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Article ; Online: Stay at Home to Stay Safe

Wang, Guihua

SSRN Electronic Journal ; ISSN 1556-5068

Effectiveness of Stay-at-Home Orders in Containing the COVID-19 Pandemic

2020

Keywords	covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.2139/ssrn.3581873
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The "Hand as Foot" teaching method in cerebrospinal fluid circulation.

Wang, Guihua / Xin, Chun

Asian journal of surgery

2022 Volume 45, Issue 9, Page(s) 1765–1767

MeSH term(s)	Foot ; Hand ; Humans ; Lower Extremity ; Upper Extremity
Language	English
Publishing date	2022-04-19
Publishing country	China
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.03.086
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Article: Response of a Mesoscale Dipole Eddy to the Passage of a Tropical Cyclone: A Case Study Using Satellite Observations and Numerical Modeling

Huang, Xiaorong / Wang, Guihua

Remote Sensing. 2022 June 15, v. 14, no. 12

2022

Abstract: Mesoscale eddies occurring in the world’s oceans typically exist in pairs known as mesoscale dipole eddies or simply dipole eddies. Tropical cyclones (hereafter TCs) that move over the world’s oceans often encounter and interact with these dipole eddies. ...

Abstract	Mesoscale eddies occurring in the world’s oceans typically exist in pairs known as mesoscale dipole eddies or simply dipole eddies. Tropical cyclones (hereafter TCs) that move over the world’s oceans often encounter and interact with these dipole eddies. Through this interaction, TCs induce significant perturbations in the mesoscale eddies. However, the specific influences that the passage of a TC on a dipole eddy have not been addressed. In this paper, a case study of the dipole eddy’s response to the passage of a TC is conducted by using satellite observations and numerical simulation. The passage of a TC induces a long-duration response in the dipole eddy. First, the cyclonic ocean eddy component (COE) of the dipole is amplified, and the anticyclonic ocean eddy component (AOE) is weakened or even destroyed during the interaction. The amplification of the COE and weakening of the AOE primarily manifests as a change in their amplitudes and radii and as the adjustment of their vertical structure. The dipole eddy’s response to the interaction with a TC manifests as an upwelling anomaly and the injection of positive relative vorticity. Following the passage of the TC, the COE gradually stabilizes, and AOE slowly recovers after the disturbance energy from the interaction dissipates, which facilitates the reestablishment of the dipole eddy. The dipole reaches an equilibrium state through a quasi-geostrophic adjustment process. As a consequence, the overall effect of the interaction of the dipole with the TC leads to an asymmetric signature on the dipole eddy. The eddy–eddy interaction in a dipole may allow it to stabilize in a shorter time relative to that of a solitary eddy.
Keywords	case studies ; energy ; hurricanes ; mathematical models ; satellites
Language	English
Dates of publication	2022-0615
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2513863-7
ISSN	2072-4292
ISSN	2072-4292
DOI	10.3390/rs14122865
Database	NAL-Catalogue (AGRICOLA)

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Article: Satellite observed quick shift events of the wind jet over the South China Sea in summer and its impacts on the ocean circulation

Shi, Qian / Wang, Guihua

Remote sensing of environment. 2022 July, v. 276

2022

Abstract: The 17 year record of daily sea surface wind observed from the QuikSCAT and ASCAT satellite scatterometers from 2000 to 2016 is used to study quick shifting wind jet events over the South China Sea (SCS) in summer. The wind jet typically undergoes a ... ...

Abstract	The 17 year record of daily sea surface wind observed from the QuikSCAT and ASCAT satellite scatterometers from 2000 to 2016 is used to study quick shifting wind jet events over the South China Sea (SCS) in summer. The wind jet typically undergoes a counter-clockwise rotation from eastward to northward in about 8 days and then back to eastward in roughly 4 days. Generally, the entire cycle takes between 4 and 21 days. Such events happen 2–6 times every summer and, in total, have occurred 72 times over the last 18 years. Model simulations demonstrate that the wind stress curl associated with quick wind shifts deform the double gyre in the SCS, with a conspicuous weakening of the northern gyre and a northwestward movement of the center of the southern gyre. In addition, a quick shift of the wind jet leads to both negative sea surface temperature (SST) anomalies in the SCS that lag about one day because of the surface latent heat flux, and positive SST anomalies around the eastward current because of decreased cold advection.
Keywords	advection ; cold ; environment ; latent heat flux ; satellites ; summer ; surface water temperature ; wind ; wind stress ; South China Sea
Language	English
Dates of publication	2022-07
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	431483-9
ISSN	0034-4257
ISSN	0034-4257
DOI	10.1016/j.rse.2022.113039
Database	NAL-Catalogue (AGRICOLA)

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Article: Meander Response of the Kuroshio in the East China Sea to Impinging Eddies

Shi, Qian / Wang, Guihua

Journal of geophysical research. 2021 Sept., v. 126, no. 9

2021

Abstract: Both observations and an idealized model demonstrate that the path of a western boundary current, like the Kuroshio, can be perturbed by the impingement of an ocean eddy. When a strong cyclonic (anti‐cyclonic) eddy approaches the axis of the Kuroshio in ... ...

