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  1. Article ; Online: Kidney Disease Following Hematopoietic Stem Cell Transplantation.

    Abudayyeh, Ala / Wanchoo, Rimda

    Advances in chronic kidney disease

    2022  Volume 29, Issue 2, Page(s) 103–115.e1

    Abstract: Hematopoietic stem cell transplantation (SCT) provides a curative option for the treatment of several malignancies. Its growing use is associated with an increased burden of kidney disease. Acute kidney injury is usually seen within the first 100 days of ...

    Abstract Hematopoietic stem cell transplantation (SCT) provides a curative option for the treatment of several malignancies. Its growing use is associated with an increased burden of kidney disease. Acute kidney injury is usually seen within the first 100 days of transplantation and has an incidence ranging between 12 and 73%, with the highest rate in myeloablative allogeneic SCT. A large subset of patients after SCT develop chronic kidney disease. They can be broadly classified into thrombotic microangiopathy, nephrotic syndrome, and calcineurin toxicity. Dialysis requirement after SCT is associated with mortality exceeding 80%. Given the higher morbidity and mortality related to development kidney disease, nephrologists need to be aware of the various causes and best treatment options.
    MeSH term(s) Graft vs Host Disease/complications ; Graft vs Host Disease/therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Renal Insufficiency, Chronic/complications ; Thrombotic Microangiopathies/etiology ; Thrombotic Microangiopathies/therapy ; Transplantation Conditioning/adverse effects
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 1548-5609 ; 1548-5595
    ISSN (online) 1548-5609
    ISSN 1548-5595
    DOI 10.1053/j.ackd.2021.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4627: Show issues Location:
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  2. Article ; Online: Nirogacestat and Hypophosphatemia.

    Gudsoorkar, Prakash / Wanchoo, Rimda / Jhaveri, Kenar D

    Kidney international reports

    2023  Volume 8, Issue 7, Page(s) 1478

    Language English
    Publishing date 2023-04-29
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2023.04.023
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  3. Article ; Online: How I Manage Hypertension and Proteinuria Associated with VEGF Inhibitor.

    Rashidi, Arash / Wanchoo, Rimda / Izzedine, Hassan

    Clinical journal of the American Society of Nephrology : CJASN

    2022  Volume 18, Issue 1, Page(s) 121–123

    MeSH term(s) Humans ; Vascular Endothelial Growth Factor A/therapeutic use ; Angiogenesis Inhibitors/adverse effects ; Hypertension/drug therapy ; Proteinuria/chemically induced ; Proteinuria/drug therapy
    Chemical Substances Vascular Endothelial Growth Factor A ; Angiogenesis Inhibitors
    Language English
    Publishing date 2022-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.05610522
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  4. Article ; Online: Immune checkpoint inhibitor-associated electrolyte disorders: query of the Food and Drug Administration Adverse Event Reporting System.

    Wanchoo, Rimda / Sakhiya, Vipulbhai / Jhaveri, Kenar D

    Kidney international

    2021  Volume 100, Issue 4, Page(s) 945–947

    MeSH term(s) Adverse Drug Reaction Reporting Systems ; Drug-Related Side Effects and Adverse Reactions ; Electrolytes ; Humans ; Immune Checkpoint Inhibitors ; United States ; United States Food and Drug Administration
    Chemical Substances Electrolytes ; Immune Checkpoint Inhibitors
    Language English
    Publishing date 2021-09-23
    Publishing country United States
    Document type Letter
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2021.06.001
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  5. Article ; Online: Adverse Events Associated With Immune Checkpoint Inhibitors.

    Jhaveri, Kenar D / Wanchoo, Rimda

    JAMA

    2019  Volume 321, Issue 12, Page(s) 1218–1219

    MeSH term(s) Immunologic Factors ; Programmed Cell Death 1 Receptor
    Chemical Substances Immunologic Factors ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2019-03-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2018.22114
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  6. Article ; Online: Selinexor for Refractory Multiple Myeloma.

