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Artikel ; Online: Rapid Geometric Evaluation of Transportation Infrastructure Based on a Proposed Low-Cost Portable Mobile Laser Scanning System.

Wang, Haochen / Feng, Dongming

2024 Band 24, Heft 2

Abstract: Efficient geometric evaluation of roads and tunnels is crucial to traffic management, especially in post-disaster situations. This paper reports on a study of the geometric feature detection method based on multi-sensor mobile laser scanning (MLS) system ...

Abstract	Efficient geometric evaluation of roads and tunnels is crucial to traffic management, especially in post-disaster situations. This paper reports on a study of the geometric feature detection method based on multi-sensor mobile laser scanning (MLS) system data. A portable, low-cost system that can be mounted on vehicles and utilizes integrated laser scanning devices was developed. Coordinate systems and timestamps from numerous devices were merged to create 3D point clouds of objects being measured. Feature points reflecting the geometric information of measuring objects were retrieved based on changes in the point cloud's shape, which contributed to measuring the road width, vertical clearance, and tunnel cross section. Self-developed software was used to conduct the measuring procedure, and a real-time online visualized platform was designed to reconstruct 3D models of the measured objects, forming a 3D digital map carrying the obtained geometric information. Finally, a case study was carried out. The measurement results of several representative nodes are discussed here, verifying the robustness of the proposed system. In addition, the main sources of interference are also discussed.
Sprache	Englisch
Erscheinungsdatum	2024-01-10
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24020425
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Efficacy and safety analysis of selective hepatic vein occlusion combined with arterial chemoembolization versus conventional transarterial chemoembolization in the treatment of hepatocellular carcinoma.

Chang, Jiang / Wang, Haochen / Li, Jian / Jin, Long

Journal of gastrointestinal oncology

2024 Band 15, Heft 2, Seite(n) 710–720

Abstract: Background: Transarterial chemoembolization (TACE) is a non-radical treatment. How to improve the local response rate of tumor is the direction we have been exploring. The purpose of this study is to compare the efficacy and safety of occlusion-TACE (O- ... ...

Abstract	Background: Transarterial chemoembolization (TACE) is a non-radical treatment. How to improve the local response rate of tumor is the direction we have been exploring. The purpose of this study is to compare the efficacy and safety of occlusion-TACE (O-TACE) versus conventional TACE (C-TACE) in the treatment of patients with early to mid-stage hepatocellular carcinoma (HCC) of lesions being confined to the same hepatic venous drainage area. Methods: In this study, 40 patients with HCC were prospectively enrolled and randomly assigned to the O-TACE and C-TACE groups, and the efficacy of all patients was assessed at 1, 2, and 3 months after the first treatment, and adverse events (AEs) occurring during the treatment period were also recorded. Results: At 1, 2 and 3 months after the first treatment, patients in the O-TACE group had significantly better complete response (CR) rates (35% Conclusions: O-TACE has a better CR rate and a favorable safety profile in patients with early to mid-stage HCC of lesions being confined to the same hepatic venous drainage area.
Sprache	Englisch
Erscheinungsdatum	2024-04-18
Erscheinungsland	China
Dokumenttyp	Journal Article
ZDB-ID	2594644-4
ISSN	2219-679X ; 2078-6891
ISSN (online)	2219-679X
ISSN	2078-6891
DOI	10.21037/jgo-23-992
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Imaging biomarkers on Angio-CT for predicting the efficacy of transarterial chemoembolization in hepatocellular carcinoma.

Wang, Haochen / Han, Yanjing / Chen, Guang / Jin, Long

Quantitative imaging in medicine and surgery

2023 Band 13, Heft 7, Seite(n) 4077–4088

Abstract: Background: This study aimed to evaluate whether the lipiodol deposition pattern on intraprocedural Angio-CT could predict tumor treatment response in hepatocellular carcinoma (HCC) patients treated with conventional transarterial chemoembolization (c- ... ...

