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Article ; Online: An electrochemical biosensor for

Wang, Caiyun / Yang, Rui / Wang, Guangtong / Liu, Shaoqin

2024 Volume 149, Issue 9, Page(s) 2594–2599

Abstract: Detection of pathogens is one of the key concerns for hospitals, the food industry, water suppliers, or other environmental engineering practices because pathogens can cause a wide range of infectious risks. ...

Abstract	Detection of pathogens is one of the key concerns for hospitals, the food industry, water suppliers, or other environmental engineering practices because pathogens can cause a wide range of infectious risks.
MeSH term(s)	Staphylococcus aureus/isolation & purification ; Biosensing Techniques/methods ; Milk/microbiology ; Limit of Detection ; Electrochemical Techniques/methods ; Nanostructures/chemistry ; Humans ; Animals ; Electrodes ; Surface Properties
Language	English
Publishing date	2024-04-29
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d4an00197d
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Article ; Online: Effects of hydrocolloids and oleogel on techno-functional properties of dairy foods.

Zhang, Shan / Ren, Chuanying / Wang, Caiyun / Han, Renjiao / Xie, Siyu

Food chemistry: X

2024 Volume 21, Page(s) 101215

Abstract: This paper aims to overview the influence of different gels that including hydrocolloids and oleogel on techno-functional changes of dairy foods. The hydrocolloids are widely added to dairy products as stabilizers, emulsifiers, and gelling agents to ... ...

Abstract	This paper aims to overview the influence of different gels that including hydrocolloids and oleogel on techno-functional changes of dairy foods. The hydrocolloids are widely added to dairy products as stabilizers, emulsifiers, and gelling agents to enhance their texture, or improve sensory properties to meet consumer needs; and the newly developed oleogel, which despite less discussed in dairy foods, this article lists its application in different dairy products. The properties of different hydrocolloids were explained in detail, meanwhile, some common hydrocolloids such as pectin, sodium alginate, carrageenan along with the interaction between gel and proteins on techno-functional properties of dairy products were mainly discussed. What's more, the composition of oleogel and its influence on dairy foods were briefly summarized. The key issues have been revealed that the use of both hydrocolloids and oleogel has great potential to be the future trend to improve the quality of dairy foods effectively.
Language	English
Publishing date	2024-02-10
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2590-1575
ISSN (online)	2590-1575
DOI	10.1016/j.fochx.2024.101215
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Article ; Online: Imazalil resulted in glucolipid metabolism disturbance and abnormal m

Jin, Cuiyuan / Wang, Caiyun / Zhang, Chen / Ye, Qi / Jin, Yuanxiang / Shi, Liyun

Ecotoxicology and environmental safety

2024 Volume 271, Page(s) 115963

Abstract: As a fungicide with the characteristics of high effectiveness, internal absorption and broad spectrum, imazalil is widely used to prevent and treat in fruits and vegetables. Here, pregnant C57BL/6 mice were exposed to imazalil at dietary levels of 0, 0 ... ...

Abstract	As a fungicide with the characteristics of high effectiveness, internal absorption and broad spectrum, imazalil is widely used to prevent and treat in fruits and vegetables. Here, pregnant C57BL/6 mice were exposed to imazalil at dietary levels of 0, 0.025‰, and 0.25‰ through drinking water during pregnancy and lactation. We then analyzed the phenotype, metabolome, and expression of related genes and proteins in the livers of mice. There was a marked decrease in the body and liver weights of male offspring mice after maternal imazalil exposure, while this effect on the dam and female offspring was slight. Metabolomics analyses revealed that imazalil significantly altered the metabolite composition of liver samples from both dams and offspring. The preliminary results of the analysis indicated that glucolipid metabolism was the pathway most significantly affected by imazalil. We performed a coabundance association analysis of metabolites with significant changes in the pathway of glycolipid metabolism, and IMZ altered the networks of both dams and offspring compared with the network in control mice, especially in male offspring. The hepatic triglyceride, non-esterified fatty acid and glucose levels were increased significantly in the dams but decreased significantly in male offspring after maternal imazalil exposure. Furthermore, the expression levels of genes associated with glycolipid metabolism and m
MeSH term(s)	Pregnancy ; Mice ; Male ; Female ; Animals ; RNA Methylation ; Mice, Inbred C57BL ; Liver/metabolism ; Glycolipids/metabolism ; Imidazoles
Chemical Substances	enilconazole (6K0NOF3XQ6) ; Glycolipids ; Imidazoles
Language	English
Publishing date	2024-01-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2024.115963
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Article ; Online: Circular RNA_0025843 Alleviated Cigarette Smoke Extract Induced Bronchoalveolar Epithelial Cells Ferroptosis.

