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Article ; Online: Effect of steam explosion modified soluble dietary fiber from Tremella fuciformis stem on the quality and digestibility of biscuits.

Wang, Changrong / Lin, Mengfan / Li, Yibin / Zhuang, Weijing / Guo, Zebin

International journal of biological macromolecules

2024 Volume 265, Issue Pt 1, Page(s) 130905

Abstract: Steam explosion (SE) technology is an effective modification method for improving resource utilization of edible fungi processing by-products. In this study, the effect of SE-modified Tremella fuciformis (T. fuciformis) stem soluble dietary fiber (SDF) ... ...

Abstract	Steam explosion (SE) technology is an effective modification method for improving resource utilization of edible fungi processing by-products. In this study, the effect of SE-modified Tremella fuciformis (T. fuciformis) stem soluble dietary fiber (SDF) on the quality and digestibility of biscuits was investigated. The results showed that the addition of SE-modified T. fuciformis stem SDF (M-SDF) changed the gluten network structure and moisture distribution in the biscuits, which improved the spread ratio of the biscuits and resulted in attractive colors. Meanwhile, as starch was embedded, the starch hydrolysis rate (from 60.9 ± 0.90 % to 43.01 ± 0.78 %) and estimated glycemic index (from 84.10 ± 4.39 to 68.45 ± 3.15) of 12 % M-SDF biscuits were reduced. Furthermore, 8 % M-SDF received the highest sensory scores. These results demonstrate the potential applicability of SE-modified edible fungi processing by-product SDF as an additive in functional foods.
MeSH term(s)	Steam ; Starch/chemistry ; Glycemic Index ; Dietary Fiber/analysis ; Basidiomycota
Chemical Substances	Steam ; Starch (9005-25-8) ; Dietary Fiber
Language	English
Publishing date	2024-03-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.130905
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Zs.B 2374: Show issues

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Article ; Online: Case report: Large-size intramuscular nodular fasciitis, a challenging histopathologic diagnosis confirmed by molecular detection of USP6 gene rearrangement: Case report and literature review.

Wang, Changrong / Wang, Wei / Xu, Rujun / Xiang, Jingjing

Pathology oncology research : POR

2023 Volume 29, Page(s) 1610785

Abstract: The intramuscular subtype of nodular fasciitis (NF) is rare with lesions normally not more than 2 cm in size and characterized by pseudosarcomatous morphology. We report a case of a 27-year-old man with a large-size intramuscular NF. The patient came for ...

Abstract	The intramuscular subtype of nodular fasciitis (NF) is rare with lesions normally not more than 2 cm in size and characterized by pseudosarcomatous morphology. We report a case of a 27-year-old man with a large-size intramuscular NF. The patient came for treatment complaining of an increasingly enlarged mass in the left upper arm for 4 months. Magnetic resonance imaging (MRI) confirmed the presence of a well-defined tumor measuring 5 cm within the outer edge of the middle humerus. Microscopically, the neoplasm was rich in fibroblasts and myofibroblasts in an interlaced pattern with high mitotic index and evident multinuclear giant cells. Erythrocyte extravasation was easily seen in the stroma. The tumor border was infiltrative. Immunohistochemically, the tumor cells were positive for smooth muscle actin (SMA) and negative for cytokeratin, desmin, H-Caldesmon, CD34, S100, ALK, and
MeSH term(s)	Male ; Humans ; Adult ; Gene Rearrangement ; Proto-Oncogene Proteins/genetics ; Ubiquitin Thiolesterase/genetics ; In Situ Hybridization, Fluorescence ; Fasciitis/diagnosis ; Fasciitis/genetics ; Fasciitis/pathology
Chemical Substances	Proto-Oncogene Proteins ; Ubiquitin Thiolesterase (EC 3.4.19.12) ; USP6 protein, human (EC 3.4.19.12)
Language	English
Publishing date	2023-01-20
Publishing country	Switzerland
Document type	Review ; Case Reports
ZDB-ID	1375979-6
ISSN	1532-2807 ; 1219-4956
ISSN (online)	1532-2807
ISSN	1219-4956
DOI	10.3389/pore.2023.1610785
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Article ; Online: Improvement of soluble dietary fiber quality in Tremella fuciformis stem by steam explosion technology: An evaluation of structure and function.