Abstract	Background: This study aimed to evaluate whether the lipiodol deposition pattern on intraprocedural Angio-CT could predict tumor treatment response in hepatocellular carcinoma (HCC) patients treated with conventional transarterial chemoembolization (c-TACE). Methods: This retrospective study enrolled intermediated and advanced HCC nodules treated with c-TACE and Angio-CT from June 2021 to June 2022. The therapeutic efficacy was evaluated according to the mRECIST standards. First, Angio-CT was used to determine lipiodol deposition at the end of c-TACE, redefined as complete, partial-complete, and incomplete groups. Second, the mean CT value of lipiodol deposition and its association with therapeutic efficacy were calculated in the complete model. Finally, the relationship between imaging biomarkers and efficacy was evaluated. Results: A total of 45 patients with 72 HCC nodules were enrolled with 28 nodules in the complete group, 31 nodules in the partial-complete group, and 13 nodules in the incomplete group. The complete response (CR) proportion was significantly higher in patients with good lipiodol deposition compared with patients with poor lipiodol deposition (P<0.0001). There was no significantly different CR rate between CT value ≥800 and <800 HU (P=0.119) in the complete group. Meanwhile, the non-CR rate in cases with hepatic vein development was significantly higher than that in cases with no hepatic vein development in the arterial phase (P<0.0001). Conclusions: Complete lipiodol deposition on Angio-CT during c-TACE was a predictive factor for therapeutic response to TACE. For HCC nodules with well-deposited lipiodol, hepatic vein development on Angio-CT in the arterial phase was strongly associated with poor efficacy of TACE.
Sprache	Englisch
Erscheinungsdatum	2023-04-03
Erscheinungsland	China
Dokumenttyp	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims-22-1355
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Microneedle-Mediated Transcutaneous Immunization: Potential in Nucleic Acid Vaccination.

Wang, Haochen / Xu, Junhua / Xiang, Lin

Advanced healthcare materials

2023 Band 12, Heft 23, Seite(n) e2300339

Abstract: Efforts aimed at exploring economical and efficient vaccination have taken center stage to combat frequent epidemics worldwide. Various vaccines have been developed for infectious diseases, among which nucleic acid vaccines have attracted much attention ... ...

Abstract	Efforts aimed at exploring economical and efficient vaccination have taken center stage to combat frequent epidemics worldwide. Various vaccines have been developed for infectious diseases, among which nucleic acid vaccines have attracted much attention from researchers due to their design flexibility and wide application. However, the lack of an efficient delivery system considerably limits the clinical translation of nucleic acid vaccines. As mass vaccinations via syringes are limited by low patient compliance and high costs, microneedles (MNs), which can achieve painless, cost-effective, and efficient drug delivery, can provide an ideal vaccination strategy. The MNs can break through the stratum corneum barrier in the skin and deliver vaccines to the immune cell-rich epidermis and dermis. In addition, the feasibility of MN-mediated vaccination is demonstrated in both preclinical and clinical studies and has tremendous potential for the delivery of nucleic acid vaccines. In this work, the current status of research on MN vaccines is reviewed. Moreover, the improvements of MN-mediated nucleic acid vaccination are summarized and the challenges of its clinical translation in the future are discussed.
Mesh-Begriff(e)	Humans ; Immunization ; Vaccination ; Skin ; Vaccines ; Drug Delivery Systems ; Nucleic Acid-Based Vaccines ; Needles ; Nucleic Acids ; Administration, Cutaneous
Chemische Substanzen	Vaccines ; Nucleic Acid-Based Vaccines ; Nucleic Acids
Sprache	Englisch
Erscheinungsdatum	2023-05-10
Erscheinungsland	Germany
Dokumenttyp	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202300339
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Natural anti-inflammatory products for osteoarthritis: From molecular mechanism to drug delivery systems and clinical trials.

Su, Jianbang / Yu, Minghao / Wang, Haochen / Wei, Yingliang

Phytotherapy research : PTR

2023 Band 37, Heft 10, Seite(n) 4321–4352

Abstract: Osteoarthritis (OA) is a degenerative joint disease that affects millions globally. The present nonsteroidal anti-inflammatory drug treatments have different side effects, leading researchers to focus on natural anti-inflammatory products (NAIPs). To ... ...

Abstract	Osteoarthritis (OA) is a degenerative joint disease that affects millions globally. The present nonsteroidal anti-inflammatory drug treatments have different side effects, leading researchers to focus on natural anti-inflammatory products (NAIPs). To review the effectiveness and mechanisms of NAIPs in the cellular microenvironment, examining their impact on OA cell phenotype and organelles levels. Additionally, we summarize relevant research on drug delivery systems and clinical randomized controlled trials (RCTs), to promote clinical studies and explore natural product delivery options. English-language articles were searched on PubMed using the search terms "natural products," "OA," and so forth. We categorized search results based on PubChem and excluded "natural products" which are mix of ingredients or compounds without the structure message. Then further review was separately conducted for molecular mechanisms, drug delivery systems, and RCTs later. At present, it cannot be considered that NAIPs can thoroughly prevent or cure OA. Further high-quality studies on the anti-inflammatory mechanism and drug delivery systems of NAIPs are needed, to determine the appropriate drug types and regimens for clinical application, and to explore the combined effects of different NAIPs to prevent and treat OA.
Sprache	Englisch
Erscheinungsdatum	2023-08-28
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.7935
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: GPro: generative AI-empowered toolkit for promoter design.

