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Article ; Online: Study on the effect of an ultrasound assisted reaction on the crystallization properties of recovered cryolite.

Wang, Chenchen / Mao, Song

RSC advances

2023 Volume 13, Issue 50, Page(s) 35359–35368

Abstract: During the treatment of spent cathode carbon from electrolytic aluminum, a large amount of fluoride containing wastewater is generated. By adding different sodium source and aluminum source reagents, under the conditions of different addition order, pH, ... ...

Abstract	During the treatment of spent cathode carbon from electrolytic aluminum, a large amount of fluoride containing wastewater is generated. By adding different sodium source and aluminum source reagents, under the conditions of different addition order, pH, temperature and time, the effects of conventional static reaction, stirring reaction and ultrasonic assisted reaction on the crystallization properties of recovered cryolite were investigated. The results showed that under the optimum reaction conditions (sodium source: NaCl, aluminum source: AlCl
Language	English
Publishing date	2023-12-04
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra06661d
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Article ; Online: Individual and mixture analyses of the associations of phenols and phthalates with lung function among US adults.

Wang, Chenchen / Wang, Huaicheng / Cai, Jinpeng / Xu, Xi

International journal of environmental health research

2024 , Page(s) 1–15

Abstract: The effects of endocrine disruptors including phenols and phthalates on adult lung function remain unclear. In the present study, data from 2007-2012 National Health and Nutrition Examination Survey (NHANES) were extracted, and 4338 participants were ... ...

Abstract	The effects of endocrine disruptors including phenols and phthalates on adult lung function remain unclear. In the present study, data from 2007-2012 National Health and Nutrition Examination Survey (NHANES) were extracted, and 4338 participants were included in the final analyses. The associations of three phenols and four phthalate metabolites with six lung function parameters were investigated. In generalized linear regression models (GLM) and restricted cubic spline (RCS) analyses, bisphenol A (BPA) was associated with decreased forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC), and 2,5-dichlorophenol (DCP) was associated with reduced FEV1, FVC and peak expiratory flow rate (PEF), and increased prevalence of restrictive lung function (RLF) in adults. Furthermore, weighted quantile sum (WQS) regression and Bayesian kernel machine regression (BKMR) models demonstrated that mixed exposures to phenols and phthalates were linked to reduced FEV1, FVC and PEF and increased prevalence of RLF, and these associations were mainly driven by BPA and 2,5-DCP. In conclusion, mixed exposure to phenols and phthalates was linked to compromised and a restrictive pattern of lung function. The mechanisms of the effects of phenol and phthalate exposures on lung function and respiratory diseases need to be further investigated.
Language	English
Publishing date	2024-05-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1104887-6
ISSN	1369-1619 ; 0960-3123
ISSN (online)	1369-1619
ISSN	0960-3123
DOI	10.1080/09603123.2024.2352609
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Zs.A 3517: Show issues

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Article ; Online: Renal function improvement correlates with 3D echocardiographic findings: Effect of surgical mitral valve repair.

Wang, Chenchen / Yang, Wenbo / Shi, Zhongwei / Fang, Yuehua

Journal of clinical ultrasound : JCU

2024 Volume 52, Issue 4, Page(s) 385–393

Abstract: Background: The association between surgical treatment of mitral regurgitation (MR) and renal function is not sufficiently well-known. We tried to evaluate renal function before and after the procedure of surgical mitral valve repair (SMVR) in ... ...

