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  1. Book ; Online ; E-Book: Computational Intelligence in Protein-Ligand Interaction Analysis

    Wang, Bing / Chen, Peng / Zhang, Jun

    2024  

    Subject code 572.6
    Language English
    Size 1 online resource (280 pages)
    Edition 1st ed.
    Publisher Elsevier Science & Technology
    Publishing place San Diego
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 9780128244357 ; 0128244356
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Article ; Online: Automatic pterygopalatine fossa segmentation and localisation based on DenseASPP.

    Wang, Bing / Shi, Weili

    The international journal of medical robotics + computer assisted surgery : MRCAS

    2024  Volume 20, Issue 2, Page(s) e2633

    Abstract: Background: Allergic rhinitis constitutes a widespread health concern, with traditional treatments often proving to be painful and ineffective. Acupuncture targeting the pterygopalatine fossa proves effective but is complicated due to the intricate ... ...

    Abstract Background: Allergic rhinitis constitutes a widespread health concern, with traditional treatments often proving to be painful and ineffective. Acupuncture targeting the pterygopalatine fossa proves effective but is complicated due to the intricate nearby anatomy.
    Methods: To enhance the safety and precision in targeting the pterygopalatine fossa, we introduce a deep learning-based model to refine the segmentation of the pterygopalatine fossa. Our model expands the U-Net framework with DenseASPP and integrates an attention mechanism for enhanced precision in the localisation and segmentation of the pterygopalatine fossa.
    Results: The model achieves Dice Similarity Coefficient of 93.89% and 95% Hausdorff Distance of 2.53 mm with significant precision. Remarkably, it only uses 1.98 M parameters.
    Conclusions: Our deep learning approach yields significant advancements in localising and segmenting the pterygopalatine fossa, providing a reliable basis for guiding pterygopalatine fossa-assisted punctures.
    MeSH term(s) Humans ; Pterygopalatine Fossa/diagnostic imaging ; Pterygopalatine Fossa/anatomy & histology ; Deep Learning ; Algorithms ; Rhinitis, Allergic/diagnostic imaging ; Rhinitis, Allergic/therapy ; Imaging, Three-Dimensional/methods ; Tomography, X-Ray Computed/methods ; Image Processing, Computer-Assisted/methods ; Reproducibility of Results
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2151860-9
    ISSN 1478-596X ; 1478-5951
    ISSN (online) 1478-596X
    ISSN 1478-5951
    DOI 10.1002/rcs.2633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Solution for sports image classification using modified MobileNetV3 optimized by modified battle royal optimization algorithm.

    Wang, Bing / Rezaei Sofla, Asad

    Heliyon

    2023  Volume 9, Issue 11, Page(s) e21603

    Abstract: Sports image classification using image processing and machine vision is a growing area of research that involves the use of algorithms and techniques to identify and analyze objects in sports images and videos. This technology has a wide range of ... ...

    Abstract Sports image classification using image processing and machine vision is a growing area of research that involves the use of algorithms and techniques to identify and analyze objects in sports images and videos. This technology has a wide range of applications, including detecting illegal plays, analyzing team performance, and creating highlight reels. Additionally, it can provide valuable visual feedback during training and competition. In this paper, we propose a novel deep learning and optimization hybrid framework for sports image classification. Specifically, we use a modified version of the Battle Royal optimization algorithm as a feature selector to reduce the dimensionality of the images and achieve higher accuracy with only the essential features. We evaluate the proposed framework using sports images and demonstrate that our WOA-based framework outperforms other methods in terms of both classification accuracy and dimensionality reduction. Our results highlight the effectiveness of the proposed approach and its potential to improve sports image classification.
    Language English
    Publishing date 2023-10-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e21603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Clinical characteristics and prognostic nomogram analysis of patients with dual primary cancers with first gastric cancer: a retrospective study in China.

    Wang, Bing / Liu, Lu

    PeerJ

    2023  Volume 11, Page(s) e15278

    Abstract: Background: With the improvement in diagnosis and treatment of gastric cancer (GC), the survival time of patients has been gradually prolonged. However, these survivors are at increased risk for other diseases, including second primary cancers (SPCs). ... ...