Chen, Jia / Deng, Xiaoyu / Xie, Hansheng / Wang, Caiyun / Huang, Jiefeng / Lian, Ningfang

International journal of chronic obstructive pulmonary disease

2024 Volume 19, Page(s) 363–374

Abstract: Purpose: Circular RNA (circRNA) plays an important role in various biological processes. However, their functions in cigarette smoke extract (CSE) induced human normal lung epithelial cells (BEAS-2B) injury remain vague. The study aimed to explore ... ...

Abstract	Purpose: Circular RNA (circRNA) plays an important role in various biological processes. However, their functions in cigarette smoke extract (CSE) induced human normal lung epithelial cells (BEAS-2B) injury remain vague. The study aimed to explore circRNA expression profiles and reveal their potential roles in CSE-treated BEAS-2B cells. Methods: 5% CSE exposure for 24 hours were used to build the BEAS-2B cells ferroptosis model. Differentially expressed circRNAs (DECs) were identified by next-generation RNA sequencing. Six randomly selected DECs were validated via quantitative reverse transcription polymerase chain reaction (qRT-PCR). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and Gene Ontology (GO) analysis were conducted to clarify the potential functions of the DECs. Furthermore, the role of hsa_circ_0025843 in CSE-related BEAS-2B cells ferroptosis was confirmed. Results: 5% CSE exposure induced BEAS-2B cells ferroptosis. Fifty-one up-regulated cirRNAs and 80 down-regulated circRNAs were revealed in CSE-treated BEAS-2B cells. Hsa_circ_0003461, hsa_circ_0007548, hsa_circ_0025843, hsa_circ_0068896, hsa_circ_0005832, and hsa_circ_0053378 were selected randomly to validate the reliability of next-generation RNA sequencing by qRT-PCR. After KEGG pathway analysis, DECs were found to participate in the process of EGFR tyrosine kinase inhibitor resistance and glycerophospholipid metabolism. The knockdown of hsa_circ_0025843 significantly alleviated CSE-induced BEAS-2B cells ferroptosis. Conclusion: The study indicated the circRNA expression profiles in CSE-treated BEAS-2B cells. Hsa_circ_0025843 alleviated CSE induced BEAS-2B cells ferroptosis, which might be a potential therapeutic target of CSE related lung injury.
MeSH term(s)	Humans ; RNA, Circular/genetics ; Reproducibility of Results ; Cigarette Smoking/adverse effects ; Ferroptosis/genetics ; Pulmonary Disease, Chronic Obstructive ; RNA/genetics ; Epithelial Cells/metabolism ; MicroRNAs/genetics
Chemical Substances	RNA, Circular ; RNA (63231-63-0) ; MicroRNAs
Language	English
Publishing date	2024-02-03
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2212419-6
ISSN	1178-2005 ; 1176-9106
ISSN (online)	1178-2005
ISSN	1176-9106
DOI	10.2147/COPD.S444402
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Article ; Online: Construction by artificial intelligence and immunovalidation of hypoallergenic mite allergen Der f 36 vaccine.

Qin, Qiao-Zhi / Tang, Jian / Wang, Cai-Yun / Xu, Zhi-Qiang / Tian, Man

Frontiers in immunology

2024 Volume 15, Page(s) 1325998

Abstract: Background: The house dust mite (HDM) is widely recognized as the most prevalent allergen in allergic diseases. Allergen-specific immunotherapy (AIT) has been successfully implemented in clinical treatment for HDM. Hypoallergenic B-cell epitope-based ... ...