Wang, Changrong / Lin, Mengfan / Li, Yibin / Guo, Zebin

Food chemistry

2023 Volume 437, Issue Pt 1, Page(s) 137867

Abstract: Edible fungi by-products are rich in dietary fiber (DF). In this study, we used steam explosion (SE) to modify Tremella fuciformis (T. fuciformis) stem DF. The SE conditions were optimized using response surface methodology (RSM), and the soluble dietary ...

Abstract	Edible fungi by-products are rich in dietary fiber (DF). In this study, we used steam explosion (SE) to modify Tremella fuciformis (T. fuciformis) stem DF. The SE conditions were optimized using response surface methodology (RSM), and the soluble dietary fiber (SDF) extraction rate increased 1.42-fold (from 23.33 ± 0.42 % to 33.21 ± 0.28 %) under optimized conditions. SE destroyed the dense structure of SDF, which improved the specific surface area and thermal stability. Furthermore, the structural changes induced by SE resulted in improved functional properties, and SDF had better hydration properties (water holding capacity, oil holding capacity, and swelling capacity increased by 1.23, 1.59, and 1.24 times, respectively) and hypoglycemic capacity (glucose adsorption capacity increased 1.84-fold at 100 mmol/L glucose). Therefore, SE is an excellent modification method for improving quality of edible fungi processing by-products SDF.
MeSH term(s)	Steam ; Chemical Phenomena ; Basidiomycota/chemistry ; Dietary Fiber/analysis
Chemical Substances	Steam ; Dietary Fiber
Language	English
Publishing date	2023-10-28
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2023.137867
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Article ; Online: 46, XX disorder of sexual development associated with mixed germ cell tumor of the prostate: a rare case report.

Wang, Changrong / Du, Jiangli / Xiang, Xueping / Wang, Yuyong / Xiang, Jingjing / Xu, Qiaoping

BMC urology

2024 Volume 24, Issue 1, Page(s) 36

Abstract: Background: Extragonadal germ cell tumors originating from the prostate are exceptionally rare. To the best of our knowledge, there have been no reported cases of mixed germ cell tumors in individuals with 46 XX disorder of sex development. In this ... ...

Abstract	Background: Extragonadal germ cell tumors originating from the prostate are exceptionally rare. To the best of our knowledge, there have been no reported cases of mixed germ cell tumors in individuals with 46 XX disorder of sex development. In this study, we conducted a comprehensive analysis using whole genome sequencing to investigate the clinicopathological and molecular genetic characteristics of a submitted case, with the objective of elucidating its underlying pathogenesis. Case presentation: A 40-year-old male patient was diagnosed with a combination of 46, XX disorder of sex development and a primary prostate mixed germ cell tumor with yolk sac tumor and teratoma components. Whole-genome sequencing revealed that the tumor cells had a high somatic mutational load. Analysis of genomic structural variations and copy number variants confirmed the patient's karyotype as 46, XX (SRY +). Additionally, the patient exhibited short stature, small bilateral testes, slightly enlarged breasts, elevated serum alpha-fetoprotein concentrations, elevated follicle-stimulating hormone and luteinizing hormone levels, and low testosterone levels. Discussion: A case of 46, XX disorder of sex development, along with a primary prostatic mixed germ cell tumor, was diagnosed. This diagnosis has contributed to advancing our understanding of the genetic and phenotypic profile of the disease and may provide some insights for its treatment.
MeSH term(s)	Male ; Humans ; Adult ; Prostate ; Neoplasms, Germ Cell and Embryonal/complications ; Neoplasms, Germ Cell and Embryonal/genetics ; Sexual Development ; Prostatic Neoplasms
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2059857-9
ISSN	1471-2490 ; 1471-2490
ISSN (online)	1471-2490
ISSN	1471-2490
DOI	10.1186/s12894-024-01420-z
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Article ; Online: Nanomedicines for an Enhanced Immunogenic Cell Death-Based

Zhao, Caiyan / Wang, Changrong / Shan, Wenbo / Wang, Zhongliang / Chen, Xiaoyuan / Deng, Hongzhang

Accounts of chemical research

2024 Volume 57, Issue 6, Page(s) 905–918

Abstract: ConspectusCancer vaccines have shown tremendous potential in preventing and treating cancer by providing immunogenic antigens to initiate specific tumor immune responses. ... ...