    Abstract Background: With the improvement in diagnosis and treatment of gastric cancer (GC), the survival time of patients has been gradually prolonged. However, these survivors are at increased risk for other diseases, including second primary cancers (SPCs). Currently, there remain few central studies concerning double primary cancers with first gastric cancer (DPCFGC). Thus, this study aimed to investigate these patients' clinical characteristics and perform prognostic nomogram analysis.
    Methods: The clinical data of 78 DPCFGC patients were retrospectively collected and analyzed through the hospital electronic medical record system. Univariate and multivariate Cox regression analyses were performed to screen independent risk factors, based on which the prognostic nomogram was further constructed and validated using the R software package. Finally, Kaplan-Meier curves were plotted to explore the association of overall survival (OS) with prognostic factors and the model.
    Results: The prevalence of DPCFGC was 0.86%, of which the proportions of synchronous and metachronous patients were 47.44% and 52.56% , respectively; 65.38% (51/78) and 34.62% (27/78) of patients were male and female, respectively. The median age at GC and SPC diagnosis was 63 and 65 years, respectively, and 52.57% of GC patients developed SPCs within 1 year. The top three SPCs were in the esophagus (19.24%), colon (16.67%), and rectum (15.39%). The most common features of GC and SPCs were adenocarcinoma, poorly and moderately differentiated histology, and pathological stages I and II. The radical resection rate of GC was significantly lower in synchronous patients than in metachronous patients (45.94% vs. 100.00%,
    Conclusions: During follow-up, clinicians should attach great importance to the screening of GC survivors, especially at early stage in older men within 1 year after diagnosis, and be alert to the possibility of occurrent digestive system malignancies. The nomogram constructed in this study can provide a theoretical basis for the early clinical development of individualized treatment plans.
    MeSH term(s) Humans ; Male ; Female ; Aged ; Prognosis ; Nomograms ; Retrospective Studies ; Stomach Neoplasms/diagnosis ; Neoplasms, Second Primary/diagnosis ; China/epidemiology
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.15278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Network Medical Framework based on Inflammatory Genes to Identify Drug Candidates for Abdominal Aortic Aneurysms.

    Niu, Xiaoyang / Wang, Bing

    Current molecular pharmacology

    2023  Volume 17, Issue 1, Page(s) e170523216998

    Abstract: Background: Clinically, abdominal aortic aneurysms (AAA) can be treated with surgical intervention, but there is currently no effective drug for the disease.: Methods: This study analyzed the biomedical data of single-cell RNA sequencing (scRNA-seq), ...

    Abstract Background: Clinically, abdominal aortic aneurysms (AAA) can be treated with surgical intervention, but there is currently no effective drug for the disease.
    Methods: This study analyzed the biomedical data of single-cell RNA sequencing (scRNA-seq), RNA-seq and the network medical data of drug-target interaction as well as protein-protein interaction to identify key targets and potential drug compounds of AAA.
    Results: Firstly, we identified 10 types of cells from AAA and nonaneurysmal control samples and screened monocyte, mast cell, smooth muscle cell and 327 genes showing significant differences between non-dilated PVATs and dilated PVATs. To further explore the association of three types of cells in AAA, we screened the common DEGs associated with the three types of cells and then identified 10 potential therapeutic targets for AAA. SLC2A3 and IER3 were the key targets that were the most closely related to immune score and significantly related to inflammatory pathways. We then designed a network-based proximity measure to identify potential drugs targeting SLC2A3. Finally, with computer simulation, we found that the compound with the highest affinity to SLC2A3 protein was DB08213, which was embedded into the SLC2A3 protein cavity and formed close contact with various amino acid residues, and was stable during the 100-ns MD simulation.
    Conclusion: This study provided a computational framework for drug design and development. It revealed key targets and potential therapeutic drug compounds for AAA, which might contribute to the drug development for AAA.
    MeSH term(s) Humans ; Computer Simulation ; Glucose Transporter Type 3 ; Aortic Aneurysm, Abdominal/drug therapy ; Aortic Aneurysm, Abdominal/genetics ; Drug Delivery Systems ; Drug Design
    Chemical Substances Glucose Transporter Type 3
    Language English
    Publishing date 2023-05-17
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1874-4702
    ISSN (online) 1874-4702
    DOI 10.2174/1874467217666230517104426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Homogenization of Functional Diversity of Rotifer Communities in Relation to Eutrophication in an Urban River of North China.

    Wang, Bing / Yin, Xuwang

    Biology

    2023  Volume 12, Issue 12

    Abstract: Rapid urbanization has triggered nutrient loading, which will inevitably lead to the eutrophication of water bodies and further affect the structure of aquatic populations. At present, eutrophication is a significant challenge for urban aquatic ... ...