    Jhaveri, Kenar D / Wanchoo, Rimda

    The New England journal of medicine

    2019  Volume 381, Issue 20, Page(s) 1977

    MeSH term(s) Dexamethasone ; Humans ; Hydrazines ; Multiple Myeloma ; Triazoles
    Chemical Substances Hydrazines ; Triazoles ; selinexor (31TZ62FO8F) ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2019-10-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1912625
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  7. Article ; Online: Lorlatinib induced proteinuria: A case report.

    Lee, Chung-Shien / Wanchoo, Rimda / Seetharamu, Nagashree

    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

    2020  Volume 27, Issue 4, Page(s) 1037–1039

    Abstract: Introduction: Lorlatinib is an oral anaplastic lymphoma kinase (ALK) and C-ros oncogene (ROS1) tyrosine kinase inhibitor with excellent central nervous system (CNS) penetrability. It is currently approved for use as second line therapy for those with ... ...

    Abstract Introduction: Lorlatinib is an oral anaplastic lymphoma kinase (ALK) and C-ros oncogene (ROS1) tyrosine kinase inhibitor with excellent central nervous system (CNS) penetrability. It is currently approved for use as second line therapy for those with ALK positive non-small cell lung cancer (NSCLC). Given its CNS penetrating effects, lorlatinib has shown to cause CNS adverse events such as seizures, hallucinations, and changes in cognitive function. To our knowledge proteinuria has not been previously described with this medication.
    Case report: We report a case lorlatinib induced proteinuria in a patient receiving lorlatinib as second line treatment for ROS1 rearranged NSCLC.
    Discussion: Our case demonstrates objective evidence for proteinuria induced by lorlatinib, which may also be dose dependent.
    MeSH term(s) Aged ; Carcinoma, Non-Small-Cell Lung/blood ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Female ; Humans ; Lactams, Macrocyclic/adverse effects ; Lung Neoplasms/blood ; Lung Neoplasms/drug therapy ; Protein Kinase Inhibitors/adverse effects ; Proteinuria/blood ; Proteinuria/chemically induced ; Proteinuria/diagnosis
    Chemical Substances Lactams, Macrocyclic ; Protein Kinase Inhibitors ; lorlatinib (OSP71S83EU)
    Language English
    Publishing date 2020-09-30
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1330764-2
    ISSN 1477-092X ; 1078-1552
    ISSN (online) 1477-092X
    ISSN 1078-1552
    DOI 10.1177/1078155220961549
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    Zs.A 4488: Show issues Location:
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  8. Article: CRRT-associated ketoacidosis: A series of 5 cases.

    Parikh, Rushang / Khanin, Yuriy / Wanchoo, Rimda / Barnett, Richard / Sharma, Purva

    Clinical nephrology

    2021  Volume 98, Issue 4, Page(s) 209–216

    Abstract: Continuous renal replacement therapy (CRRT) is a dialysis modality used in critically ill patients with acute kidney injury (AKI). Although most dialysate and replacement fluids are dextrose-containing, CRRT-associated hypophosphatemia sometimes warrants ...

