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  1. Article ; Online: Exploration of the Path of Innovation and Entrepreneurship Education for College Students from the Perspective of Mental Health Education.

    Wang, Beibei

    Journal of healthcare engineering

    2022  Volume 2022, Page(s) 2659160

    Abstract: Innovation and entrepreneurship education must be based on quality education to train more innovative and high-energy talents, so as to achieve mutual promotion between national development and education reform. The level of college students' ... ...

    Abstract Innovation and entrepreneurship education must be based on quality education to train more innovative and high-energy talents, so as to achieve mutual promotion between national development and education reform. The level of college students' psychological quality is the key factor that determines whether they can successfully start a business and succeed. Entrepreneurship requires college students to have the courage and boldness to prevent risks and have the courage and tolerance to face all adverse consequences in the process of entrepreneurship. With the reform of education and teaching in the new era, it has become an inevitable trend to integrate mental health education with entrepreneurship and innovation education in colleges and universities. The development of the country has a greater demand for talents, and colleges and universities are also an indispensable way for talent development and innovation and entrepreneurship education. Combined with the educational practice of contemporary college students, this paper discusses how to promote the integration of mental health education and innovation and entrepreneurship. The educational concept must be innovated in the footsteps of the times so that the two can be organically combined, which is beneficial to the educational cause and can achieve efficient and sustainable development.
    MeSH term(s) Educational Status ; Entrepreneurship ; Health Education ; Humans ; Students ; Universities
    Language English
    Publishing date 2022-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2545054-2
    ISSN 2040-2309 ; 2040-2295
    ISSN (online) 2040-2309
    ISSN 2040-2295
    DOI 10.1155/2022/2659160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The structure, self-assembly and dynamics of lipid nanodiscs revealed by computational approaches.

    Wang, Beibei / Tieleman, D Peter

    Biophysical chemistry

    2024  Volume 309, Page(s) 107231

    Abstract: Nanodisc technology is increasingly being used in structural, biochemical and biophysical studies of membrane proteins. The computational approaches have revealed many important features of nanodisc assembly, structures and dynamics. Therefore, we ... ...

    Abstract Nanodisc technology is increasingly being used in structural, biochemical and biophysical studies of membrane proteins. The computational approaches have revealed many important features of nanodisc assembly, structures and dynamics. Therefore, we reviewed the application of computational approaches, especially molecular modeling and molecular dyncamics (MD) simulations, to characterize nanodiscs, including the structural models, assembly and disassembly, protocols for modeling, structural properties and dynamics, and protein-lipid interactions in nanodiscs. More amazing computational studies about nanodiscs are looked forward to in the future.
    MeSH term(s) Nanostructures/chemistry ; Lipid Bilayers/chemistry ; Membrane Proteins/chemistry ; Models, Molecular
    Chemical Substances Lipid Bilayers ; Membrane Proteins
    Language English
    Publishing date 2024-03-29
    Publishing country Netherlands
    Document type Review ; Journal Article
    ZDB-ID 185052-0
    ISSN 1873-4200 ; 0301-4622
    ISSN (online) 1873-4200
    ISSN 0301-4622
    DOI 10.1016/j.bpc.2024.107231
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  3. Article ; Online: Regarding the risk of hypertriglyceridemic acute pancreatitis.

    Wang, Beibei / Peng, Zheng

    Pancreas

    2024  

    Language English
    Publishing date 2024-05-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632831-3
    ISSN 1536-4828 ; 0885-3177
    ISSN (online) 1536-4828
    ISSN 0885-3177
    DOI 10.1097/MPA.0000000000002361
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  4. Article ; Online: The risk factors for delayed hemothorax in patients with rib fracture in the emergency department.

    Wang, Beibei / Peng, Zheng

    The American journal of emergency medicine

    2024  

    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Letter
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2024.04.014
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  5. Article: Early neonatal complications in pregnant women with gestational diabetes mellitus and the effects of glycemic control on neonatal infection.

    Wang, Bei-Bei / Xue, Mei

    World journal of diabetes

    2023  Volume 14, Issue 9, Page(s) 1393–1402

    Abstract: Background: Gestational diabetes mellitus (GDM) has become increasingly prevalent globally. Glycemic control in pregnant women with GDM has a critical role in neonatal complications.: Aim: To analyze the early neonatal complications in GDM, and ... ...

    Abstract Background: Gestational diabetes mellitus (GDM) has become increasingly prevalent globally. Glycemic control in pregnant women with GDM has a critical role in neonatal complications.
    Aim: To analyze the early neonatal complications in GDM, and examine the effect of blood glucose control level on neonatal infection.
    Methods: The clinical data of 236 pregnant women with GDM and 240 healthy pregnant women and newborns during from March 2020 to December 2021 the same period were retrospectively analyzed, and the early complications in newborns in the two groups were compared. The patients were divided into the conforming glycemic control group (CGC group) and the non-conforming glycemic control group (NCGC group) based on whether glycemic control in the pregnant women with GDM conformed to standards. Baseline data, immune function, infection-related markers, and infection rates in neonates were compared between the two groups.
    Results: The incidence of neonatal complications in the 236 neonates in the GDM group was significantly higher than that in the control group (
    Conclusion: The risk of neonatal complications increased in pregnant women with GDM. Poor glycemic control decreased neonatal immune function, and increased the incidence of neonatal infections.
    Language English
    Publishing date 2023-08-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2583471-X
    ISSN 1948-9358
    ISSN 1948-9358
    DOI 10.4239/wjd.v14.i9.1393
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  6. Article ; Online: Release of nanodiscs from charged nano-droplets in the electrospray ionization revealed by molecular dynamics simulations.