    Abstract Rapid urbanization has triggered nutrient loading, which will inevitably lead to the eutrophication of water bodies and further affect the structure of aquatic populations. At present, eutrophication is a significant challenge for urban aquatic ecosystems. However, we still know little about the correlation between eutrophication in urban rivers and the composition of aquatic functional groups. The effects of urban river eutrophication on rotifer communities were investigated using an annual field survey of the Jinan section of the Xiaoqing River, a typical urban river in northern China. Using functional diversity (FD) and beta diversity, the spatiotemporal variation of the aquatic biological functional groups regime along stretches subject to different eutrophication was investigated. The functional evenness (FEve) and functional divergence (FDiv) decreased significantly with the increment of the trophic level index. Functional diversity exhibits an extremely low level across functional groups, with the richness difference (RichDiff) being an important component. The results indicate that eutrophication led to the homogenization of rotifer communities. This can be attributed to the functional homogenization of the rotifer community in the Jinan section of the Xiaoqing River. The observed homogenization may be due to widely distributed species complementing the ecological niche space. Our findings provide valuable information on the conservation of the urban river under the threat of eutrophication caused by high-intensity human activities.
    Language English
    Publishing date 2023-12-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12121488
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  7. Article ; Online: A new era for equity in meningococcal disease prevention.

    Wang, Bing / Marshall, Helen S

    The Lancet. Infectious diseases

    2023  Volume 23, Issue 12, Page(s) 1329–1330

    MeSH term(s) Humans ; Meningococcal Infections/epidemiology ; Meningococcal Infections/prevention & control ; Neisseria meningitidis ; Meningococcal Vaccines
    Chemical Substances Meningococcal Vaccines
    Language English
    Publishing date 2023-08-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00232-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
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  8. Article ; Online: π-Extended Octupolar Cyclized Indole Tetramer and Trimer Derivatives with Second- and Third-Order Nonlinear Optical Properties.

    Wang, Bing / Fang, Qi

    The Journal of organic chemistry

    2023  Volume 88, Issue 9, Page(s) 5520–5529

    Abstract: Several aromatic-fused octupolar tetraindole (TTI) and triindole (TI) derivatives have been synthesized via ... ...

    Abstract Several aromatic-fused octupolar tetraindole (TTI) and triindole (TI) derivatives have been synthesized via POCl
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c00072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
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  9. Article ; Online: Comparative transcriptome analysis of the antenna and proboscis reveals feeding state-dependent chemosensory genes in

    Chen, Ruipeng / Ai, Dong / Wang, Guirong / Wang, Bing

    Open biology

    2024  Volume 14, Issue 1, Page(s) 230208

    Abstract: The physiological state of an insect can affect its olfactory system. However, the molecular mechanism underlying the effect of nutrition-dependent states on odour-guided behaviours in hoverflies remains unclear. In this study, comparative transcriptome ... ...

    Abstract The physiological state of an insect can affect its olfactory system. However, the molecular mechanism underlying the effect of nutrition-dependent states on odour-guided behaviours in hoverflies remains unclear. In this study, comparative transcriptome analysis of the antenna and proboscis from
    MeSH term(s) Female ; Male ; Humans ; Transcriptome ; Gene Expression Profiling ; Drosophila Proteins
    Chemical Substances Drosophila Proteins
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2630944-0
    ISSN 2046-2441 ; 2046-2441
    ISSN (online) 2046-2441
    ISSN 2046-2441
    DOI 10.1098/rsob.230208
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  10. Article ; Online: Investment analysis of the private firm under different financial arrangements in infrastructure projects.

    Ding, Qianxing / Huang, Shanshan / Fu, Guohua / Wang, Bing

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0287418

    Abstract: This study investigates the impact of various financial arrangements on the investment behavior of the private firm in PPP (Public-Private Partnership) projects. The results manifest that: first, the private firm will invest in the project earlier under ... ...

    Abstract This study investigates the impact of various financial arrangements on the investment behavior of the private firm in PPP (Public-Private Partnership) projects. The results manifest that: first, the private firm will invest in the project earlier under long-term debt financing than under short-term debt financing or all equity financing; second, the investment boundary of the private sector decreasing with the probability of obtaining long-term debt financing under short-term debt financing, while increasing with the probability of obtaining long-term debt financing under long-term debt financing; third, the optimal debt level under short-term debt financing displays a U-shaped relationship with the refinancing risk probability; fourth, under short-term debt financing, the difference in the optimal capital structure between projects with different volatility of cash flow is larger when the refinancing risk probability is lower; and fifth, the private firm may exit the project earlier under short-term debt financing than under long-term debt financing. These results can help us to understand the investment behavior of the private firm under different financial arrangements.
    MeSH term(s) Investments ; Public-Private Sector Partnerships ; Probability ; Financial Statements
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0287418
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