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  1. AU="Wang, Elena"
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  1. Article ; Online: Nationale VersorgungsLeitlinie "Unipolare Depression" aktualisiert.

    Schüle, Cornelius / Wang, Elena

    MMW Fortschritte der Medizin

    2023  Volume 165, Issue 3, Page(s) 40–45

    Title translation Important innovations of the German "National Health Care Guideline Unipolar Depression": Significance for clinical practice in the treatment of depressed patients.
    MeSH term(s) Humans ; Depressive Disorder, Major ; Delivery of Health Care
    Language German
    Publishing date 2023-02-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1478211-x
    ISSN 1613-3560 ; 1438-3276
    ISSN (online) 1613-3560
    ISSN 1438-3276
    DOI 10.1007/s15006-022-2229-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.20: Show issues Location:
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    Zs.MG 72: Show issues

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  2. Article ; Online: Modulation of Primary Cilia by Alvocidib Inhibition of CILK1.

    Wang, Elena X / Turner, Jacob S / Brautigan, David L / Fu, Zheng

    International journal of molecular sciences

    2022  Volume 23, Issue 15

    Abstract: The primary cilium provides cell sensory and signaling functions. Cilia structure and function are regulated by ciliogenesis-associated kinase 1 (CILK1). Ciliopathies caused ... ...

    Abstract The primary cilium provides cell sensory and signaling functions. Cilia structure and function are regulated by ciliogenesis-associated kinase 1 (CILK1). Ciliopathies caused by
    MeSH term(s) Cilia/metabolism ; Ciliopathies/metabolism ; Flavonoids/metabolism ; Hedgehog Proteins/metabolism ; Humans ; Piperidines
    Chemical Substances Flavonoids ; Hedgehog Proteins ; Piperidines ; alvocidib (45AD6X575G)
    Language English
    Publishing date 2022-07-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23158121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Scaffold Protein KATNIP Enhances CILK1 Control of Primary Cilia.

    Turner, Jacob S / McCabe, Ellie A / Kuang, Kevin W / Gailey, Casey D / Brautigan, David L / Limerick, Ana / Wang, Elena X / Fu, Zheng

    Molecular and cellular biology

    2023  Volume 43, Issue 9, Page(s) 472–480

    Abstract: The primary cilium functions as a cellular sensory organelle and signaling antenna that detects and transduces extracellular signals. Mutations in the human ... ...

    Abstract The primary cilium functions as a cellular sensory organelle and signaling antenna that detects and transduces extracellular signals. Mutations in the human gene
    MeSH term(s) Humans ; Cilia/metabolism ; Hedgehog Proteins ; Katanin ; Phosphorylation ; Signal Transduction
    Chemical Substances Hedgehog Proteins ; Katanin (EC 5.6.1.1) ; KATNA1 protein, human (EC 5.6.1.1) ; CILK1 protein, human (EC 2.7.1.-)
    Language English
    Publishing date 2023-09-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1080/10985549.2023.2246870
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    Zs.A 1666: Show issues Location:
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  4. Article ; Online: Calpains as mechanistic drivers and therapeutic targets for ocular disease.

    Vu, Jennifer T / Wang, Elena / Wu, Jolan / Sun, Young Joo / Velez, Gabriel / Bassuk, Alexander G / Lee, Soo Hyeon / Mahajan, Vinit B

    Trends in molecular medicine

    2022  Volume 28, Issue 8, Page(s) 644–661

    Abstract: Ophthalmic neurodegenerative diseases encompass a wide array of molecular pathologies unified by calpain dysregulation. Calpains are calcium-dependent proteases that perpetuate cellular death and inflammation when hyperactivated. Calpain inhibition ... ...

    Abstract Ophthalmic neurodegenerative diseases encompass a wide array of molecular pathologies unified by calpain dysregulation. Calpains are calcium-dependent proteases that perpetuate cellular death and inflammation when hyperactivated. Calpain inhibition trials in other organs have faced pharmacological challenges, but the eye offers many advantages for the development and testing of targeted molecular therapeutics, including small molecules, peptides, engineered proteins, drug implants, and gene-based therapies. This review highlights structural mechanisms underlying calpain activation, distinct cellular expression patterns, and in vivo models that link calpain hyperactivity to human retinal and developmental disease. Optimizing therapeutic approaches for calpain-mediated eye diseases can help accelerate clinically feasible strategies for treating calpain dysregulation in other diseased tissues.
    MeSH term(s) Calcium/metabolism ; Calpain/metabolism ; Cell Death ; Humans ; Retina/metabolism
    Chemical Substances Calpain (EC 3.4.22.-) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-05-29
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2022.05.007
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    Zs.A 4345: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Direct Effects of Lipopolysaccharide on Human Pancreatic Cancer Cells.

