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  1. Book ; Online: Frontiers in Clinical Neurosurgery

    Lv, Xianli / Wang, Guihuai / Wang, James / Wu, Zhongxue

    2021  

    Keywords Neurosurgery ; stroke, fmri, medical education, endoscopy, aneurysm, traumatic brain injury
    Language English
    Size 1 electronic resource (268 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030647585
    ISBN 9781839686887 ; 183968688X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: [Development of diagnosis and treatment of spinal cord tumors].

    Wang, Guihuai

    Zhonghua yi xue za zhi

    2014  Volume 94, Issue 19, Page(s) 1441–1443

    MeSH term(s) China ; Humans ; Spinal Cord Neoplasms/diagnosis ; Spinal Cord Neoplasms/therapy
    Language Chinese
    Publishing date 2014-05-20
    Publishing country China
    Document type Editorial
    ZDB-ID 132513-9
    ISSN 0376-2491
    ISSN 0376-2491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2011: Show issues Location:
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  3. Article: Real-Time Navigation with Guide Template for Pedicle Screw Placement Using an Augmented Reality Head-Mounted Device: A Proof-of-Concept Study.

    Li, Haowei / Zhang, Peihai / Wang, Guangzhi / Liu, Huiting / Yang, Xuejun / Wang, Guihuai / Sun, Zhenxing

    Indian journal of orthopaedics

    2023  Volume 57, Issue 5, Page(s) 776–781

    Abstract: Objective: This study aims to explore the real-time navigation with guide template using an augmented reality head-mounted device (ARHMD) for pedicle screw placement.: Methods: The spatial coordinate relationships between augmented reality images and ...

    Abstract Objective: This study aims to explore the real-time navigation with guide template using an augmented reality head-mounted device (ARHMD) for pedicle screw placement.
    Methods: The spatial coordinate relationships between augmented reality images and real objects were established through the custom-made guide template, and the registration and tracking were completed using an ARHMD. The feasibility and accuracy of this method were verified by pedicle screw placement in 2 lumbar models. According to the Gertzbein-Robbins grading scale, the accuracy of pedicle screw placement was assessed. The navigation errors were estimated by measuring the deviation values of entry point and trajectory angle.
    Results: A total of 20 pedicle K-wires were placed into L1-L5 in 2 lumbar models, which were successfully completed, with an average time of 11.5 min per model and 69 s per screw. The overall K-wires placement accuracy was 100% (20 screws). The navigation error was 2.77 ± 0.82 mm for the deviation value of entry point, and 3.03° ± 0.94° for the deviation value of trajectory angle.
    Conclusions: The application of an ARHMD combined with guide template for pedicle screw placement is a promising navigation approach.
    Language English
    Publishing date 2023-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 603194-8
    ISSN 0019-5413
    ISSN 0019-5413
    DOI 10.1007/s43465-023-00859-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1720: Show issues Location:
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  4. Article ; Online: Incidence, Outcomes and Predictors of Primary Central Nervous System Melanoma: A SEER-Based Study.

    Man, Weitao / Wang, Guihuai

    World neurosurgery

    2019  Volume 129, Page(s) e782–e790

    Abstract: Introduction: Primary central nervous system (pCNS) melanoma is an extremely rare malignant tumor. We explored the incidence, outcomes, and predictors of pCNS melanoma.: Methods: We queried the Surveillance, Epidemiology, and End Results database to ... ...

    Abstract Introduction: Primary central nervous system (pCNS) melanoma is an extremely rare malignant tumor. We explored the incidence, outcomes, and predictors of pCNS melanoma.
    Methods: We queried the Surveillance, Epidemiology, and End Results database to identify all patients diagnosed with pCNS melanoma during 1973-2015. Overall survival (OS) was obtained by using the Kaplan-Meier curves. Log-rank test was used to compare survival across groups of age, sex, race, tumor location, size, surgical resection, radiotherapy, chemotherapy and year of diagnosis. Cox regression was used for univariate and multivariate analysis of survival.
    Results: A total of 84 pCNS melanomas were identified with a 5-year OS of 37.7%. The overall age-adjusted incidence rate was 0.52 per 10,000,000 person-years. Age ≤19 years (vs. age 20-59 years, hazard ratio [HR] = 2.37, 95% confidence interval [CI]: 1.11-5.07, P = 0.03) and intracranial location (vs. intraspinal, HR = 1.98, 95% CI: 1.04-3.77, P = 0.04) were associated with decreased survival rate. Gross total resection surgery (vs. partial resection, HR = 0.31, 95% CI: 0.15-0.66, P = 0.002) was associated with improved survival rate. There was no significant association between other demographic characteristics, tumor size, therapy methods, year of diagnosis, and OS.
    Conclusions: The overall age-adjusted incidence rate of pCNS melanoma is 0.52 per 10,000,000 person-years. Age ≤19 years and intracranial tumor location are independent risk factors of low survival rate, whereas gross total resection is associated with better survival rate.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Central Nervous System Neoplasms/epidemiology ; Central Nervous System Neoplasms/mortality ; Central Nervous System Neoplasms/pathology ; Central Nervous System Neoplasms/therapy ; Child ; Child, Preschool ; Female ; Humans ; Incidence ; Infant ; Infant, Newborn ; Male ; Melanoma/epidemiology ; Melanoma/mortality ; Melanoma/pathology ; Melanoma/therapy ; Middle Aged ; Prognosis ; Risk Factors ; SEER Program ; Survival Rate ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2019-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2019.06.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1159: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Review of de novo cerebral arteriovenous malformation: haemorrhage risk, treatment approaches and outcomes.

