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  1. Article ; Online: 3D Face Point Cloud Reconstruction and Recognition Using Depth Sensor.

    Wang, Cheng-Wei / Peng, Chao-Chung

    Sensors (Basel, Switzerland)

    2021  Volume 21, Issue 8

    Abstract: Facial recognition has attracted more and more attention since the rapid growth of artificial intelligence (AI) techniques in recent years. However, most of the related works about facial reconstruction and recognition are mainly based on big data ... ...

    Abstract Facial recognition has attracted more and more attention since the rapid growth of artificial intelligence (AI) techniques in recent years. However, most of the related works about facial reconstruction and recognition are mainly based on big data collection and image deep learning related algorithms. The data driven based AI approaches inevitably increase the computational complexity of CPU and usually highly count on GPU capacity. One of the typical issues of RGB-based facial recognition is its applicability in low light or dark environments. To solve this problem, this paper presents an effective procedure for facial reconstruction as well as facial recognition via using a depth sensor. For each testing candidate, the depth camera acquires a multi-view of its 3D point clouds. The point cloud sets are stitched for 3D model reconstruction by using the iterative closest point (ICP). Then, a segmentation procedure is designed to separate the model set into a body part and head part. Based on the segmented 3D face point clouds, certain facial features are then extracted for recognition scoring. Taking a single shot from the depth sensor, the point cloud data is going to register with other 3D face models to determine which is the best candidate the data belongs to. By using the proposed feature-based 3D facial similarity score algorithm, which composes of normal, curvature, and registration similarities between different point clouds, the person can be labeled correctly even in a dark environment. The proposed method is suitable for smart devices such as smart phones and smart pads with tiny depth camera equipped. Experiments with real-world data show that the proposed method is able to reconstruct denser models and achieve point cloud-based 3D face recognition.
    MeSH term(s) Algorithms ; Artificial Intelligence ; Face ; Humans ; Imaging, Three-Dimensional
    Language English
    Publishing date 2021-04-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s21082587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Predicting clinical pregnancy using clinical features and machine learning algorithms in in vitro fertilization.

    Wang, Cheng-Wei / Kuo, Chao-Yang / Chen, Chi-Huang / Hsieh, Yu-Hui / Su, Emily Chia-Yu

    PloS one

    2022  Volume 17, Issue 6, Page(s) e0267554

    Abstract: Introduction: Assisted reproductive technology has been proposed for women with infertility. Moreover, in vitro fertilization (IVF) cycles are increasing. Factors contributing to successful pregnancy have been widely explored. In this study, we used ... ...

    Abstract Introduction: Assisted reproductive technology has been proposed for women with infertility. Moreover, in vitro fertilization (IVF) cycles are increasing. Factors contributing to successful pregnancy have been widely explored. In this study, we used machine learning algorithms to construct prediction models for clinical pregnancies in IVF.
    Materials and methods: A total of 24,730 patients entered IVF and intracytoplasmic sperm injection cycles with clinical pregnancy outcomes at Taipei Medical University Hospital. Data used included patient characteristics and treatment. We used machine learning methods to develop prediction models for clinical pregnancy and explored how each variable affects the outcome of interest using partial dependence plots.
    Results: Experimental results showed that the random forest algorithm outperforms logistic regression in terms of areas under the receiver operating characteristics curve. The ovarian stimulation protocol is the most important factor affecting pregnancy outcomes. Long and ultra-long protocols have shown positive effects on clinical pregnancy among all protocols. Furthermore, total frozen and transferred embryos are positive for a clinical pregnancy, but female age and duration of infertility have negative effects on clinical pregnancy.
    Conclusion: Our findings show the importance of variables and propensity of each variable by random forest algorithm for clinical pregnancy in the assisted reproductive technology cycle. This study provides a ranking of variables affecting clinical pregnancy and explores the effects of each treatment on successful pregnancy. Our study has the potential to help clinicians evaluate the success of IVF in patients.
    MeSH term(s) Algorithms ; Female ; Fertilization in Vitro ; Humans ; Infertility/therapy ; Machine Learning ; Pregnancy ; Pregnancy Rate ; Retrospective Studies ; Sperm Injections, Intracytoplasmic
    Language English
    Publishing date 2022-06-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0267554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A conserved mechanism for JNK-mediated loss of Notch function in advanced prostate cancer.