Abstract	Background: The association between surgical treatment of mitral regurgitation (MR) and renal function is not sufficiently well-known. We tried to evaluate renal function before and after the procedure of surgical mitral valve repair (SMVR) in degenerative severe MR. Methods: Patients with primary severe (4+) MR and normal left ventricular ejection fraction (LVEF) that underwent SMVR, examined by a cutting-edge 3-dimensional (3D) echocardiographic probe were enrolled in this study. We took three CKD-EPI equations to measure estimated glomerular filtration rate (eGFR) before SMVR and shortly before patients discharge. A total of 40 patients with baseline lower mean eGFR were evaluated. Results: Measurements substantiated statistically significant improvements in eGFR (p < 0.001), multivariable linear regression modeling indicating prominent associations between increase in eGFR and decrease of MR (p = 0.003), decline of pulmonary arterial systolic pressure (p = 0.018), as well as increment of forward stroke volume (p = 0.02), in spite of LVEF reduction, left ventricular global longitudinal strain worsening and left atrial ejection fraction impairment. Conclusions: Renal function improves after SMVR in patients with degenerative significant MR and preserved LVEF, regardless of cardiac functional worsening.
MeSH term(s)	Humans ; Female ; Male ; Mitral Valve Insufficiency/surgery ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/physiopathology ; Echocardiography, Three-Dimensional/methods ; Middle Aged ; Glomerular Filtration Rate ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Mitral Valve/physiopathology ; Treatment Outcome ; Kidney/diagnostic imaging ; Kidney/physiopathology ; Kidney/surgery ; Aged ; Stroke Volume/physiology
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	189393-2
ISSN	1097-0096 ; 0091-2751
ISSN (online)	1097-0096
ISSN	0091-2751
DOI	10.1002/jcu.23646
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Zs.A 1186: Show issues

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Article ; Online: Functional Analysis of Wild-Type and 27 CYP3A4 Variants on Dronedarone Metabolism

Wang, Chen-Chen / Lan, Tian

Current drug metabolism

2022 Volume 23, Issue 7, Page(s) 562–570

Abstract: Background: Cytochrome P450 (P450) is the largest family of enzymatic proteins in the human liver, and its features have been studied in physiology, medicine, biotechnology, and phytoremediation.: Objective: The aim of this study was to assess the ... ...

Abstract	Background: Cytochrome P450 (P450) is the largest family of enzymatic proteins in the human liver, and its features have been studied in physiology, medicine, biotechnology, and phytoremediation. Objective: The aim of this study was to assess the catalytic activities of 28 human CYP3A4 alleles by using dronedarone as a probe drug in vitro, including 7 novel alleles recently found in the Han Chinese population. Methods: We expressed 28 CYP3A4 alleles in insect microsomes and incubated them with 1-100 μM of dronedarone at 37 °C for 40 minutes to obtain the metabolites of N-debutyl-dronedarone. Results: Compared with the wild type of CYP3A4, the 27 defective alleles can be classified into four categories. Three alleles had no detectable enzyme activity leading to a lack of kinetic parameters of N-debutyl-dronedarone; the other three alleles slightly despaired when it comes to intrinsic clearance values compared with the features of the wild type. Sixteen alleles exhibited 35.91%~79.70% relative values (in comparison to the wild-type) and could be defined as the "moderate decrease group". The rest of the alleles showed a considerable decrease in intrinsic clearance values, ranging from 11.88%~23.34%. Therefore they were classified as a "significantly decreased group". More specifically, 18 CYP3A4 alleles exhibited a substrate inhibition trend toward dronedarone when the concentration rises to 20 μM. Conclusion: The outcomes of this novel study on the metabolism of dronedarone by CYP3A4 alleles can be used as experimental data support for the individualized use of this modern drug.
MeSH term(s)	Humans ; Cytochrome P-450 CYP3A/genetics ; Cytochrome P-450 CYP3A/metabolism ; Dronedarone/metabolism ; Microsomes/metabolism ; Cytochrome P-450 Enzyme System/metabolism ; Alleles
Chemical Substances	Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Dronedarone (JQZ1L091Y2) ; Cytochrome P-450 Enzyme System (9035-51-2) ; CYP3A4 protein, human (EC 1.14.14.55)
Language	English
Publishing date	2022-06-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2064815-7
ISSN	1875-5453 ; 1389-2002
ISSN (online)	1875-5453
ISSN	1389-2002
DOI	10.2174/1389200223666220613153917
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Zs.A 5584: Show issues

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Article: No evidence for a causal link between

Wang, Chenchen / Zhang, Jing / Han, Fengli / Liu, Dong / Han, Yuying

Frontiers in microbiology

2024 Volume 14, Page(s) 1268492

Abstract: Background: Although clinical studies have revealed a potential link between : Method: A two-sample Mendelian randomization (MR) analysis using the inverse variance weighted (IVW), weighted mode, weighted median and MR-Egger methods was performed. We ...

