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  1. Article ; Online: Antibiotic bone cement accelerates diabetic foot wound healing: Elucidating the role of ROCK1 protein expression.

    Yang, Chenglan / Wang, Dali

    International wound journal

    2024  Volume 21, Issue 4, Page(s) e14590

    Abstract: Clinical studies indicate antibiotic bone cement with propeller flaps improves diabetic foot wound repair and reduces amputation rates, but the molecular mechanisms, particularly key proteins' role remain largely unexplored. This study assessed the ... ...

    Abstract Clinical studies indicate antibiotic bone cement with propeller flaps improves diabetic foot wound repair and reduces amputation rates, but the molecular mechanisms, particularly key proteins' role remain largely unexplored. This study assessed the efficacy of antibiotic bone cement for treating diabetic foot wounds, focusing on molecular impact on ROCK1. Sixty patients were randomized into experimental (EXP, n = 40) and control (CON, n = 20) groups, treated with antibiotic bone cement and negative pressure. Wound healing rate, amputation rate, wound secretion culture and C-reactive protein (CRP) changes, were monitored. Comprehensive molecular investigations were conducted and animal experiments were performed to further validate the findings. Statistical methods were employed to verify significant differences between the groups and treatment outcomes. The EXP group showed significant improvements in wound healing (
    MeSH term(s) Humans ; Diabetic Foot/therapy ; Bone Cements/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Wound Healing ; Amputation, Surgical ; Diabetes Mellitus ; rho-Associated Kinases/therapeutic use
    Chemical Substances Bone Cements ; Anti-Bacterial Agents ; ROCK1 protein, human (EC 2.7.11.1) ; rho-Associated Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2024-03-24
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2170920-8
    ISSN 1742-481X ; 1742-4801
    ISSN (online) 1742-481X
    ISSN 1742-4801
    DOI 10.1111/iwj.14590
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  2. Article: Potential of

    Zhang, Fenghua / Wang, Dali

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1191445

    Abstract: The gut microbiota varies dramatically among individuals, and changes over time within the same individual, due to diversities in genetic backgrounds, diet, nutrient supplementations and use of antibiotics. Up until now, studies on dysbiosis of ... ...

    Abstract The gut microbiota varies dramatically among individuals, and changes over time within the same individual, due to diversities in genetic backgrounds, diet, nutrient supplementations and use of antibiotics. Up until now, studies on dysbiosis of microbiota have expanded to a wider range of diseases, with
    Language English
    Publishing date 2023-06-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1191445
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  3. Article ; Online: Mutual effects of microplastics and microbes: tiny things have big impacts.

    Ding, Qi / Yu, Jing / Wang, Dali / You, Jing

    Future microbiology

    2023  Volume 18, Page(s) 159–162

    MeSH term(s) Microplastics/pharmacology ; Plastics/pharmacology ; Gastrointestinal Microbiome
    Chemical Substances Microplastics ; Plastics
    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2254620-0
    ISSN 1746-0921 ; 1746-0913
    ISSN (online) 1746-0921
    ISSN 1746-0913
    DOI 10.2217/fmb-2022-0237
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  4. Article ; Online: Drug-Grafted DNA for Cancer Therapy.

    Wang, Dali / Zhang, Xinyue / Zhu, Xinyuan

    The journal of physical chemistry. B

    2023  Volume 127, Issue 24, Page(s) 5379–5388

    Abstract: With the development of solid-phase synthesis and DNA nanotechnology, DNA-based drug delivery systems have seen large advancements over the past decades. By combining various drugs (small-molecular drugs, oligonucleotides, peptides, and proteins) with ... ...

    Abstract With the development of solid-phase synthesis and DNA nanotechnology, DNA-based drug delivery systems have seen large advancements over the past decades. By combining various drugs (small-molecular drugs, oligonucleotides, peptides, and proteins) with DNA technology, drug-grafted DNA has demonstrated great potential as a promising platform in recent years, in which complementary properties of both components have been discovered; for instance, the synthesis of amphiphilic drug-grafted DNA has enabled the production of DNA nanomedicines for gene therapy and chemotherapy. Through the design of linkages between drug and DNA parts, stimuli-responsiveness can be instilled, which has boosted the application of drug-grafted DNA in various biomedical applications such as cancer therapy. This review discusses the progress of various drug-grafted DNA therapeutic agents, exploring the synthetic techniques and anticancer applications afforded through the combination of drug and nucleic acids.
    MeSH term(s) Humans ; Pharmaceutical Preparations ; DNA/chemistry ; Drug Delivery Systems/methods ; Nanotechnology/methods ; Neoplasms/drug therapy
    Chemical Substances Pharmaceutical Preparations ; DNA (9007-49-2)
    Language English
    Publishing date 2023-06-09
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.3c01321
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  5. Article ; Online: Spatial pattern of the ecological environment in Yunnan Province.