    Wang, Beibei / Tieleman, D Peter

    Communications chemistry

    2023  Volume 6, Issue 1, Page(s) 21

    Abstract: Electrospray ionization (ESI) is essential for application of mass spectrometry in biological systems, as it prevents the analyte being split into fragments. However, due to lack of a clear understanding of the mechanism of ESI, the interpretation of ... ...

    Abstract Electrospray ionization (ESI) is essential for application of mass spectrometry in biological systems, as it prevents the analyte being split into fragments. However, due to lack of a clear understanding of the mechanism of ESI, the interpretation of mass spectra is often ambiguous. This is a particular challenge for complex biological systems. Here, we focus on systems that include nanodiscs as membrane environment, which are essential for membrane proteins. We performed microsecond atomistic molecular dynamics simulations to study the release of nanodiscs from highly charged nano-droplets into the gas phase, the late stage of ESI. We observed two distinct major scenarios, highlighting the diversity of morphologies of gaseous product ions. Our simulations are in reasonable agreement with experimental results. Our work provides a detailed atomistic view of the ESI process of a heterogeneous system (lipid nanodisc), which may give insights into the interpretation of mass spectra of all lipid-protein systems.
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2929562-2
    ISSN 2399-3669 ; 2399-3669
    ISSN (online) 2399-3669
    ISSN 2399-3669
    DOI 10.1038/s42004-023-00818-4
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  7. Article ; Online: Progress of CRISPR-based programmable RNA manipulation and detection.

    Wang, Beibei / Yang, Hui

    Wiley interdisciplinary reviews. RNA

    2023  Volume 14, Issue 6, Page(s) e1804

    Abstract: Prokaryotic clustered regularly interspaced short palindromic repeats and CRISPR associated (CRISPR-Cas) systems provide adaptive immunity by using RNA-guided endonucleases to recognize and eliminate invading foreign nucleic acids. Type II Cas9, type V ... ...

    Abstract Prokaryotic clustered regularly interspaced short palindromic repeats and CRISPR associated (CRISPR-Cas) systems provide adaptive immunity by using RNA-guided endonucleases to recognize and eliminate invading foreign nucleic acids. Type II Cas9, type V Cas12, type VI Cas13, and type III Csm/Cmr complexes have been well characterized and developed as programmable platforms for selectively targeting and manipulating RNA molecules of interest in prokaryotic and eukaryotic cells. These Cas effectors exhibit remarkable diversity of ribonucleoprotein (RNP) composition, target recognition and cleavage mechanisms, and self discrimination mechanisms, which are leveraged for various RNA targeting applications. Here, we summarize the current understanding of mechanistic and functional characteristics of these Cas effectors, give an overview on RNA detection and manipulation toolbox established so far including knockdown, editing, imaging, modification, and mapping RNA-protein interactions, and discuss the future directions for CRISPR-based RNA targeting tools. This article is categorized under: RNA Methods > RNA Analyses in Cells RNA Processing > RNA Editing and Modification RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications.
    MeSH term(s) RNA/genetics ; Gene Editing/methods ; CRISPR-Cas Systems ; Ribonucleoproteins/genetics
    Chemical Substances RNA (63231-63-0) ; Ribonucleoproteins
    Language English
    Publishing date 2023-06-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2634714-3
    ISSN 1757-7012 ; 1757-7004
    ISSN (online) 1757-7012
    ISSN 1757-7004
    DOI 10.1002/wrna.1804
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  8. Article ; Online: Low temperature synthesis of chiral carbon dots for reducing H

    Wang, Beibei / Wang, Yuying / Zhang, Xiaoyang / Liu, Yi

    Colloids and surfaces. B, Biointerfaces

    2024  Volume 235, Page(s) 113784

    Abstract: Recently, researches focused towards the chiral nanostructures have attracted vast attention. However, the synthesis of chiral carbon dots (CDs) through one-step method is still rather scarce. Herein, a universal approach to green synthesis of chiral CDs ...

