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  1. Article: Investigating role of ASIC2 in synaptic and behavioral responses to drugs of abuse.

    Fuller, Margaret J / Gupta, Subhash C / Fan, Rong / Taugher-Hebl, Rebecca J / Wang, Grace Z / Andrys, Noah R R / Bera, Amal K / Radley, Jason J / Wemmie, John A

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1118754

    Abstract: Drugs of abuse produce rearrangements at glutamatergic synapses thought to contribute to drug-reinforced behaviors. Acid-Sensing Ion Channels (ASICs) have been suggested to oppose these effects, largely due to observations in mice lacking the ASIC1A ... ...

    Abstract Drugs of abuse produce rearrangements at glutamatergic synapses thought to contribute to drug-reinforced behaviors. Acid-Sensing Ion Channels (ASICs) have been suggested to oppose these effects, largely due to observations in mice lacking the ASIC1A subunit. However, the ASIC2A and ASIC2B subunits are known to interact with ASIC1A, and their potential roles in drugs of abuse have not yet been investigated. Therefore, we tested the effects of disrupting ASIC2 subunits in mice exposed to drugs of abuse. We found conditioned place preference (CPP) to both cocaine and morphine were increased in
    Language English
    Publishing date 2023-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1118754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Staphylococcal

    Wang, Grace Z / Warren, Elizabeth A / Haas, Allison L / Peña, Andrea Sánchez / Kiedrowski, Megan R / Lomenick, Brett / Chou, Tsui-Fen / Bomberger, Jennifer M / Tirrell, David A / Limoli, Dominique H

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Coinfection with two notorious opportunistic pathogens, the Gram- ... ...

    Abstract Coinfection with two notorious opportunistic pathogens, the Gram-negative
    Language English
    Publishing date 2023-01-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.29.526047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Post-acquisition CO

    Taugher, Rebecca J / Wunsch, Amanda M / Wang, Grace Z / Chan, Aubrey C / Dlouhy, Brian J / Wemmie, John A

    Frontiers in behavioral neuroscience

    2021  Volume 15, Page(s) 767426

    Abstract: A growing body of evidence suggests that memories of fearful events may be altered after initial acquisition or learning. Although much of this work has been done in rodents using Pavlovian fear conditioning, it may have important implications for fear ... ...

    Abstract A growing body of evidence suggests that memories of fearful events may be altered after initial acquisition or learning. Although much of this work has been done in rodents using Pavlovian fear conditioning, it may have important implications for fear memories in humans such as in post-traumatic stress disorder (PTSD). A recent study suggested that cued fear memories, made labile by memory retrieval, were made additionally labile and thus more vulnerable to subsequent modification when mice inhaled 10% carbon dioxide (CO
    Language English
    Publishing date 2021-10-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2021.767426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Intoxicating effects of alcohol depend on acid-sensing ion channels.

    Harmata, Gail I S / Chan, Aubrey C / Merfeld, Madison J / Taugher-Hebl, Rebecca J / Harijan, Anjit K / Hardie, Jason B / Fan, Rong / Long, Jeffrey D / Wang, Grace Z / Dlouhy, Brian J / Bera, Amal K / Narayanan, Nandakumar S / Wemmie, John A

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2022  Volume 48, Issue 5, Page(s) 806–815

    Abstract: Persons at risk for developing alcohol use disorder (AUD) differ in their sensitivity to acute alcohol intoxication. Alcohol effects are complex and thought to depend on multiple mechanisms. Here, we explored whether acid-sensing ion channels (ASICs) ... ...

    Abstract Persons at risk for developing alcohol use disorder (AUD) differ in their sensitivity to acute alcohol intoxication. Alcohol effects are complex and thought to depend on multiple mechanisms. Here, we explored whether acid-sensing ion channels (ASICs) might play a role. We tested ASIC function in transfected CHO cells and amygdala principal neurons, and found alcohol potentiated currents mediated by ASIC1A homomeric channels, but not ASIC1A/2 A heteromeric channels. Supporting a role for ASIC1A in the intoxicating effects of alcohol in vivo, we observed marked alcohol-induced changes on local field potentials in basolateral amygdala, which differed significantly in Asic1a
    MeSH term(s) Cricetinae ; Humans ; Mice ; Animals ; Acid Sensing Ion Channels/genetics ; Acid Sensing Ion Channels/pharmacology ; Cricetulus ; Neurons ; Electrophysiological Phenomena ; Ethanol/pharmacology
    Chemical Substances Acid Sensing Ion Channels ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2022-10-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-022-01473-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2379: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity.

    Posfai, Dora / Eubanks, Amber L / Keim, Allison I / Lu, Kuan-Yi / Wang, Grace Z / Hughes, Philip F / Kato, Nobutaka / Haystead, Timothy A / Derbyshire, Emily R

    Antimicrobial agents and chemotherapy

    2018  Volume 62, Issue 4

    Abstract: Malaria remains a global health burden partly due ... ...

    Abstract Malaria remains a global health burden partly due to
    MeSH term(s) Antimalarials/therapeutic use ; Benzamides/therapeutic use ; HSP90 Heat-Shock Proteins/antagonists & inhibitors ; HSP90 Heat-Shock Proteins/metabolism ; Host-Pathogen Interactions ; Humans ; Hydrazones/therapeutic use ; Indoles/therapeutic use ; Malaria/drug therapy ; Malaria/metabolism ; Plasmodium falciparum/drug effects ; Plasmodium falciparum/metabolism ; Plasmodium falciparum/pathogenicity ; Sulfonamides/therapeutic use ; ortho-Aminobenzoates/therapeutic use
    Chemical Substances 2-fluoro-6-(tetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)benzamide ; Antimalarials ; Benzamides ; HSP90 Heat-Shock Proteins ; Hydrazones ; Indoles ; PIK 75 ; Sulfonamides ; ortho-Aminobenzoates
    Language English
    Publishing date 2018-03-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01799-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 809: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Einzelsignatur: Show issues

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