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Article: Network Pharmacology and Experimental Verification Strategies to Illustrate the Mechanism of Jian-Pi-Yi-Shen Formula in Suppressing Epithelial-Mesenchymal Transition.

Zhao, Yuan / Li, Xiangbin / Wang, Fochang / Huang, Shiying / Du, Hanqian / Li, Shunmin / Chen, Jianping

2022 Volume 13, Page(s) 873023

Abstract: Jian-Pi-Yi-Shen formula (JPYSF), a traditional Chinese medicine, has been recommended to treat renal fibrosis for decades. Previous studies had shown that JPYSF could inhibit epithelial-mesenchymal transition (EMT), an important regulatory role in renal ... ...

Abstract	Jian-Pi-Yi-Shen formula (JPYSF), a traditional Chinese medicine, has been recommended to treat renal fibrosis for decades. Previous studies had shown that JPYSF could inhibit epithelial-mesenchymal transition (EMT), an important regulatory role in renal fibrosis. However, the mechanism of JPYSF action is largely unknown. In this study, network pharmacology and experimental verification were combined to elucidate and identify the potential mechanism of JPYSF against renal fibrosis by suppressing EMT at molecular and pathway levels. Network pharmacology was first performed to explore the mechanism of JPYSF against renal fibrosis targeting EMT, and then a 5/6 nephrectomy (5/6 Nx)-induced rat model of renal fibrosis was selected to verify the predictive results by Masson's trichrome stains and western blot analysis. Two hundred and thirty-two compounds in JPYSF were selected for the network approach analysis, which identified 137 candidate targets of JPYSF and 4,796 known therapeutic targets of EMT. The results of the Gene Ontology (GO) function enrichment analysis included 2098, 88, and 133 GO terms for biological processes (BPs), molecular functions (MFs), and cell component entries, respectively. The top 10 enrichment items of BP annotations included a response to a steroid hormone, a metal ion, oxygen levels, and so on. Cellular composition (CC) is mainly enriched in membrane raft, membrane microdomain, membrane region, etc. The MF of JPYSF analysis on EMT was predominately involved in proximal promoter sequence-specific DNA binding, protein heterodimerization activity, RNA polymerase II proximal promoter sequence-specific DNA binding, and so on. The involvement signaling pathway of JPYSF in the treatment of renal fibrosis targeting EMT was associated with anti-fibrosis, anti-inflammation, podocyte protection, and metabolism regulation. Furthermore, the
Language	English
Publishing date	2022-05-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.873023
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Jujube polysaccharides mitigated anemia in rats with chronic kidney disease: Regulation of short chain fatty acids release and erythropoietin production

Huang, Shiying / Jiang, Xue / Chen, Qiugu / Hu, Zhaoliu / Wang, Fochang / Zhao, Yuan / Xin, Gui-Zhong / Chen, Jianping

Journal of functional foods. 2021 Nov., v. 86

2021

Abstract: Jujube polysaccharides (JP) is one of the active food sourced glycans in dietary fruit of Ziziphus jujuba, which has been considered for the treatment of blood deficiency. In this study, a chronic kidney disease (CKD) rat model was used to evaluate the ... ...

Abstract	Jujube polysaccharides (JP) is one of the active food sourced glycans in dietary fruit of Ziziphus jujuba, which has been considered for the treatment of blood deficiency. In this study, a chronic kidney disease (CKD) rat model was used to evaluate the effect of JP and its mechanism on CKD-associated anemia. In CKD rats, JP treatment significantly ameliorated kidney function, kidney pathological injury and hematological parameters, including increasing red blood cells, hemoglobin, hematocrit and platelet count. Moreover, LC-MS/MS targeted metabolomics results showed that JP promoted short chain fatty acids (SCFAs) release in CKD rats. Besides, JP alternated the serum erythropoietin (EPO) level, kidney EPO mRNA and kidney EPO protein via HIF-α signaling. Collectively, these results provide evidence that the effect of JP on CKD-associated anemia may be involved in regulation of SCFAs release and erythropoietin production, supporting further development of JP as food supplements in treating CKD-associated anemia.
Keywords	Ziziphus jujuba ; anemia ; animal models ; blood platelet count ; blood serum ; erythropoietin ; fruits ; hematocrit ; hemoglobin ; kidney diseases ; kidneys ; metabolomics ; polysaccharides ; renal function
Language	English
Dates of publication	2021-11
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2511964-3
ISSN	1756-4646
ISSN	1756-4646
DOI	10.1016/j.jff.2021.104673
Database	NAL-Catalogue (AGRICOLA)

