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  1. Article: Editorial: Epigenetic and molecular control of development and germ cell fate determination.

    Liu, Kui / Wang, Hengbin

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1274602

    Language English
    Publishing date 2023-08-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1274602
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  2. Article: Antibacterial Ingredients and Modes of the Methanol-Phase Extract from the Fruit of

    Zhang, Kaiyue / Cao, Fengfeng / Zhao, Yueliang / Wang, Hengbin / Chen, Lanming

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 6

    Abstract: Epidemics of infectious diseases threaten human health and society stability. Pharmacophagous plants are rich in bioactive compounds that constitute a safe drug library for antimicrobial agents. In this study, we have deciphered for the first time ... ...

    Abstract Epidemics of infectious diseases threaten human health and society stability. Pharmacophagous plants are rich in bioactive compounds that constitute a safe drug library for antimicrobial agents. In this study, we have deciphered for the first time antibacterial ingredients and modes of the methanol-phase extract (MPE) from the fruit of
    Language English
    Publishing date 2024-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13060834
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correction for Shi et al., "USP49-Mediated Histone H2B Deubiquitination Regulates HCT116 Cell Proliferation through MDM2-p53 Axis".

    Shi, Lei / Shen, Xiangyu / Wang, Hengbin / Shen, Yuan

    Molecular and cellular biology

    2022  Volume 42, Issue 6, Page(s) e0013922

    Language English
    Publishing date 2022-05-12
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1128/mcb.00139-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1666: Show issues Location:
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  4. Article ; Online: Integrated serum metabolomics and network pharmacology analysis on the bioactive metabolites and mechanism exploration of Bufei huoxue capsule on chronic obstructive pulmonary disease rats.

    Ren, Hui / Wu, Wenxing / Chen, Jiangyan / Li, Quan / Wang, Hengbin / Qian, Dawei / Guo, Sheng / Duan, Jin-Ao

    Journal of ethnopharmacology

    2024  Volume 324, Page(s) 117816

    Abstract: Ethnopharmacological relevance: Bufei Huoxue capsule (BHC) as a classic Chinese patent medicine formula, has the efficacy of tonifying the lungs and activating the blood. It has been extensively used in China for the treatment of chronic obstructive ... ...

    Abstract Ethnopharmacological relevance: Bufei Huoxue capsule (BHC) as a classic Chinese patent medicine formula, has the efficacy of tonifying the lungs and activating the blood. It has been extensively used in China for the treatment of chronic obstructive pulmonary disease (COPD) clinically. However, its mechanism is still unclear, which hampers the applications of BHC in treating COPD.
    Aim of the study: The purpose of the present study was to demonstrate the protective efficacy and mechanism of BHC on COPD model rats by integrating serum metabolomics analysis and network pharmacology study.
    Materials and methods: A COPD rat model was established by cigarette fumigation combined with lipopolysaccharide (LPS) airway drip for 90 consecutive days. After oral administration for 30 days, the rats were placed in the body tracing box of the EMKA Small Animal Noninvasive Lung Function Test System to determine lung function related indexes. Histopathological alteration was observed by H&E staining and Masson staining. The serum levels of inflammatory cytokine, matrix metalloprotein 9, and laminin were determined by ELISA kits. Oxidative stress levels were tested by biochemical methods. UHPLC-Q-TOF/MS analysis of serum metabolomics and network pharmacology were performed to reveal the bioactive metabolites, key components and pathways for BHC treating COPD. WB and ELISA kits were used to verify the effects of BHC on key pathway.
    Results: BHC could improve lung function, immunity, lung histopathological changes and collagen deposition in COPD model rats. It also could significantly reduce inflammatory response in vivo, regulate oxidative stress level, reduce laminin content, and regulate protease-antiprotease balance. Metabolomics analysis found 46 biomarkers of COPD, of which BHC significantly improved the levels of 23 differential metabolites including arachidonic acid, leukotriene B4 and prostaglandin E2. Combined with the results of network pharmacology, the components of BHC, such as calycosin, oxypaeoniflora, (S)-bavachin and neobavaisoflavone could play therapeutic roles through the arachidonic acid pathway. In addition, the results of WB and ELISA indicated that BHC could suppress the expressions of COX2 and 5-LOX in lung tissues and inhibit the generation of AA and its metabolites in serum samples. Regulation of arachidonic acid metabolic pathway may be the crucial mechanism for BHC treating COPD.
    Conclusions: In summary, the studies indicated that BHC exhibited the protective effect on COPD model rats by anti-inflammatory and anti-oxidative properties through arachidonic acid metabolism pathway. This study provided beneficial support for the applications of BHC in treating COPD.
    MeSH term(s) Rats ; Animals ; Network Pharmacology ; Arachidonic Acid ; Rats, Sprague-Dawley ; Pulmonary Disease, Chronic Obstructive/metabolism ; Metabolomics/methods ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Laminin ; Medicine, Chinese Traditional
    Chemical Substances Bufei Huoxue ; Arachidonic Acid (27YG812J1I) ; Drugs, Chinese Herbal ; Laminin
    Language English
    Publishing date 2024-01-28
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.117816
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: O-GlcNAcylation stimulates the deubiquitination activity of USP16 and regulates cell cycle progression.