    Massoumi, Roxanne L / Teper, Yaroslav / Ako, Soichiro / Ye, Linda / Wang, Elena / Hines, O Joe / Eibl, Guido

    Pancreas

    2021  Volume 50, Issue 4, Page(s) 524–528

    Abstract: Objectives: Obesity, a risk factor for pancreatic adenocarcinoma (PDAC), is often accompanied by a systemic increase in lipopolysaccharide (LPS; metabolic endotoxemia), which is thought to mediate obesity-associated inflammation. However, the direct ... ...

    Abstract Objectives: Obesity, a risk factor for pancreatic adenocarcinoma (PDAC), is often accompanied by a systemic increase in lipopolysaccharide (LPS; metabolic endotoxemia), which is thought to mediate obesity-associated inflammation. However, the direct effects of LPS on PDAC cells are poorly understood.
    Methods: The expression of toll-like receptor 4, the receptor for LPS, was confirmed in PDAC cell lines. AsPC-1 and PANC-1 cells were exposed to LPS, and differential gene expression was determined by RNA sequencing. The activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway by LPS in PDAC cells was assessed by Western blotting.
    Results: The expression of toll-like receptor 4 was confirmed in all PDAC cell lines. The exposure to LPS led to differential expression of 3083 genes (426 ≥5-fold) in AsPC-1 and 2584 genes (339 ≥5-fold) in PANC-1. A top canonical pathway affected by LPS in both cell lines was PI3K/Akt/mTOR. Western blotting confirmed activation of this pathway as measured by phosphorylation of the ribosomal protein S6 and Akt.
    Conclusions: The exposure of PDAC cells to LPS led to differential gene expression. A top canonical pathway was PI3K/Akt/mTOR, a known oncogenic driver. Our findings provided evidence that LPS can directly induce differential gene expression in PDAC cells.
    MeSH term(s) Blotting, Western ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Lipopolysaccharides/pharmacology ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Phosphatidylinositol 3-Kinase/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; RNA-Seq/methods ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/metabolism ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism ; Transcriptome/drug effects
    Chemical Substances Lipopolysaccharides ; Toll-Like Receptor 4 ; MTOR protein, human (EC 2.7.1.1) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; AKT1 protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2021-04-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 632831-3
    ISSN 1536-4828 ; 0885-3177
    ISSN (online) 1536-4828
    ISSN 0885-3177
    DOI 10.1097/MPA.0000000000001790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2160: Show issues Location:
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  6. Article ; Online: Liquid-biopsy proteomics combined with AI identifies cellular drivers of eye aging and disease in vivo.

    Wolf, Julian / Rasmussen, Ditte K / Sun, Young Joo / Vu, Jennifer T / Wang, Elena / Espinosa, Camilo / Bigini, Fabio / Chang, Robert T / Montague, Artis A / Tang, Peter H / Mruthyunjaya, Prithvi / Aghaeepour, Nima / Dufour, Antoine / Bassuk, Alexander G / Mahajan, Vinit B

    Cell

    2023  Volume 186, Issue 22, Page(s) 4868–4884.e12

    Abstract: Single-cell analysis in living humans is essential for understanding disease mechanisms, but it is impractical in non-regenerative organs, such as the eye and brain, because tissue biopsies would cause serious damage. We resolve this problem by ... ...

    Abstract Single-cell analysis in living humans is essential for understanding disease mechanisms, but it is impractical in non-regenerative organs, such as the eye and brain, because tissue biopsies would cause serious damage. We resolve this problem by integrating proteomics of liquid biopsies with single-cell transcriptomics from all known ocular cell types to trace the cellular origin of 5,953 proteins detected in the aqueous humor. We identified hundreds of cell-specific protein markers, including for individual retinal cell types. Surprisingly, our results reveal that retinal degeneration occurs in Parkinson's disease, and the cells driving diabetic retinopathy switch with disease stage. Finally, we developed artificial intelligence (AI) models to assess individual cellular aging and found that many eye diseases not associated with chronological age undergo accelerated molecular aging of disease-specific cell types. Our approach, which can be applied to other organ systems, has the potential to transform molecular diagnostics and prognostics while uncovering new cellular disease and aging mechanisms.
    MeSH term(s) Humans ; Aging/metabolism ; Aqueous Humor/chemistry ; Artificial Intelligence ; Biopsy ; Liquid Biopsy ; Proteomics ; Parkinson Disease/diagnosis
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2023.09.012
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    Zs.A 1167: Show issues Location:
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    Zs.MG 58: Show issues

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  7. Article ; Online: Nox4-dependent upregulation of S100A4 after peripheral nerve injury modulates neuropathic pain processing.