Wang, Haochen / Du, Qixiu / Wang, Ye / Xu, Hanwen / Wei, Zheng / Wang, Xiaowo

Bioinformatics (Oxford, England)

2024 Band 40, Heft 3

Abstract: Motivation: Promoters with desirable properties are crucial in biotechnological applications. Generative AI (GenAI) has demonstrated potential in creating novel synthetic promoters with significantly enhanced functionality. However, these methods' ... ...

Abstract	Motivation: Promoters with desirable properties are crucial in biotechnological applications. Generative AI (GenAI) has demonstrated potential in creating novel synthetic promoters with significantly enhanced functionality. However, these methods' reliance on various programming frameworks and specific task-oriented contexts limits their flexibilities. Overcoming these limitations is essential for researchers to fully leverage the power of GenAI to design promoters for their tasks. Results: Here, we introduce GPro (Generative AI-empowered toolkit for promoter design), a user-friendly toolkit that integrates a collection of cutting-edge GenAI-empowered approaches for promoter design. This toolkit provides a standardized pipeline covering essential promoter design processes, including training, optimization, and evaluation. Several detailed demos are provided to reproduce state-of-the-art promoter design pipelines. GPro's user-friendly interface makes it accessible to a wide range of users including non-AI experts. It also offers a variety of optional algorithms for each design process, and gives users the flexibility to compare methods and create customized pipelines. Availability and implementation: GPro is released as an open-source software under the MIT license. The source code for GPro is available on GitHub for Linux, macOS, and Windows: https://github.com/WangLabTHU/GPro, and is available for download via Zenodo repository at https://zenodo.org/doi/10.5281/zenodo.10681733.
Mesh-Begriff(e)	Software ; Algorithms ; Promoter Regions, Genetic ; Artificial Intelligence
Sprache	Englisch
Erscheinungsdatum	2024-03-02
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1422668-6
ISSN	1367-4811 ; 1367-4803
ISSN (online)	1367-4811
ISSN	1367-4803
DOI	10.1093/bioinformatics/btae123
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Transcription factors RhbZIP17 and RhWRKY30 enhance resistance to Botrytis cinerea by increasing lignin content in rose petals.

Li, Dandan / Li, Xiaomei / Wang, Zicheng / Wang, Haochen / Gao, Junzhao / Liu, Xintong / Zhang, Zhao

Journal of experimental botany

2024 Band 75, Heft 5, Seite(n) 1633–1646

Abstract: The petals of ornamental plants such as roses (Rosa spp.) are the most economically important organs. This delicate, short-lived plant tissue is highly susceptible to pathogens, in large part because the walls of petal cells are typically thinner and ... ...

Abstract	The petals of ornamental plants such as roses (Rosa spp.) are the most economically important organs. This delicate, short-lived plant tissue is highly susceptible to pathogens, in large part because the walls of petal cells are typically thinner and more flexible compared with leaf cells, allowing the petals to fold and bend without breaking. The cell wall is a dynamic structure that rapidly alters its composition in response to pathogen infection, thereby reinforcing its stability and boosting plant resistance against diseases. However, little is known about how dynamic changes in the cell wall contribute to resistance to Botrytis cinerea in rose petals. Here, we show that the B. cinerea-induced transcription factor RhbZIP17 is required for the defense response of rose petals. RhbZIP17 is associated with phenylpropanoid biosynthesis and binds to the promoter of the lignin biosynthesis gene RhCAD1, activating its expression. Lignin content showed a significant increase under gray mold infection compared with the control. RhCAD1 functions in the metabolic regulation of lignin production and, consequently, disease resistance, as revealed by transient silencing and overexpression in rose petals. The WRKY transcription factor RhWRKY30 is also required to activate RhCAD1 expression and enhance resistance against B. cinerea. We propose that RhbZIP17 and RhWRKY30 increase lignin biosynthesis, improve the resistance of rose petals to B. cinerea, and regulate RhCAD1 expression.
Mesh-Begriff(e)	Transcription Factors/genetics ; Transcription Factors/metabolism ; Rosa/genetics ; Lignin/metabolism ; Gene Expression Regulation ; Botrytis/physiology ; Plant Diseases/genetics ; Disease Resistance/genetics ; Gene Expression Regulation, Plant
Chemische Substanzen	Transcription Factors ; Lignin (9005-53-2)
Sprache	Englisch
Erscheinungsdatum	2024-01-04
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2976-2
ISSN	1460-2431 ; 0022-0957
ISSN (online)	1460-2431
ISSN	0022-0957
DOI	10.1093/jxb/erad473
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The M2 Macrophages Derived Migrasomes From the Surface of Titania Nanotubes Array as a New Concept for Enhancing Osteogenesis.