    Wang, Cheng-Wei / Clémot, Marie / Hashimoto, Takao / Diaz, Johnny A / Goins, Lauren M / Goldstein, Andrew S / Nagaraj, Raghavendra / Banerjee, Utpal

    Science signaling

    2023  Volume 16, Issue 810, Page(s) eabo5213

    Abstract: Dysregulated Notch signaling is a common feature of cancer; however, its effects on tumor initiation and progression are highly variable, with Notch having either oncogenic or tumor-suppressive functions in various cancers. To better understand the ... ...

    Abstract Dysregulated Notch signaling is a common feature of cancer; however, its effects on tumor initiation and progression are highly variable, with Notch having either oncogenic or tumor-suppressive functions in various cancers. To better understand the mechanisms that regulate Notch function in cancer, we studied Notch signaling in a
    MeSH term(s) Animals ; Male ; Humans ; Drosophila Proteins/metabolism ; Receptors, Notch/genetics ; Receptors, Notch/metabolism ; Drosophila ; Signal Transduction ; Prostatic Neoplasms/metabolism
    Chemical Substances Drosophila Proteins ; Receptors, Notch
    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2417226-1
    ISSN 1937-9145 ; 1945-0877
    ISSN (online) 1937-9145
    ISSN 1945-0877
    DOI 10.1126/scisignal.abo5213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comment on Sewell and Eastwood: Screening and treatment in developmental dysplasia of the hip--where do we go from here?

    Wang, Cheng-Wei

    International orthopaedics

    2012  Volume 36, Issue 7, Page(s) 1529

    MeSH term(s) Hip Dislocation, Congenital/diagnosis ; Hip Dislocation, Congenital/therapy ; Humans ; Mass Screening/methods ; Splints
    Language English
    Publishing date 2012-04-28
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 80384-4
    ISSN 1432-5195 ; 0341-2695
    ISSN (online) 1432-5195
    ISSN 0341-2695
    DOI 10.1007/s00264-012-1551-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Targeting myotonic dystrophy by preimplantation genetic diagnosis-karyomapping.

    Wang, Cheng-Wei / Liu, Yung-Liang / Chen, Chi-Huang

    Taiwanese journal of obstetrics & gynecology

    2019  Volume 58, Issue 6, Page(s) 891–894

    Abstract: Objective: To report a case with Myotonic dystrophy type I with successful preimplantation genetic diagnosis-karyomapping.: Case report: A 34-year-old female carrier of myotonic dystrophy type I was treated at our clinic with a successful pregnancy ... ...

    Abstract Objective: To report a case with Myotonic dystrophy type I with successful preimplantation genetic diagnosis-karyomapping.
    Case report: A 34-year-old female carrier of myotonic dystrophy type I was treated at our clinic with a successful pregnancy after preimplantation genetic testing for monogenic disorders using karyomapping of her blastocysts.
    Conclusion: Myotonic dystrophy type I is an inherited autosomal dominant disease producing various neuromuscular disturbances. Offspring of carriers have a 50% chance of carrying CTG repeat sequences in the DMPK gene, and various time-consuming methodologies have been developed for genetic diagnosis. With a novel, efficient, and precise method by karyomapping using single nucleotide polymorphism arrays to diagnose single gene disorders, one could terminate the transmission of single gene disorder. Herein, we reported a 34-year-old female carrier of myotonic dystrophy type I achieve a successful pregnancy after preimplantation genetic testing for monogenic disorders using karyomapping method of her blastocysts.
    MeSH term(s) Adult ; Blastocyst ; Female ; Genetic Testing/methods ; Humans ; Karyotyping ; Myotonic Dystrophy/diagnosis ; Myotonic Dystrophy/genetics ; Pregnancy ; Preimplantation Diagnosis/methods
    Language English
    Publishing date 2019-11-24
    Publishing country China (Republic : 1949- )
    Document type Case Reports ; Journal Article
    ISSN 1875-6263
    ISSN (online) 1875-6263
    DOI 10.1016/j.tjog.2019.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Hyperreactio luteinalis mimicking malignancy during pregnancy with elevated CA-125.

    Wang, Cheng-Wei / Liu, Wei-Min / Chen, Ching-Hui

    Taiwanese journal of obstetrics & gynecology

    2019  Volume 58, Issue 6, Page(s) 885–887

    Abstract: Objective: To report a case with benign bilateral ovarian tumor during pregnancy mimicking malignancy.: Case report: A 32-year-old women at 20 weeks gestation with large bilateral adnexal masses found on prenatal ultrasound. The cysts had been ... ...