    Wack, Gesine / Metzner, Katharina / Kuth, Miriam S / Wang, Elena / Bresnick, Anne / Brandes, Ralf P / Schröder, Katrin / Wittig, Ilka / Schmidtko, Achim / Kallenborn-Gerhardt, Wiebke

    Free radical biology & medicine

    2021  Volume 168, Page(s) 155–167

    Abstract: Previous studies suggested that reactive oxygen species (ROS) produced by NADPH oxidase 4 (Nox4) affect the processing of neuropathic pain. However, mechanisms underlying Nox4-dependent pain signaling are incompletely understood. In this study, we aimed ... ...

    Abstract Previous studies suggested that reactive oxygen species (ROS) produced by NADPH oxidase 4 (Nox4) affect the processing of neuropathic pain. However, mechanisms underlying Nox4-dependent pain signaling are incompletely understood. In this study, we aimed to identify novel Nox4 downstream interactors in the nociceptive system. Mice lacking Nox4 specifically in sensory neurons were generated by crossing Advillin-Cre mice with Nox4
    MeSH term(s) Animals ; Ganglia, Spinal ; Hyperalgesia/genetics ; Mice ; NADPH Oxidase 4/genetics ; Neuralgia/genetics ; Peripheral Nerve Injuries/genetics ; Proteomics ; S100 Calcium-Binding Protein A4 ; Up-Regulation
    Chemical Substances S100 Calcium-Binding Protein A4 ; S100a4 protein, mouse ; NADPH Oxidase 4 (EC 1.6.3.-) ; Nox4 protein, mouse (EC 1.6.3.-)
    Language English
    Publishing date 2021-03-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2021.03.021
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    Zs.A 2109: Show issues Location:
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  8. Article ; Online: A rapid detection method for apoptosis and necrosis measurement using the Cellometer imaging cytometry.

    Chan, Leo Li-Ying / Lai, Ning / Wang, Elena / Smith, Tim / Yang, Xifeng / Lin, Bo

    Apoptosis : an international journal on programmed cell death

    2011  Volume 16, Issue 12, Page(s) 1295–1303

    Abstract: Apoptosis and necrosis play an important role in various aspects of preclinical pharmaceutical drug discovery and validation. The ability to quickly determine the cytotoxic effect of chemical compounds on cancer cells allows researchers to efficiently ... ...

    Abstract Apoptosis and necrosis play an important role in various aspects of preclinical pharmaceutical drug discovery and validation. The ability to quickly determine the cytotoxic effect of chemical compounds on cancer cells allows researchers to efficiently identify potential drug candidates for further development in the pharmaceutical discovery pipeline. Recently, a new imaging cytometry system has been developed by Nexcelom Bioscience LLC (Lawrence, MA, USA) for fluorescence-based cell population analysis. Currently, fluorescence-based cell death assays have not been demonstrated by the Cellometer system, which can potentially provide a quick, simple, and inexpensive alternative method for smaller biomedical research laboratories. In this study, we demonstrate for the first time the use of Cellometer imaging cytometry for necrosis/apoptosis detection by studying the dose-response effect of heat and drug-induced cell death in Jurkat cells labeled with annexin V-FITC (apoptotic) and propidium iodide (necrotic). The experimental results were evaluated to validate the imaging cytometric capabilities of the Cellometer system as compared to the conventional flow cytometry. Similar cell population results were obtained from the two methods. The ability of Cellometer to rapidly and cost-effectively perform fluorescent cell-based assays has the potential of improving research efficiency, especially where a flow or laser scanning cytometer is not available or in situations where a rapid analysis of data is desired.
    MeSH term(s) Apoptosis ; Humans ; Image Cytometry/economics ; Image Cytometry/instrumentation ; Image Cytometry/methods ; Jurkat Cells ; Necrosis ; Neoplasms/diagnosis ; Neoplasms/physiopathology
    Language English
    Publishing date 2011-12
    Publishing country Netherlands
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 1452360-7
    ISSN 1573-675X ; 1360-8185
    ISSN (online) 1573-675X
    ISSN 1360-8185
    DOI 10.1007/s10495-011-0651-8
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