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Article ; Online: Host Response and Hemodynamics

WANG Guangjian / WANG Xiaoting

Xiehe Yixue Zazhi, Vol 13, Iss 6, Pp 929-

2022 Volume 935

Abstract: With the continuous exploration of the pathophysiological mechanisms of critical illness, the host response, a 'bridge' between different etiologies and the development of critical illness, has received much attention. Host response is the focus of ... ...

Abstract	With the continuous exploration of the pathophysiological mechanisms of critical illness, the host response, a 'bridge' between different etiologies and the development of critical illness, has received much attention. Host response is the focus of critical illness pathophysiology, and hemodynamics is the core of critical illness development. On the one hand, the host response has a significant impact on hemodynamics; on the other hand, the intervention of the host response through analgesic-sedative-anti-sympathetic therapy and the management of inflammation, immunity, coagulation, metabolism, and bioenergy can stabilize the hemodynamics and achieve the goal of critical illness treatment. A deepening understanding of host response not only enriches the connotation of hemodynamics but also facilitates further study and exploration of the pathophysiological mechanisms of critical illness. Therefore, we describe host response from three aspects: a new understanding of critical illness based on host response, the effect of host response on hemodynamics, and hemodynamic therapy based on the host response.
Keywords	critical illness ; host response ; hemodynamics ; host/organ unregulated response ; critical unit ; Medicine ; R
Subject code	630
Language	Chinese
Publishing date	2022-11-01T00:00:00Z
Publisher	Editorial Office of Medical Journal of Peking Union Medical College Hospital
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Energy Harvesting Performance of a Tandem-Hydrofoil Based Closely-Interconnected Tidal Array

Wang, Guangjian / Feng Ng, Bing

Energy Conversion and Management. 2023, p.116796-

2023 , Page(s) 116796–

Abstract: Hydrofoil based tidal arrays have emerged as a promising solution for large-scale power generation due to their high efficiency, cost effectiveness, and minimal interferences to the marine environment. In order to further maximize their power production ... ...

Abstract	Hydrofoil based tidal arrays have emerged as a promising solution for large-scale power generation due to their high efficiency, cost effectiveness, and minimal interferences to the marine environment. In order to further maximize their power production and economic viability, an efficient tandem-hydrofoil based closely-interconnected tidal array is proposed, where the fore and hindfoils are closely spaced and interconnected to achieve constructive foil-foil interactions for energy capture. The power production, energy efficiency, capacity density, and levelized cost of electricity are obtained using a comprehensive approach that combines water tunnel experiments and computational fluid dynamics modeling. The results demonstrate that the capacity density of the proposed tandem configuration achieves at least 3 times higher than those of existing studies, while the hydrofoil deployment density is 4 times higher. Moreover, the energy efficiency and capacity density can be enhanced by enlarging the forefoil pitching amplitude or shortening the inter-foil spacing. Furthermore, the levelized cost of electricity is minimized to 50% that of existing studies, achieved by enhancing the energy capture and reducing the capital expenditures, thereby maximizing the commercial potential of the hydrofoil based tidal array.
Keywords	administrative management ; capital ; cost effectiveness ; economic sustainability ; electricity ; energy efficiency ; fluid mechanics ; marine environment ; power generation ; Tandem hydrofoils ; Tidal array ; Capacity density ; Levelized cost of electricity (LCOE) ; Capital expenditure (CAPEX)
Language	English
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	2000891-0
ISSN	0196-8904
ISSN	0196-8904
DOI	10.1016/j.enconman.2023.116796
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Letter to the Editor: Is right heart assessment vital for evaluating terlipressin-related outcomes in hepatorenal syndrome-acute kidney injury?

Guo, Qirui / Wang, Jie / Wang, Guangjian / Wang, Xiaoting

Hepatology (Baltimore, Md.)

2024

Language	English
Publishing date	2024-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1097/HEP.0000000000000832
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Article ; Online: Prospective Evaluation of the Peripheral Perfusion Index in Assessing the Organ Dysfunction and Prognosis of Adult Patients With Sepsis in the ICU.