    Lv, Xianli / Wang, Guihuai

    The neuroradiology journal

    2018  Volume 31, Issue 3, Page(s) 224–229

    Abstract: Objective A small number of patients has been reported to develop a completely new or de novo arteriovenous malformation (AVM) after brain surgery, haemorrhage, head trauma or ischaemic stroke. The natural history of these lesions is unknown. In this ... ...

    Abstract Objective A small number of patients has been reported to develop a completely new or de novo arteriovenous malformation (AVM) after brain surgery, haemorrhage, head trauma or ischaemic stroke. The natural history of these lesions is unknown. In this review, both ruptured and unruptured de novo AVMs and their treatments were reviewed. Methods Published literature in the PubMed database citing 'de novo cerebral arteriovenous malformation' was reviewed. Additional studies were identified through reference searches in each reviewed article. A review was performed using all published cases, the treatment approaches and outcomes. Results A total of 38 patients, including 37 de novo AVMs reported from 1988 to 17 November 2017 and our one patient, was collected. The age at AVM diagnosis was 5-73 years (mean ± SD, 27.6 ± 20.5 years). The duration time, from negative examination to AVM diagnosis, was 2 months to 25 years (mean ± SD, 6.6 ± 4.9 years). The presentation of de novo AVM was headaches in three (7.9%) patients, bleedings in 12 (31.6%), incidental in 14 (36.8%) and seizure in nine (23.7%). The estimated risk of haemorrhage was 4.8% per year. Seventeen (44.7%) patients were treated with surgical resection, 10 (26.3%) were conservatively observed, nine (23.7%) were treated with radiosurgery and two (5.3%) were endovascularly embolised. The morbidity and mortality were reported as 5.3% and 7.9%, respectively. Conclusion Post-natal de novo AVMs have been reported. Their annual haemorrhage risk is 4.8%. Most of them are treated by surgical resection and are associated with morbidity and mortality.
    MeSH term(s) Adolescent ; Adult ; Aged ; Chi-Square Distribution ; Child ; Child, Preschool ; Embolization, Therapeutic/methods ; Female ; Headache/etiology ; Hemorrhage/etiology ; Humans ; Intracranial Arteriovenous Malformations/complications ; Intracranial Arteriovenous Malformations/diagnostic imaging ; Intracranial Arteriovenous Malformations/mortality ; Intracranial Arteriovenous Malformations/therapy ; Longitudinal Studies ; Male ; Middle Aged ; Neuroimaging ; PubMed ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2018-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2257770-1
    ISSN 2385-1996 ; 1971-4009 ; 1120-9976
    ISSN (online) 2385-1996
    ISSN 1971-4009 ; 1120-9976
    DOI 10.1177/1971400918759811
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2823: Show issues Location:
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  6. Article ; Online: Giant Recurrent Sacral Chordoma.

    Jing, Linkai / Wang, Guihuai

    World neurosurgery

    2018  Volume 122, Page(s) 96–97

    Abstract: A 65-year-old man presented with a giant recurrent sacral chordoma after undergoing 7 surgical resections. Neurologic examination revealed urinary incontinence. Magnetic resonance imaging showed a huge mass lesion in the bilateral gluteal regions and ... ...

    Abstract A 65-year-old man presented with a giant recurrent sacral chordoma after undergoing 7 surgical resections. Neurologic examination revealed urinary incontinence. Magnetic resonance imaging showed a huge mass lesion in the bilateral gluteal regions and multiple metastatic chordomas. Colostomy and wide en bloc excision of the giant recurrent chordoma were performed in April 2017. The tumor weighed 13.15 kg, and histopathologic examination revealed a chordoma. Magnetic resonance imaging performed at the 12-month follow-up showed slight recurrence. In addition, multiple metastatic chordomas localized to the pelvic cavity and the subcutaneous layer of the gluteal region showed significant enlargement. The metastatic chordomas were resected in May 2018. At his last follow-up, the patient presented with an indwelling catheter and a colostomy bag, and the recurrent chordoma showed no visible enlargement.
    MeSH term(s) Aged ; Chordoma/diagnostic imaging ; Chordoma/pathology ; Chordoma/surgery ; Humans ; Male ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/surgery ; Sacrum ; Spinal Neoplasms/diagnostic imaging ; Spinal Neoplasms/pathology ; Spinal Neoplasms/surgery
    Language English
    Publishing date 2018-11-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2018.10.165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1159: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Predictive Analyses of Prognostic-Related Immune Genes and Immune Infiltrates for Glioblastoma.