Abstract	Background: Although clinical studies have revealed a potential link between Method: A two-sample Mendelian randomization (MR) analysis using the inverse variance weighted (IVW), weighted mode, weighted median and MR-Egger methods was performed. We used the publicly available summary statistics data sets of genome-wide association studies (GWAS) for Results: We selected 10 single nucleotide polymorphisms at genome-wide significance from GWASs on Conclusion: The results of MR analysis support that
Language	English
Publishing date	2024-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1268492
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Article ; Online: Molecular dynamics simulation study on the binding mechanism between carbon nanotubes and RNA-dependent RNA polymerase.

Ma, Zhaopeng / Xu, Jianqiang / Wang, Chenchen / Liu, Zhicong / Zhu, Guanglai

Journal of biomolecular structure & dynamics

2024 , Page(s) 1–10

Abstract: Carbon nanotubes (CNTs) have potential prospects in disease treatment, so it is of great significance to study CNTs as the possible inhibitors of RNA-dependent RNA polymerase (RdRp). Through the way of using the RdRp of SARS-COV-2 as a model, five ... ...

Abstract	Carbon nanotubes (CNTs) have potential prospects in disease treatment, so it is of great significance to study CNTs as the possible inhibitors of RNA-dependent RNA polymerase (RdRp). Through the way of using the RdRp of SARS-COV-2 as a model, five armchair single-walled carbon nanotubes (SWCNTs) (namely Dn, which stands for CNTs (n, m = n),
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2024.2308781
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Zs.A 2093: Show issues

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Article ; Online: Research Progress of Long Non-Coding RNA in Tumor Drug Resistance: A New Paradigm.

Zhang, Jing / Wu, Le / Wang, Chenchen / Xie, Xin / Han, Yuying

Drug design, development and therapy

2024 Volume 18, Page(s) 1385–1398

Abstract: In the past few decades, chemotherapy has been one of the most effective cancer treatment options. Drug resistance is currently one of the greatest obstacles to effective cancer treatment. Even though drug resistance mechanisms have been extensively ... ...

Abstract	In the past few decades, chemotherapy has been one of the most effective cancer treatment options. Drug resistance is currently one of the greatest obstacles to effective cancer treatment. Even though drug resistance mechanisms have been extensively investigated, they have not been fully elucidated. Recent genome-wide investigations have revealed the existence of a substantial quantity of long non-coding RNAs (lncRNAs) transcribed from the human genome, which actively participate in numerous biological processes, such as transcription, splicing, epigenetics, the cell cycle, cell differentiation, development, pluripotency, immune microenvironment. The abnormal expression of lncRNA is considered a contributing factor to the drug resistance. Furthermore, drug resistance may be influenced by genetic and epigenetic variations, as well as individual differences in patient treatment response, attributable to polymorphisms in metabolic enzyme genes. This review focuses on the mechanism of lncRNAs resistance to target drugs in the study of tumors with high mortality, aiming to establish a theoretical foundation for targeted therapy.
MeSH term(s)	Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Drug Resistance, Neoplasm ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/pathology ; Antineoplastic Agents/pharmacology ; Animals
Chemical Substances	RNA, Long Noncoding ; Antineoplastic Agents
Language	English
Publishing date	2024-04-26
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S448707
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Article ; Online: Distribution characteristics and controlling factors of typical heavy metals in Huanghe River estuary, China

Lu, Yuxi / Pan, Dawei / Yang, Tingting / Wang, Chenchen

J. Ocean. Limnol.. 2023 Jan., v. 41, no. 1 p.150-165

2023

Abstract: The geochemical characteristics and potential controlling factors of colloidal Zn, Cd, and Pb in Huanghe (Yellow) River estuary (HRE), China were investigated. The three metals were highly variable over a range of spatiotemporal scales, comprehensively ... ...