Guo, Qirui / Lian, Hui / Wang, Guangjian / Zhang, Hongmin / Wang, Xiaoting

Journal of intensive care medicine

2024 , Page(s) 8850666241252758

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-05-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	632828-3
ISSN	1525-1489 ; 0885-0666
ISSN (online)	1525-1489
ISSN	0885-0666
DOI	10.1177/08850666241252758
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Article: Microcirculation and Mitochondria: The Critical Unit.

Wang, Guangjian / Lian, Hui / Zhang, Hongmin / Wang, Xiaoting

Journal of clinical medicine

2023 Volume 12, Issue 20

Abstract: Critical illness is often accompanied by a hemodynamic imbalance between macrocirculation and microcirculation, as well as mitochondrial dysfunction. Microcirculatory disorders lead to abnormalities in the supply of oxygen to tissue cells, while ... ...

Abstract	Critical illness is often accompanied by a hemodynamic imbalance between macrocirculation and microcirculation, as well as mitochondrial dysfunction. Microcirculatory disorders lead to abnormalities in the supply of oxygen to tissue cells, while mitochondrial dysfunction leads to abnormal energy metabolism and impaired tissue oxygen utilization, making these conditions important pathogenic factors of critical illness. At the same time, there is a close relationship between the microcirculation and mitochondria. We introduce here the concept of a "critical unit", with two core components: microcirculation, which mainly comprises the microvascular network and endothelial cells, especially the endothelial glycocalyx; and mitochondria, which are mainly involved in energy metabolism but perform other non-negligible functions. This review also introduces several techniques and devices that can be utilized for the real-time synchronous monitoring of the microcirculation and mitochondria, and thus critical unit monitoring. Finally, we put forward the concepts and strategies of critical unit-guided treatment.
Language	English
Publishing date	2023-10-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12206453
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Article ; Online: The Exosome-Mediated Bone Regeneration: An Advanced Horizon Toward the Isolation, Engineering, Carrying Modalities, and Mechanisms.

Zhu, Fukang / Wang, Taiyou / Wang, Guangjian / Yan, Caiping / He, Bin / Qiao, Bo

Advanced healthcare materials

2024 , Page(s) e2400293

Abstract: Exosomes, nanoparticles secreted by various cells, composed of a bilayer lipid membrane, and containing bioactive substances such as proteins, nucleic acids, metabolites, etc., have been intensively investigated in tissue engineering owing to their high ... ...

Abstract	Exosomes, nanoparticles secreted by various cells, composed of a bilayer lipid membrane, and containing bioactive substances such as proteins, nucleic acids, metabolites, etc., have been intensively investigated in tissue engineering owing to their high biocompatibility and versatile biofunction. However, there is still a lack of a high-quality review on bone defect regeneration potentiated by exosomes. In this review, the biogenesis and isolation methods of exosomes are first introduced. More importantly, the engineered exosomes of the current state of knowledge are discussed intensively in this review. Afterward, the biomaterial carriers of exosomes and the mechanisms of bone repair elucidated by compelling evidence are presented. Thus, future perspectives and concerns are revealed to help devise advanced modalities based on exosomes to overcome the challenges of bone regeneration. It is totally believed this review will attract special attention from clinicians and provide promising ideas for their future works.
Language	English
Publishing date	2024-03-01
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202400293
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Zs.A 6966: Show issues

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Article ; Online: Resuscitation fluids as drugs: targeting the endothelial glycocalyx.

Wang, Guangjian / Zhang, Hongmin / Liu, Dawei / Wang, Xiaoting

Chinese medical journal

2022 Volume 135, Issue 2, Page(s) 137–144

Abstract: Abstract: Fluid resuscitation is an essential intervention in critically ill patients, and its ultimate goal is to restore tissue perfusion. Critical illnesses are often accompanied by glycocalyx degradation caused by inflammatory reactions, ... ...