    Abstract Recently, researches focused towards the chiral nanostructures have attracted vast attention. However, the synthesis of chiral carbon dots (CDs) through one-step method is still rather scarce. Herein, a universal approach to green synthesis of chiral CDs at low temperature was proposed. In brief, L-FruCDs and D-FruCDs were obtained by only heating the fructose and chiral cysteine molecules in the sodium hydroxide aqueous solution under atmospheric pressure. Circular dichroism spectra show that these prepared CDs exhibit opposite chirality ranging from 210 to 260 nm. Specially, the prepared L-FruCDs could reduce the intracellular oxidative damage induced by hydrogen peroxide and display a superior performance than that of D-FruCDs. Mechanism studies indicate that the probably protect mechanism is ascribed to the directly consumption the intracellular ROS. And the clearance efficiency of intracellular reactive oxygen species of L-FruCDs is 3-times than that of D-FruCDs. Furthermore, this newly synthesized method is scalable by replacing fructose precursor with ascorbic acid, sucrose or lactose. In sum, our work provides a new method for the preparation of chiral CDs and achieve a great success in exploring the chiral biological effects at nanoscale.
    MeSH term(s) Carbon/chemistry ; Hydrogen Peroxide ; Quantum Dots/chemistry ; Temperature ; Fructose
    Chemical Substances Carbon (7440-44-0) ; Hydrogen Peroxide (BBX060AN9V) ; Fructose (30237-26-4)
    Language English
    Publishing date 2024-02-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2024.113784
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  9. Article ; Online: Comparison of the effectiveness of different normalization methods for metagenomic cross-study phenotype prediction under heterogeneity.

    Wang, Beibei / Sun, Fengzhu / Luan, Yihui

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 7024

    Abstract: The human microbiome, comprising microorganisms residing within and on the human body, plays a crucial role in various physiological processes and has been linked to numerous diseases. To analyze microbiome data, it is essential to account for inherent ... ...

    Abstract The human microbiome, comprising microorganisms residing within and on the human body, plays a crucial role in various physiological processes and has been linked to numerous diseases. To analyze microbiome data, it is essential to account for inherent heterogeneity and variability across samples. Normalization methods have been proposed to mitigate these variations and enhance comparability. However, the performance of these methods in predicting binary phenotypes remains understudied. This study systematically evaluates different normalization methods in microbiome data analysis and their impact on disease prediction. Our findings highlight the strengths and limitations of scaling, compositional data analysis, transformation, and batch correction methods. Scaling methods like TMM show consistent performance, while compositional data analysis methods exhibit mixed results. Transformation methods, such as Blom and NPN, demonstrate promise in capturing complex associations. Batch correction methods, including BMC and Limma, consistently outperform other approaches. However, the influence of normalization methods is constrained by population effects, disease effects, and batch effects. These results provide insights for selecting appropriate normalization approaches in microbiome research, improving predictive models, and advancing personalized medicine. Future research should explore larger and more diverse datasets and develop tailored normalization strategies for microbiome data analysis.
    MeSH term(s) Humans ; Microbiota/genetics ; Metagenome ; Metagenomics ; Research Design ; Phenotype
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-57670-2
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  10. Article ; Online: The RNA-binding protein sorbin and SH3 domain-containing 2 are transcriptionally regulated by specificity protein 1 and function as tumor suppressors in bladder cancer by stabilizing tissue factor pathway inhibitor.

    Wang, Beibei / Fan, Xin / Wang, Lingang / Wei, Xiaosong

    Molecular carcinogenesis

    2024  

    Abstract: Sorbin and SH3 domain-containing 2 (SORBS2) is an RNA-binding protein and has been implicated in the development of some cancers. However, its role in bladder cancer (BC) is yet to be established. The expression of SORBS2 in BC tissues was determined ... ...

    Abstract Sorbin and SH3 domain-containing 2 (SORBS2) is an RNA-binding protein and has been implicated in the development of some cancers. However, its role in bladder cancer (BC) is yet to be established. The expression of SORBS2 in BC tissues was determined from the Gene Expression Omnibus and Gene Expression Profiling Interactive Analysis databases and collected paired tumor/normal samples. The effects of SORBS2 on BC cells were detected by CCK-8, colony formation, Transwell, dual-luciferase, RNA immunoprecipitation, chromatin immunoprecipitation, and DNA pull-down assays. In vivo, BC cell growth and metastasis were studied by a xenograft subcutaneous model and a tail-vein metastasis model. The results showed that SORBS2 expression was significantly decreased in BC tissues and cells. SORBS2 overexpression inhibited cell proliferation, migration, invasion, and epithelial-mesenchymal transition in vitro and tumor growth and metastasis in vivo, while silencing SORBS2 produced the opposite effect. Mechanistically, we found that SORBS2 enhanced the stability of tissue factor pathway inhibitor (TFPI) mRNA via direct binding to its 3' UTR. Restoration of TFPI expression reversed SORBS2 knockdown-induced malignant phenotypes of BC cells. In addition, SORBS2 expression was negatively regulated by the transcription factor specificity protein 1 (SP1). Conversely, SORBS2 can be transcriptionally regulated by SP1 and inhibit BC cell growth and metastasis via stabilization of TFPI mRNA, indicating SORBS2 may be a promising therapeutic target for BC.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1004029-8
    ISSN 1098-2744 ; 0899-1987
    ISSN (online) 1098-2744
    ISSN 0899-1987
    DOI 10.1002/mc.23717
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