LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 236

Search options

  1. Article ; Online: Novel NF-κB Inhibitor-Conjugated Pt(IV) Prodrug to Enable Cancer Therapy through ROS/ER Stress and Mitochondrial Dysfunction and Overcome Multidrug Resistance.

    Wang, Meng / Li, Guimei / Jiang, Guiyang / Cai, Jinyuan / Liu, Zhikun / Huang, Rizhen / Huang, Xiaochao / Wang, Hengshan

    Journal of medicinal chemistry

    2024  Volume 67, Issue 8, Page(s) 6218–6237

    Abstract: Although cisplatin has been widely used for clinical purposes, its application is limited due to its obvious side effects. To mitigate the defects of cisplatin, here, six "multitarget prodrugs" were synthesized by linking cisplatin and NF-κB inhibitors. ... ...

    Abstract Although cisplatin has been widely used for clinical purposes, its application is limited due to its obvious side effects. To mitigate the defects of cisplatin, here, six "multitarget prodrugs" were synthesized by linking cisplatin and NF-κB inhibitors. Notably, complex
    MeSH term(s) Humans ; Prodrugs/pharmacology ; Prodrugs/chemistry ; Prodrugs/chemical synthesis ; Prodrugs/therapeutic use ; Reactive Oxygen Species/metabolism ; NF-kappa B/metabolism ; NF-kappa B/antagonists & inhibitors ; Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/therapeutic use ; Mitochondria/drug effects ; Mitochondria/metabolism ; Endoplasmic Reticulum Stress/drug effects ; Drug Resistance, Neoplasm/drug effects ; Mice ; Cisplatin/pharmacology ; Mice, Nude ; Apoptosis/drug effects ; Mice, Inbred BALB C ; Cell Line, Tumor ; Organoplatinum Compounds/pharmacology ; Organoplatinum Compounds/chemistry ; Organoplatinum Compounds/chemical synthesis ; Organoplatinum Compounds/therapeutic use ; Xenograft Model Antitumor Assays
    Chemical Substances Prodrugs ; Reactive Oxygen Species ; NF-kappa B ; Antineoplastic Agents ; Cisplatin (Q20Q21Q62J) ; Organoplatinum Compounds
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c02182
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MB 1: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Foegraecumoside O and P, a Pair of Triterpenoid Saponins with a 4/5/6 Fused Tricyclic Oleanane Carbon Skeleton from

    Dai, Lumei / He, Shuang / Zhang, Bin / Wang, Hengshan / Wang, Yan / Liang, Dong

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 13

    Abstract: Lysimachia foenum- ... ...

    Abstract Lysimachia foenum-graecum
    MeSH term(s) Molecular Structure ; Lysimachia ; Saponins/pharmacology ; Saponins/chemistry ; Oleanolic Acid/pharmacology ; Oleanolic Acid/chemistry ; Triterpenes/chemistry
    Chemical Substances oleanane ; Saponins ; Oleanolic Acid (6SMK8R7TGJ) ; Triterpenes
    Language English
    Publishing date 2023-06-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28135061
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Glycosides with galloyl groups from

    Zhao, Hai-Yan / He, Shuang / Lan, Qian / Su, Bao-Jun / Wang, Heng-Shan / Liang, Dong

    Natural product research

    2023  Volume 38, Issue 6, Page(s) 947–955

    Abstract: Seven new glycosides ( ...

    Abstract Seven new glycosides (
    MeSH term(s) Glycosides/pharmacology ; Glycosides/chemistry ; Magnetic Resonance Spectroscopy ; Microglia ; Nitric Oxide ; Molecular Structure ; Sapium
    Chemical Substances Glycosides ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2023-05-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2023.2208356
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Chiral separation of sesquineolignans from the stems and leaves of Neoshirakia japonica.

    Zhao, Hai-Yan / He, Shuang / Lan, Qian / Su, Bao-Jun / Wang, Heng-Shan / Liang, Dong

    Phytochemistry

    2023  Volume 211, Page(s) 113683

    Abstract: Twelve pairs of sesquineolignan enantiomers (1a/1b-6a/6b and 1c/1d-6c/6d), including twenty one undescribed and three known (2b, 3b, and 4b) sesquineolignans were isolated from an ethanol extract of the stems and leaves of Neoshirakia japonica ( ... ...