Abstract	ConspectusCancer vaccines have shown tremendous potential in preventing and treating cancer by providing immunogenic antigens to initiate specific tumor immune responses. An
MeSH term(s)	Humans ; Cancer Vaccines/therapeutic use ; Nanomedicine ; Immunogenic Cell Death ; Neoplasms/therapy ; Vaccination ; Adjuvants, Immunologic ; Tumor Microenvironment
Chemical Substances	Cancer Vaccines ; Adjuvants, Immunologic
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1483291-4
ISSN	1520-4898 ; 0001-4842
ISSN (online)	1520-4898
ISSN	0001-4842
DOI	10.1021/acs.accounts.3c00771
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Biodirected Screening and Preparation of

Yang, Zhizhi / Wang, Changrong / Huang, Baote / Chen, Yihui / Liu, Zhiyu / Chen, Hongbin / Chen, Jicheng

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 5

Abstract: Food-derived angiotensin-I-converting enzyme (ACE)-inhibitory peptides have gained attention for their potent and safe treatment of hypertensive disorders. However, there are some limitations of conventional methods for preparing ACE-inhibitory peptides. ...

Abstract	Food-derived angiotensin-I-converting enzyme (ACE)-inhibitory peptides have gained attention for their potent and safe treatment of hypertensive disorders. However, there are some limitations of conventional methods for preparing ACE-inhibitory peptides. In this study, in silico hydrolysis, the quantitative structure-activity relationship (QSAR) model, LC-MS/MS, inhibition kinetics, and molecular docking were used to investigate the stability, hydrolyzability, in vitro activity, and inhibition mechanism of bioactive peptides during the actual hydrolysis process. Six novel ACE-inhibitory peptides were screened from the
MeSH term(s)	Angiotensin-Converting Enzyme Inhibitors/chemistry ; Molecular Docking Simulation ; Peptidyl-Dipeptidase A/metabolism ; Chromatography, Liquid ; Reproducibility of Results ; Tandem Mass Spectrometry ; Peptides/chemistry ; Angiotensins
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; Peptides ; Angiotensins
Language	English
Publishing date	2024-03-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29051134
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Article ; Online: Efficient ocular delivery of siRNA

Cao, Xiaowen / Wang, Changrong / Deng, Zhennv / Zhong, Yiming / Chen, Hao

International journal of pharmaceutics: X

2023 Volume 5, Page(s) 100183

Abstract: Corneal neovascularization (CoNV)-induced blindness is an enduring and challenging condition with limited management options. Small interfering RNA (siRNA) is a promising strategy for preventing CoNV. This study reported a new strategy using siVEGFA to ... ...

Abstract	Corneal neovascularization (CoNV)-induced blindness is an enduring and challenging condition with limited management options. Small interfering RNA (siRNA) is a promising strategy for preventing CoNV. This study reported a new strategy using siVEGFA to silence vascular endothelial growth factor A (VEGFA) for CoNV treatment. To improve the efficacy of siVEGFA delivery, a pH-sensitive polycationic mPEG
Language	English
Publishing date	2023-04-29
Publishing country	Netherlands
Document type	Journal Article
ISSN	2590-1567
ISSN (online)	2590-1567
DOI	10.1016/j.ijpx.2023.100183
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Article ; Online: Surface Engineering of Nanoparticles toward Cancer Theranostics.

Huang, Pei / Wang, Changrong / Deng, Hongzhang / Zhou, Yongfeng / Chen, Xiaoyuan

Accounts of chemical research

2023 Volume 56, Issue 13, Page(s) 1766–1779

Abstract: Development of multifunctional nanoparticles (NPs) with desired properties is a significant topic in the field of nanotechnology and has been anticipated to revolutionize cancer diagnosis and treatment modalities. The surface character is one of the most ...

