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  1. Article: Experimental studies and theoretical analysis of the residual properties of three-span small-scale continuous concrete slabs after a fire

    Wang, Yong / Wang, Gongchen / Huang, Zhaohui / Huang, Yuner / Wang, Benmiao / Gu, Aolin / Zhang, Cong / Jiang, Yaqiang / Zhang, Xiaoyue

    Fire safety journal. 2021 Dec., v. 126

    2021  

    Abstract: This study investigated the effect of travelling fire scenarios, span–thickness ratios, and recurring ages on the post-fire residual behaviour of small-scale continuous reinforced concrete slabs. The mechanical performance of five fire-damaged continuous ...

    Abstract This study investigated the effect of travelling fire scenarios, span–thickness ratios, and recurring ages on the post-fire residual behaviour of small-scale continuous reinforced concrete slabs. The mechanical performance of five fire-damaged continuous slabs and one reference slab were investigated, including load–deflection curves, concrete and reinforcement strains, cracking patterns, and failure modes, and the observations were compared with those discussed in companion papers. In addition to considering the boundary restraint and failure criteria, this study proposed a simple ellipse equation to determine the tensile membrane action region and residual ultimate loads of concrete slabs at the limit state. The results indicated that the travelling fire scenario, including the fire direction and time delay, had a slight effect on the residual behaviour of fire-damaged slabs with larger span–thickness ratios. For fire-damaged slabs with larger span–thickness ratios, flexural failure easily occurred with sufficient development of the tensile membrane action. The proposed ellipse method can be used to accurately determine the residual ultimate loads of fire-damaged continuous slabs with large span–thickness ratios.
    Keywords concrete ; equations ; fire safety
    Language English
    Dates of publication 2021-12
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1483569-1
    ISSN 0379-7112
    ISSN 0379-7112
    DOI 10.1016/j.firesaf.2021.103481
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  2. Article: Numerical modelling of in-plane restrained concrete two-way slabs subjected to fire

    Wang, Yong / Wang, Gongchen / Huang, Zhaohui / Li, Lingzhi / Bu, Yixiang / Zhong, Bo / Zhang, Yajun / Ma, Shuai

    Fire safety journal. 2021 May, v. 121

    2021  

    Abstract: This paper presents a numerical investigation of the fire performance of eight reinforced concrete two-way slabs subjected to different in-plane restraints. A comparison of the experimental results with results predicted by a numerical model showed ... ...

    Abstract This paper presents a numerical investigation of the fire performance of eight reinforced concrete two-way slabs subjected to different in-plane restraints. A comparison of the experimental results with results predicted by a numerical model showed generally satisfactory agreement. The effects of geometric nonlinearity, or linearity, and concrete thermal strain on the fire behaviour of the tested slabs were analysed. It was found that neglecting the geometric nonlinearity led to lower predicted deflections for in-plane restrained slabs and higher predicted deflections for simply supported slabs, while a larger concrete thermal strain led to larger deflections for the concrete slabs under either restraint condition. Parametric studies were conducted to investigate the influence of in-plane restraint type, restraint level, aspect ratio, reinforcement ratio and layout, and slab thickness on the fire behaviour of the in-plane restrained slabs. The results of the parametric studies showed that the in-plane restraint type, restraint level, and aspect ratio significantly affect the deflection trends, failure mode, and fire resistance of in-plane restrained slabs. In addition, the fire-resistant performance for in-plane restrained rectangular slabs can be improved by increasing the reinforcement ratios along the short span.
    Keywords fire behavior ; fire resistance ; fire safety ; geometry ; mathematical models
    Language English
    Dates of publication 2021-05
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1483569-1
    ISSN 0379-7112
    ISSN 0379-7112
    DOI 10.1016/j.firesaf.2021.103307
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  3. Article: Anti-TIM1 suppresses airway inflammation and hyperresponsiveness via the STAT6 /STAT1 pathways in mice with allergic asthma.