    Abstract Twelve pairs of sesquineolignan enantiomers (1a/1b-6a/6b and 1c/1d-6c/6d), including twenty one undescribed and three known (2b, 3b, and 4b) sesquineolignans were isolated from an ethanol extract of the stems and leaves of Neoshirakia japonica (Euphorbiaceae). The successful separation of twelve pairs of enantiomers with mirror image-like electronic circular dichroism (ECD) curves and opposite specific rotation values, as one of the most important steps in compound isolation, was carried out by chiral HPLC columns. The absolute configurations of all undescribed sesquineolignans were elucidated by comprehensive analysis of their experimental ECD spectra. The effects of all the isolates on antineuroinflammatory and radical scavenging activity were evaluated. Compared with the positive control minocycline (IC
    MeSH term(s) Plant Leaves ; Euphorbiaceae ; Microglia ; Molecular Structure
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2023.113683
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 1586: Show issues
    Z 8.5: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Chiral separation of sesquineolignans from the stems and leaves of Neoshirakia japonica

    Zhao, Hai-Yan / He, Shuang / Lan, Qian / Su, Bao-Jun / Wang, Heng-Shan / Liang, Dong

    Phytochemistry. 2023 July, v. 211 p.113683-

    2023  

    Abstract: Twelve pairs of sesquineolignan enantiomers (1a/1b−6a/6b and 1c/1d−6c/6d), including twenty one undescribed and three known (2b, 3b, and 4b) sesquineolignans were isolated from an ethanol extract of the stems and leaves of Neoshirakia japonica ( ... ...

    Abstract Twelve pairs of sesquineolignan enantiomers (1a/1b−6a/6b and 1c/1d−6c/6d), including twenty one undescribed and three known (2b, 3b, and 4b) sesquineolignans were isolated from an ethanol extract of the stems and leaves of Neoshirakia japonica (Euphorbiaceae). The successful separation of twelve pairs of enantiomers with mirror image-like electronic circular dichroism (ECD) curves and opposite specific rotation values, as one of the most important steps in compound isolation, was carried out by chiral HPLC columns. The absolute configurations of all undescribed sesquineolignans were elucidated by comprehensive analysis of their experimental ECD spectra. The effects of all the isolates on antineuroinflammatory and radical scavenging activity were evaluated. Compared with the positive control minocycline (IC₅₀ = 1.2 μM), compounds 1a/1b/1c/1d−6a/6b/6c/6d with IC₅₀ values being greater than 50 μM displayed almost no effect on the inhibition of NO production in LPS-induced BV-2 microglial cells. The results of DPPH-radical scavenging activity for them showed that compound 3c had moderate radical scavenging ability (EC₅₀ = 48.47 μM), while the EC₅₀ value of positive control vitamin C was 18.21 μM.
    Keywords Euphorbiaceae ; ascorbic acid ; circular dichroism spectroscopy ; enantiomers ; ethanol ; minocycline ; plant biochemistry ; Neoshirakia japonica ; Sesquineolignans ; Chiral HPLC separation ; Antineuroinflammatory activity ; Radical scavenging activity
    Language English
    Dates of publication 2023-07
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2023.113683
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 1586: Show issues
    Z 8.5: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article: Organocatalytic Three-Component Acyldifluoromethylation of Vinylarenes via N-Heterocyclic Carbene-Catalyzed Radical Relay

    She, Kun / Liang, Feng / Tian, Shichao / Wang, Hengshan / Tsui, Gavin Chit / Wang, Quande

    Organic letters. 2022 June 27, v. 24, no. 26

    2022  

    Abstract: We herein describe an N-hetercyclic carbene-catalyzed three-component acyldifluoromethylation of vinylarenes, aldehydes, and NaSO₂CF₂H. This organocatalytic approach provides a practical route for the synthesis of pharmaceutically relevant α-aryl-β- ... ...

    Abstract We herein describe an N-hetercyclic carbene-catalyzed three-component acyldifluoromethylation of vinylarenes, aldehydes, and NaSO₂CF₂H. This organocatalytic approach provides a practical route for the synthesis of pharmaceutically relevant α-aryl-β-difluormethyl ketones without the need for transition metals or photocatalysts. The late-stage acyldifluoromethylation of drug analogues was also demonstrated. The reaction design employs NaSO₂CF₂H as the source of the CF₂H radical in the presence of an oxidant for the radical relay.
    Keywords catalytic activity ; drugs ; heterocyclic nitrogen compounds ; oxidants ; photocatalysts
    Language English
    Dates of publication 2022-0627
    Size p. 4840-4844.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.2c02093
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Organocatalytic Three-Component Acyldifluoromethylation of Vinylarenes via

    She, Kun / Liang, Feng / Tian, Shichao / Wang, Hengshan / Tsui, Gavin Chit / Wang, Quande

    Organic letters

    2022  Volume 24, Issue 26, Page(s) 4840–4844

    Abstract: We herein describe ... ...