Abstract	Background: The house dust mite (HDM) is widely recognized as the most prevalent allergen in allergic diseases. Allergen-specific immunotherapy (AIT) has been successfully implemented in clinical treatment for HDM. Hypoallergenic B-cell epitope-based vaccine designed by artificial intelligence (AI) represents a significant progression of recombinant hypoallergenic allergen derivatives. Method: The three-dimensional protein structure of Der f 36 was constructed using Alphafold2. AI-based tools were employed to predict B-cell epitopes, which were subsequently verified through IgE-reaction testing. Hypoallergenic Der f 36 was then synthesized, expressed, and purified. The reduced allergenicity was assessed by enzyme-linked immunosorbent assay (ELISA), immunoblotting, and basophil activation test. T-cell response to hypoallergenic Der f 36 and Der f 36 was evaluated based on cytokine expression in the peripheral blood mononuclear cells (PBMCs) of patients. The immunogenicity was evaluated and compared through rabbit immunization with hypoallergenic Der f 36 and Der f 36, respectively. The inhibitory effect of the blocking IgG antibody on the specific IgE-binding activity and basophil activation of Der f 36 allergen was also examined. Results: The final selected non-allergic B-cell epitopes were 25-48, 57-67, 107-112, 142-151, and 176-184. Hypoallergenic Der f 36 showed significant reduction in IgE-binding activity. The competitive inhibition of IgE-binding to Der f 36 was investigated using the hypoallergenic Der f 36, and only 20% inhibition could be achieved, which is greatly reduced when compared with inhibition by Der f 36 (98%). The hypoallergenic Der f 36 exhibited a low basophil-stimulating ratio similar to that of the negative control, and it could induce an increasing level of IFN-γ but not Th2 cytokines IL-5 and IL-13 in PBMCs. The vaccine-specific rabbit blocking IgG antibodies could inhibit the patients' IgE binding and basophil stimulation activity of Derf 36. Conclusion: This study represents the first application of an AI strategy to facilitate the development of a B-cell epitope-based hypoallergenic Der f 36 vaccine, which may become a promising immunotherapy for HDM-allergic patients due to its reduced allergenicity and its high immunogenicity in inducing blocking of IgG.
MeSH term(s)	Animals ; Humans ; Rabbits ; Epitopes, B-Lymphocyte ; Leukocytes, Mononuclear ; Artificial Intelligence ; Immunoglobulin E ; Arthropod Proteins ; Vaccines ; Hypersensitivity/therapy ; Allergens ; Pyroglyphidae ; Dermatophagoides pteronyssinus ; Cytokines/metabolism ; Immunoglobulin G
Chemical Substances	Epitopes, B-Lymphocyte ; Immunoglobulin E (37341-29-0) ; Arthropod Proteins ; Vaccines ; Allergens ; Cytokines ; Immunoglobulin G
Language	English
Publishing date	2024-03-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1325998
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Article ; Online: Unraveling volatilomics profiles of milk products from diverse regions in China.

Huang, Yun / Cao, Hongfang / Pan, Minghui / Wang, Caiyun / Sun, Baoguo / Ai, Nasi

Food research international (Ottawa, Ont.)

2024 Volume 179, Page(s) 114006

Abstract: To distinguish Chinese milks from different regions, 13 milk samples were gathered from 13 regions of China in this study: Inner Mongolia (IM), Xinjiang (XJ), Hebei (HB), Shanghai (SH), Beijing (BJ), Sichuan (SC), Ningxia (NX), Henan (HN), Tianjin (TJ), ... ...

Abstract	To distinguish Chinese milks from different regions, 13 milk samples were gathered from 13 regions of China in this study: Inner Mongolia (IM), Xinjiang (XJ), Hebei (HB), Shanghai (SH), Beijing (BJ), Sichuan (SC), Ningxia (NX), Henan (HN), Tianjin (TJ), Qinghai (QH), Yunnan (YN), Guangxi (GX), and Tibet (XZ). Headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry (HS-SPME-GC-MS) combined with the electronic nose (E-nose) technology, was used to detect and analyze the volatile compounds in these milk samples. The qualitative and quantitative results identified 29 volatile chemicals, and we established a database of flavor profiles for the main milk-producing regions in China. E-nose analysis revealed variations in the odor of milk across different areas. Furthermore, results from partial least squares discriminant analysis (PLS-DA) and odor activity values (OAVs) suggested that seven volatile compounds: decane, 2-heptanone, 2-undecanone, 2-nonanone, 1-hexadecanol, 1-octen-3-ol, and (E)-2-nonenal, could be considered as key flavor compounds in Chinese milk products.
MeSH term(s)	Animals ; Milk/chemistry ; China ; Gas Chromatography-Mass Spectrometry/methods ; Odorants/analysis ; Discriminant Analysis
Language	English
Publishing date	2024-01-09
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2024.114006
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Article: Potential uses of milk proteins as encapsulation walls for bioactive compounds: A review

Xie, Siyu / Qu, Peng / Luo, Shubo / Wang, Caiyun

American Dairy Science Association Journal of dairy science. 2022 May 11,

2022

Abstract: Milk proteins have received much awareness due to their bioactivity. However, their encapsulation functions have not attracted enough attention. Milk proteins as encapsulation walls can increase the bioavailability of bioactive compounds. As the benefits ...

