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  1. Book ; Online ; E-Book: Toxicology at environmentally relevant concentrations in Caenorhabditis elegans

    Wang, Dayong

    2022  

    Author's details Dayong Wang
    Keywords Nematodes ; Environmental toxicology
    Subject code 595.182
    Language English
    Size 1 online resource (371 pages)
    Publisher Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-16-6745-4 ; 981-16-6746-2 ; 978-981-16-6745-9 ; 978-981-16-6746-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Toxicology at Environmentally Relevant Concentrations in Caenorhabditis elegans

    Wang, Dayong

    2022  

    Author's details Dr. Dayong Wang is a professor at the Medical School, Southeast University, China. He obtained his Ph.D. from Peking University in 2001 and completed his post-doctoral training at the University of Toronto from 2002 to 2004. His research focuses on toxicology and pathology using Caenorhabditis elegans as a model animal, fields in which he has published more than 250 research articles. Dr. Wang has published five books with Springer, all of which are centered on the toxicology in Caenorhabditis elegans.§
    Keywords Environmentallyrelevantconcentrations ; Caenorhabditiselegans ; EnvironmentalExposure ; Molecularsignallingpathways ; ionchannels ; Toxicology ; Environmentally relevant concentrations ; Caenorhabditis elegans ; Environmental exposure ; Molecular signalling pathways ; Ion channels
    Language English
    Size 376 p.
    Edition 1
    Publisher Springer Nature Singapore
    Document type Book
    Note PDA Manuell_13
    Format 160 x 241 x 26
    ISBN 9789811667459 ; 9811667454
    Database PDA

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  3. Book ; Online ; E-Book: Exposure Toxicology in Caenorhabditis elegans

    Wang, Dayong

    2020  

    Abstract: This book focuses on exposure toxicology in C. elegans. The nematode Caenorhabditis elegans is sensitive to various environmental toxicants and stresses, and has proven to be an important animal model in both molecular and target-organ toxicology. As a ... ...

    Author's details by Dayong Wang
    Abstract This book focuses on exposure toxicology in C. elegans. The nematode Caenorhabditis elegans is sensitive to various environmental toxicants and stresses, and has proven to be an important animal model in both molecular and target-organ toxicology. As a result, over the past 30 years, there has been extensive research on the exposure to environmental toxicants or stresses in nematodes. Based on the available data, the book offers an introduction to the exposure system established in nematodes, discussing various aspects of endpoints that can potentially be used to assess the toxicity of environmental toxicants or stresses. Also exploring various factors affecting toxicity induction, and exposure to environmental toxicants and stresses, it allows readers to gain a systematic understanding of exposure toxicology in C. elegans. .
    Keywords Medicine ; Pharmacology ; Biomedicine, general ; Pharmacology/Toxicology ; Nematodes ; Toxicologia ambiental
    Subject code 615.902
    Language English
    Size 1 online resource (692 pages)
    Edition 1st ed. 2020.
    Publisher Springer Singapore ; Imprint: Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-15-6129-X ; 981-15-6128-1 ; 978-981-15-6129-0 ; 978-981-15-6128-3
    DOI 10.1007/978-981-15-6129-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Online ; E-Book: Target organ toxicology in Caenorhabditis elegans

    Wang, Dayong

    2019  

    Author's details Dayong Wang
    Keywords Toxicology ; Cytology ; Invertebrates
    Subject code 615
    Language English
    Size 1 Online-Ressource (xiii, 337 Seiten), Illustrationen
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020029204
    ISBN 978-981-13-6010-7 ; 9789811360091 ; 981-13-6010-3 ; 981136009X
    DOI 10.1007/978-981-13-6010-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Protein-Engineered Hirudins with Enhanced Anticoagulant Activities Developed by a Molecular Integrative Approach.

    Sun, Yan / Wang, Dayong

    Journal of medicinal chemistry

    2024  Volume 67, Issue 5, Page(s) 3203–3204

    MeSH term(s) Hirudins ; Anticoagulants/pharmacology ; Amino Acid Sequence ; Recombinant Proteins
    Chemical Substances Hirudins ; Anticoagulants ; Recombinant Proteins
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Letter
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.4c00003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Polyethylene nanoparticles at environmentally relevant concentrations enhances neurotoxicity and accumulation of 6-PPD quinone in Caenorhabditis elegans.

    Hua, Xin / Wang, Dayong

    The Science of the total environment

    2024  Volume 918, Page(s) 170760

    Abstract: The exposure risk of 6-PPD quinone (6-PPDQ) has aroused increasing concern. In the natural environment, 6-PPDQ could interact with other pollutants, posing more severe environmental problems and toxicity to organisms. We here examined the effect of ... ...