    Liang, Ping / Chai, Yi / Zhao, He / Wang, Guihuai

    Diagnostics (Basel, Switzerland)

    2020  Volume 10, Issue 3

    Abstract: Glioblastoma (GBM), the most common and aggressive brain tumor, has a very poor outcome and high tumor recurrence rate. The immune system has positive interactions with the central nervous system. Despite many studies investigating immune prognostic ... ...

    Abstract Glioblastoma (GBM), the most common and aggressive brain tumor, has a very poor outcome and high tumor recurrence rate. The immune system has positive interactions with the central nervous system. Despite many studies investigating immune prognostic factors, there is no effective model to identify predictive biomarkers for GBM. Genomic data and clinical characteristic information of patients with GBM were evaluated by Kaplan-Meier analysis and proportional hazard modeling. Deseq2 software was used for differential expression analysis. Immune-related genes from ImmPort Shared Data and the Cistrome Project were evaluated. The model performance was determined based on the area under the receiver operating characteristic (ROC) curve. CIBERSORT was used to assess the infiltration of immune cells. The results of differential expression analyses showed a significant difference in the expression levels of 2942 genes, comprising 1338 upregulated genes and 1604 downregulated genes (
    Language English
    Publishing date 2020-03-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics10030177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Multicentric Exophytic Primary Spinal Cord Glioblastoma Mimicking Teratoma.

    Yang, Kaiyuan / Wang, James / Wang, Guihuai

    World neurosurgery

    2020  Volume 144, Page(s) 262–263.e2

    Abstract: Primary spinal cord glioblastoma is an extremely rare disease that shows dismal prognosis. Here we report the first case, to our knowledge, of multicentric primary spinal cord glioblastoma presenting with exophytic involvement mimicking teratoma. A 12- ... ...

    Abstract Primary spinal cord glioblastoma is an extremely rare disease that shows dismal prognosis. Here we report the first case, to our knowledge, of multicentric primary spinal cord glioblastoma presenting with exophytic involvement mimicking teratoma. A 12-year-old girl presented to our hospital with a 6-month history of back pain and progressive paraplegia. Spinal magnetic resonance imaging findings were suspicious for spinal teratoma with cerebrospinal fluid dissemination. The patient underwent laminotomy and laminoplasty from T10-S2 and subtotal resection of the tumor was achieved. Histopathological analysis revealed typical histological indications of glioblastoma. After surgery, the patient underwent further adjuvant therapy consisting of radiotherapy and temozolomide. However, 8 months after surgery, the follow-up magnetic resonance imaging scan revealed tumor recurrence with intracranial dissemination. The patient is still alive at the current stage (9 months after surgery).
    MeSH term(s) Chemoradiotherapy ; Child ; Combined Modality Therapy ; Diagnosis, Differential ; Female ; Glioblastoma/pathology ; Glioblastoma/surgery ; Humans ; Magnetic Resonance Imaging ; Neoplasm Recurrence, Local ; Neurosurgical Procedures ; Paraplegia/etiology ; Spinal Cord Neoplasms/pathology ; Spinal Cord Neoplasms/surgery ; Teratoma/pathology ; Treatment Outcome
    Language English
    Publishing date 2020-08-08
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.08.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Intraspinal tumors

    WANG Gui-huai

    Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 13, Iss 12, Pp 983-

    2013  Volume 985

    Keywords Spinal cord neoplasms ; Spinal canal ; Microsurgery ; Review ; Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Neurology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language Chinese
    Publishing date 2013-12-01T00:00:00Z
    Publisher Tianjin Huanhu Hospital
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Diffuse midline glioma treated with epigenetic agent-based immunotherapy.

    Jing, Linkai / Qian, Zhihong / Gao, Qiang / Sun, Rui / Zhen, Zili / Wang, Guihuai / Yang, Xuejun / Li, Haitao / Guo, Tiannan / Zhang, Wei

    Signal transduction and targeted therapy

    2023  Volume 8, Issue 1, Page(s) 23

    MeSH term(s) Humans ; Brain Neoplasms/genetics ; Brain Neoplasms/therapy ; Glioma/genetics ; Glioma/therapy ; Epigenomics ; Epigenesis, Genetic/genetics
    Language English
    Publishing date 2023-01-20
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-022-01274-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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