Abstract	Both observations and an idealized model demonstrate that the path of a western boundary current, like the Kuroshio, can be perturbed by the impingement of an ocean eddy. When a strong cyclonic (anti‐cyclonic) eddy approaches the axis of the Kuroshio in the East China Sea, the current path can be repelled (attracted) by the eddy. The subsequent disruption occurs primarily near the interaction region and propagates downstream, forming a dissipating wavelike fluctuation. The spatial‐temporal evolution of Kuroshio axis shift by impinging eddy can be explained by idealized vorticity dynamics on the current‐eddy interaction process, and the magnitude of current path shift is shown to be determined by two nondimensional factors: the ratio of eddy strength to the Kuroshio strength; and the ratio of horizontal shearing strength in the background to that in the current.
Keywords	evolution ; geophysics ; models ; research ; East China Sea
Language	English
Dates of publication	2021-09
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	161667-5
ISSN	2169-9291 ; 2169-9275 ; 0148-0227 ; 0196-2256
ISSN (online)	2169-9291
ISSN	2169-9275 ; 0148-0227 ; 0196-2256
DOI	10.1029/2021JC017512
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Article ; Online: Proteasome activation is critical for cell death induced by inhibitors of polo-like kinase 1 (PLK1) in multiple cancers.

Wang, Yufei / Wang, Guihua / Xiang, Wei / Liu, Xueting / Jiang, Manli / Hu, Jinyue

European journal of pharmacology

2024 Volume 972, Page(s) 176558

Abstract: Inhibitors of polo-like kinase (PLK) are currently being evaluated as anticancer drugs. However, the molecular mechanism of PLK inhibitor-induced cell death is not fully understood. In this study, we found that GW843682X and BI2536, two inhibitors of ... ...

Abstract	Inhibitors of polo-like kinase (PLK) are currently being evaluated as anticancer drugs. However, the molecular mechanism of PLK inhibitor-induced cell death is not fully understood. In this study, we found that GW843682X and BI2536, two inhibitors of PLK1, significantly induced cell death in multiple type cells. The induction of cell death was related to the preferring expression of PLK1. However, in human umbilical vascular endothelial cells (HUVEC) and human colorectal carcinoma cells, which expressed higher levels of both PLK1 and PLK2, PLK1 inhibitors induced very low levels of cell death. Clinical analysis reveals PLK1 presence in 26 of 30 NPC tumor tissues. In in vivo NPC lung metastasis nude mouse models, PLK1 inhibitors decreased NPC progress. Mechanistically, the PLK1 inhibitor did not activate p53, and the cell death was not reversed by p53 inhibition. Moreover, PLK1 inhibitor-induced cell death was PARP- and caspase-independent. Although PLK1 inhibitors induced down-regulation of calpain inhibitor calpastatin and calpain was activated by PLK1 inhibition, calpain blocking did not reverse cell death induced by PLK1 inhibitors, suggesting the non-involvement of calpain. Surprisingly, we found that PLK1 inhibitors induced the activation of proteasome, and the treatment of cells with PLK1 inhibitors reduced the levels of ubiquitinated proteins. And proteasome inhibitors reversed cell death induced by PLK1 inhibitors in various cell types in which PLK1 was preferentially expressed. Moreover, PLK1 inhibition reversed the degradation of proteins including p53, caspase 8, PARP and calpastatin. These results suggest that the activation of proteasome is critical for cell death induced by PLK1 inhibition.
MeSH term(s)	Polo-Like Kinase 1 ; Humans ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/metabolism ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Protein Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins/antagonists & inhibitors ; Proto-Oncogene Proteins/metabolism ; Animals ; Proteasome Endopeptidase Complex/metabolism ; Cell Death/drug effects ; Mice ; Cell Line, Tumor ; Protein Kinase Inhibitors/pharmacology ; Mice, Nude ; Pteridines/pharmacology ; Human Umbilical Vein Endothelial Cells/drug effects ; Calpain/antagonists & inhibitors ; Calpain/metabolism ; Enzyme Activation/drug effects ; Xenograft Model Antitumor Assays ; Tumor Suppressor Protein p53/metabolism ; Antineoplastic Agents/pharmacology
Chemical Substances	Polo-Like Kinase 1 ; Cell Cycle Proteins ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Proto-Oncogene Proteins ; Proteasome Endopeptidase Complex (EC 3.4.25.1) ; BI 2536 ; Protein Kinase Inhibitors ; Pteridines ; Calpain (EC 3.4.22.-) ; Tumor Suppressor Protein p53 ; Antineoplastic Agents
Language	English
Publishing date	2024-04-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2024.176558
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Article: Hydrological Evaluation of Satellite-Based Precipitation Products in Hunan Province

