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  1. Book ; Online ; Thesis: Identification and characterization of the promoter region of the SLA-LP gene

    Wang, Chunxia

    2007  

    Author's details vorgelegt von Chunxia Wang
    Language English
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Hamburg, Univ., Diss., 2006
    HBZ-ID HT015011123
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: [Research advances in exosomes involved in the occurrence, development and clinical diagnosis and treatment of sepsis].

    Zhao, Yilin / Liu, Tiantian / Wang, Chunxia

    Zhonghua wei zhong bing ji jiu yi xue

    2024  Volume 36, Issue 2, Page(s) 221–224

    Abstract: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host immune response to infection. The development of sepsis is accompanied by the secretion of exosomes by a variety of cells, including non-coding RNA, metabolic small molecules ... ...

    Abstract Sepsis is a life-threatening organ dysfunction caused by a dysregulated host immune response to infection. The development of sepsis is accompanied by the secretion of exosomes by a variety of cells, including non-coding RNA, metabolic small molecules and proteins, which play an important role in immune inflammatory response, oxidative stress, and coagulation dysfunction. The rapid development of new detection technologies has promoted the application of exosomes in the early warning, severity stratification, treatment effect and prognosis evaluation of sepsis. This article reviews the new detection technology of exosomes, the involvement of exosomes in the pathological progress of sepsis, and the latest progress in the early diagnosis, disease assessment and treatment of sepsis, in order to provide new ideas for the diagnosis and treatment of sepsis.
    MeSH term(s) Humans ; Exosomes ; Sepsis/diagnosis ; Sepsis/therapy ; Blood Coagulation ; Oxidative Stress
    Language Chinese
    Publishing date 2024-03-05
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ISSN 2095-4352
    ISSN 2095-4352
    DOI 10.3760/cma.j.cn121430-20230809-00601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Commentary: Serum total bilirubin with hospital survival in adults during extracorporeal membrane oxygenation.

    Wang, Chunxia / Zhang, Yucai

    Frontiers in medicine

    2022  Volume 9, Page(s) 1022207

    Language English
    Publishing date 2022-09-28
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.1022207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Focusing on the long-term recovery of severe acute respiratory syndrome coronavirus 2 infection: Clinically relevant observations.

    Wang, Chunxia / Zhang, Yucai

    Clinical and translational discovery

    2022  Volume 2, Issue 2, Page(s) e99

    Abstract: Background: The long-term implications of COVID-19 attract global attention in the post-COVID-19 pandemic era. Impaired lung function is the main sequelae in adults' survivors of SARS-CoV-2 infection.: Methods and results: The plasma proteomic ... ...

    Abstract Background: The long-term implications of COVID-19 attract global attention in the post-COVID-19 pandemic era. Impaired lung function is the main sequelae in adults' survivors of SARS-CoV-2 infection.
    Methods and results: The plasma proteomic pattern provides novel evidence on multiple biological domains relevant to monitoring lung function and targeting the clinical application in adults with acute respiratory distress syndrome (ARDS) secondary to SARS-CoV-2 infection (SARS-CoV-2-ARDS). Preliminary studies support the evidence of pulmonary function tests (PFT) and computed tomography (CT) scan as routine follow-up tools. Combining the early fibrotic indicators and D-dimer levels could prove the validity and reliability of the proactive management of lung function assessment during the long-term recovery in SARS-CoV-2 infection.
    Conclusion: In summary, protocolized PFT and CT scan and effective biomarkers for early fibrotic changes should be applied to clinical practice during the long follow-up in patients with severe COVID-19.
    Language English
    Publishing date 2022-06-22
    Publishing country United States
    Document type Journal Article
    ISSN 2768-0622
    ISSN (online) 2768-0622
    DOI 10.1002/ctd2.99
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: In Rheumatoid Arthritis, A Review of ncRNAs Related to NF-κB Signaling Pathways.

    Wang, Chun-Xia / Cheng, Hsiang-Hung / Luo, Mei / Jiang, Jing-Rong

    Current pharmaceutical biotechnology

    2024  

    Abstract: Rheumatoid arthritis (RA) is an autoimmune disease with no known cure that results in joint deformities and dysfunction, significantly impacting the quality of life of patients. The abnormal NF-ＫB signaling pathway in RA has emerged as a crucial research ...