Abstract	Milk proteins have received much awareness due to their bioactivity. However, their encapsulation functions have not attracted enough attention. Milk proteins as encapsulation walls can increase the bioavailability of bioactive compounds. As the benefits of bioactive compounds are critically determined by bioavailability, the effect of interactions between milk proteins and active substances is a critical topic. In the present review, we summarize the effects of milk proteins as encapsulation walls on the bioavailability of active substances with a special focus. The methods and mechanisms of interactions between milk proteins and active substances are also discussed. The evidence collected in the present review suggests that when active substances are encapsulated by milk proteins, the bioavailability of active substances can be significantly affected. This review also provides valuable guidelines for the use of milk protein-based microcarriers.
Keywords	bioactive properties ; bioavailability ; dairy science ; encapsulation ; milk
Language	English
Dates of publication	2022-0511
Publishing place	Elsevier Inc.
Document type	Article
Note	Pre-press version
ZDB-ID	242499-x
ISSN	1525-3198 ; 0022-0302
ISSN (online)	1525-3198
ISSN	0022-0302
DOI	10.3168/jds.2021-21127
Database	NAL-Catalogue (AGRICOLA)

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Article: [Overview of the application of knowledge graphs in the medical field].

Wang, Caiyun / Zheng, Zengliang / Cai, Xiaoqiong / Huang, Jihan / Su, Qianmin

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi

2023 Volume 40, Issue 5, Page(s) 1040–1044

Abstract: With the booming development of medical information technology and computer science, the medical services industry is gradually transiting from information technology to intelligence. The medical knowledge graph plays an important role in intelligent ... ...

Abstract	With the booming development of medical information technology and computer science, the medical services industry is gradually transiting from information technology to intelligence. The medical knowledge graph plays an important role in intelligent medical applications such as knowledge questions and answers and intelligent diagnosis, and is a key technology for promoting wise medical care and the basis for intelligent management of medical information. In order to fully exploit the great potential of knowledge graphs in the medical field, this paper focuses on five aspects: inter-drug relationship discovery, assisted diagnosis, personalized recommendation, decision support and intelligent prediction. The latest research progress on medical knowledge graphs is introduced, and relevant suggestions are made in light of the current challenges and problems faced by medical knowledge graphs to provide reference for promoting the wide application of medical knowledge graphs.
MeSH term(s)	Pattern Recognition, Automated ; Medical Informatics
Language	Chinese
Publishing date	2023-10-23
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2576847-5
ISSN	1001-5515
ISSN	1001-5515
DOI	10.7507/1001-5515.202204016
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Article ; Online: Graduate Student Literature Review: Potential uses of milk proteins as encapsulation walls for bioactive compounds.

Xie, Siyu / Qu, Peng / Luo, Shubo / Wang, Caiyun

Journal of dairy science

2022 Volume 105, Issue 10, Page(s) 7959–7971

Abstract	Milk proteins have received much awareness due to their bioactivity. However, their encapsulation functions have not attracted enough attention. Milk proteins as encapsulation walls can increase the bioavailability of bioactive compounds. As the benefits of bioactive compounds are critically determined by bioavailability, the effect of interactions between milk proteins and active substances is a critical topic. In the present review, we summarize the effects of milk proteins as encapsulation walls on the bioavailability of active substances with a special focus. The methods and mechanisms of interactions between milk proteins and active substances are also discussed. The evidence collected in the present review suggests that when active substances are encapsulated by milk proteins, the bioavailability of active substances can be significantly affected. This review also provides valuable guidelines for the use of milk protein-based microcarriers.
MeSH term(s)	Animals ; Biological Availability ; Humans ; Milk Proteins ; Students
Chemical Substances	Milk Proteins
Language	English
Publishing date	2022-08-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	242499-x
ISSN	1525-3198 ; 0022-0302
ISSN (online)	1525-3198
ISSN	0022-0302
DOI	10.3168/jds.2021-21127
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Article ; Online: In vitro behaviour of human gingival fibroblasts cultured on 3D-printed titanium alloy with hydrogenated TiO

Guo, Yatong / Wang, Xin / Wang, Caiyun / Chen, Su

Journal of materials science. Materials in medicine

2022 Volume 33, Issue 3, Page(s) 27

Abstract: Selective laser melting (SLM), as one of the most common 3D-printed technologies, can form personalized implants, which after further surface modification can obtain excellent osseointegration. To study the surface properties of SLM titanium alloy ( ... ...

Abstract	Selective laser melting (SLM), as one of the most common 3D-printed technologies, can form personalized implants, which after further surface modification can obtain excellent osseointegration. To study the surface properties of SLM titanium alloy (Ti6Al4V) with hydrogenated titanium dioxide (TiO
MeSH term(s)	Alloys ; Cell Adhesion ; Cell Proliferation ; Fibroblasts ; Humans ; Nanotubes/chemistry ; Printing, Three-Dimensional ; Surface Properties ; Titanium/chemistry
Chemical Substances	Alloys ; titanium dioxide (15FIX9V2JP) ; Titanium (D1JT611TNE)
Language	English
Publishing date	2022-03-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1031752-1
ISSN	1573-4838 ; 0957-4530
ISSN (online)	1573-4838
ISSN	0957-4530
DOI	10.1007/s10856-022-06649-4
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