Yan, Yan / Wang, Guihua / Nanding, Nergui / Chen, Weitian

Remote Sensing. 2022 June 29, v. 14, no. 13

2022

Abstract: The quality of satellite-based precipitation products including TMPA 3B42, IMERG-early, IMERG-final, and CMORPH-CRT, is evaluated by comparing with gauge observations in Hunan province of China between 2017 and 2019. By using the outputs of the Dominant ... ...

Abstract	The quality of satellite-based precipitation products including TMPA 3B42, IMERG-early, IMERG-final, and CMORPH-CRT, is evaluated by comparing with gauge observations in Hunan province of China between 2017 and 2019. By using the outputs of the Dominant River Routing Integrated with VIC Environment (DRIVE) model, the hydrological applications of gauge- and satellite-based precipitation products are analyzed by comparing them with streamflow observations. Furthermore, we conduct a case study considering Typhoon Bailu. It is found that IMERG-final can produce better results compared to the other three satellite-based products against gauge-based precipitation. In terms of discharge simulations, the gauge-based precipitation provides the most accurate results, followed by IMERG-final. During Typhoon Bailu, the peak of the mean gauge-based precipitation in the rainfall center (24.5°N–26°N, 111°E–114°E) occurred on 25 August 2019, whereas the daily streamflow reached its peak one day later, suggesting the lagged impact of precipitation on streamflow. From the Taylor diagram, the gauge-based precipitation is the most accurate for estimating the streamflow during Typhoon Bailu, followed by IMERG-final, IMERG-early, TMPA 3B42, and CMORPH-CRT, respectively. Overall, gauge-based precipitation has the best performance in terms of hydrological application, whereas IMERG-final performs the best among four satellite-based precipitation products.
Keywords	case studies ; models ; rain ; rivers ; satellites ; stream flow ; typhoons ; China
Language	English
Dates of publication	2022-0629
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2513863-7
ISSN	2072-4292
ISSN	2072-4292
DOI	10.3390/rs14133127
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Article ; Online: A Multi‐Layer Linear Rossby Wave Dispersion Relation for Vertical Tilt of Mesoscale Eddies

Li, Hong / Xu, Fanghua / Wang, Guihua / Shi, Ruizi

Journal of Geophysical Research: Oceans. 2022 Dec., v. 127, no. 12 p.e2022JC018703-

2022

Abstract: Vertical tilt of mesoscale eddies has been frequently observed in world oceans. The observations of composite eddies, individual eddies from an oceanic reanalysis product, and idealized numerical experiments of mesoscale eddies all show that the eddy ... ...

Abstract	Vertical tilt of mesoscale eddies has been frequently observed in world oceans. The observations of composite eddies, individual eddies from an oceanic reanalysis product, and idealized numerical experiments of mesoscale eddies all show that the eddy vertical tilt is gradually increased with time in eddy mature stage, implying that the eddy translation speed changes with depth. However, eddy vertical tilt cannot be explained by the classic linear Rossby wave dispersion relation, since the classic zonal translation speed (Cx ${C}_{x}$) of linear Rossby waves is depth‐independent from the quasi‐geostrophic potential vorticity (QGPV) equation. To deduce a depth‐dependent linear Rossby wave dispersion relation, we solved the QGPV equation by assuming that the stratified water column in oceans can be separated into a number of fine layers with constant stratification in each layer, whereas the stratification changes among layers. A multi‐layer linear Rossby wave (MLRW) dispersion relation in stratified oceans is then deduced. The MLRW dispersion relation shows that Cx ${C}_{x}$ changes with depth. In each layer, Cx ${C}_{x}$ is proportional to stratification and layer thickness but inversely proportional to Earth's rotation. The estimated Cx ${C}_{x}$ structure from the MLRW dispersion relation is consistent with the Cx ${C}_{x}$ structure of eddies in numerical experiments and the observed composite eddies. Noticeably, there are some discrepancies between the theoretical estimates and those from observations and numerical simulations, primarily due to the sensitivity of the theoretical estimates to layer thickness. The study attempts to provide an approach to describe and predict mesoscale eddy vertical tilt.
Keywords	equations ; geophysics ; research
Language	English
Dates of publication	2022-12
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	161667-5
ISSN	2169-9291 ; 2169-9275 ; 0148-0227 ; 0196-2256
ISSN (online)	2169-9291
ISSN	2169-9275 ; 0148-0227 ; 0196-2256
DOI	10.1029/2022JC018703
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Global Mapping of Mesoscale Eddy Vertical Tilt

