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  1. Article ; Online: Radiotherapy Combined with Intralesional Immunostimulatory Agents for Soft Tissue Sarcomas.

    Su, Chang / Kim, Soo Kyoung / Wang, Charles X / Kirsch, David G / Monjazeb, Arta M

    Seminars in radiation oncology

    2024  Volume 34, Issue 2, Page(s) 243–257

    Abstract: Immunotherapy has shifted the treatment paradigm for many types of cancer. Unfortunately, the most commonly used immunotherapies, such as immune checkpoint inhibitors (ICI), have yielded limited benefit for most types of soft tissue sarcoma (STS). ... ...

    Abstract Immunotherapy has shifted the treatment paradigm for many types of cancer. Unfortunately, the most commonly used immunotherapies, such as immune checkpoint inhibitors (ICI), have yielded limited benefit for most types of soft tissue sarcoma (STS). Radiotherapy (RT) is a mainstay of sarcoma therapy and can induce immune modulatory effects. Combining immunotherapy and RT in STS may be a promising strategy to improve sarcoma response to RT and increase the efficacy of immunotherapy. Most combination strategies have employed immunotherapies, such as ICI, that derepress immune suppressive networks. These have yielded only modest results, possibly due to the limited immune stimulatory effects of RT. Combining RT with immune stimulatory agents has yielded promising preclinical and clinical results but can be limited by the toxic nature of systemic administration of immune stimulants. Using intralesional immune stimulants may generate stronger RT immune modulation and less systemic toxicity, which may be a feasible strategy in accessible tumors such as STS. In this review, we summarize the immune modulatory effects of RT, the mechanism of action of various immune stimulants, including toll-like receptor agonists, and data for combinatorial strategies utilizing these agents.
    MeSH term(s) Humans ; Sarcoma/drug therapy ; Sarcoma/radiotherapy ; Immunotherapy/methods ; Immune Checkpoint Inhibitors/therapeutic use
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1146999-7
    ISSN 1532-9461 ; 1053-4296
    ISSN (online) 1532-9461
    ISSN 1053-4296
    DOI 10.1016/j.semradonc.2024.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3654: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Advances in Radiotherapy Immune Modulation: From Bench-to-Bedside and Back Again.

    Wang, Charles X / Hunt, Jared / Feinstein, Shera / Kim, Soo Kyoung / Monjazeb, Arta M

    Surgical oncology clinics of North America

    2023  Volume 32, Issue 3, Page(s) 617–629

    Abstract: Pre-clinical and clinical data clearly demonstrate the immune modulatory effects of radiotherapy (RT) but clinical trials testing RT + immunotherapy have been equivocal. An improved understanding of the immune modulatory effects of RT and how practical ... ...

    Abstract Pre-clinical and clinical data clearly demonstrate the immune modulatory effects of radiotherapy (RT) but clinical trials testing RT + immunotherapy have been equivocal. An improved understanding of the immune modulatory effects of RT and how practical parameters of RT delivery (site and number of lesions, dose, fractionation, timing) influence these effects are needed to optimally combine RT with immunotherapy. Additionally, increased exploration of immunotherapy combinations with RT, beyond immune checkpoint inhibitors, are needed. A "bench-to-bedside and back again" approach will improve our understanding of RT immune modulation and allow for the implementation of more effective RT + immunotherapy strategies.
    MeSH term(s) Humans ; Combined Modality Therapy ; Radiation Oncology ; Dose Fractionation, Radiation ; Immunotherapy
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1196919-2
    ISSN 1558-5042 ; 1055-3207
    ISSN (online) 1558-5042
    ISSN 1055-3207
    DOI 10.1016/j.soc.2023.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 1339: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The Post-Synaptic Function of Brca2.

    Wang, Charles X / Jimenez-Sainz, Judit / Jensen, Ryan B / Mazin, Alexander V

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 4554

    Abstract: Homologous Recombination (HR) is a high-fidelity process with a range of biologic functions from generation of genetic diversity to repair of DNA double-strand breaks (DSBs). In mammalian cells, BRCA2 facilitates the polymerization of RAD51 onto ssDNA to ...

    Abstract Homologous Recombination (HR) is a high-fidelity process with a range of biologic functions from generation of genetic diversity to repair of DNA double-strand breaks (DSBs). In mammalian cells, BRCA2 facilitates the polymerization of RAD51 onto ssDNA to form a presynaptic nucleoprotein filament. This filament can then strand invade a homologous dsDNA to form the displacement loop (D-loop) structure leading to the eventual DSB repair. Here, we have found that RAD51 in stoichiometric excess over ssDNA can cause D-loop disassembly in vitro; furthermore, we show that this RAD51 activity is countered by BRCA2. These results demonstrate that BRCA2 may have a previously unexpected activity: regulation of HR at a post-synaptic stage by modulating RAD51-mediated D-loop dissociation. Our in vitro results suggest a mechanistic underpinning of homeostasis between RAD51 and BRCA2, which is an important factor of HR in mammalian cells.
    MeSH term(s) BRCA2 Protein/chemistry ; BRCA2 Protein/metabolism ; DNA/chemistry ; DNA/metabolism ; DNA Breaks, Double-Stranded ; DNA Repair ; Homologous Recombination ; Humans ; Nucleic Acid Conformation ; Rad51 Recombinase/chemistry ; Rad51 Recombinase/metabolism
    Chemical Substances BRCA2 Protein ; BRCA2 protein, human ; DNA (9007-49-2) ; RAD51 protein, human (EC 2.7.7.-) ; Rad51 Recombinase (EC 2.7.7.-)
    Language English
    Publishing date 2019-03-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-41054-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Post-death Vesicles of Senescent Bone Marrow Mesenchymal Stromal Polyploids Promote Macrophage Aging and Breast Cancer.