    Qiang, Lixia / Li, Zhiheng / Wang, Gongchen / Li, Xiangshun / Lv, Meiyu / Wang, Baocai / Shi, Zhaoquan / Jin, Shoude

    Die Pharmazie

    2022  Volume 77, Issue 1, Page(s) 14–20

    Abstract: T cell immunoglobulin and mucin domain-1 (TIM-1) is a transmembrane glycoprotein and has been reported as an molecular mechanism of allergic diseases. This study aimed to explore the effects of anti-TIM-1 monoclonal antibodies (anti-TIM1) on the ... ...

    Abstract T cell immunoglobulin and mucin domain-1 (TIM-1) is a transmembrane glycoprotein and has been reported as an molecular mechanism of allergic diseases. This study aimed to explore the effects of anti-TIM-1 monoclonal antibodies (anti-TIM1) on the development of allergic asthma. Female C57BL/6 mice were induced and challenged with ovalbumin (OVA) and received subsequent intranasal administration of anti-TIM1. The airway resistance of all mice was evaluated using a Buxco PFT system. Flow cytometry was used to detect the expression of TIM-1 in peripheral blood mononuclear cells. The level of cytokine production in the bronchial alveolar lavage fluid and serum was determined using ELISA. Mucous cells were observed using Alcian blue and periodic acid-Schiff staining. In addition, B-cell lymphoma gene 2(BCL2), T-box transcription factor (T-bet), GATA binding protein-3(GATA3), signal transducer and activator of transcription (STAT) 1, STAT6 were analyzed by western blot analysis. Their corresponding mRNA expression levels were determined by quantitative PCR. The mRNA expression level of Mucin 5AC in the lung tissues was also detected using quantitative RT-PCR. The results showed that the intranasal administration of anti-TIM1 ameliorated airway inflammation and hyperresponsiveness in an acute model of asthma. Following administration of anti-TIM1, both the mRNA and protein levels of T-bet were upregulated, while those of BCL2 and GATA3 were downregulated. Moreover, the phosphorylation levels of STAT1 and STAT6 were increased. Taken together, these findings demonstrated that intranasal administration of anti-TIM1 ameliorated allergic lung inflammation and remodeling in mouse models of asthma by repairing both the STAT1 and STAT6 pathways.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/pharmacology ; Asthma/drug therapy ; Cytokines/metabolism ; Disease Models, Animal ; Female ; Inflammation/pathology ; Leukocytes, Mononuclear/metabolism ; Lung/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA, Messenger/metabolism ; STAT1 Transcription Factor/metabolism ; STAT1 Transcription Factor/pharmacology ; STAT6 Transcription Factor/metabolism ; STAT6 Transcription Factor/pharmacology
    Chemical Substances Anti-Inflammatory Agents ; Cytokines ; Proto-Oncogene Proteins c-bcl-2 ; RNA, Messenger ; STAT1 Transcription Factor ; STAT6 Transcription Factor ; Stat1 protein, mouse ; Stat6 protein, mouse
    Language English
    Publishing date 2022-01-20
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208793-5
    ISSN 0031-7144
    ISSN 0031-7144
    DOI 10.1691/ph.2022.1670
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  4. Article ; Online: Efficacy and safety of oxaliplatin-based regimen versus cisplatin-based regimen in the treatment of gastric cancer: a meta-analysis of randomized controlled trials.

    Wang, Gongchen / Yang, Binfeng / Fu, Zhaoyuan / Wang, Xin / Zhang, Zhiming

    International journal of clinical oncology

    2019  Volume 24, Issue 6, Page(s) 614–623

    Abstract: Background: Cisplatin played an important role in the treatment of gastric cancer (GC). Oxaliplatin has been shown to be at least as effective as cisplatin for GC, with less toxicity and a better tolerability profile. We performed a meta-analysis to ... ...

