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  1. Book: Autophagy and cancer

    Wang, Hong-Gang

    (Current cancer research)

    2013  

    Author's details Hong-Gang Wang ed
    Series title Current cancer research
    Language English
    Size XI, 261 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017615235
    ISBN 978-1-4614-6560-7 ; 1-4614-6560-5 ; 9781461465614 ; 1461465613
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 601 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Leukocyte immunoglobulin-like receptor B2: A promising biomarker for colorectal cancer.

    Zhao, Wen-Zhuo / Wang, Hong-Gang / Yang, Xiao-Zhong

    World journal of gastroenterology

    2024  Volume 30, Issue 4, Page(s) 421–423

    Abstract: According to the latest global cancer statistics, colorectal cancer (CRC) has emerged as the third most prevalent malignant tumor across the globe. In recent decades, the medical field has implemented several levels of CRC screening tests, encompassing ... ...

    Abstract According to the latest global cancer statistics, colorectal cancer (CRC) has emerged as the third most prevalent malignant tumor across the globe. In recent decades, the medical field has implemented several levels of CRC screening tests, encompassing fecal tests, endoscopic examinations, radiological examinations and blood tests. Previous studies have shown that leukocyte immunoglobulin-like receptor B2 (LILRB2) is involved in inhibiting immune cell function, immune evasion, and promoting tumor progression in acute myeloid leukemia and non-small cell lung cancer. However, its interaction with CRC has not been reported yet. Recently, a study published in the
    MeSH term(s) Humans ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/metabolism ; Membrane Glycoproteins/genetics ; Signal Transduction ; Biomarkers, Tumor/metabolism ; Receptors, Immunologic/genetics
    Chemical Substances Membrane Glycoproteins ; Biomarkers, Tumor ; LILRB2 protein, human ; Receptors, Immunologic
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v30.i4.421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6039: Show issues Location:
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  3. Article ; Online: Role of Helicobacter pylori virulence factors and alteration of the Tumor Immune Microenvironment: challenges and opportunities for Cancer Immunotherapy.

    Zhou, Junyi / Zhang, Minna / Wang, HongGang / Zhong, Xiaomin / Yang, XiaoZhong

    Archives of microbiology

    2024  Volume 206, Issue 4, Page(s) 167

    Abstract: Various forms of malignancies have been linked to Helicobacter pylori. Despite advancements in chemotherapeutic and surgical approaches, the management of cancer, particularly at advanced stages, increasingly relies on the integration of immunotherapy. ... ...

    Abstract Various forms of malignancies have been linked to Helicobacter pylori. Despite advancements in chemotherapeutic and surgical approaches, the management of cancer, particularly at advanced stages, increasingly relies on the integration of immunotherapy. As a novel, safe therapeutic modality, immunotherapy harnesses the immune system of the patient to treat cancer, thereby broadening treatment options. However, there is evidence that H. pylori infection may influence the effectiveness of immunotherapy in various types of cancer. This association is related to H. pylori virulence factors and the tumor microenvironment. This review discusses the influence of H. pylori infection on immunotherapy in non-gastrointestinal and gastrointestinal tumors, the mechanisms underlying this relationship, and directions for the development of improved immunotherapy strategies.
    MeSH term(s) Humans ; Virulence Factors/genetics ; Helicobacter pylori/genetics ; Neoplasms/therapy ; Immunotherapy ; Helicobacter Infections/therapy ; Tumor Microenvironment
    Chemical Substances Virulence Factors
    Language English
    Publishing date 2024-03-15
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124824-8
    ISSN 1432-072X ; 0302-8933
    ISSN (online) 1432-072X
    ISSN 0302-8933
    DOI 10.1007/s00203-024-03908-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Therapeutic targeting of FLT3 and associated drug resistance in acute myeloid leukemia.

    Gebru, Melat T / Wang, Hong-Gang

    Journal of hematology & oncology

    2020  Volume 13, Issue 1, Page(s) 155

    Abstract: Acute myeloid leukemia (AML) is a heterogeneous disease caused by several gene mutations and cytogenetic abnormalities affecting differentiation and proliferation of myeloid lineage cells. FLT3 is a receptor tyrosine kinase commonly overexpressed or ... ...

