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Article ; Online: Physiology and pharmacological targeting of phase separation.

Wang, Fangfang / Zhang, Youwei

2024 Volume 31, Issue 1, Page(s) 11

Abstract: Liquid-liquid phase separation (LLPS) in biology describes a process by which proteins form membraneless condensates within a cellular compartment when conditions are met, including the concentration and posttranslational modifications of the protein ... ...

Abstract	Liquid-liquid phase separation (LLPS) in biology describes a process by which proteins form membraneless condensates within a cellular compartment when conditions are met, including the concentration and posttranslational modifications of the protein components, the condition of the aqueous solution (pH, ionic strength, pressure, and temperature), and the existence of assisting factors (such as RNAs or other proteins). In these supramolecular liquid droplet-like inclusion bodies, molecules are held together through weak intermolecular and/or intramolecular interactions. With the aid of LLPS, cells can assemble functional sub-units within a given cellular compartment by enriching or excluding specific factors, modulating cellular function, and rapidly responding to environmental or physiological cues. Hence, LLPS is emerging as an important means to regulate biology and physiology. Yet, excessive inclusion body formation by, for instance, higher-than-normal concentrations or mutant forms of the protein components could result in the conversion from dynamic liquid condensates into more rigid gel- or solid-like aggregates, leading to the disruption of the organelle's function followed by the development of human disorders like neurodegenerative diseases. In summary, well-controlled formation and de-formation of LLPS is critical for normal biology and physiology from single cells to individual organisms, whereas abnormal LLPS is involved in the pathophysiology of human diseases. In turn, targeting these aggregates or their formation represents a promising approach in treating diseases driven by abnormal LLPS including those neurodegenerative diseases that lack effective therapies.
MeSH term(s)	Humans ; Phase Separation ; Proteins ; Neurodegenerative Diseases
Chemical Substances	Proteins
Language	English
Publishing date	2024-01-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1193378-1
ISSN	1423-0127 ; 1021-7770
ISSN (online)	1423-0127
ISSN	1021-7770
DOI	10.1186/s12929-024-00993-z
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Article ; Online: Hybrid 2D/3D-quantitative structure-activity relationship studies on the bioactivities and molecular mechanism of antibacterial peptides.

Yan, Qingguo / Wang, Fangfang / Zhou, Bo / Lin, Xiangna

Amino acids

2024 Volume 56, Issue 1, Page(s) 16

Abstract: Antimicrobial peptide (AMP) is the polypeptide, which protects the organism avoiding attack from pathogenic bacteria. Studies have shown that there were some antimicrobial peptides with molecular action mechanism involved in crossing the cell membrane ... ...

Abstract	Antimicrobial peptide (AMP) is the polypeptide, which protects the organism avoiding attack from pathogenic bacteria. Studies have shown that there were some antimicrobial peptides with molecular action mechanism involved in crossing the cell membrane without inducing severe membrane collapse, then interacting with cytoplasmic target-nucleic acid, and exerting antibacterial activity by interfacing the transmission of genetic information of pathogenic microorganisms. However, the relationship between the antibacterial activities and peptide structures was still unclear. Therefore, in the present work, a series of AMPs with a sequence of 20 amino acids was extracted from DBAASP database, then, quantitative structure-activity relationship (QSAR) methods were conducted on these peptides. In addition, novel antimicrobial peptides with stronger antimicrobial activities were designed according to the information originated from the constructed models. Hence, the outcome of this study would lay a solid foundation for the in-silico design and exploration of novel antibacterial peptides with improved activity activities.
MeSH term(s)	Quantitative Structure-Activity Relationship ; Peptides/pharmacology ; Antimicrobial Peptides ; Amino Acids ; Anti-Bacterial Agents/pharmacology
Chemical Substances	Peptides ; Antimicrobial Peptides ; Amino Acids ; Anti-Bacterial Agents
Language	English
Publishing date	2024-02-15
Publishing country	Austria
Document type	Journal Article
ZDB-ID	1121341-3
ISSN	1438-2199 ; 0939-4451
ISSN (online)	1438-2199
ISSN	0939-4451
DOI	10.1007/s00726-024-03381-x
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Zs.A 3490: Show issues

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Article ; Online: Spatial structure and network characteristics of the coupling coordination innovation ecosystems in the Guangdong-Hong Kong-Macao Greater Bay area.

Yang, Zhichen / Li, Xiangtao / Wang, Fangfang / Chen, Rongjian / Ma, Renwen

Scientific reports

2024 Volume 14, Issue 1, Page(s) 395

Abstract: In recent times, a new wave of scientific and technological advancements has significantly reshaped the global economic structure. This shift has redefined the role of regional innovation, particularly in its contribution to developing the Guangdong-Hong ...