    Xie, Bowen / Fan, Ming / Wang, Charles X / Zhang, Yanhong / Xu, Shanxiu / Mizenko, Rachel / Lin, Tzu-Yin / Duan, Yixin / Zhang, Yanyan / Huang, Jie / Berg, Jonathan I / Wu, Douglas / Li, Anna / Hao, Dake / Gao, Kewa / Sun, Yaohui / Tepper, Clifford G / Carney, Randy / Li, Yuanpei /
    Wang, Aijun / Gong, Qizhi / Daly, Magen / Jao, Li-En / Monjazeb, Arta M / Fierro, Fernando A / Li, Jian Jian

    bioRxiv : the preprint server for biology

    2024  

    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.06.583755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Closed-loop supply chain models for a high-tech product under alternative reverse channel and collection cost structures

    Chuang, Chia-hung / Wang, Charles X / Zhao, Yabing

    International journal of production economics Vol. 156 , p. 108-123

    2014  Volume 156, Page(s) 108–123

    Author's details Chia--Hung Chuang; Charles X. Wang; Yabing Zhao
    Keywords Closed-loop supply chain ; Newsvendor model ; Remanufacturing ; Environment
    Language English
    Size graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam [u.a.]
    Document type Article
    ZDB-ID 1092526-0 ; 2020829-7
    ISSN 0925-5273
    ISSN 0925-5273
    Database ECONomics Information System

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  6. Article: Robust price-setting newsvendor model with interval market size and consumer willingness-to-pay

    Wang, Charles X / Webster, Scott / Zhang, Sidong

    International journal of production economics Vol. 154 , p. 100-112

    2014  Volume 154, Page(s) 100–112

    Author's details Charles X. Wang; Scott Webster; Sidong Zhang
    Keywords Inventory ; Pricing ; Newsvendor model ; Robust optimization
    Language English
    Size graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam [u.a.]
    Document type Article
    ZDB-ID 1092526-0 ; 2020829-7
    ISSN 0925-5273
    ISSN 0925-5273
    Database ECONomics Information System

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  7. Article: Markdown money contracts for perishable goods with clearance pricing

    Wang, Charles X / Webster, Scott

    European journal of operational research : EJOR Vol. 196, No. 3 , p. 1113-1122

    2009  Volume 196, Issue 3, Page(s) 1113–1122

    Author's details Charles X. Wang; Scott Webster
    Language English
    Publisher Elsevier
    Publishing place Amsterdam
    Document type Article
    ZDB-ID 243003-4
    Database ECONomics Information System

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  8. Article: The loss-averse newsvendor problem

    Wang, Charles X / Webster, Scott

    Omega : the international journal of management science Vol. 37, No. 1 , p. 93-105

    2009  Volume 37, Issue 1, Page(s) 93–105

    Author's details Charles X. Wang; Scott Webster
    Keywords Lagerhaltungsmodell ; Risikoaversion ; Operations Research
    Language English
    Size graph. Darst.
    Publisher Elsevier
    Publishing place Oxford [u.a.]
    Document type Article
    ZDB-ID 124502-8
    Database ECONomics Information System

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  9. Article ; Online: Mathematical prediction of clinical outcomes in advanced cancer patients treated with checkpoint inhibitor immunotherapy.

    Butner, Joseph D / Elganainy, Dalia / Wang, Charles X / Wang, Zhihui / Chen, Shu-Hsia / Esnaola, Nestor F / Pasqualini, Renata / Arap, Wadih / Hong, David S / Welsh, James / Koay, Eugene J / Cristini, Vittorio

    Science advances

    2020  Volume 6, Issue 18, Page(s) eaay6298

    Abstract: We present a mechanistic mathematical model of immune checkpoint inhibitor therapy to address the oncological need for early, broadly applicable readouts (biomarkers) of patient response to immunotherapy. The model is built upon the complex biological ... ...

    Abstract We present a mechanistic mathematical model of immune checkpoint inhibitor therapy to address the oncological need for early, broadly applicable readouts (biomarkers) of patient response to immunotherapy. The model is built upon the complex biological and physical interactions between the immune system and cancer, and is informed using only standard-of-care CT. We have retrospectively applied the model to 245 patients from multiple clinical trials treated with anti-CTLA-4 or anti-PD-1/PD-L1 antibodies. We found that model parameters distinctly identified patients with common (
    MeSH term(s) Humans ; Immunologic Factors ; Immunotherapy ; Neoplasms/drug therapy ; Retrospective Studies
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2020-04-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.aay6298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A comparison of two sourcing tactics for a new component

    Wang, Charles X / Webster, Scott / Zhang, Sidong

    European journal of operational research : EJOR Vol. 211, No. 2 , p. 310-317

    2011  Volume 211, Issue 2, Page(s) 310–317

    Author's details Charles X. Wang; Scott Webster; Sidong Zhang
    Language English
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    Publisher Elsevier
    Publishing place Amsterdam ; Boston ; London ; New York,NY ; Oxford ; Paris ; Philadelphia ; San Diego ; St. Louis
    Document type Article
    ZDB-ID 243003-4
    ISSN 0377-2217
    Database ECONomics Information System

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