    Abstract Acute myeloid leukemia (AML) is a heterogeneous disease caused by several gene mutations and cytogenetic abnormalities affecting differentiation and proliferation of myeloid lineage cells. FLT3 is a receptor tyrosine kinase commonly overexpressed or mutated, and its mutations are associated with poor prognosis in AML. Although aggressive chemotherapy often followed by hematopoietic stem cell transplant is the current standard of care, the recent approval of FLT3-targeted drugs is revolutionizing AML treatment that had remained unchanged since the 1970s. However, despite the dramatic clinical response to targeted agents, such as FLT3 inhibitors, remission is almost invariably short-lived and ensued by relapse and drug resistance. Hence, there is an urgent need to understand the molecular mechanisms driving drug resistance in order to prevent relapse. In this review, we discuss FLT3 as a target and highlight current understanding of FLT3 inhibitor resistance.
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Drug Resistance, Neoplasm/drug effects ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; Molecular Targeted Therapy ; Mutation/drug effects ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Signal Transduction/drug effects ; fms-Like Tyrosine Kinase 3/antagonists & inhibitors ; fms-Like Tyrosine Kinase 3/chemistry ; fms-Like Tyrosine Kinase 3/genetics ; fms-Like Tyrosine Kinase 3/metabolism
    Chemical Substances Antineoplastic Agents ; Protein Kinase Inhibitors ; FLT3 protein, human (EC 2.7.10.1) ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1)
    Language English
    Publishing date 2020-11-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2429631-4
    ISSN 1756-8722 ; 1756-8722
    ISSN (online) 1756-8722
    ISSN 1756-8722
    DOI 10.1186/s13045-020-00992-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Direct Observation of Compartment-Specific Localization and Dynamics of Voltage-Gated Sodium Channels.

    Liu, Hui / Wang, Hong-Gang / Pitt, Geoffrey / Liu, Zhe

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2022  Volume 42, Issue 28, Page(s) 5482–5498

    Abstract: Brain enriched voltage-gated sodium channel (VGSC) ... ...

    Abstract Brain enriched voltage-gated sodium channel (VGSC) Na
    Language English
    Publishing date 2022-07-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.0086-22.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1668: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Distinct noncoding RNAs and RNA binding proteins associated with high-risk pediatric and adult acute myeloid leukemias detected by regulatory network analysis.

    Liu, Zhenqiu / Spiegelman, Vladimir S / Wang, Hong-Gang

    Cancer reports (Hoboken, N.J.)

    2021  Volume 5, Issue 10, Page(s) e1592

    Abstract: Background: Acute myeloid leukemia (AML) is a heterogeneous disease in both children and adults. Although it is well-known that adult and pediatric AMLs are genetically distinct diseases, the driver genes for high-risk pediatric and adult AMLs are still ...

    Abstract Background: Acute myeloid leukemia (AML) is a heterogeneous disease in both children and adults. Although it is well-known that adult and pediatric AMLs are genetically distinct diseases, the driver genes for high-risk pediatric and adult AMLs are still not fully understood. Particularly, the interactions between RNA binding proteins (RBPs) and noncoding RNAs (ncRNAs) for high-risk AMLs have not been explored.
    Aim: To identify RBPs and noncoding RNAs (ncRNAs) that are the master regulators of high-risk AML.
    Methods: In this manuscript, we identify over 400 upregulated genes in high-risk adult and pediatric AMLs respectively with the expression profiles of TCGA and TARGET cohorts. There are less than 5% genes commonly upregulated in both cohorts, highlighting the genetic differences in adult and childhood AMLs. A novel distance correlation test is proposed for gene regulatory network construction. We build RBP-based regulatory networks with upregulated genes in high-risk adult and pediatric AMLs, separately.
    Results: We discover that three RBPs, three snoRNAs, and two circRNAs function together and regulate over 100 upregulated RNA targets in adult AML, whereas two RBPs are associated with 17 long noncoding RNAs (lncRNAs), and all together regulate over 90 upregulated RNA targets in pediatric AML. Of which, two RBPs, MLLT3 and RBPMS, and their circRNA targets, PTK2 and NRIP1, are associated with the overall survival (OS) in adult AML (p ≤ 0.01), whereas two different RBPs, MSI2 and DNMT3B, and 13 (out of 17) associated lncRNAs are prognostically significant in pediatric AML.
    Conclusions: Both RBPs and ncRNAs are known to be the major regulators of transcriptional processes. The RBP-ncRNA pairs identified from the regulatory networks will allow better understanding of molecular mechanisms underlying high-risk adult and pediatric AMLs, and assist in the development of novel RBPs and ncRNAs based therapeutic strategies.
    MeSH term(s) Adult ; Child ; Gene Regulatory Networks ; Humans ; Leukemia, Myeloid, Acute/genetics ; RNA, Circular ; RNA, Long Noncoding/genetics ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
    Chemical Substances MSI2 protein, human ; RNA, Circular ; RNA, Long Noncoding ; RNA-Binding Proteins
    Language English
    Publishing date 2021-12-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2573-8348
    ISSN (online) 2573-8348
    DOI 10.1002/cnr2.1592
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  7. Article ; Online: What's in an E3: role of highly curved membranes in facilitating LC3-phosphatidylethanolamine conjugation during autophagy.

    Ye, Yansheng / Bewley, Maria C / Wang, Hong-Gang / Tian, Fang / Flanagan, John M

    Autophagy

    2023  Volume 20, Issue 3, Page(s) 709–711

    Abstract: During autophagosome formation, ATG3, an E2-like enzyme, catalyzes the transfer of LC3-family proteins (including Atg8 in yeast and LC3- and GABARAP-subfamily members in more complex eukaryotes) from the covalent conjugated ATG3-LC3 intermediate to PE ... ...

