Article ; Online: Unfolded protein response pathway in leishmaniasis: A review.
2023 Volume 45, Issue 11, Page(s) e13009
Abstract: Alteration in the physiological state of the endoplasmic reticulum (ER) leads to the specific response known as unfolded protein response (UPR) or ER stress response. The UPR is driven by three sensor proteins, namely: Inositol-Requiring Enzyme 1, ... ...
| Abstract | Alteration in the physiological state of the endoplasmic reticulum (ER) leads to the specific response known as unfolded protein response (UPR) or ER stress response. The UPR is driven by three sensor proteins, namely: Inositol-Requiring Enzyme 1, Protein Kinase RNA-like ER kinase and Activating Transcription Factor 6 to restore ER homeostasis. Pathogenic infection can initiate UPR activation; some pathogens can subvert the UPR to promote their survival and replication. Many intracellular pathogens, including Leishmania, can interact and hijack ER for their survival and replication, triggering ER stress and subsequently ER stress response. This review aims to provide a comprehensive overview of the ER stress response in infections with the Leishmania species. |
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| MeSH term(s) | Animals ; Unfolded Protein Response ; Endoplasmic Reticulum Stress/physiology ; Leishmaniasis/pathology ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum/pathology ; Leishmania |
| Language | English |
| Publishing date | 2023-08-11 |
| Publishing country | England |
| Document type | Journal Article ; Review |
| ZDB-ID | 424444-8 |
| ISSN | 1365-3024 ; 0141-9838 |
| ISSN (online) | 1365-3024 |
| ISSN | 0141-9838 |
| DOI | 10.1111/pim.13009 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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