Abstract	Abstract: Fluid resuscitation is an essential intervention in critically ill patients, and its ultimate goal is to restore tissue perfusion. Critical illnesses are often accompanied by glycocalyx degradation caused by inflammatory reactions, hypoperfusion, shock, and so forth, leading to disturbed microcirculatory perfusion and organ dysfunction. Therefore, maintaining or even restoring the glycocalyx integrity may be of high priority in the therapeutic strategy. Like drugs, however, different resuscitation fluids may have beneficial or harmful effects on the integrity of the glycocalyx. The purpose of this article is to review the effects of different resuscitation fluids on the glycocalyx. Many animal studies have shown that normal saline might be associated with glycocalyx degradation, but clinical studies have not confirmed this finding. Hydroxyethyl starch (HES), rather than other synthetic colloids, may restore the glycocalyx. However, the use of HES also leads to serious adverse events such as acute kidney injury and bleeding tendencies. Some studies have suggested that albumin may restore the glycocalyx, whereas others have suggested that balanced crystalloids might aggravate glycocalyx degradation. Notably, most studies did not correct the effects of the infusion rate or fluid volume; therefore, the results of using balanced crystalloids remain unclear. Moreover, mainly animal studies have suggested that plasma may protect and restore glycocalyx integrity, and this still requires confirmation by high-quality clinical studies.
MeSH term(s)	Animals ; Colloids ; Crystalloid Solutions/therapeutic use ; Fluid Therapy ; Glycocalyx ; Humans ; Hydroxyethyl Starch Derivatives ; Isotonic Solutions ; Microcirculation ; Resuscitation
Chemical Substances	Colloids ; Crystalloid Solutions ; Hydroxyethyl Starch Derivatives ; Isotonic Solutions
Language	English
Publishing date	2022-01-04
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000001869
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Article: Comprehensive treatment of deep frostbite of multiple fingers after trauma: A case report.

Wang, Xi-Hua / Li, Min / Cheng, Yue / Wang, Guang-Jian / Lin, Guo-Le / Liu, Wei-Nan

World journal of clinical cases

2023 Volume 11, Issue 34, Page(s) 8219–8227

Abstract: Background: Frostbite is becoming increasingly common in urban environments, and severe cases can lead to tissue loss. The treatment goal is to preserve tissue and function; the sooner appropriate treatment is administered, the more tissue can be saved. ...

Abstract	Background: Frostbite is becoming increasingly common in urban environments, and severe cases can lead to tissue loss. The treatment goal is to preserve tissue and function; the sooner appropriate treatment is administered, the more tissue can be saved. However, not every patient with deep frostbite seeks medical care promptly. Case summary: We report the case of a 73-year-old male patient who was lost in the wilderness for 2 d due to trauma and confusion. He experienced deep frostbite on multiple fingers. Treatment should not be discontinued for patients with deep frostbite who present after the optimum treatment timing. Bullae that no longer form (bloody) blisters within 24 h of aspiration should be removed. Mucopolysaccharide polysulfate cream has clinical value in frostbite treatment. The patient was transferred to Chinese Academy of Medical Sciences and Peking Union Medical College Hospital 12 h after being rescued. The patient had contraindications for thrombolysis, the most effective treatment, due to intracranial hemorrhage and presenting past the optimum treatment timing. We devised a comprehensive treatment plan, which involved delayed use vasodilators and high-pressure oxygen therapy at day 49 post-injury. We experimented with mucopolysaccharide polysulfate cream to treat the frostbite. The aim of the treatment was to safeguard as much tissue as possible. In the end, the fingers that suffered from frostbite were able to be partially preserved. Conclusion: The case indicated that patients with severe frostbite who missed the optimal treatment time and had contraindications for thrombolysis could still partially preserve the affected limbs through comprehensive treatment.
Language	English
Publishing date	2023-09-11
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i34.8219
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Identification of key genes for IgA nephropathy based on machine learning algorithm and correlation analysis of immune cells.

Chen, Suzhi / Li, Yongzhang / Wang, Guangjian / Song, Lei / Tan, Jinchuan / Yang, Fengwen

Transplant immunology

2023 Volume 78, Page(s) 101824

Abstract: Introduction: The pathogenesis and progression mechanism of Immunoglobulin A nephropathy (IgAN) is not fully understood. There is a lack of panoramic analysis of IgAN immune cell infiltration and algorithms that are more efficient and accurate for ... ...