Abstract	In recent times, a new wave of scientific and technological advancements has significantly reshaped the global economic structure. This shift has redefined the role of regional innovation, particularly in its contribution to developing the Guangdong-Hong Kong-Macao Greater Bay area (GBA) into a renowned center for science, technology, and innovation. This study constructs a comprehensive evaluation system for the Regional Innovation Ecosystem (RIE). By applying the coupling coordination degree model and social network analysis, we have extensively analyzed the spatial structure and network attributes of the coupled and coordinated innovation ecosystem in the GBA from 2010 to 2019. Our findings reveal several key developments: (1) There has been a noticeable rightward shift in the kernel density curve, indicating an ongoing optimization of the overall coupling coordination level. Notably, the center of gravity for coupling coordination has progressively moved southeast. This shift has led to a reduction in the elliptical area each year, while the trend surface consistently shows a convex orientation toward the center. The most significant development is observed along the 'Guangdong-Shenzhen-Hong Kong-Macao Science and Technology Innovation Corridor', where the level of coupling coordination has become increasingly pronounced. (2) The spatial linkages within the GBA have been strengthening. There are significant spatial transaction costs in the regional innovation ecological network. In the context of the 2019 US-China trade war, the cities of Jiangmen and Zhaoqing experienced a notable decrease in connectivity with other cities, raising concerns about their potential marginalization. (3) Guangzhou, Shenzhen, and Hong Kong have emerged as core nodes within the network. The network exhibits a distinctive "core-edge" spatial structure, characterized by both robustness and vulnerability in various aspects.
MeSH term(s)	Hong Kong ; Macau ; Ecosystem ; China ; Cities
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-50771-4
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Article ; Online: Relationship between phthalates exposure, risk of decreased ovarian reserve, and oxidative stress levels.

Hu, Weihuan / Jin, Zheng / Wang, Huihua / Wang, Fangfang / Qu, Fan

Toxicology and industrial health

2024 Volume 40, Issue 4, Page(s) 156–166

Abstract: Phthalates (PAEs), a group of environmental endocrine disruptors, are associated with oxidative stress and have adverse effects on female ovarian reserves. However, this association has been poorly investigated, particularly with respect to clinical ... ...

Abstract	Phthalates (PAEs), a group of environmental endocrine disruptors, are associated with oxidative stress and have adverse effects on female ovarian reserves. However, this association has been poorly investigated, particularly with respect to clinical evidence. In this study, we provided clinical evidence of a relationship between exposure levels of PAEs, oxidative stress and decreased ovarian reserve (DOR). Firstly, the urinary concentrations of metabolites of PAEs were measured by high performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). The serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and anti-Mullerian hormone (AMH), and the biomarkers of oxidative stress, malondialdehyde (MDA), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC), were determined. Finally, statistical analyses were conducted to describe the relationship between the PAEs exposure, oxidative stress and DOR. We found that the levels of monomethyl phthalate (MMP), monoisobutyl phthalate (MiBP), mono-(2-ethylhexyl) phthalate (MEHP), and mono-(2-ethyl-5-hydroxypentyl) phthalate (MECPP) in the DOR group were significantly higher than those in the control group. There was a significant negative association between AMH and MMP, MiBP levels. and a significant positive association between FSH and MMP levels. PAEs exposure was also associated with a significant increase in MDA levels and decrease in SOD levels. In conclusion, the exposure of PAEs was closely associated with DOR, potentially mediated by oxidative stress pathways; however, small sample size was a limitation in this study.
MeSH term(s)	Humans ; Female ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis ; Ovarian Reserve ; Tandem Mass Spectrometry ; Oxidative Stress ; Follicle Stimulating Hormone ; Superoxide Dismutase ; Phthalic Acids
Chemical Substances	phthalic acid (6O7F7IX66E) ; Follicle Stimulating Hormone (9002-68-0) ; Superoxide Dismutase (EC 1.15.1.1) ; Phthalic Acids
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	56831-4
ISSN	1477-0393 ; 0748-2337
ISSN (online)	1477-0393
ISSN	0748-2337
DOI	10.1177/07482337241229761
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Article ; Online: In silico

Jiang, Yuhan / Yang, Wei / Wang, Fangfang / Zhou, Bo

RSC advances

2023 Volume 13, Issue 22, Page(s) 14808–14824

Abstract: The vascular endothelial growth factor receptor-2 kinases (VEGFR-2) expressed on tumor cells and vessels are attractive targets for cancer treatment. Potent inhibitors for the VEGFR-2 receptor are novel strategies to develop anti-cancer drugs. In this ... ...