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Article: Impaired Nicotinamide Adenine Dinucleotide Biosynthesis in the Kidney of Chronic Kidney Disease.

Liu, Xinhui / Luo, Denggui / Huang, Shiying / Liu, Siqi / Zhang, Bing / Wang, Fochang / Lu, Jiandong / Chen, Jianping / Li, Shunmin

Frontiers in physiology

2021 Volume 12, Page(s) 723690

Abstract: Chronic kidney disease (CKD) is a global public health problem with high morbidity and mortality. Decreased nicotinamide adenine dinucleotide ( ... ...

Abstract	Chronic kidney disease (CKD) is a global public health problem with high morbidity and mortality. Decreased nicotinamide adenine dinucleotide (NAD
Language	English
Publishing date	2021-09-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2021.723690
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Article: Involvement of Circulating Exosomal MicroRNAs in Jian-Pi-Yi-Shen Formula Protection Against Adenine-Induced Chronic Kidney Disease.

Liu, Xinhui / Liu, Siqi / Luo, Denggui / Huang, Shiying / Wang, Fochang / Zhang, Bing / Chen, Yulian / Zheng, Lin / Lu, Jiandong / Li, Shunmin

Frontiers in pharmacology

2021 Volume 11, Page(s) 622658

Abstract: Jian-Pi-Yi-Shen formula (JPYSF) is a traditional Chinese medicine (TCM) formula used in clinic to treat chronic kidney disease (CKD) for decades. However, the mechanisms of JPYSF in treating CKD have not been fully elucidated. The aim of the present ... ...

Abstract	Jian-Pi-Yi-Shen formula (JPYSF) is a traditional Chinese medicine (TCM) formula used in clinic to treat chronic kidney disease (CKD) for decades. However, the mechanisms of JPYSF in treating CKD have not been fully elucidated. The aim of the present study was to test the renoprotective effect of JPYSF on CKD rat model and investigate the potential mechanism from the perspective of serum exosomal microRNAs (miRNAs). CKD rat model was induced by feeding Sprague-Dawley rats a diet containing 0.75%
Language	English
Publishing date	2021-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.622658
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Article: Jian-Pi-Yi-Shen Formula Alleviates Chronic Kidney Disease in Two Rat Models by Modulating QPRT/NAD

Liu, Xinhui / Liu, Siqi / Zhang, Bing / Luo, Denggui / Huang, Shiying / Wang, Fochang / Zheng, Lin / Lu, Jiandong / Chen, Jianping / Li, Shunmin

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 6625345

Abstract: Objective: Jian-Pi-Yi-Shen formula (JPYSF) is a traditional Chinese herbal decoction and has been used for treating chronic kidney disease (CKD) in clinics for decades. However, the potential mechanisms have not been fully elucidated. This study was ... ...

Abstract	Objective: Jian-Pi-Yi-Shen formula (JPYSF) is a traditional Chinese herbal decoction and has been used for treating chronic kidney disease (CKD) in clinics for decades. However, the potential mechanisms have not been fully elucidated. This study was designed to test the efficacy of JPYSF in treating CKD and explore the underlying mechanism. Methods: Two CKD rat models were established by 5/6 nephrectomy (5/6 Nx) and feeding with adenine-containing feed, respectively. The intervention dose of JPYSF was 10.89 g/kg/d by gastric irrigation. Renal function was assessed by serum creatinine (Scr) and blood urea nitrogen (BUN). Periodic acid-Schiff (PAS) and Masson's trichrome staining were used to evaluate renal histopathological changes. The levels of nicotinamide adenine dinucleotide (NAD Results: The results show that administration of JPYSF significantly lowered Scr and BUN levels, improved renal tubular atrophy and interstitial fibrosis, and decreased renal extracellular matrix deposition in two CKD rat models. In addition, CKD rats exhibited suppressed QPRT/NAD Conclusion: In conclusion, administration of JPYSF effectively alleviated CKD progression in two rat models, which may be related with regulation of the QPRT/NAD
Language	English
Publishing date	2021-12-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/6625345
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Article: Huangqi-Danshen Decoction Ameliorates Adenine-Induced Chronic Kidney Disease by Modulating Mitochondrial Dynamics.