    Wang, Dali / Ding, Wenli

    PloS one

    2021  Volume 16, Issue 6, Page(s) e0248090

    Abstract: Ecological science focuses on the structure and function of the natural environment. However, the study of ecological environments primarily focuses on single-element research and lacks a comprehensive perspective. To examine ecological environmental ... ...

    Abstract Ecological science focuses on the structure and function of the natural environment. However, the study of ecological environments primarily focuses on single-element research and lacks a comprehensive perspective. To examine ecological environmental trends on different scales, the present paper selected Yunnan Province as the study area. Chemical oxygen demand, rocky desertification, forest coverage, natural disaster data and spatial analysis methods were used to obtain the ecological environmental characteristics of each county and construct a comprehensive evaluation method of the ecological environment. The present paper revealed that the environmental capacity in Yunnan Province was at a moderate level, the ecological environment fragility was remarkable, the significance of the ecological environment was very high, natural disasters occurred frequently, and spatial differentiation between ecological environments was obvious. The province may be divided into three functional areas: the comprehensive-balanced area, the efficiency-dominated area and the environment-dominated area. Central Yunnan was a key development zone and the main area for the manufacturing and service industries, which were built as a modern industrial system in Yunnan Province. The ecological environment in northwestern Yunnan and southern Yunnan is of high significance, and this region was an ecological environment protection area that was important area for the construction of the modern agricultural system in Yunnan Province. To achieve sustainable development of the ecological environment, the spatial characteristics of the ecological environment must be determined at the county scale.
    MeSH term(s) Agriculture/methods ; China ; Conservation of Natural Resources/methods ; Conservation of Natural Resources/trends ; Demography/methods ; Demography/statistics & numerical data ; Ecological and Environmental Phenomena/physiology ; Ecosystem ; Forests
    Language English
    Publishing date 2021-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0248090
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  6. Article: Identification of a shared gene signature and biological mechanism between diabetic foot ulcers and cutaneous lupus erythemnatosus by transcriptomic analysis.

    Wu, Siqi / Wang, Yuetong / Duan, Jingyi / Teng, Ying / Wang, Dali / Qi, Fang

    Frontiers in physiology

    2024  Volume 15, Page(s) 1297810

    Abstract: Diabetic foot ulcers (DFU) and cutaneous lupus erythematosus (CLE) are both diseases that can seriously affect a patient's quality of life and generate economic pressure in society. Symptomatically, both DLU and CLE exhibit delayed healing and excessive ... ...

    Abstract Diabetic foot ulcers (DFU) and cutaneous lupus erythematosus (CLE) are both diseases that can seriously affect a patient's quality of life and generate economic pressure in society. Symptomatically, both DLU and CLE exhibit delayed healing and excessive inflammation; however, there is little evidence to support a molecular and cellular connection between these two diseases. In this study, we investigated potential common characteristics between DFU and CLE at the molecular level to provide new insights into skin diseases and regeneration, and identify potential targets for the development of new therapies. The gene expression profiles of DFU and CLE were obtained from the Gene Expression Omnibus (GEO) database and used for analysis. A total of 41 common differentially expressed genes (DEGs), 16 upregulated genes and 25 downregulated genes, were identified between DFU and CLE. GO and KEGG analysis showed that abnormalities in epidermal cells and the activation of inflammatory factors were both involved in the occurrence and development of DFU and CLE. Protein-protein interaction network (PPI) and sub-module analysis identified enrichment in seven common key genes which is
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2024.1297810
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  7. Article ; Online: Di-CNN: Domain-Knowledge-Informed Convolutional Neural Network for Manufacturing Quality Prediction.

    Guo, Shenghan / Wang, Dali / Feng, Zhili / Chen, Jian / Guo, Weihong

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 11

    Abstract: In manufacturing, convolutional neural networks (CNNs) are widely used on image sensor data for data-driven process monitoring and quality prediction. However, as purely data-driven models, CNNs do not integrate physical measures or practical ... ...