Abstract	Development of multifunctional nanoparticles (NPs) with desired properties is a significant topic in the field of nanotechnology and has been anticipated to revolutionize cancer diagnosis and treatment modalities. The surface character is one of the most important parameters of NPs that can directly affect their
MeSH term(s)	Humans ; Precision Medicine ; Neoplasms/diagnostic imaging ; Neoplasms/therapy ; Nanoparticles/therapeutic use ; Nanoparticles/chemistry ; Engineering
Language	English
Publishing date	2023-06-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1483291-4
ISSN	1520-4898 ; 0001-4842
ISSN (online)	1520-4898
ISSN	0001-4842
DOI	10.1021/acs.accounts.3c00122
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Principle of Steam Explosion Technology and Its Application in Food Processing By-Products.

Wang, Changrong / Lin, Mengfan / Yang, Qingyu / Fu, Chenying / Guo, Zebin

Foods (Basel, Switzerland)

2023 Volume 12, Issue 17

Abstract: Steam explosion technology is an emerging pretreatment method that has shown great promise for food processing due to its ability to efficiently destroy the natural barrier structure of materials. This narrative review summarizes the principle of steam ... ...

Abstract	Steam explosion technology is an emerging pretreatment method that has shown great promise for food processing due to its ability to efficiently destroy the natural barrier structure of materials. This narrative review summarizes the principle of steam explosion technology, its similarities and differences with traditional screw extrusion technology, and the factors that affect the technology. In addition, we reviewed the applications in food processing by-products in recent years. The results of the current study indicate that moderate steam explosion treatment can improve the quality and extraction rate of the target products. Finally, we provided an outlook on the development of steam explosion technology with a reference for a wider application of this technology in the food processing field.
Language	English
Publishing date	2023-09-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12173307
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Article ; Online: Biomimetic noncationic lipid nanoparticles for mRNA delivery.

Wang, Changrong / Zhao, Caiyan / Wang, Weipeng / Liu, Xiaoqing / Deng, Hongzhang

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 51, Page(s) e2311276120

Abstract: Although the tremendous progress has been made for mRNA delivery based on classical cationic carriers, the excess cationic charge density of lipids was necessary to compress mRNA through electrostatic interaction, and with it comes inevitably adverse ... ...

Abstract	Although the tremendous progress has been made for mRNA delivery based on classical cationic carriers, the excess cationic charge density of lipids was necessary to compress mRNA through electrostatic interaction, and with it comes inevitably adverse events including the highly inflammatory and cytotoxic effects. How to develop the disruptive technologies to overcome cationic nature of lipids remains a major challenge for safe and efficient mRNA delivery. Here, we prepared noncationic thiourea lipids nanoparticles (NC-TNP) to compress mRNA by strong hydrogen bonds interaction between thiourea groups of NC-TNP and the phosphate groups of mRNA, abandoning the hidebound and traditional electrostatic force to construct mRNA-cationic lipids formulation. NC-TNP was a delivery system for mRNA with simple, convenient, and repeatable preparation technology and showed negligible inflammatory and cytotoxicity side effects. Furthermore, we found that NC-TNP could escape the recycling pathway to inhibit the egress of internalized nanoparticles from the intracellular compartment to the extracellular milieu which was a common fact in mRNA-LNP (lipid nanoparticles) formulation. Therefore, NC-TNP-encapsulated mRNA showed higher gene transfection efficiency in vitro and in vivo than mRNA-LNP formulation. Unexpectedly, NC-TNP showed spleen targeting delivery ability with higher accumulation ratio (spleen/liver), compared with traditional LNP. Spleen-targeting NC-TNP with mRNA exhibited high mRNA-encoded antigen expression in spleen and elicited robust immune responses. Overall, our work establishes a proof of concept for the construction of a noncationic system for mRNA delivery with good inflammatory safety profiles, high gene transfection efficiency, and spleen-targeting delivery to induce permanent and robust humoral and cell-mediated immunity for disease treatments.
MeSH term(s)	RNA, Messenger/metabolism ; Biomimetics ; Lipids/chemistry ; Nanoparticles/chemistry ; Cations/chemistry ; Thiourea ; RNA, Small Interfering/genetics
Chemical Substances	Lipid Nanoparticles ; RNA, Messenger ; Lipids ; Cations ; Thiourea (GYV9AM2QAG) ; RNA, Small Interfering
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2311276120
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