Abstract	The vascular endothelial growth factor receptor-2 kinases (VEGFR-2) expressed on tumor cells and vessels are attractive targets for cancer treatment. Potent inhibitors for the VEGFR-2 receptor are novel strategies to develop anti-cancer drugs. In this work, template ligand-based 3D-QSAR studies were performed on a series of benzoxazole derivatives toward different cell lines (HepG2, HCT-116 and MCF-7). Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) techniques were used to generate 3D-QSAR models. Good predictability was derived for the optimal CoMFA models (HepG2:
Language	English
Publishing date	2023-05-15
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra01316b
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Article ; Online: Association of lactate/albumin ratio with in-hospital mortality in ICU patients with acute respiratory failure: A retrospective analysis based on MIMIC-IV database.

Ren, Jing / Kang, Quou / Wang, Fangfang / Yu, Wencheng

Medicine

2023 Volume 102, Issue 39, Page(s) e35410

Abstract: We aimed to investigate the association between the lactate/albumin ratio (LAR), and in-hospital mortality in critically ill patients with acute respiratory failure. This retrospective cohort study was conducted based on the medical information mart for ... ...

Abstract	We aimed to investigate the association between the lactate/albumin ratio (LAR), and in-hospital mortality in critically ill patients with acute respiratory failure. This retrospective cohort study was conducted based on the medical information mart for intensive care-IV database, which included critically ill adult patients with acute respiratory failure whose primary endpoint was in-hospital death. The analyses included curve fitting, a logistic multivariate regression model, and subgroup analysis. In this study, 6028 intensive care unit patients with acute respiratory failure were analyzed. Of these, 1843 (30.57%) died. After adjusting for confounding factors, a nonlinear relationship between LAR and in-hospital mortality was observed, and the risk of death was found to decrease by 81% with a reduction of 1 unit of LAR when it was < 4.46. The association between LAR and in-hospital mortality was not statistically significant when LAR was > 4.46. Hence, the relationship between LAR and in-hospital mortality could only be observed when the LAR was < 4.46. There is a nonlinear relationship between LAR and the risk of in-hospital death in intensive care unit patients with acute respiratory failure, and there is a saturation effect.
MeSH term(s)	Adult ; Humans ; Hospital Mortality ; Lactic Acid ; Retrospective Studies ; Critical Illness ; Respiratory Distress Syndrome ; Albumins ; Respiratory Insufficiency ; Intensive Care Units
Chemical Substances	Lactic Acid (33X04XA5AT) ; Albumins
Language	English
Publishing date	2023-09-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000035410
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Article: Global epidemiological characteristics of uterine fibroids.

Li, Bo / Wang, Fangfang / Chen, Lingying / Tong, Haofei

Archives of medical science : AMS

2023 Volume 19, Issue 6, Page(s) 1802–1810

Abstract: Introduction: The aim of the study was to examine the burden of uterine fibroids at global, regional and national levels in terms of age and the Socio-demographic Index (SDI).: Material and methods: Data were extracted from the GBD 2019 dataset. ... ...

Abstract	Introduction: The aim of the study was to examine the burden of uterine fibroids at global, regional and national levels in terms of age and the Socio-demographic Index (SDI). Material and methods: Data were extracted from the GBD 2019 dataset. Estimated annual percentage changes (EAPCs) were calculated to assess the incidence of uterine fibroids, and trends in disability-adjusted life years (DALYs) were examined. All measures examined were stratified by region, country, age and SDI to assess the effects of these variables on the incidence of uterine fibroids. Results: The global age-standardized incidence rate of uterine fibroids increased from 1990 to 2019, with an EAPC of 0.25 (95% confidence interval (CI): 0.24 to 0.27). In contrast, the global age-standardized DALY rate decreased from 1990 to 2019, with an EAPC of -0.27 (95% CI: -0.31 to -0.23). High and low-middle SDI regions experienced significantly higher age-standardized incidence rates. Moreover, in 2019, low and low-middle SDI regions had significantly higher age-standardized DALY rates due to uterine fibroids than other SDI regions. Regionally, Eastern Europe had the highest age-standardized incidence rate of uterine fibroids in 2019, and Tropical Latin America experienced the greatest increase in age-standardized incidence rates from 1990 to 2019. Nationally, Brazil (EAPC = 1.46; 95% CI: 1.35-1.57) and India (EAPC = 1.09; 95% CI: 0.94-1.25) experienced the most significant increases in age-standardized uterine fibroid incidence. Age-standardized DALY rates increased the most in Tropical Latin America, high-income North America and Oceania. Conclusions: Globally, the age-standardized incidence of uterine fibroids has been increasing in recent years. In contrast, age-standardized DALY rates have exhibited a decreasing trend. Eastern Europe, Tropical Latin America, Brazil and India experience the greatest uterine fibroid burden. Globally, women aged 35-39 years and older have an increased risk of uterine fibroids, as reflected in the higher incidence rates among these age groups.
Language	English
Publishing date	2023-10-30
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2203781-0
ISSN	1734-1922
ISSN	1734-1922
DOI	10.5114/aoms/171786
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Article ; Online: Exploring details about structure requirements based on antioxidant tripeptide derived from β-Lactoglobulin by in silico approaches.