    Abstract In manufacturing, convolutional neural networks (CNNs) are widely used on image sensor data for data-driven process monitoring and quality prediction. However, as purely data-driven models, CNNs do not integrate physical measures or practical considerations into the model structure or training procedure. Consequently, CNNs' prediction accuracy can be limited, and model outputs may be hard to interpret practically. This study aims to leverage manufacturing domain knowledge to improve the accuracy and interpretability of CNNs in quality prediction. A novel CNN model, named Di-CNN, was developed that learns from both design-stage information (such as working condition and operational mode) and real-time sensor data, and adaptively weighs these data sources during model training. It exploits domain knowledge to guide model training, thus improving prediction accuracy and model interpretability. A case study on resistance spot welding, a popular lightweight metal-joining process for automotive manufacturing, compared the performance of (1) a Di-CNN with adaptive weights (the proposed model), (2) a Di-CNN without adaptive weights, and (3) a conventional CNN. The quality prediction results were measured with the mean squared error (MSE) over sixfold cross-validation. Model (1) achieved a mean MSE of 6.8866 and a median MSE of 6.1916, Model (2) achieved 13.6171 and 13.1343, and Model (3) achieved 27.2935 and 25.6117, demonstrating the superior performance of the proposed model.
    MeSH term(s) Neural Networks, Computer ; Commerce
    Language English
    Publishing date 2023-06-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23115313
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  8. Article ; Online: Value of contrast-enhanced ultrasound in the differential diagnosis of ureteral tuberculosis from ureteral malignant tumour in women.

    Zhang, Wenzhi / Yang, Gaoyi / Xu, Jianping / Wang, Dali / Ni, Tu

    Epidemiology and infection

    2023  Volume 151, Page(s) e53

    Abstract: This study aimed to evaluate the contrast-enhanced ultrasound (CEUS) features of ureteral tuberculosis (UTB) and ureteral malignant tumour and to explore its application value in the differentiation of UTB from ureteral tumour. The ultrasound (US) and ... ...

    Abstract This study aimed to evaluate the contrast-enhanced ultrasound (CEUS) features of ureteral tuberculosis (UTB) and ureteral malignant tumour and to explore its application value in the differentiation of UTB from ureteral tumour. The ultrasound (US) and CEUS imaging features of 33 and 12 cases of pathologically confirmed UTB and ureteral malignant tumour, respectively, were retrospectively evaluated, and echo of the ureteral wall, abnormal echo of the lumen, degree of ureteral dilation and CEUS patterns of the two diseases were statistically analysed. The results revealed that the lumen echo of UTB was hyperechoic or anechoic, whereas that of ureteral tumour lesions was hypoechoic (
    MeSH term(s) Humans ; Female ; Ureteral Neoplasms ; Diagnosis, Differential ; Retrospective Studies ; Contrast Media ; Tuberculosis
    Chemical Substances Contrast Media
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632982-2
    ISSN 1469-4409 ; 0950-2688
    ISSN (online) 1469-4409
    ISSN 0950-2688
    DOI 10.1017/S0950268823000419
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  9. Article ; Online: Relationship between ozone and air temperature in future conditions: A case study in sichuan basin, China.

    Wang, Ju / Li, Juan / Li, Xinlong / Wang, Dali / Fang, Chunsheng

    Environmental pollution (Barking, Essex : 1987)

    2023  Volume 343, Page(s) 123276

    Abstract: The Sichuan Basin (SCB) is located in southwestern China and has a unique topography where ozone ( ... ...

    Abstract The Sichuan Basin (SCB) is located in southwestern China and has a unique topography where ozone (O
    MeSH term(s) Ozone/analysis ; Temperature ; Air Pollutants/analysis ; Environmental Monitoring/methods ; Air Pollution/analysis ; China
    Chemical Substances Ozone (66H7ZZK23N) ; Air Pollutants
    Language English
    Publishing date 2023-12-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.123276
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  10. Article ; Online: Sciatic Nerve Schwannoma in the Lower Limb Mimicking Ganglion Cyst.

    Zhang, Yanji / Wei, Zairong / Zhang, Gaofeng / Wang, Dali

    American journal of physical medicine & rehabilitation

    2022  Volume 101, Issue 9, Page(s) e143–e144

    MeSH term(s) Ganglion Cysts/diagnostic imaging ; Humans ; Lower Extremity ; Neurilemmoma/diagnostic imaging ; Neurilemmoma/surgery ; Sciatic Nerve
    Language English
    Publishing date 2022-03-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219390-5
    ISSN 1537-7385 ; 0002-9491 ; 0894-9115
    ISSN (online) 1537-7385
    ISSN 0002-9491 ; 0894-9115
    DOI 10.1097/PHM.0000000000002013
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