Liu, Xinhui / Huang, Shiying / Wang, Fochang / Zheng, Lin / Lu, Jiandong / Chen, Jianping / Li, Shunmin

Evidence-based complementary and alternative medicine : eCAM

2019 Volume 2019, Page(s) 9574045

Abstract: Chronic kidney disease (CKD) is a leading public health problem with high morbidity and mortality. However, the therapies remain limited. Traditional Chinese medicine (TCM) has been used for treating kidney disease for thousands of years and is an ... ...

Abstract	Chronic kidney disease (CKD) is a leading public health problem with high morbidity and mortality. However, the therapies remain limited. Traditional Chinese medicine (TCM) has been used for treating kidney disease for thousands of years and is an effective alternative treatment for CKD patients in China and other Asian countries. In the present study, we aimed to investigate the effect and mechanism of Huangqi-Danshen decoction (HDD), a TCM herbal decoction, on treating CKD. CKD rat model was induced by adding 0.75% adenine to the diet for 4 weeks. HDD extract was administrated orally to CKD rats at the dose of 4.7 g/kg/d for consecutive 4 weeks in adenine-induced CKD rats. Kidney function was evaluated by the levels of serum creatinine (Scr) and blood urea nitrogen (BUN). The pathological changes of kidney tissues were observed by periodic acid-Schiff (PAS) and Masson's trichrome staining. The proteins expression of renal fibrosis and mitochondrial dynamics were determined and quantified by Western blot analysis. CKD rats showed obvious decline in renal function as evidenced by increased levels of Scr and BUN, which were blunted by HDD treatment. HDD could also improve tubular atrophy and interstitial fibrosis of CKD rats. Moreover, HDD downregulated fibronectin, type IV collagen, and
Language	English
Publishing date	2019-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2019/9574045
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Article: Jian-Pi-Yi-Shen Regulates EPO and Iron Recycling Protein Expressions in Anemic Rats with Chronic Kidney Disease: Accumulation of Hypoxia Inducible Factor-2

Wang, Fochang / Yu, Huimin / Huang, Shiying / Zheng, Lin / Zheng, Ping / Zhang, Shangbin / Li, Shunmin / Chen, Jianping

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 8894257

Abstract: Jian-Pi-Yi-Shen (JPYS), the traditional Chinese medicine (TCM) decoction, has been commonly used to treat chronic kidney disease (CKD) and its complications such as anemia. JPYS has been previously found to induce erythropoietin (EPO) production in ... ...

Abstract	Jian-Pi-Yi-Shen (JPYS), the traditional Chinese medicine (TCM) decoction, has been commonly used to treat chronic kidney disease (CKD) and its complications such as anemia. JPYS has been previously found to induce erythropoietin (EPO) production in HEK293T cells and CKD rats. However, the mechanism of JPYS in treating anemia of CKD rats has remained largely unknown. Here, we further extend our effort to investigate the translational control of hypoxia inducible factor- (HIF-)
Language	English
Publishing date	2020-10-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/8894257
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Article ; Online: Chemical characterisation and quantification of the major constituents in the Chinese herbal formula Jian-Pi-Yi-Shen pill by UPLC-Q-TOF-MS/MS and HPLC-QQQ-MS/MS.