Li, Guangwen / Zhao, Yuqi / Wang, Haochen / Zhang, Yan / Cai, Dongxuan / Zhang, Yumei / Song, Wen

Advanced healthcare materials

2024 , Seite(n) e2400257

Abstract: As newly discovered substrate anchored extracellular vesicles, migrasomes (Migs) may bring a new opportunity for manipulating target cells bioactivities. In this study, the M2 macrophages derived Migs are obtained by titania nanotubes surface (NTs). Due ... ...

Abstract	As newly discovered substrate anchored extracellular vesicles, migrasomes (Migs) may bring a new opportunity for manipulating target cells bioactivities. In this study, the M2 macrophages derived Migs are obtained by titania nanotubes surface (NTs). Due to the benefits of nanostructuring, the NTs surface is not only able to induce RAW264.7 for M2 polarization but also to generate more Migs formation, which can be internalized by following seeded mesenchymal stem cells (MSCs). Then, the NTs surface induced Migs are collected by density-gradient centrifugation for MSCs treatment. As indicated by immunofluorescence staining, alkaline phosphatase activity, and alizarin red staining, the osteogenic differentiation capacity of MSCs is significantly enhanced by Migs treatment, in line with the dosage. By RNA-sequence analysis, the enhancement of osteogenic differentiation is correlated with PI3K-AKT pathway activation that may originate from the M2 polarization state of donor cells. Finally, the Migs are coated onto Ti surface for therapeutic application. Both the in vitro and in vivo analysis reveal that the Migs coated Ti implant shows significant enhancement of osteogenesis. In conclusion, this study suggests that the nanosurface may be a favorable platform for Migs production, which may bring a new concept for tissue regeneration.
Sprache	Englisch
Erscheinungsdatum	2024-03-23
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202400257
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: PGC-1α in osteoarthritic chondrocytes: From mechanism to target of action.

Wang, Haochen / Su, Jianbang / Yu, Minghao / Xia, Yang / Wei, Yingliang

Frontiers in pharmacology

2023 Band 14, Seite(n) 1169019

Abstract: Osteoarthritis (OA) is one of the most common degenerative joint diseases, often involving the entire joint. The degeneration of articular cartilage is an important feature of OA, and there is growing evidence that the mitochondrial biogenesis master ... ...

Abstract	Osteoarthritis (OA) is one of the most common degenerative joint diseases, often involving the entire joint. The degeneration of articular cartilage is an important feature of OA, and there is growing evidence that the mitochondrial biogenesis master regulator peroxisome proliferator-activated receptor
Sprache	Englisch
Erscheinungsdatum	2023-04-06
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1169019
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: New insights into the role of adipocytes in pancreatic cancer progression: paving the way towards novel therapeutic targets.

Lin, Yu-Chun / Hou, Ya-Chin / Wang, Hao-Chen / Shan, Yan-Shen

Theranostics

2023 Band 13, Heft 12, Seite(n) 3925–3942

Abstract: Pancreatic cancer (PC) remains one of the most lethal malignancies across the world, which is due to delayed diagnosis and resistance to current therapies. The interactions between pancreatic tumor cells and their tumor microenvironment (TME) allow ... ...

Abstract	Pancreatic cancer (PC) remains one of the most lethal malignancies across the world, which is due to delayed diagnosis and resistance to current therapies. The interactions between pancreatic tumor cells and their tumor microenvironment (TME) allow cancer cells to escape from anti-cancer therapies, leading to difficulties in treating PC. With endocrine function and lipid storage capacity, adipose tissue can maintain energy homeostasis. Direct or indirect interaction between adipocytes and PC cells leads to adipocyte dysfunction characterized by morphological change, fat loss, abnormal adipokine secretion, and fibroblast-like transformation. Various adipokines released from dysfunctional adipocytes have been reported to promote proliferation, invasion, metastasis, stemness, and chemoresistance of PC cells via different mechanisms. Additional lipid outflow from adipocytes can be taken into the TME and thus alter the metabolism in PC cells and surrounding stromal cells. Besides, the trans-differentiation potential enables adipocytes to turn into various cell types, which may give rise to an inflammatory response as well as extracellular matrix reorganization to modulate tumor burden. Understanding the molecular basis behind the protumor functions of adipocytes in PC may offer new therapeutic targets.
Mesh-Begriff(e)	Humans ; Adipocytes/metabolism ; Adipose Tissue/metabolism ; Pancreatic Neoplasms/pathology ; Adipokines ; Lipids ; Tumor Microenvironment ; Pancreatic Neoplasms
Chemische Substanzen	Adipokines ; Lipids
Sprache	Englisch
Erscheinungsdatum	2023-07-03
Erscheinungsland	Australia
Dokumenttyp	Journal Article ; Review
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.82911
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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