Abstract	The geochemical characteristics and potential controlling factors of colloidal Zn, Cd, and Pb in Huanghe (Yellow) River estuary (HRE), China were investigated. The three metals were highly variable over a range of spatiotemporal scales, comprehensively forced by various physical and biological processes. Total dissolved Zn, Cd, and Pb varied from 200.1 to 321.7, 2.6 to 4.1, and 0.5 to 1.0 nmol/L, respectively. Only one near-estuarine station of Zn had contamination factor values >1, which indicate the lower contaminant levels. Five dissolved species of Zn, Cd and Pb were fractionated, namely <1 kDa, 1–3 kDa, 3–10 kDa, 10–100 kDa, and 100 kDa–0.45 µm. The <1 kDa truly dissolved phase was the main fraction of the three dissolved metals (50%–62%), while the 100-kDa–0.45-µm high molecular weight colloidal fraction was dominant in their respective colloidal phase. Territorial input and sediment acted as important sources of strong ligands and natural colloids for the HRE water system. <3-kDa Zn and Pb were susceptible to the dissolved oxygen, the behaviors of colloidal Zn and 3–10-kDa Pb were related to dissolved organic carbon (DOC). However, no significant correlation between each dissolved fraction of Cd and salinity, pH, temperature, colloidal organic carbon, and DOC was found in this study. Overall, these findings, completed by the evaluation of the dissolved species of Zn, Cd, and Pb at 10 sites over the river-sea mixing zone, provided new insights into the colloidal heterogeneity that affect metals geochemical features, migration and fate in estuaries.
Keywords	dissolved organic carbon ; dissolved oxygen ; estuaries ; ligands ; molecular weight ; pH ; rivers ; salinity ; sediments ; temperature ; China ; Yellow River
Language	English
Dates of publication	2023-01
Size	p. 150-165.
Publishing place	Science Press
Document type	Article ; Online
ISSN	2096-5508
DOI	10.1007/s00343-021-1320-6
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Correction: Study on ultrasonic leaching and recovery of fluoride from spent cathode carbon of aluminum electrolysis.

Wang, Chenchen / Mao, Song / Li, Longjiang

RSC advances

2023 Volume 13, Issue 26, Page(s) 18128

Abstract: This corrects the article DOI: 10.1039/D3RA02088F.]. ...

Abstract	[This corrects the article DOI: 10.1039/D3RA02088F.].
Language	English
Publishing date	2023-06-15
Publishing country	England
Document type	Published Erratum
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra90052e
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Article ; Online: Study on ultrasonic leaching and recovery of fluoride from spent cathode carbon of aluminum electrolysis.

Wang, Chenchen / Mao, Song / Li, Longjiang

RSC advances

2023 Volume 13, Issue 24, Page(s) 16300–16310

Abstract: Under the assistance of ultrasound, the fluoride in the spent cathode carbon of aluminum electrolysis was recovered by the process of washing first and then leaching. The effects of time, temperature, liquid-solid ratio, ultrasonic power, alkali amount ... ...

Abstract	Under the assistance of ultrasound, the fluoride in the spent cathode carbon of aluminum electrolysis was recovered by the process of washing first and then leaching. The effects of time, temperature, liquid-solid ratio, ultrasonic power, alkali amount and acid concentration on the leaching rate of fluoride were investigated. The useful components in the leaching solution were recovered by evaporation crystallization and cryolite regeneration. The tests of X-ray diffraction (XRD), X-ray fluorescence spectroscopy (XRF), and scanning electron microscopy combined with energy dispersive spectroscopy (SEM-EDS) showed that under the optimal experimental conditions (water washing: 50 s, 3 : 1, 420 W; alkaline leaching: alkali amount 1 g, 60 min, 70 °C, 7 : 1, 480 W; acid leaching: acid concentration 0.6 mol L
Language	English
Publishing date	2023-05-31
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra02088f
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