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  1. Article ; Online: Visible-Light-Promoted Intermolecular β-Acyl Difunctionalization of Alkenes via Oxidative Radical-Polar Crossover.

    Li, Hao-Cong / Zhao, Ke-Yuan / Tan, Yan / Wang, Hao-Sen / Wang, Wen-Shan / Chen, Xiao-Lan / Yu, Bing

    Organic letters

    2023  Volume 25, Issue 45, Page(s) 8067–8071

    Abstract: A visible-light-induced β-acyl difunctionalization of alkenes with acyl oxime esters and various nucleophiles was developed to achieve molecular complexity from readily available raw materials via oxidative radical-polar crossover. A variety of ... ...

    Abstract A visible-light-induced β-acyl difunctionalization of alkenes with acyl oxime esters and various nucleophiles was developed to achieve molecular complexity from readily available raw materials via oxidative radical-polar crossover. A variety of nucleophiles, including
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c03121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prognostic value of normal positron emission tomography myocardial perfusion imaging in patients with known or suspected coronary artery disease: a meta-analysis.

    Chen, A'Di / Wang, HaoSen / Fan, Bing / Xu, YaWei / Chen, Wei / Dai, Neng

    The British journal of radiology

    2017  Volume 90, Issue 1074, Page(s) 20160702

    Abstract: Objective: Several studies have confirmed high diagnostic performance of positron emission tomography (PET) myocardial perfusion imaging (MPI) in patients with known or suspected coronary artery disease. However, whether the superior diagnostic accuracy ...

    Abstract Objective: Several studies have confirmed high diagnostic performance of positron emission tomography (PET) myocardial perfusion imaging (MPI) in patients with known or suspected coronary artery disease. However, whether the superior diagnostic accuracy could translate into improved mortality outcomes remains unknown. The aim of this study was to define the prognostic value of normal PET MPI.
    Methods: PubMed and EMBASE were searched to identify related studies up to June 2016. All studies using PET MPI to evaluate subjects with known or suspected coronary artery disease and providing absolute number of patients with a negative test and primary data on clinical outcomes with a follow-up time ≥3 months were included for analysis.
    Results: The search yielded 11 studies comprising 20,471 patients for final analysis. The negative-predictive value (NPV) for cardiac death, all-cause death and major adverse cardiovascular events (MACE) were 98.80% [95% confidence interval (CI), 97.64%-99.39%], 94.89% (95% CI: 92.99-96.30%) and 90.26% (95% CI: 78.01-96.03%), over 36.9 months of follow-up for cardiac death, over 26.8 months for all-cause death and 35.7 months for MACE. The corresponding annualized event rates were 0.39%, 2.29% and 3.27%, respectively. In subgroup analyses of different imaging analysis methods for PET MPI, studies using perfusion abnormity had a similar NPV as compared with those using coronary flow reserve (98.46% vs 98.86%, p-value = NS), with a corresponding annualized event rate after negative tests (equal to 1 - NPV) as 0.45% and 0.42%, respectively.
    Conclusion: Normal PET has a high NPV for cardiac death, MACE and all-cause mortality. Different indexes used for PET imaging analysis have a comparable prognostic value. Advances in knowledge: A normal PET MPI conferred a very low risk of cardiac death of 0.39% per year, which is close to that of a normal aged-matched population.
    MeSH term(s) Coronary Artery Disease/diagnostic imaging ; Humans ; Myocardial Perfusion Imaging/methods ; Prognosis ; Radiopharmaceuticals
    Chemical Substances Radiopharmaceuticals
    Language English
    Publishing date 2017-06
    Publishing country England
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20160702
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The effect of Danshen extract on lipoprotein-associated phospholipase A

    Chen, A-Di / Wang, Chun-Ling / Qin, Yang / Tian, Liang / Chen, Li-Bin / Yuan, Xiao-Ming / Ma, Lin-Xiu / Wang, Yu-Feng / Sun, Ji-Rong / Wang, Hao-Sen / Dai, Neng

    Trials

    2017  Volume 18, Issue 1, Page(s) 606

    Abstract: Background: Lipoprotein-associated phospholipase A: Methods/design: This is a randomized, single-blind, placebo-controlled, adaptive clinical trial. A total of 156 patients meeting the eligibility criteria will be randomly assigned to either the ... ...

    Abstract Background: Lipoprotein-associated phospholipase A
    Methods/design: This is a randomized, single-blind, placebo-controlled, adaptive clinical trial. A total of 156 patients meeting the eligibility criteria will be randomly assigned to either the Danshen extract (DanshenDuofensuanyan injection and Danshen drop spill) group or the placebo group in a 1:1 ratio. Participants will then undergo treatment with DanshenDuofensuanyan injection or placebo (glucose) during hospitalization, followed by open-label Danshen drop spill (30 pills/day) in Danshen extract group for 60 days after discharge. Because this is an adaptive trial, two interim analyses are prospectively planned. These will be performed after one-third and two-thirds of the patients, respectively, have completed the trial. On the basis of the results of these interim analyses, a data monitoring committee will determine how to modify aspects of the study without undermining the validity and integrity of the trial. The primary outcome measure is the serum level of Lp-PLA
    Discussion: This study will provide evidence that Danshen extract is beneficial for stable angina and may establish a possible mechanism of Danshen treatment effects on cardiovascular disease. This study may also validate an objective blood test (LP-PLA
    Trial registration: ClinicalTrials.gov, NCT02870764 . Registered on 13 August 2016.
    MeSH term(s) 1-Alkyl-2-acetylglycerophosphocholine Esterase/blood ; Adolescent ; Adult ; Aged ; Angina, Stable/diagnosis ; Angina, Stable/drug therapy ; Angina, Stable/enzymology ; Biomarkers/blood ; Cardiovascular Agents/adverse effects ; Cardiovascular Agents/therapeutic use ; Carotid Intima-Media Thickness ; China ; Clinical Protocols ; Drugs, Chinese Herbal/adverse effects ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Research Design ; Single-Blind Method ; Surveys and Questionnaires ; Time Factors ; Treatment Outcome ; Young Adult
    Chemical Substances Biomarkers ; Cardiovascular Agents ; Drugs, Chinese Herbal ; dan-shen root extract (79483-68-4) ; 1-Alkyl-2-acetylglycerophosphocholine Esterase (EC 3.1.1.47) ; PLA2G7 protein, human (EC 3.1.1.47)
    Language English
    Publishing date 2017-12-20
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1468-6708
    ISSN (online) 1745-6215 ; 1468-6694
    ISSN 1468-6708
    DOI 10.1186/s13063-017-2336-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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