    Abstract Rheumatoid arthritis (RA) is an autoimmune disease with no known cure that results in joint deformities and dysfunction, significantly impacting the quality of life of patients. The abnormal NF-ＫB signaling pathway in RA has emerged as a crucial research area for the development of RA therapies, with non-coding RNAs (ncRNAs) serving as a potentially meaningful avenue to regulate it. Thus, understanding the role of ncRNAs in RA and the identification of new therapeutic targets have become pressing issues in the field. In this review, we aim to summarize recent studies on ncRNAs that regulate the NF-ＫB signaling pathway in RA, including miRNAs, lncRNAs, and circRNAs, as well as the mechanisms by which drugs modulate NF-Ｋ B activity. By highlighting these recent advances, we hope to promote further research into targeted RA therapy and provide novel directions and ideas for researchers in the field.
    Language English
    Publishing date 2024-02-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/0113892010262829240214061103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Sequential respiratory support in septic patients undergoing continuous renal replacement therapy: A study based on MIMIC-III database.

    Wang, Chunxia / Zheng, Jianli / Zhao, Yilin / Liu, Tiantian / Zhang, Yucai

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e27563

    Abstract: Objective: Oxygen and hemodynamic management are important for providing a sufficient adequate oxygen-containing blood to the organs for septic patients. In present study, we aimed to explore the application of sequential respiratory support (SRS) and ... ...

    Abstract Objective: Oxygen and hemodynamic management are important for providing a sufficient adequate oxygen-containing blood to the organs for septic patients. In present study, we aimed to explore the application of sequential respiratory support (SRS) and the association of SRS with the outcome of septic patients who needed continuous renal replacement therapy (CRRT).
    Methods: We extracted the medical information of septic patients who received CRRT within 24 h of intensive care unit (ICU) admission from the MIMIC-III v1.4. SRS was defined as receiving firstly oxygen therapy followed by mechanical ventilation (MV) within 24 h of admission to ICU. The
    Results: A total of 181 patients entered in this study, and there were 80 patients undergoing MV including SRS group (n = 61) and non-SRS group (n = 19). In the multivariate
    Conclusions: Receiving SRS within the first 24 h upon admission to the ICU was independently associated with the hospital mortality in patient with sepsis undergoing CRRT, and patients who were directly received MV had a high risk of death.
    Language English
    Publishing date 2024-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: An Activated Structure Transformable Ratiometric Photoacoustic Nanoprobe for Real-Time Dynamic Monitoring of H

    Wen, Xingwang / Bi, Shenghui / Wang, Chunxia / Zeng, Songjun

    Nano letters

    2023  Volume 23, Issue 22, Page(s) 10642–10650

    Abstract: ... ...

    Abstract H
    MeSH term(s) Humans ; Spectrum Analysis ; Metformin ; Chemical and Drug Induced Liver Injury ; Fluorescent Dyes/chemistry
    Chemical Substances Metformin (9100L32L2N) ; Fluorescent Dyes
    Language English
    Publishing date 2023-11-13
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c03980
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Leaf spot of Kerria japonica caused by Diaporthe pescicola in China

    Zhang, Hulei / Wang, Chunxia / Wang, Shenhai / Mao, Shengfeng

    Canadian Journal of Plant Pathology. 2023 Mar. 04, v. 45, no. 2 p.118-127

    2023  

    Abstract: This article reports the first known occurrence of leaf spot of Kerria japonica caused by Diaporthe pescicola in China and worldwide. Leaves of K. japonica with leaf spot symptoms were collected in September 2020 from Nanjing, Jiangsu, China. Leaf ... ...

    Abstract This article reports the first known occurrence of leaf spot of Kerria japonica caused by Diaporthe pescicola in China and worldwide. Leaves of K. japonica with leaf spot symptoms were collected in September 2020 from Nanjing, Jiangsu, China. Leaf lesions were of irregular shape and sizes forming mostly in the middle of the leaves, and most of the lesions were white and hazel in colour. A fungus was isolated from diseased leaves and identified as Diaporthe pescicola based on morphological features and multigene phylogenetic analysis of the internal transcribed spacer (ITS) region, elongation factor 1-alpha (EF1-α), beta-tubulin (β-tub), histone H3 (HIS) and calmodulin (CAL) genes. Three strains of isolated fungus caused leaf spot symptoms on inoculated wounded leaves of K. japonica, which were similar to the natural symptoms observed in the field. This disease greatly reduces the ornamental value of affected plants, and identification of the pathogen is significant for the prevention and control of the disease.
    Keywords Diaporthe ; Kerria japonica ; calmodulin ; color ; fungi ; histones ; internal transcribed spacers ; leaf spot ; leaves ; ornamental value ; pathogens ; peptide elongation factors ; phylogeny ; plant pathology ; tubulin ; China ; morphology ; multi-gene phylogeny ; pathogenicity
    Language English
    Dates of publication 2023-0304
    Size p. 118-127.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 763044-x
    ISSN 0706-0661 ; 1715-2992
    ISSN 0706-0661 ; 1715-2992
    DOI 10.1080/07060661.2022.2142671
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3709: Show issues