    Abstract Background: Cisplatin played an important role in the treatment of gastric cancer (GC). Oxaliplatin has been shown to be at least as effective as cisplatin for GC, with less toxicity and a better tolerability profile. We performed a meta-analysis to compare the efficacy and safety of oxaliplatin-based regimen versus cisplatin-based regimen in the treatment of GC.
    Methods: Databases of CNKI, CBM, VIP, Wanfang, PubMed, Embase, Cochrane Library were searched for eligible literatures from their establishments to November 2018. Randomized controlled trials that compared the efficacy and safety of oxaliplatin-based regimen with that of cisplatin-based regimen in the treatment of GC were included. Statistical analyses were calculated using RevMan 5.3 software.
    Results: Seven randomized controlled trials including 2297 patients were included. Compared with cisplatin-based regimen intervention in GC, oxaliplatin-based regimen treatment was able to significantly improve the partial response rate (OR = 1.26, 95% CI 1.07-1.49; p = 0.007), disease progression rate (OR = 0.41, 95% CI 0.25-0.66; p = 0.0002) and 1-year survival (OR = 1.25, 95% CI 1.00-1.56; p = 0.05). The toxicities of hematopoietic system were significantly higher in cisplatin-based regimen group (OR = 0.6, 95% CI 0.46-0.79; p = 0.0002), while oxaliplatin-based regimen group had higher neurosensory toxicity (OR = 2.21, 95% CI 1.52-3.21; p < 0.0001), In addition, gastrointestinal toxicity was similar between the two groups (OR = 1.01, 95% CI 0.5-2.01; p = 0.27).
    Conclusions: Compared with cisplatin-based regimen, oxaliplatin-based regimen treatment has an obvious advantage in patients with GC with acceptable tolerance.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cisplatin/administration & dosage ; Humans ; Oxaliplatin/administration & dosage ; Randomized Controlled Trials as Topic ; Safety ; Stomach Neoplasms/drug therapy
    Chemical Substances Oxaliplatin (04ZR38536J) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2019-03-27
    Publishing country Japan
    Document type Comparative Study ; Journal Article ; Meta-Analysis ; Review
    ZDB-ID 1400227-9
    ISSN 1437-7772 ; 1341-9625
    ISSN (online) 1437-7772
    ISSN 1341-9625
    DOI 10.1007/s10147-019-01425-x
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  5. Article: Multi-Objective Scheduling of Electric Vehicles in Smart Distribution Network

    Deng, Changhong / Liang, Ning / Tan, Jin / Wang, Gongchen

    Sustainability. 2016 Nov. 28, v. 8, no. 12

    2016  

    Abstract: Due to the energy savings and environmental protection they provide, plug-in electric vehicles (PEVs) are increasing in number quickly. Rapid development of PEVs brings new opportunities and challenges to the electricity distribution network’s ... ...

    Abstract Due to the energy savings and environmental protection they provide, plug-in electric vehicles (PEVs) are increasing in number quickly. Rapid development of PEVs brings new opportunities and challenges to the electricity distribution network’s dispatching. A high number of uncoordinated charging PEVs has significant negative impacts on the secure and economic operation of a distribution network. In this paper, a bi-level programming approach that coordinates PEVs’ charging with the network load and electricity price of the open market is presented. The major objective of the upper level model is to minimize the total network costs and the deviation of electric vehicle aggregators’ charging power and the equivalent power. The subsequent objective of the lower level model after the upper level decision is to minimize the dispatching deviation of the sum of PEVs’ charging power and their optimization charging power under the upper level model. An improved particle swarm optimization algorithm is used to solve the bi-level programming. Numerical studies using a modified IEEE 69-bus distribution test system including six electric vehicle aggregators verify the efficiency of the proposed model.
    Keywords algorithms ; electric vehicles ; electricity ; electricity costs ; energy conservation ; environmental protection ; markets ; models
    Language English
    Dates of publication 2016-1128
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518383-7
    ISSN 2071-1050
    ISSN 2071-1050
    DOI 10.3390/su8121234
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  6. Article ; Online: A study on spleen transient elastography in predicting the degree of esophageal varices and bleeding.

    Wang, Xie-Kui / Wang, Ping / Zhang, Yong / Qi, Sheng-Lin / Chi, Kun / Wang, Gong-Chen

    Medicine

    2019  Volume 98, Issue 9, Page(s) e14615

    Abstract: This study aims to investigate the value and determine the accuracy of spleen stiffness in predicting the degree of esophageal varices and bleeding in patients with liver cirrhosis.The age, gender, liver stiffness, spleen stiffness, and gastroscopy ... ...