Abstract	Introduction: The pathogenesis and progression mechanism of Immunoglobulin A nephropathy (IgAN) is not fully understood. There is a lack of panoramic analysis of IgAN immune cell infiltration and algorithms that are more efficient and accurate for screening key pathogenic genes. Methods: RNA sequencing (RNA-seq) data sets on IgAN were downloaded from the Gene Expression Omnibus (GEO) database, including GSE93798, GSE35489, and GSE115857. The RNA-seq data set of kidney tissue as control samples were downloaded from the Genotype-Tissue Expression (GTEx) database. Three machine learning algorithms-weighted gene co-expression network analysis (WGCNA), least absolute shrinkage and selection operator (LASSO), and support vector machine-were used to identify the key pathogenic gene sets of the IgAN disease. The ssGSEA method was applied to calculate the immune cell infiltration (ICI) of IgAN samples, whereas the Spearman test was used for correlation analysis. The receiver operator characteristic curve (ROC) was used to evaluate the diagnostic efficacy of key genes. The correlation between the key genes and ICI was analyzed using the Spearman test. Results: A total of 177 genes were screened out as differentially expressed genes (DEGs) for IgAN, including 135 up-regulated genes and 42 down-regulated genes. The DEGs were significantly enriched in the inflammatory- or immune-related pathways (gene sets). Activating transcription factor 3 (AFT3), C-X-C Motif Chemokine Ligand 6 (CXCL6), and v-fos FBJ murine osteosarcoma viral oncogene homolog B (FOSB) were identified using WGCNA, support vector machine, and LASSO algorithms. These three genes revealed good diagnostic efficacy in the training and test cohorts. The CXCL6 expression positively correlated with activated B cells and memory B cells. Conclusion: ATF3, FOSB, and CXCL6 genes were identified as potential biomarkers of IgAN. These three genes exhibited good diagnostic efficacy for IgAN. We described the landscape of immune cell infiltration for IgAN. Activated B cells and memory B cells were more highly expressed in the IgAN samples than in the control samples. CXCL6 seems crucial to the pathogenesis of IgAN and may induce IgAN by enriching immune cells. Our study may contribute to developing CXCL6 inhibitors that target B cells for IgAN therapy.
MeSH term(s)	Animals ; Mice ; Algorithms ; B-Lymphocytes ; Gene Expression Profiling ; Glomerulonephritis, IGA/genetics ; Machine Learning ; Humans
Language	English
Publishing date	2023-03-21
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1160846-8
ISSN	1878-5492 ; 0966-3274
ISSN (online)	1878-5492
ISSN	0966-3274
DOI	10.1016/j.trim.2023.101824
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Zs.A 3784: Show issues

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Article ; Online: Hypoxia-inducible factor-1α is a biomarker for predicting patients with sepsis.

Tong, Zewen / Wang, Guangjian / Huang, Wei / Zhang, Hongmin / Xie, Fang / Wang, Xiaoting

The Journal of international medical research

2023 Volume 51, Issue 9, Page(s) 3000605231202139

Abstract: Objective: This study aimed to investigate the potential value of serum hypoxia-inducible factor-1α (HIF-1α) concentrations as a biomarker in patients with sepsis.: Methods: The enrolled patients were divided into the following four groups: the ... ...

Abstract	Objective: This study aimed to investigate the potential value of serum hypoxia-inducible factor-1α (HIF-1α) concentrations as a biomarker in patients with sepsis. Methods: The enrolled patients were divided into the following four groups: the intensive care unit (ICU) control group (n = 33), infection group (n = 29), septic nonshock group (n = 40), and septic shock group (n = 94). An enzyme-linked immunosorbent assay was used to measure serum HIF-1α concentrations on ICU admission. Clinical parameters and laboratory test results were also collected. Results: Serum HIF-1α concentrations were significantly higher in the infection group, septic nonshock group, and septic shock group than in the ICU control group. Moreover, HIF-1α concentrations were associated with a better predictive ability for diagnosing sepsis than the Acute Physiology and Chronic Health Evaluation II score, procalcitonin concentrations, and lactate concentrations. Patients with sepsis and HIF-1α concentrations >161.14 pg/mL had a poor prognosis. Conclusions: Serum HIF-1α concentrations are a useful biomarker for the diagnosis of sepsis and predicting the prognosis of patients.
MeSH term(s)	Humans ; Shock, Septic/diagnosis ; Hypoxia-Inducible Factor 1, alpha Subunit ; Sepsis/diagnosis ; Biomarkers ; Prognosis ; Lactic Acid ; Intensive Care Units
Chemical Substances	Hypoxia-Inducible Factor 1, alpha Subunit ; Biomarkers ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2023-09-29
Publishing country	England
Document type	Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605231202139
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