    Abstract Objective: To report a case with benign bilateral ovarian tumor during pregnancy mimicking malignancy.
    Case report: A 32-year-old women at 20 weeks gestation with large bilateral adnexal masses found on prenatal ultrasound. The cysts had been growing gradually over the course of the pregnancy. MRI show huge multiple cysts in both ovaries. CA-125 was elevated at 260 U/mL. Due to initial impression was malignancy, an excisional surgery was done. Pathology revealed multiple luteinized granulosa cells with benign nature.
    Conclusion: Hyperreactio luteinalis (HL) is often asymptomatic and discovered incidentally on ultrasound or at the time of cesarean section. As the lesions are self-resolving, management is conservative and surgical intervention is required only in cases with severe complications. HL can be mistaken for malignancy, especially in cases in which the tumor marker CA-125 is elevated, leading to inadvertent surgery.
    MeSH term(s) Adult ; CA-125 Antigen/blood ; Diagnosis, Differential ; Fatal Outcome ; Female ; Fetal Death ; Humans ; Laparotomy/methods ; Magnetic Resonance Imaging/methods ; Ovarian Cysts/blood ; Ovarian Cysts/diagnosis ; Ovarian Cysts/surgery ; Ovarian Neoplasms/diagnosis ; Ovariectomy/methods ; Pregnancy ; Pregnancy Complications, Neoplastic ; Ultrasonography, Prenatal/methods
    Chemical Substances CA-125 Antigen
    Language English
    Publishing date 2019-11-24
    Publishing country China (Republic : 1949- )
    Document type Case Reports ; Journal Article
    ISSN 1875-6263
    ISSN (online) 1875-6263
    DOI 10.1016/j.tjog.2019.07.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: 聚苯乙烯与邻苯二甲酸二丁酯共存对紫叶生菜的毒性效应.

    Wang, Sheng-Li / Song, Zheng-Guo / Wang, Cheng-Wei / Liu, Yu / Gao, Min-Ling

    Ying yong sheng tai xue bao = The journal of applied ecology

    2021  Volume 32, Issue 9, Page(s) 3335–3340

    Abstract: As a carrier of environmental pollutants, microplastics have received wide concerns in recent years. However, the direct and indirect effects of the coexistence of polystyrene particles (PS) and pollutants on vegetables are still unclear. Here, the ... ...

    Title translation Toxic effects of polystyrene and dibutyl phthalate on purple lettuce.
    Abstract As a carrier of environmental pollutants, microplastics have received wide concerns in recent years. However, the direct and indirect effects of the coexistence of polystyrene particles (PS) and pollutants on vegetables are still unclear. Here, the combined effects of 0.25, 0.50, 1.0 mg·mL
    MeSH term(s) Dibutyl Phthalate/toxicity ; Lactuca ; Microplastics ; Plastics ; Polystyrenes/toxicity
    Chemical Substances Microplastics ; Plastics ; Polystyrenes ; Dibutyl Phthalate (2286E5R2KE)
    Language Chinese
    Publishing date 2021-10-11
    Publishing country China
    Document type Journal Article
    ZDB-ID 2881809-X
    ISSN 1001-9332
    ISSN 1001-9332
    DOI 10.13287/j.1001-9332.202109.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Early brainstem hemorrhage progression: multi-sequence magnetic resonance imaging and histopathology.

    Guo, Xi / Xu, Jia-Ke / Qi, Xin / Wei, Yang / Wang, Cheng-Wei / Li, Hao / Ma, Lu / You, Chao / Tian, Meng

    Neural regeneration research

    2022  Volume 18, Issue 1, Page(s) 170–175

    Abstract: According to clinical statistics, the mortality of patients with early brainstem hemorrhage is high. In this study, we established rat models of brainstem hemorrhage by injecting type VII collagenase into the right basotegmental pontine and investigated ... ...

    Abstract According to clinical statistics, the mortality of patients with early brainstem hemorrhage is high. In this study, we established rat models of brainstem hemorrhage by injecting type VII collagenase into the right basotegmental pontine and investigated the pathological changes of early brainstem hemorrhage using multi-sequence magnetic resonance imaging and histopathological methods. We found that brainstem hematoma gradually formed in the injured rats over the first 3 days and then reduced after 7 days. The edema that occurred was mainly of the vasogenic type. No complete myelin sheath structure was found around the focus of the brainstem hemorrhage. The integrity and continuity of nerve fibers gradually deteriorated over the first 7 days. Neuronal degeneration was mild in the first 3 days and then obviously aggravated on the 7
    Language English
    Publishing date 2022-07-07
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.344838
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Associations between Physical Activity, Functional Fitness, and Life Satisfaction among Community-Dwelling Older Adults.

