding.
MeSH term(s)	Humans ; Meningitis, Cryptococcal/complications ; Meningitis, Cryptococcal/drug therapy ; Meningitis, Cryptococcal/cerebrospinal fluid ; Lenalidomide/therapeutic use ; Prospective Studies ; HIV ; HIV Infections/complications ; HIV Infections/drug therapy ; Inflammation/complications ; Albumins/therapeutic use
Chemical Substances	Lenalidomide (F0P408N6V4) ; Albumins
Language	English
Publishing date	2023-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2156455-3
ISSN	1742-2094 ; 1742-2094
ISSN (online)	1742-2094
ISSN	1742-2094
DOI	10.1186/s12974-023-02717-w
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Article: Distinct Lipidomic Profiles between People Living with HIV Treated with E/C/F/TAF or B/F/TAF: An Open-Label Prospective Cohort Study.

Wan, Zhikai / Su, Junwei / Zhu, Xueling / Liu, Xiang / Guo, Yongzheng / Xiang, Dairong / Zhou, Xiaotang / Peng, Xiaorong / Tao, Ran / Cao, Qing / Lang, Guanjing / Huang, Ying / Zhu, Biao

Infectious diseases and therapy

2024 Volume 13, Issue 4, Page(s) 727–744

Abstract: Introduction: Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) has been increasingly replaced by bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in the treatment of human immunodeficiency virus (HIV) owing to its more ... ...

Abstract	Introduction: Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) has been increasingly replaced by bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in the treatment of human immunodeficiency virus (HIV) owing to its more favorable pharmacokinetics and fewer drug-drug interactions. However, the effect of this switch on plasma lipids and lipidomic profiles remains poorly characterized. Methods: HIV infected patients on an E/C/F/TAF regimen were recruited into the study and followed up every 12 weeks. Participants were divided into E/C/F/TAF and B/F/TAF groups depending on whether they were switched to B/F/TAF during follow-up. Clinical information and blood samples were collected at 0, 12, and 24 weeks, and lipidomic analysis was performed using liquid chromatography mass spectrometry. Results: No significant differences were observed between the groups at baseline. At week 24, patients switched to B/F/TAF had lower triglyceride [mmol/L; 1.23 (0.62) versus 2.03 (0.75), P = 0.001] and very low-density lipoprotein cholesterol [mmol/L; 0.64 (0.26) versus 0.84 (0.32), P = 0.037) compared with patients who continued E/C/F/TAF therapy. Small decrease from baseline in Framingham general cardiovascular risk score (FRS) was observed in the B/F/TAF arm [week (W) 0: 2.59 (1.57) versus W24: 2.18 (1.01), P = 0.043]. Lipidomic analysis indicated that E/C/F/TAF treatment increased the levels of several diglycerides (DGs), triacylglycerols (TAGs), and lyso-phosphatidylcholines (LPCs), whereas switching to B/F/TAF led to increased sphingolipids and glycerophospholipids. After adjusting for demographic and clinical parameters, only DG (16:0/18:2), DG (18:2/22:6), DG (18:3/18:2), DG (20:5/18:2), TAG (18:3/18:2/21:5), TAG (20:5/18:2/22:6), and LPC (22:6) were found to be significantly associated with FRS (regression coefficient of 0.17-6.02, P < 0.05). Most of these FRS associate lipid species were significantly elevated in individuals treated with E/C/F/TAF instead of individuals treated with B/F/TAF. Conclusion: E/C/F/TAF promotes the accumulation of lipid species closely associated with cardiovascular disease (CVD) risk among people living with HIV, whereas B/F/TAF has a decreased impact on CVD-related lipid profile and is associated with lower CVD risk. A graphical abstract is available with this article. Trial registration: ClinicalTrials.gov; identifier, NCT06019273.
Language	English
Publishing date	2024-03-15
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2701611-0
ISSN	2193-6382 ; 2193-8229
ISSN (online)	2193-6382
ISSN	2193-8229
DOI	10.1007/s40121-024-00943-0
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Article: [Advances in the role of autoantibodies in diabetic nephropathy: Review].

Zhou, Zhifeng / Luo, Rui / Wan, Zhikai / Kuang, Huang / Lyu, Jinlei

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

2020 Volume 36, Issue 2, Page(s) 175–179

Abstract: Diabetic nephropathy (DN) is the most common cause of global end-stage renal disease (ESRD) and is one of the leading causes of mortality in patients with type 1 and type 2 diabetes. Recent studies have found that autoimmunity is closely related to the ... ...

Abstract	Diabetic nephropathy (DN) is the most common cause of global end-stage renal disease (ESRD) and is one of the leading causes of mortality in patients with type 1 and type 2 diabetes. Recent studies have found that autoimmunity is closely related to the occurrence and development of DN, especially the autoantibodies which play a crucial role in the pathogenesis of DN. Currently, autoantibodies found in the serum of DN patients mainly include G-protein coupled receptor autoantibodies, pancreatic autoantibodies and autoantibodies related to endothelial cell damage. In the special environment of diabetes, high glucose (HG) can stimulate the production of a variety of autoantibodies, which can mediate the damage of renal function via different mechanisms and affect the progression of DN. Therefore, it is important to explore the role of autoantibodies in the pathogenesis of DN.
MeSH term(s)	Autoantibodies/immunology ; Diabetes Mellitus, Type 2/complications ; Diabetic Nephropathies/immunology ; Disease Progression ; Endothelium/pathology ; Humans
Chemical Substances	Autoantibodies
Language	Chinese
Publishing date	2020-04-20
Publishing country	China
Document type	Journal Article ; Review
ISSN	1007-8738
ISSN	1007-8738
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