    Abstract We herein describe an
    MeSH term(s) Aldehydes ; Catalysis ; Ketones ; Methane/analogs & derivatives ; Molecular Structure
    Chemical Substances Aldehydes ; Ketones ; carbene (2465-56-7) ; Methane (OP0UW79H66)
    Language English
    Publishing date 2022-06-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c02093
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Novel combretastatin A-4 derivative containing aminophosphonates as dual inhibitors of tubulin and matrix metalloproteinases for lung cancer treatment.

    Huang, Xiaochao / Chen, Yuanhang / Zhong, Wentian / Liu, Zhikun / Zhang, Haijiang / Zhang, Bin / Wang, Hengshan

    European journal of medicinal chemistry

    2022  Volume 244, Page(s) 114817

    Abstract: Here, sixteen novel conjugates containing tubulin inhibitor and matrix metalloproteinase inhibitor was synthesized together with their activity evaluated. Among them, 9e exhibited the most potent activity against various human cancer cells ( ... ...

    Abstract Here, sixteen novel conjugates containing tubulin inhibitor and matrix metalloproteinase inhibitor was synthesized together with their activity evaluated. Among them, 9e exhibited the most potent activity against various human cancer cells (IC
    MeSH term(s) Humans ; Tubulin/metabolism ; Tubulin Modulators/pharmacology ; Tubulin Modulators/therapeutic use ; Cell Line, Tumor ; Cell Proliferation ; Lung Neoplasms/drug therapy ; Apoptosis ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Matrix Metalloproteinases ; Drug Screening Assays, Antitumor
    Chemical Substances Tubulin ; fosbretabulin (I5590ES2QZ) ; Tubulin Modulators ; combretastatin (7O62J06F18) ; Antineoplastic Agents ; Matrix Metalloproteinases (EC 3.4.24.-)
    Language English
    Publishing date 2022-10-04
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2022.114817
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 784: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Novel Indole-Chalcone Derivative-Ligated Platinum(IV) Prodrugs Attenuate Cisplatin Resistance in Lung Cancer through ROS/ER Stress and Mitochondrial Dysfunction.

    Liu, Zhikun / Wang, Meng / Huang, Rizhen / Hu, Tianhui / Jing, Yi / Huang, Xiaochao / Hu, Weiwei / Cao, Guoxiu / Wang, Hengshan

    Journal of medicinal chemistry

    2023  Volume 66, Issue 7, Page(s) 4868–4887

    Abstract: Developing multifunctional platinum(IV) prodrugs via integrating bioactive pharmacophores into one entity is an attractive strategy to ameliorate the defects of platinum(II) drugs. Herein, a series of indole-chalcone derivative-ligated platinum(IV) ... ...

    Abstract Developing multifunctional platinum(IV) prodrugs via integrating bioactive pharmacophores into one entity is an attractive strategy to ameliorate the defects of platinum(II) drugs. Herein, a series of indole-chalcone derivative-ligated platinum(IV) complexes were synthesized and evaluated for their anticancer activities. Among them, optimal complex
    MeSH term(s) Humans ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Platinum/pharmacology ; Platinum/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/metabolism ; Prodrugs/pharmacology ; Prodrugs/therapeutic use ; Prodrugs/metabolism ; Reactive Oxygen Species/metabolism ; Chalcones/pharmacology ; Chalcones/therapeutic use ; Cell Line, Tumor ; Lung Neoplasms/metabolism ; Apoptosis ; Mitochondria
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Platinum (49DFR088MY) ; Antineoplastic Agents ; Prodrugs ; Reactive Oxygen Species ; Chalcones
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.2c02036
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MB 1: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Field-Induced Transport Anisotropy in Single-Crystalline All-Inorganic Lead-Halide Perovskite Nanowires.

    Wang, Hengshan / Yin, Yanfeng / Xu, Jiao / Li, Jing / Bao, Yanan / An, Meiqi / Tang, Lingzhi / Jin, Shengye / Tian, Wenming / Yang, Yiming

    ACS nano

    2023  Volume 17, Issue 23, Page(s) 23671–23678

    Abstract: The dynamic crystal lattice of halide perovskites facilitates the coupled transport of ions and electrons, offering innovative concepts in semiconductor iontronic devices that surpass solar cell applications. However, a comprehensive understanding of the ...

    Abstract The dynamic crystal lattice of halide perovskites facilitates the coupled transport of ions and electrons, offering innovative concepts in semiconductor iontronic devices that surpass solar cell applications. However, a comprehensive understanding of the intricacies of coupled ionic and electronic transport at the microscale remains ambiguous, owing to the inhomogeneity in ploy-crystalline perovskite thin films. In this work, we employed one-dimensional (1D) single-crystalline CsPbBr
    Language English
    Publishing date 2023-11-17
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c06944
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top