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  9. Article ; Online: Novel CPLANE1 c.8948dupT (p.P2984Tfs*7) variant in a child patient with Joubert syndrome

    Wang Huiping / Nie Wensha / Wang Chunxia / Wang Zuohua / Zheng Yuxia

    Open Life Sciences, Vol 18, Iss 1, Pp 813-

    2023  Volume 25

    Abstract: Joubert syndrome (JBTS) is a class of heterogeneous ciliopathy genetically associated with CPLANE1 mutations. The characteristics of clinical phenotypes and CPLANE1 variants were analyzed in a 2-month-old patient. A 2-month-old patient with JBTS was ... ...

    Abstract Joubert syndrome (JBTS) is a class of heterogeneous ciliopathy genetically associated with CPLANE1 mutations. The characteristics of clinical phenotypes and CPLANE1 variants were analyzed in a 2-month-old patient. A 2-month-old patient with JBTS was diagnosed after clinical evaluation including family history, physical examination, cerebral MRI, ultrasonography imaging, VEGG, ocular fundus examination, and comprehensive blood and urine testing. Whole exome sequencing (WES) was performed to detect CPLANE1 variants, and Sanger sequencing was used to confirm the variants. This JBTS patient presented with oculomotor apraxia, dysregulation of breathing pattern, and ataxia. MRI revealed poor continuity of cerebelli, batwing appearance, and molar tooth sign. This patient was noted with abnormal hematology, dysregulation of hepatic function, thyroid function, immunity, and renal function, and encephalopathy. CPLANE1 (c.8948dupT (p.P2984Tfs*7) and c.247G > T (p.G83X)) variants were noticed in the patient as a pathogenic variant and caused autosomal recessive inheritance. The JBTS patient with mutations in CPLANE1 (c.8948dupT (p.P2984Tfs*7) and c.247G > T (p.G83X)) developed JBTS phenotypes. The novel CPLANE1 c.8948dupT (p.P2984Tfs*7) variant will assist clinicians and geneticists in reaching a precise diagnosis for JBTS.
    Keywords joubert syndrome ; cplane1 ; oculomotor apraxia ; ataxia ; molar tooth sign ; Biology (General) ; QH301-705.5
    Subject code 616
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Predictive value of PAPP-A for ectopic pregnancy and analysis of related factors.

    Zhang, Xiaoyun / Wang, Chunxia

    Experimental and therapeutic medicine

    2021  Volume 22, Issue 2, Page(s) 801

    Abstract: The present study was designed to analyze the expression of pregnancy-associated plasma protein-A (PAPP-A) in the serum of patients with ectopic pregnancy (EP) and related factors inducing this condition. Seventy-five patients with EP admitted to the ... ...

    Abstract The present study was designed to analyze the expression of pregnancy-associated plasma protein-A (PAPP-A) in the serum of patients with ectopic pregnancy (EP) and related factors inducing this condition. Seventy-five patients with EP admitted to the Affiliated Hospital of Jining Medical University from January 2018 to February 2019 were selected as the research group, and another 59 healthy pregnant women of the corresponding age, gravidity and gestational week were enrolled in the control group. ELISA was employed to detect the serum expression levels of PAPP-A and inflammatory factors such as interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α). ROC was adopted to evaluate the diagnostic value of serum PAPP-A in patients with EP, and Pearson correlation coefficient was applied to analyze the correlation of PAPP-A with inflammatory factors IL-8 and TNF-α. Serum PAPP-A expression was significantly lower in EP patients than those in the control group. The area under the curve (AUC) of serum PAPP-A in diagnosing EP patients was 0.812, and the PAPP-A value in the control group was significantly higher than that of the research group at 7-8 weeks and ≥9 weeks. With regard to the expression of inflammatory factors, the research group presented markedly higher IL-8 and TNF-α levels than the control group. PAPP-A was negatively related to inflammatory factors IL-8 and TNF-α in the research group. In addition, it was revealed that patients with a history of genital surgery, salpingotomy, pelvic infection, EP or low PAPP-A expression were at high risk of EP. In conclusion, PAPP-A was revealed to be lowly expressed in the serum of EP patients, and to negatively be correlated with inflammatory factors IL-8 and TNF-α, which may serve as a useful marker for the diagnosis and prognosis of EP.
    Language English
    Publishing date 2021-05-26
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2021.10233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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