Wang, Fangfang / Wen, Menghao / Zhou, Bo

Amino acids

2023 Volume 55, Issue 12, Page(s) 1909–1922

Abstract: β-Lactoglobulin is one of the proteins in milk possessing antioxidant activity. The peptides derived from β-Lactoglobulin exhibit higher antioxidant activities than the most commonly used antioxidant. Furthermore, the detailed structure-activity ... ...

Abstract	β-Lactoglobulin is one of the proteins in milk possessing antioxidant activity. The peptides derived from β-Lactoglobulin exhibit higher antioxidant activities than the most commonly used antioxidant. Furthermore, the detailed structure-activity relationship of these antioxidant peptides has not been elucidated. Therefore, in the present work, two-dimensional quantitative structure-activity relationship (2D-QSAR) and three-dimensional quantitative structure-activity relationship (3D-QSAR) models were constructed to investigate the structural factors affecting activities and gave information for the rational design of novel antioxidant peptides. After calculation and screening of molecular descriptors, linear and nonlinear models were developed by multiple linear regression (MLR), partial least squares regression (PLSR) and support vector machines (SVM) approaches. The statistical parameters are as follows: R
MeSH term(s)	Antioxidants/pharmacology ; Lactoglobulins ; Quantitative Structure-Activity Relationship ; Linear Models ; Peptides
Chemical Substances	Antioxidants ; Lactoglobulins ; Peptides
Language	English
Publishing date	2023-11-02
Publishing country	Austria
Document type	Journal Article
ZDB-ID	1121341-3
ISSN	1438-2199 ; 0939-4451
ISSN (online)	1438-2199
ISSN	0939-4451
DOI	10.1007/s00726-023-03350-w
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Zs.A 3490: Show issues

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Article ; Online: Multifunctional conductive hydrogels based on the alkali lignin-Fe

Liu, Jiankang / Wang, Fangfang / Zhao, Qian / Liu, Yu

International journal of biological macromolecules

2023 Volume 235, Page(s) 123817

Abstract: Requirements for sustainable development have led to the urgent need for low cost, green, and reproducible resources. Lignin is one of the resources meeting this requirement. Herein, an alkali lignin (AL)- ... ...

Abstract	Requirements for sustainable development have led to the urgent need for low cost, green, and reproducible resources. Lignin is one of the resources meeting this requirement. Herein, an alkali lignin (AL)-Fe
MeSH term(s)	Hydrogen Peroxide ; Lignin ; Alkalies ; Electric Conductivity ; Hydrogels
Chemical Substances	Hydrogen Peroxide (BBX060AN9V) ; Lignin (9005-53-2) ; Alkalies ; Hydrogels
Language	English
Publishing date	2023-02-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.123817
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Article ; Online: On generalized latent factor modeling and inference for high‐dimensional binomial data

Ma, Ting Fung / Wang, Fangfang / Zhu, Jun

Biometrics. 2023 Sept., v. 79, no. 3 p.2311-2320

2023

Abstract: We explore a hierarchical generalized latent factor model for discrete and bounded response variables and in particular, binomial responses. Specifically, we develop a novel two‐step estimation procedure and the corresponding statistical inference that ... ...

Abstract	We explore a hierarchical generalized latent factor model for discrete and bounded response variables and in particular, binomial responses. Specifically, we develop a novel two‐step estimation procedure and the corresponding statistical inference that is computationally efficient and scalable for the high dimension in terms of both the number of subjects and the number of features per subject. We also establish the validity of the estimation procedure, particularly the asymptotic properties of the estimated effect size and the latent structure, as well as the estimated number of latent factors. The results are corroborated by a simulation study and for illustration, the proposed methodology is applied to analyze a dataset in a gene–environment association study.
Keywords	data collection ; models ; statistical inference
Language	English
Dates of publication	2023-09
Size	p. 2311-2320.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	213543-7
ISSN	0099-4987 ; 0006-341X
ISSN	0099-4987 ; 0006-341X
DOI	10.1111/biom.13768
Database	NAL-Catalogue (AGRICOLA)

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