    Abstract This study aims to investigate the value and determine the accuracy of spleen stiffness in predicting the degree of esophageal varices and bleeding in patients with liver cirrhosis.The age, gender, liver stiffness, spleen stiffness, and gastroscopy results of 124 inpatients or outpatients with liver cirrhosis and healthy volunteers, who underwent both gastroscopy and FibroScan testing in the fasting state, were retrospectively analyzed. According to the gastroscopy results, the patients and healthy volunteers were divided into six groups: varicose bleeding, severe varices, moderate varices, mild varices, no varices, and healthy control group. Then, the receiver operating characteristic curves were drawn, and the corresponding area under each curve was calculated and evaluated to predict the severity of varices based on the relevance of the area and its parameters.The area under the receiver operating characteristic curve of liver stiffness and spleen stiffness for predicting severe and moderate varices in the bleeding group was 0.955 and 0.989, respectively. The cut-off values were 29.6 kPa and 45.5 kPa, respectively. The area under the receiver operating characteristic curve of liver stiffness for predicting varicose bleeding was 0.860 (95% CI: 0.789-0.931). The liver stiffness cut-off value for predicting varicose bleeding was 33.2 kPa, with a specificity and sensitivity of 66.02% and 95.24%, respectively. The area under the receiver operating characteristic curve of spleen stiffness for predicting varicose bleeding was 0.923 (95% CI: 0.875-0.971). A spleen stiffness cut-off value of 55.2 kPa had a sensitivity and specificity of 90.48% and 86.41%, respectively.Spleen stiffness can predict the degree of esophageal varices and bleeding in liver cirrhosis patients, and has good predictive accuracy.
    MeSH term(s) Aged ; Area Under Curve ; Elasticity ; Elasticity Imaging Techniques/methods ; Elasticity Imaging Techniques/statistics & numerical data ; Esophageal and Gastric Varices/diagnostic imaging ; Esophageal and Gastric Varices/etiology ; Female ; Gastrointestinal Hemorrhage/diagnostic imaging ; Gastrointestinal Hemorrhage/etiology ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/physiopathology ; Male ; Middle Aged ; Predictive Value of Tests ; ROC Curve ; Retrospective Studies ; Sensitivity and Specificity ; Spleen/diagnostic imaging ; Spleen/physiopathology
    Language English
    Publishing date 2019-02-19
    Publishing country United States
    Document type Evaluation Study ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000014615
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  7. Article ; Online: Effects of Depression, Anxiety, Stigma, and Disclosure on Health-Related Quality of Life among Chronic Hepatitis B Patients in Dalian, China.

    Li, Ge / Wang, Gongchen / Hsu, Fang-Chi / Xu, Jianzhao / Pei, Xia / Zhao, Bo / Shetty, Avinash

    The American journal of tropical medicine and hygiene

    2020  Volume 102, Issue 5, Page(s) 988–994

    Abstract: Chronic hepatitis B virus (HBV) infection is a major public health problem in China. We evaluated the impact of psychosocial factors (stigma, disclosure, depression, and anxiety) on health-related quality of life (HRQoL) among people living with chronic ... ...