    Zhao, Jianxin / Hua, Jie / Zhan, Yahui / Chen, Chunxu / Liu, Yue / Yang, Liqian / Wang, Haiying / Wang, Hengbin / Li, Jing

    The Journal of biological chemistry

    2024  Volume 300, Issue 4, Page(s) 107150

    Abstract: Histone 2A monoubiquitination (uH2A) underscores a key epigenetic regulation of gene expression. In this report, we show that the deubiquitinase for uH2A, ubiquitin-specific peptidase 16 (USP16), is modified by O-linked N-acetylglucosamine (O-GlcNAc). O- ... ...

    Abstract Histone 2A monoubiquitination (uH2A) underscores a key epigenetic regulation of gene expression. In this report, we show that the deubiquitinase for uH2A, ubiquitin-specific peptidase 16 (USP16), is modified by O-linked N-acetylglucosamine (O-GlcNAc). O-GlcNAcylation involves the installation of the O-GlcNAc moiety to Ser/Thr residues. It crosstalks with Ser/Thr phosphorylation, affects protein-protein interaction, alters enzyme activity or protein folding, and changes protein subcellular localization. In our study, we first confirmed that USP16 is glycosylated on Thr203 and Ser214, as reported in a previous chemoenzymatic screen. We then discovered that mutation of the O-GlcNAcylation site Thr203, which is adjacent to deubiquitination-required Cys204, reduces the deubiquitination activity toward H2AK119ub in vitro and in cells, while mutation on Ser214 had the opposite effects. Using USP16 Ser552 phosphorylation-specific antibodies, we demonstrated that O-GlcNAcylation antagonizes cyclin-dependent kinase 1-mediated phosphorylation and promotes USP16 nuclear export. O-GlcNAcylation of USP16 is also required for deubiquitination of Polo-like kinase 1, a mitotic master kinase, and the subsequent chromosome segregation and cytokinesis. In summary, our study revealed that O-GlcNAcylation of USP16 at Thr203 and Ser214 coordinates deubiquitination of uH2A and Polo-like kinase 1, thus ensuring proper cell cycle progression.
    MeSH term(s) Humans ; Ubiquitination ; Phosphorylation ; Glycosylation ; Ubiquitin Thiolesterase/metabolism ; Ubiquitin Thiolesterase/genetics ; Acetylglucosamine/metabolism ; Cell Cycle ; HEK293 Cells ; HeLa Cells ; Cell Cycle Proteins/metabolism ; Cell Cycle Proteins/genetics ; Histones/metabolism ; Active Transport, Cell Nucleus ; Protein Serine-Threonine Kinases/metabolism ; Protein Serine-Threonine Kinases/genetics ; Polo-Like Kinase 1
    Chemical Substances USP16 protein, human ; Ubiquitin Thiolesterase (EC 3.4.19.12) ; Acetylglucosamine (V956696549) ; Cell Cycle Proteins ; Histones ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Polo-Like Kinase 1
    Language English
    Publishing date 2024-03-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2024.107150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Recognition of H2AK119ub plays an important role in RSF1-regulated early

    Parast, Saeid Mohammad / Yu, Deli / Chen, Chunxu / Dickinson, Amanda J / Chang, Chenbei / Wang, Hengbin

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1168643

    Abstract: Polycomb group (PcG) proteins are key regulators of gene expression and developmental programs via covalent modification of histones, but the factors that interpret histone modification marks to regulate embryogenesis are less studied. We previously ... ...

    Abstract Polycomb group (PcG) proteins are key regulators of gene expression and developmental programs via covalent modification of histones, but the factors that interpret histone modification marks to regulate embryogenesis are less studied. We previously identified Remodeling and Spacing Factor 1 (RSF1) as a reader of histone H2A lysine 119 ubiquitination (H2AK119ub), the histone mark deposited by Polycomb Repressive Complex 1 (PRC1). In the current study, we used
    Language English
    Publishing date 2023-07-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1168643
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  7. Article ; Online: The Pleiotropic Ubiquitin-Specific Peptidase 16 and Its Many Substrates.

    Zheng, Jiahuan / Chen, Chunxu / Guo, Chunqing / Caba, Cody / Tong, Yufeng / Wang, Hengbin

    Cells

    2023  Volume 12, Issue 6

    Abstract: Ubiquitin-specific peptidase 16 (USP16) is a deubiquitinase that plays a role in the regulation of gene expression, cell cycle progression, and various other functions. It was originally identified as the major deubiquitinase for histone H2A and has ... ...