    Abstract Continuous renal replacement therapy (CRRT) is a dialysis modality used in critically ill patients with acute kidney injury (AKI). Although most dialysate and replacement fluids are dextrose-containing, CRRT-associated hypophosphatemia sometimes warrants the use of phosphorus-containing solutions which are dextrose free. The other less commonly used dextrose-free dialysate solutions are certain formulations of Prismasol and Prismasate. As glucose is a small molecule, which is readily cleared with dialysis, use of these solutions can result in increased caloric loss, net glucose deficit, and shifting of the metabolic pathway towards gluconeogenesis and ketogenesis. Starvation ketosis is usually a benign entity, however when combined with factors such as stress of critical illness, can produce metabolic acidosis which at times can be severe. We describe five patients who developed worsening metabolic acidosis despite adequate clearance from CRRT and were diagnosed with CRRT-associated ketoacidosis. Administration of dextrose-containing fluids or tube feeds promptly resulted in resolution of ketonemia and acidosis. Recognition of this entity is of great importance as the reflexive reaction to increase the prescribed dose of CRRT to improve the acidosis, in fact worsens the problem.
    MeSH term(s) Acidosis ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Continuous Renal Replacement Therapy ; Critical Illness/therapy ; Dialysis Solutions ; Glucose/therapeutic use ; Humans ; Ketosis/etiology ; Ketosis/therapy ; Phosphorus ; Renal Replacement Therapy/methods
    Chemical Substances Dialysis Solutions ; Phosphorus (27YLU75U4W) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2021-06-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185101-9
    ISSN 0301-0430
    ISSN 0301-0430
    DOI 10.5414/CN110460
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    Zs.A 873: Show issues Location:
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  9. Article ; Online: Onconephrology 2022: An Update.

    Bonilla, Marco / Gudsoorkar, Prakash / Wanchoo, Rimda / Herrmann, Sandra M / Jhaveri, Kenar D

    Kidney360

    2022  Volume 4, Issue 2, Page(s) 258–271

    Abstract: Onconephrology is an upcoming and expanding subspecialty that deals with the intersections between hematology/oncology and nephrology. With the paradigm shift in the understanding of cancer immunobiology and mechanisms of oncotherapeutic drug toxicities, ...

    Abstract Onconephrology is an upcoming and expanding subspecialty that deals with the intersections between hematology/oncology and nephrology. With the paradigm shift in the understanding of cancer immunobiology and mechanisms of oncotherapeutic drug toxicities, it is important for a nephrologist to have a sound understanding of this field. Over the last 5 years, there have been immense developments in our understanding of kidney-related adverse events from various targeted, immuno- and cellular-based therapies. Pathogenic mechanisms of electrolyte imbalance, hypertension (oncohypertension), and AKI from multiple forms of cancer therapies have been explored. Significant research has also been conducted in the field of transplant onconephrology. In this review, we have tried to assimilate the most recent updates in the last 2 years in this ever-growing and fascinating field.
    MeSH term(s) Humans ; Antineoplastic Agents/therapeutic use ; Neoplasms/drug therapy ; Medical Oncology ; Nephrology ; Kidney
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2022-12-09
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0001582022
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  10. Article ; Online: Chronic Kidney Disease in Cancer Survivors.

    Lee, Meghan / Wang, Qiyu / Wanchoo, Rimda / Eswarappa, Meghana / Deshpande, Priya / Sise, Meghan E

    Advances in chronic kidney disease

    2022  Volume 28, Issue 5, Page(s) 469–476.e1

    Abstract: As breakthroughs in cancer care are leading to improved long-term outcomes in a subset of advanced cancers, there is a growing population of long-term cancer survivors that are at risk of long-term complications. In this review, we summarize what is ... ...

    Abstract As breakthroughs in cancer care are leading to improved long-term outcomes in a subset of advanced cancers, there is a growing population of long-term cancer survivors that are at risk of long-term complications. In this review, we summarize what is known about chronic kidney disease in cancer survivors, focusing on the following high-risk groups: survivors of childhood cancers, stem cell transplant recipients, patients with renal cell carcinoma, patients exposed to cisplatin and other nephrotoxic chemotherapies, and patients receiving immunotherapy for cancer. As new anticancer therapies are developed, more research is needed to understand the long-term risks of kidney function decline and to devise methods to prevent chronic kidney disease.
    MeSH term(s) Cancer Survivors ; Cisplatin/adverse effects ; Humans ; Neoplasms/complications ; Neoplasms/therapy ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/therapy ; Survivors
    Chemical Substances Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1548-5609 ; 1548-5595
    ISSN (online) 1548-5609
    ISSN 1548-5595
    DOI 10.1053/j.ackd.2021.10.007
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