Li, Hong / Xu, Fanghua / Wang, Guihua

Journal of Geophysical Research: Oceans. 2022 Nov., v. 127, no. 11 p.e2022JC019131-

2022

Abstract: Vertical motion induced by oceanic mesoscale eddies can strengthen ocean ventilation, and regulate vertical distribution of heat, dissolved CO₂ and other tracers on a global scale. Eddy‐induced vertical motion is closely related to eddy vertical ... ...

Abstract	Vertical motion induced by oceanic mesoscale eddies can strengthen ocean ventilation, and regulate vertical distribution of heat, dissolved CO₂ and other tracers on a global scale. Eddy‐induced vertical motion is closely related to eddy vertical structure. Here, based on available satellite observations and Argo profiles, we find that mesoscale eddies in global oceans are prevalently vertical tilted. Anticyclonic eddies are frequently tilted westward and poleward from 300 dbar up to sea surface, while cyclonic eddies are frequently tilted westward and equatorward. The horizontal tilting distance of eddies is significantly correlated (r ≥ 0.84) with the Burger number (the ratio of vertical stratification to planetary rotation and eddy size), indicating a strong constraint of Earth's rotation and ocean stratification on eddy vertical tilt. On average, the maximum vertical velocity in tilted circular eddies is at least one order of magnitude larger than that in non‐tilted circular eddies. This finding would improve estimates of eddy‐induced vertical motion, ventilation, so as to heat/salt and biogeochemical responses.
Keywords	carbon dioxide ; geophysics ; heat ; research ; satellites ; spatial distribution
Language	English
Dates of publication	2022-11
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	161667-5
ISSN	2169-9291 ; 2169-9275 ; 0148-0227 ; 0196-2256
ISSN (online)	2169-9291
ISSN	2169-9275 ; 0148-0227 ; 0196-2256
DOI	10.1029/2022JC019131
Database	NAL-Catalogue (AGRICOLA)

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Article: Importance of High‐Frequency (≤30‐day) Wind Variability to the Annual Climatology of the Surface Latent Heat Flux Inferred From the Global Tropical Moored Buoy Array

Yan, Yunwei / Song, Xiangzhou / Wang, Guihua / Chen, Changlin

Journal of geophysical research. 2022 Mar., v. 127, no. 3

2022

Abstract: Previous studies conducted based on reanalysis data sets have suggested that high‐frequency (≤30‐day) wind variability has a significant impact on the climatology of surface latent heat flux (LHF). The present study quantifies the impact of high‐ ... ...

Abstract	Previous studies conducted based on reanalysis data sets have suggested that high‐frequency (≤30‐day) wind variability has a significant impact on the climatology of surface latent heat flux (LHF). The present study quantifies the impact of high‐frequency winds using field measurements derived from the global tropical moored buoy array (GTMBA) and, in turn, evaluates the performance of existing reanalysis products on capturing the role of these high‐frequency winds. The buoy observations demonstrate that high‐frequency winds at the n‐day (n = 1, 2, …, 30) timescale make a positive contribution to the annual climatology of LHF by nonlinearly enhancing the mean surface wind speed. Furthermore, this contribution increases as the timescale decreases, with maxima occurring at the 1‐day (subdaily) timescale. The subdaily winds contribute 4.6 W m⁻², on average over all GTMBA sites. The largest contribution exceeds 10.0 W m⁻² over the equatorial western Pacific Ocean. Hourly reanalysis products underestimate the contribution of the high‐frequency winds at timescales shorter than about a week, especially at the subdaily timescale, which is underestimated by approximately 50–60%. This finding suggests that an improvement in the performance of subdaily wind variability is needed to improve the fidelity of next‐generation reanalysis products.
Keywords	climatology ; geophysics ; latent heat flux ; research ; wind speed ; Pacific Ocean
Language	English
Dates of publication	2022-03
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	161667-5
ISSN	2169-9291 ; 2169-9275 ; 0148-0227 ; 0196-2256
ISSN (online)	2169-9291
ISSN	2169-9275 ; 0148-0227 ; 0196-2256
DOI	10.1029/2021JC018094
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