    Abstract The exposure risk of 6-PPD quinone (6-PPDQ) has aroused increasing concern. In the natural environment, 6-PPDQ could interact with other pollutants, posing more severe environmental problems and toxicity to organisms. We here examined the effect of polyethylene nanoplastic (PE-NP) on 6-PPDQ neurotoxicity and the underling mechanisms in Caenorhabditis elegans. In nematodes, PE-NP (1 and 10 μg/L) decreased locomotion behavior, but did not affect development of D-type neurons. Exposure to PE-NP (1 and 10 μg/L) strengthened neurotoxicity of 6-PPDQ (10 μg/L) on the aspect of locomotion and neurodegeneration induction of D-type motor neurons. Exposure to PE-NPs (10 μg/L) caused increase in expressions of mec-4, asp-3, and asp-4 governing neurodegeneration in 10 μg/L 6-PPDQ exposed nematodes. Moreover, exposure to PE-NP (10 μg/L) increased expression of some neuronal genes (daf-7, dbl-1, jnk-1, and mpk-1) in 6-PPDQ exposed nematodes, and RNAi of these genes resulted in susceptibility to neurotoxicity of PE-NP and 6-PPDQ. 6-PPDQ could be adsorbed by PE-NPs, and resuspension of PE-NP and 6-PPDQ after adsorption equilibrium exhibited similar neurotoxicity to co-exposure of PE-NP and 6-PPDQ. In addition, exposure to PE-NP (1 and 10 μg/L) increased 6-PPDQ accumulation in body of nematodes and increased defecation cycle length in 6-PPDQ exposed nematodes. Therefore, 6-PPDQ could be adsorbed on nanoplastics (such as PE-NPs) and enhance both neurotoxicity and accumulation of 6-PPDQ in organisms.
    MeSH term(s) Animals ; Caenorhabditis elegans/physiology ; Polyethylene ; Quinones ; Nanoparticles/toxicity ; Polystyrenes/toxicity ; Benzoquinones
    Chemical Substances Polyethylene (9002-88-4) ; quinone (3T006GV98U) ; Quinones ; Polystyrenes ; Benzoquinones
    Language English
    Publishing date 2024-02-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.170760
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  7. Article ; Online: Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Inhibits Both Lifespan and Healthspan in

    Hua, Xin / Wang, Dayong

    Environmental science & technology

    2023  Volume 57, Issue 48, Page(s) 19295–19303

    Abstract: ... ...

    Abstract N
    MeSH term(s) Animals ; Caenorhabditis elegans/drug effects ; Caenorhabditis elegans/physiology ; Caenorhabditis elegans Proteins/metabolism ; Insulin/metabolism ; Longevity/drug effects ; Environmental Exposure ; Phenylenediamines/toxicity ; Benzoquinones/toxicity ; Receptor, Insulin/metabolism ; Signal Transduction/drug effects
    Chemical Substances Caenorhabditis elegans Proteins ; Insulin ; N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone ; Phenylenediamines ; Benzoquinones ; DAF-2 protein, C elegans (EC 2.7.10.1) ; Receptor, Insulin (EC 2.7.10.1)
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.3c05325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Disruption of dopamine metabolism by exposure to 6-PPD quinone in Caenorhabditis elegans.

    Hua, Xin / Wang, Dayong

    Environmental pollution (Barking, Essex : 1987)

    2023  Volume 337, Page(s) 122649

    Abstract: Caenorhabditis elegans is a useful model for examining metabolic processes and related mechanisms. We here examined the effect of exposure to N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6-PPDQ) on dopamine metabolism and underling ... ...

    Abstract Caenorhabditis elegans is a useful model for examining metabolic processes and related mechanisms. We here examined the effect of exposure to N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6-PPDQ) on dopamine metabolism and underling molecular basis in nematodes. The dopamine content was reduced by 6-PPDQ (1 and 10 μg/L). Meanwhile, dopamine related behaviors (basal slowing response and area restricted searching) were changed by 6-PPDQ (1 and 10 μg/L). Exposure to 6-PPDQ (1 and 10 μg/L) decreased expressions of genes (cat-2 and bas-1) encoding enzymes governing dopamine synthesis and cat-1 encoding dopamine transporter. Development of dopaminergic neurons was also affected by 10 μg/L 6-PPDQ as reflected by decrease in fluorescence intensity, neuronal loss, and defect in dendrite development. Exposure to 6-PPDQ (1 and 10 μg/L) altered expressions of ast-1 and rcat-1 encoding upregulators of cat-2 and bas-1. The dopamine content and expressions of cat-2 and bas-1 were inhibited by RNAi of ast-1 and increased by RNAi of rcat-1 in 6-PPDQ exposed nematodes. Using endpoints of locomotion behavior and brood size, in 6-PPDQ exposed nematodes, the susceptibility to toxicity was caused by RNAi of ast-1, cat-2, bas-1, and cat-1, and the resistance to toxicity was induced by RNAi of rcat-1. Therefore, 6-PPDQ exposure disrupted dopamine metabolism and the altered molecular basis for dopamine metabolism was associated with 6-PPDQ toxicity induction. Moreover, the defects in dopamine related behaviors and toxicity on locomotion and reproduction could be rescued by treatment with 0.1 mM dopamine.
    MeSH term(s) Animals ; Caenorhabditis elegans/drug effects ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/metabolism ; Dopamine/metabolism ; Oxidative Stress ; Phenylenediamines/toxicity ; Benzoquinones/toxicity
    Chemical Substances Caenorhabditis elegans Proteins ; Dopamine (VTD58H1Z2X) ; N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone ; Phenylenediamines ; Benzoquinones
    Language English
    Publishing date 2023-09-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.122649
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    Zs.A 2599: Show issues Location:
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  9. Article ; Online: Tire-rubber related pollutant 6-PPD quinone: A review of its transformation, environmental distribution, bioavailability, and toxicity.