    Abstract Chronic hepatitis B virus (HBV) infection is a major public health problem in China. We evaluated the impact of psychosocial factors (stigma, disclosure, depression, and anxiety) on health-related quality of life (HRQoL) among people living with chronic HBV infection (CHB) in the city of Dalian, Liaoning Province, China. In this hospital-based cross-sectional study, 401 patients living with chronic HBV infection were enrolled as study participants. Study measures included the Beck depression and anxiety inventory, the WHO Quality of Life (WHOQOL-BREF) assessment, the Toronto Chinese HBV Stigma Scale, and disclosure of HBV status to sexual partners. The primary outcome was HRQoL score as measured by the WHOQOL-BREF. A linear regression model was used to examine the association between HRQoL and the potential risk factors including stigma, disclosure, depression, anxiety, and sociodemographic variables. Stigma, disclosure, depression, and anxiety were the covariates of interest. A majority of the participants were females (
    MeSH term(s) Anxiety/epidemiology ; Anxiety/etiology ; Anxiety/psychology ; China/epidemiology ; Cross-Sectional Studies ; Depression/epidemiology ; Depression/etiology ; Depression/psychology ; Female ; Hepatitis B, Chronic/psychology ; Humans ; Linear Models ; Male ; Middle Aged ; Quality of Life/psychology ; Self Disclosure ; Sexual Partners/psychology ; Social Stigma
    Language English
    Publishing date 2020-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.19-0007
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    Ud II Zs.61: Show issues Location:
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  8. Article ; Online: The calcium-sensing receptor participates in testicular damage in streptozotocin-induced diabetic rats.

    Kong, Wei-Yuan / Tong, Li-Quan / Zhang, Hai-Jun / Cao, Yong-Gang / Wang, Gong-Chen / Zhu, Jin-Zhi / Zhang, Feng / Sun, Xue-Ying / Zhang, Tie-Hui / Zhang, Lin-Lin

    Asian journal of andrology

    2016  Volume 18, Issue 5, Page(s) 803–808

    Abstract: Male infertility caused by testicular damage is one of the complications of diabetes mellitus. The calcium-sensing receptor (CaSR) is expressed in testicular tissues and plays a pivotal role in calcium homeostasis by activating cellular signaling ... ...

    Abstract Male infertility caused by testicular damage is one of the complications of diabetes mellitus. The calcium-sensing receptor (CaSR) is expressed in testicular tissues and plays a pivotal role in calcium homeostasis by activating cellular signaling pathways, but its role in testicular damage induced by diabetes remains unclear. A diabetic model was established by a single intraperitoneal injection of streptozotocin (STZ, 40 mg kg-1 ) in Wistar rats. Animals then received GdCl 3 (an agonist of CaSR, 8.67 mg kg-1 ), NPS-2390 (an antagonist of CaSR, 0.20 g kg-1 ), or a combination of both 2 months after STZ injection. Diabetic rats had significantly lower testes weights and serum levels of testosterone compared to healthy rats, indicating testicular damage and dysfunction in STZ-induced diabetic rats. Compared with healthy controls, the testicular tissues of diabetic rats overexpressed the CaSR protein and had higher levels of malondialdehyde (MDA), lower superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity, and higher numbers of apoptotic germ cells. The testicular tissues from diabetic rats also expressed lower levels of Bcl-2 and higher levels of Bax and cleaved caspase-3 in addition to higher phosphorylation rates of c-Jun NH 2 -terminal protein kinase (JNK), p38, and extracellular signaling-regulated kinase (ERK) 1/2. The above parameters could be further increased or aggravated by the administration of GdCl 3 , but could be attenuated by injection of NPS-2390. In conclusion, the present results indicate that CaSR activation participates in diabetes-induced testicular damage, implying CaSR may be a potential target for protective strategies against diabetes-induced testicular damage and could help to prevent infertility in diabetic men.
    MeSH term(s) Animals ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/metabolism ; Infertility, Male/etiology ; Infertility, Male/metabolism ; Male ; Malondialdehyde/blood ; Membrane Glycoproteins ; Oxidative Stress/physiology ; Rats ; Receptors, Calcium-Sensing/metabolism ; Receptors, Interleukin-1 ; Signal Transduction/physiology ; Superoxide Dismutase/blood ; Testis/metabolism ; Testosterone/blood
    Chemical Substances Membrane Glycoproteins ; Receptors, Calcium-Sensing ; Receptors, Interleukin-1 ; TIRAP protein, human ; Testosterone (3XMK78S47O) ; Malondialdehyde (4Y8F71G49Q) ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2016-09
    Publishing country China
    Document type Journal Article
    ZDB-ID 2075824-8
    ISSN 1745-7262 ; 1008-682X
    ISSN (online) 1745-7262
    ISSN 1008-682X
    DOI 10.4103/1008-682X.160885
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