    Syue, Shih-Huei / Yang, Hui-Fei / Wang, Cheng-Wei / Hung, Shih-Yu / Lee, Pei-Hsuan / Fan, Sheng-Yu

    International journal of environmental research and public health

    2022  Volume 19, Issue 13

    Abstract: Previous studies showed physical activity had benefits for older adults’ life satisfaction, but the mechanism was unclear. This study aimed to investigate whether older adults with more physical activity had better functional fitness and life ... ...

    Abstract Previous studies showed physical activity had benefits for older adults’ life satisfaction, but the mechanism was unclear. This study aimed to investigate whether older adults with more physical activity had better functional fitness and life satisfaction, and whether functional fitness mediated the relationship between physical activity and life satisfaction. A cross-sectional study design was employed, and 623 older adults (73.71 ± 5.91 years) were recruited. Physical activity, functional fitness, life satisfaction, and demographic characteristics were collected. Compared with older adults with low physical activity, those with high (B = 0.41, p = 0.025) and moderate (B = 0.40, p = 0.041) physical activity had better life satisfaction; those with high physical activity had better lower limb muscle strength (B = 1.71, p = 0.001), upper (B = 2.91, p = 0.032) and lower (B = 3.12, p = 0.006) limb flexibility, cardiorespiratory endurance (B = 6.65, p = 0.008), and dynamic balance ability (B = −1.12, p < 0.001). Functional fitness did not mediate the relationship between physical activity and life satisfaction. Promoting physical activity may be useful for increasing older adults’ functional fitness and life satisfaction, but the effects on functional fitness only occurred at a high level of physical activity, and the effect of physical activity on life satisfaction was not mediated by functional fitness.
    MeSH term(s) Cross-Sectional Studies ; Exercise ; Independent Living ; Muscle Strength/physiology ; Physical Fitness
    Language English
    Publishing date 2022-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19138043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Live birth in male de novo Kallmann syndrome after cross-generational genetic sequencing.

    Chan, Cindy / Wang, Cheng-Wei / Chen, Ching-Hui / Chen, Chi-Huang

    Journal of assisted reproduction and genetics

    2019  Volume 36, Issue 12, Page(s) 2481–2484

    Abstract: Purpose: To present the first case proposing the use of preimplantation genetic testing for monogeneic disorders for Kallmann syndrome, providing comprehensive care in the genomic era of precision medicine.: Methods: Gonadotropin therapy was used for ...

    Abstract Purpose: To present the first case proposing the use of preimplantation genetic testing for monogeneic disorders for Kallmann syndrome, providing comprehensive care in the genomic era of precision medicine.
    Methods: Gonadotropin therapy was used for spermatogenesis, followed by in vitro fertilization by intracytoplasmic sperm injection and embryo transfer. Cross-generational targeted next-generation sequencing was then done for genes known to cause Kallmann syndrome.
    Results: A heterozygous mutation at codon 102 of the FGFR1 gene was found in the patient, but the father was found to have the same mutation yet is unaffected by Kallmann syndrome. Since no causative mutation was found, a de novo or sporadic mutation was suspected as the cause of Kallmann syndrome in this case.
    Conclusions: Comprehensive care must be available for male Kallmann syndrome patients, as treatment should not stop at spermatogenesis, but continue with genetic counseling due to possible inheritance.
    MeSH term(s) Embryo Transfer ; Female ; Fertilization in Vitro ; Gonadotropins/administration & dosage ; High-Throughput Nucleotide Sequencing ; Humans ; Hypogonadism/drug therapy ; Hypogonadism/genetics ; Hypogonadism/pathology ; Kallmann Syndrome/diagnosis ; Kallmann Syndrome/drug therapy ; Kallmann Syndrome/genetics ; Kallmann Syndrome/pathology ; Live Birth/epidemiology ; Live Birth/genetics ; Male ; Mutation ; Pedigree ; Precision Medicine ; Pregnancy ; Pregnancy, Multiple ; Preimplantation Diagnosis ; Receptor, Fibroblast Growth Factor, Type 1/genetics ; Spermatogenesis/drug effects
    Chemical Substances Gonadotropins ; FGFR1 protein, human (EC 2.7.10.1) ; Receptor, Fibroblast Growth Factor, Type 1 (EC 2.7.10.1)
    Language English
    Publishing date 2019-11-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1112577-9
    ISSN 1573-7330 ; 1058-0468
    ISSN (online) 1573-7330
    ISSN 1058-0468
    DOI 10.1007/s10815-019-01604-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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