    Hua, Xin / Wang, Dayong

    Journal of hazardous materials

    2023  Volume 459, Page(s) 132265

    Abstract: The antioxidant 6-PPD has been widely used to prevent cracking and thermal oxidative degradation and to extend the service life of tire rubber. 6-PPD quinone (6-PPDQ) is formed via the reaction of 6-PPD with ... ...

    Abstract The antioxidant 6-PPD has been widely used to prevent cracking and thermal oxidative degradation and to extend the service life of tire rubber. 6-PPD quinone (6-PPDQ) is formed via the reaction of 6-PPD with O
    MeSH term(s) Animals ; Biological Availability ; Environmental Pollutants/analysis ; Environmental Pollutants/metabolism ; Environmental Pollutants/toxicity ; Rubber/toxicity ; Phenylenediamines/analysis ; Phenylenediamines/metabolism ; Phenylenediamines/toxicity ; Benzoquinones/analysis ; Benzoquinones/metabolism ; Benzoquinones/toxicity
    Chemical Substances Environmental Pollutants ; Rubber (9006-04-6) ; N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone ; N-(1,3-dimethylbutyl)-N'-phenyl-1,4-phenylenediamine (HJD0U67PS1) ; Phenylenediamines ; Benzoquinones
    Language English
    Publishing date 2023-08-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2023.132265
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  10. Article ; Online: Polystyrene nanoparticles strengthen high glucose toxicity associated with alteration in insulin signaling pathway in C. elegans.

    Zhuang, Ziheng / Liu, Tianwen / Liu, Zhengying / Wang, Dayong

    Ecotoxicology and environmental safety

    2024  Volume 272, Page(s) 116056

    Abstract: Using Caenorhabditis elegans as animal model, we investigated the effect of exposure to polystyrene nanoparticles (PS-NPs) in the range of μg/L on high glucose toxicity induction. With lifespan and locomotion behavior as endpoints, we observed that PS-NP ...

    Abstract Using Caenorhabditis elegans as animal model, we investigated the effect of exposure to polystyrene nanoparticles (PS-NPs) in the range of μg/L on high glucose toxicity induction. With lifespan and locomotion behavior as endpoints, we observed that PS-NP (10 and 100 μg/L) enhanced toxicity in 50 mM glucose treated animals. In insulin signaling pathway, expressions of genes encoding insulin receptor (daf-2), kinases (age-1 and akt-1/2), and insulin peptides (ins-9, ins-6, and daf-28) were increased, and expressions of daf-16 and its target of sod-3 were decreased in high glucose treated nematodes followed by PS-NP exposure. Toxicity enhancement in high glucose treated nematodes by PS-NP exposure was inhibited by RNAi of daf-2, age-1, akt-2, akt-1, and 3 insulin peptides genes, but increased by RNAi of daf-16 and sod-3. The resistance of animals with RNAi of daf-2 to toxicity in high glucose treated nematodes followed by PS-NP exposure could be suppressed by RNAi of daf-16. Moreover, in high glucose treated animals followed by PS-NP exposure, daf-2 expression was inhibited by RNAi of ins-6, ins-9, and daf-28. Our data demonstrated the risk of PS-NP exposure in enhancing the high glucose toxicity. More importantly, alteration in expression of genes in insulin signaling pathway was associated with the toxicity enhancement in high glucose treated nematodes followed by PS-NP exposure.
    MeSH term(s) Animals ; Caenorhabditis elegans ; Insulin/metabolism ; Polystyrenes/toxicity ; Polystyrenes/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Nanoparticles/toxicity ; Longevity
    Chemical Substances Insulin ; Polystyrenes ; Caenorhabditis elegans Proteins ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2024.116056
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