Wang, Fochang / Huang, Shiying / Chen, Qiugu / Hu, Zhaoliu / Li, Zhonggui / Zheng, Ping / Liu, Xinhui / Li, Shunmin / Zhang, Shangbin / Chen, Jianping

Phytochemical analysis : PCA

2020 Volume 31, Issue 6, Page(s) 915–929

Abstract: Introduction: Jian-Pi-Yi-Shen pill (JPYSP) is a Chinese medicine formula developed for the treatment of anaemic patients with chronic kidney disease (CKD).: Objective: To investigate the chemical profile of JPYSP in the treatment of renal anaemia.: ...

Abstract	Introduction: Jian-Pi-Yi-Shen pill (JPYSP) is a Chinese medicine formula developed for the treatment of anaemic patients with chronic kidney disease (CKD). Objective: To investigate the chemical profile of JPYSP in the treatment of renal anaemia. Methods: A method coupling ultra-performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS) was established to characterise the chemical constituents present in JPYSP. Subsequently, a high-performance liquid chromatography method coupled with triple-quadrupole tandem mass spectrometry (HPLC-QQQ-MS/MS) was developed to quantify the major constituents from the identified compounds related to the treatment of CKD and anaemia. Results: A total of 71 compounds were tentatively identified from JPYSP, including saponins, flavonoids, sesquiterpenoids, coumarins, phenylpropanoids, anthranones, anthraquinones, tannins, phenolic acids and others. Amongst them, 12 compounds (i.e. astragaloside IV, calycosin, calycosin 7-O-glucoside, salvianolic acid A, rosmarinic acid, rhein, liquiritin, formononetin, atractylenolide I, dioscin, tanshinone IIA, and acteoside) were further quantified simultaneously by HPLC-QQQ-MS/MS. Conclusion: The newly developed approach is suitable for the chemical profiling analysis and quality control of JPYSP, and could lead to additional pharmacodynamic studies involving the components of JPYSP.
MeSH term(s)	Asian Continental Ancestry Group ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal ; Gas Chromatography-Mass Spectrometry ; Humans ; Tandem Mass Spectrometry
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2020-06-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1073576-8
ISSN	1099-1565 ; 0958-0344
ISSN (online)	1099-1565
ISSN	0958-0344
DOI	10.1002/pca.2963
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Article: Chemical characterisation and quantification of the major constituents in the Chinese herbal formula Jian‐Pi‐Yi‐Shen pill by UPLC‐Q‐TOF‐MS/MS and HPLC‐QQQ‐MS/MS

Wang, Fochang / Huang, Shiying / Chen, Qiugu / Hu, Zhaoliu / Li, Zhonggui / Zheng, Ping / Liu, Xinhui / Li, Shunmin / Zhang, Shangbin / Chen, Jianping

Phytochemical analysis. 2020 Nov., v. 31, no. 6

2020

Abstract: INTRODUCTION: Jian‐Pi‐Yi‐Shen pill (JPYSP) is a Chinese medicine formula developed for the treatment of anaemic patients with chronic kidney disease (CKD). OBJECTIVE: To investigate the chemical profile of JPYSP in the treatment of renal anaemia. METHODS: ...