    Abstract Ubiquitin-specific peptidase 16 (USP16) is a deubiquitinase that plays a role in the regulation of gene expression, cell cycle progression, and various other functions. It was originally identified as the major deubiquitinase for histone H2A and has since been found to deubiquitinate a range of other substrates, including proteins from both the cytoplasm and nucleus. USP16 is phosphorylated when cells enter mitosis and dephosphorylated during the metaphase/anaphase transition. While much of USP16 is localized in the cytoplasm, separating the enzyme from its substrates is considered an important regulatory mechanism. Some of the functions that USP16 has been linked to include DNA damage repair, immune disease, tumorigenesis, protein synthesis, coronary artery health, and male infertility. The strong connection to immune response and the fact that multiple oncogene products are substrates of USP16 suggests that USP16 may be a potential therapeutic target for the treatment of certain human diseases.
    MeSH term(s) Humans ; Male ; Histones/metabolism ; Mitosis ; DNA Repair ; Ubiquitin-Specific Proteases/metabolism ; Deubiquitinating Enzymes/metabolism
    Chemical Substances Histones ; Ubiquitin-Specific Proteases (EC 3.4.19.12) ; Deubiquitinating Enzymes (EC 3.4.19.12)
    Language English
    Publishing date 2023-03-13
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12060886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Catalytic Defluoroalkylation of Trifluoromethylaromatics with Unactivated Alkenes.

    Wang, Hengbin / Jui, Nathan T

    Journal of the American Chemical Society

    2018  Volume 140, Issue 1, Page(s) 163–166

    Abstract: We describe a new catalytic approach to selective functionalization of the strong C-F bonds in trifluoromethylaromatic (Ar- ... ...

    Abstract We describe a new catalytic approach to selective functionalization of the strong C-F bonds in trifluoromethylaromatic (Ar-CF
    Language English
    Publishing date 2018--10
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.7b12590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  9. Article: Catalytic Defluoroalkylation of Trifluoromethylaromatics with Unactivated Alkenes

    Wang, Hengbin / Nathan T. Jui

    Journal of the American Chemical Society. 2018 Jan. 10, v. 140, no. 1

    2018  

    Abstract: We describe a new catalytic approach to selective functionalization of the strong C–F bonds in trifluoromethylaromatic (Ar–CF3) systems. In this approach, single electron reduction of Ar–CF3 substrates (using a photoredox catalyst) results in ... ...

    Abstract We describe a new catalytic approach to selective functionalization of the strong C–F bonds in trifluoromethylaromatic (Ar–CF3) systems. In this approach, single electron reduction of Ar–CF3 substrates (using a photoredox catalyst) results in difluorobenzylic radical formation through a C–F cleavage mechanism. These radicals undergo efficient intermolecular coupling with simple alkenes in a defluoroalkylation process where radical termination is accomplished by a polarity reversal catalyst. This mild catalytic protocol engages a wide range of substrates to give medicinally relevant fluorinated substructures with complete regiocontrol.
    Keywords alkenes ; catalysts ; chemical bonding ; free radicals ; redox reactions
    Language English
    Dates of publication 2018-0110
    Size p. 163-166.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.7b12590
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  10. Article: Cropformer: A new generalized deep learning classification approach for multi-scenario crop classification.

    Wang, Hengbin / Chang, Wanqiu / Yao, Yu / Yao, Zhiying / Zhao, Yuanyuan / Li, Shaoming / Liu, Zhe / Zhang, Xiaodong

    Frontiers in plant science

    2023  Volume 14, Page(s) 1130659

    Abstract: Accurate and efficient crop classification using remotely sensed data can provide fundamental and important information for crop yield estimation. Existing crop classification approaches are usually designed to be strong in some specific scenarios but ... ...

    Abstract Accurate and efficient crop classification using remotely sensed data can provide fundamental and important information for crop yield estimation. Existing crop classification approaches are usually designed to be strong in some specific scenarios but not for multi-scenario crop classification. In this study, we proposed a new deep learning approach for multi-scenario crop classification, named Cropformer. Cropformer can extract global features and local features, to solve the problem that current crop classification methods extract a single feature. Specifically, Cropformer is a two-step classification approach, where the first step is self-supervised pre-training to accumulate knowledge of crop growth, and the second step is a fine-tuned supervised classification based on the weights from the first step. The unlabeled time series and the labeled time series are used as input for the first and second steps respectively. Multi-scenario crop classification experiments including full-season crop classification, in-season crop classification, few-sample crop classification, and transfer of classification models were conducted in five study areas with complex crop types and compared with several existing competitive approaches. Experimental results showed that Cropformer can not only obtain a very significant accuracy advantage in crop classification, but also can obtain higher accuracy with fewer samples. Compared to other approaches, the classification performance of Cropformer during model transfer and the efficiency of the classification were outstanding. The results showed that Cropformer could build up
    Language English
    Publishing date 2023-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1130659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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