Abstract	INTRODUCTION: Jian‐Pi‐Yi‐Shen pill (JPYSP) is a Chinese medicine formula developed for the treatment of anaemic patients with chronic kidney disease (CKD). OBJECTIVE: To investigate the chemical profile of JPYSP in the treatment of renal anaemia. METHODS: A method coupling ultra‐performance liquid chromatography with quadrupole time‐of‐flight tandem mass spectrometry (UPLC‐Q‐TOF‐MS/MS) was established to characterise the chemical constituents present in JPYSP. Subsequently, a high‐performance liquid chromatography method coupled with triple‐quadrupole tandem mass spectrometry (HPLC‐QQQ‐MS/MS) was developed to quantify the major constituents from the identified compounds related to the treatment of CKD and anaemia. RESULTS: A total of 71 compounds were tentatively identified from JPYSP, including saponins, flavonoids, sesquiterpenoids, coumarins, phenylpropanoids, anthranones, anthraquinones, tannins, phenolic acids and others. Amongst them, 12 compounds (i.e. astragaloside IV, calycosin, calycosin 7‐O‐glucoside, salvianolic acid A, rosmarinic acid, rhein, liquiritin, formononetin, atractylenolide I, dioscin, tanshinone IIA, and acteoside) were further quantified simultaneously by HPLC‐QQQ‐MS/MS. CONCLUSION: The newly developed approach is suitable for the chemical profiling analysis and quality control of JPYSP, and could lead to additional pharmacodynamic studies involving the components of JPYSP.
Keywords	Oriental traditional medicine ; anemia ; anthraquinones ; astragalosides ; coumarins ; formononetin ; high performance liquid chromatography ; kidney diseases ; pharmacodynamics ; quality control ; rosmarinic acid ; salvianolic acid ; sesquiterpenoids ; tandem mass spectrometry ; ultra-performance liquid chromatography
Language	English
Dates of publication	2020-11
Size	p. 915-929.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	1073576-8
ISSN	1099-1565 ; 0958-0344
ISSN (online)	1099-1565
ISSN	0958-0344
DOI	10.1002/pca.2963
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Apoptosis induced by 9,11‑dehydroergosterol peroxide from Ganoderma Lucidum mycelium in human malignant melanoma cells is Mcl‑1 dependent.

Zheng, Lin / Wong, Yum-Shing / Shao, Mumin / Huang, Shiying / Wang, Fochang / Chen, Jianping

Molecular medicine reports

2018 Volume 18, Issue 1, Page(s) 938–944

Abstract: 9,11-Dehydroergosterol peroxide [9(11)-DHEP] is an important steroid from medicinal mushroom, which has been reported to exert antitumor activity in several tumor types. However, the role of 9(11)‑DHEP toward the malignant melanoma cells has not been ... ...

Abstract	9,11-Dehydroergosterol peroxide [9(11)-DHEP] is an important steroid from medicinal mushroom, which has been reported to exert antitumor activity in several tumor types. However, the role of 9(11)‑DHEP toward the malignant melanoma cells has not been investigated. In the present study, the steroid from Ganoderma lucidum was purified on a submerged culture, and its antitumor mechanisms on A375 human malignant melanoma cells was investigated by MTT, flow cytometry and western blotting. The studies demonstrated that apoptotic mechanisms of the steroid were caspase‑dependent and mediated via the mitochondrial pathway. The steroid did not cause significant changes in the expression levels of B‑cell lymphoma 2 (Bcl‑2) family proteins, Bcl‑2‑like protein 11, p53 upregulated modulator of apoptosis, Bcl‑2‑associated X protein, BH3 interacting‑domain death agonist, Bcl‑2‑associated death promoter and Bcl‑2, but it significantly downregulated induced myeloid leukemia cell differentiation protein Mcl‑1 (Mcl‑1) in melanoma cells, suggesting the key role of Mcl‑1 in regulating apoptosis of melanoma cells induced by the steroid. These properties of 9(11)‑DHEP advocate its usage as supplements in human malignant melanoma chemoprevention. The present study also suggests that mycelium of G. lucidum has a potential for producing bioactive substances and extracts with applications in medicine.
MeSH term(s)	Apoptosis/drug effects ; Apoptosis/genetics ; Ergosterol/analogs & derivatives ; Ergosterol/chemistry ; Ergosterol/pharmacology ; Ganoderma/chemistry ; Humans ; MCF-7 Cells ; Melanoma/genetics ; Melanoma/metabolism ; Melanoma/pathology ; Mycelium/chemistry ; Myeloid Cell Leukemia Sequence 1 Protein/genetics ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism
Chemical Substances	9,11-dehydroergosterol peroxide ; MCL1 protein, human ; Myeloid Cell Leukemia Sequence 1 Protein ; Ergosterol (Z30RAY509F)
Language	English
Publishing date	2018-05-17
Publishing country	Greece
Document type	Journal Article
ISSN	1791-3004
ISSN (online)	1791-3004
DOI	10.3892/mmr.2018.9035
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