    Abstract During autophagosome formation, ATG3, an E2-like enzyme, catalyzes the transfer of LC3-family proteins (including Atg8 in yeast and LC3- and GABARAP-subfamily members in more complex eukaryotes) from the covalent conjugated ATG3-LC3 intermediate to PE lipids in targeted membranes. A recent study has shown that the catalytically important regions of human ATG3 (hereafter referred to as ATG3), including residues 262 to 277 and 291 to 300, in cooperation with its N-terminal curvature-sensing amphipathic helix (NAH), directly interact with the membrane. These membrane interactions are functionally necessary for in vitro conjugation and in vivo cellular assays. They provide a molecular mechanism for how the membrane curvature-sensitive interaction of the NAH of ATG3 is closely coupled to its conjugase activity. Together, the data are consistent with a model in which the highly curved phagophore rims facilitate the recruitment of the ATG3-LC3 complex and promote the conjugation of LC3 to PE lipids. Mechanistically, the highly curved membranes of the phagophore rims act in much the same manner as classical E3 enzymes in the sumo/ubiquitin system, bringing substrates into proximity and rearranging the catalytic center of ATG3. Future studies will investigate how this multifaceted membrane interaction of ATG3 works with the putative E3 complex, ATG12-ATG5-ATG16L1, to promote LC3-PE conjugation.
    MeSH term(s) Humans ; Autophagy-Related Proteins ; Autophagy ; Phosphatidylethanolamines ; Proteins ; Autophagosomes ; Microtubule-Associated Proteins ; Ubiquitin-Conjugating Enzymes
    Chemical Substances Autophagy-Related Proteins ; Phosphatidylethanolamines ; Proteins ; Microtubule-Associated Proteins ; Ubiquitin-Conjugating Enzymes (EC 2.3.2.23)
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2023.2288527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6741: Show issues Location:
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  8. Article ; Online: Sphingolipids as Regulators of Autophagy and Endocytic Trafficking.

    Young, Megan M / Wang, Hong-Gang

    Advances in cancer research

    2018  Volume 140, Page(s) 27–60

    Abstract: Macroautophagy (herein referred to as autophagy) is a highly conserved stress response that engulfs damaged proteins, lipids, and/or organelles within double-membrane vesicles called autophagosomes for lysosomal degradation. Dysregulated autophagy is a ... ...

    Abstract Macroautophagy (herein referred to as autophagy) is a highly conserved stress response that engulfs damaged proteins, lipids, and/or organelles within double-membrane vesicles called autophagosomes for lysosomal degradation. Dysregulated autophagy is a hallmark of cancer; and thus, there is great interest in modulating autophagy for cancer therapy. Sphingolipids regulate each step of autophagosome biogenesis with roles for sphingolipid metabolites and enzymes spanning from the initial step of de novo ceramide synthesis to the sphingosine-1-phosphate lyase 1-mediated exit from the sphingolipid pathway. Notably, sphingolipid metabolism occurs at several of the organelles that contribute to autophagosome biogenesis to suggest that local changes in sphingolipids may regulate autophagy. As sphingolipid metabolism is frequently dysregulated in cancer, a molecular understanding of sphingolipids in stress-induced autophagy may provide insight into the mechanisms driving tumor development and progression. On the contrary, modulation of sphingolipid metabolites and/or enzymes can induce autophagy-dependent cell death for cancer therapy. This chapter will overview the major steps in mammalian autophagy, discuss the regulation of each step by sphingolipid metabolites, and describe the functions of sphingolipid-mediated autophagy in cancer. While our understanding of the signaling and biophysical properties of sphingolipids in autophagy remains in its infancy, the unique cross talk between the two pathways is an exciting area for further development, particularly in the context of cancer therapy.
    MeSH term(s) Animals ; Autophagy ; Endocytosis/drug effects ; Humans ; Neoplasms/drug therapy ; Neoplasms/pathology ; Protein Transport ; Signal Transduction/drug effects ; Sphingolipids/pharmacology
    Chemical Substances Sphingolipids
    Language English
    Publishing date 2018-05-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 127-2
    ISSN 2162-5557 ; 0065-230X
    ISSN (online) 2162-5557
    ISSN 0065-230X
    DOI 10.1016/bs.acr.2018.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Data-Driven Math Model of FLT3-ITD Acute Myeloid Leukemia Reveals Potential Therapeutic Targets.

    Wooten, David J / Gebru, Melat / Wang, Hong-Gang / Albert, Réka

    Journal of personalized medicine

    2021  Volume 11, Issue 3

    Abstract: ... ...

    Abstract FLT3
    Language English
    Publishing date 2021-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm11030193
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  10. Article ; Online: Itaconate aggravates experimental colitis.

    Wang, Hong-Gang / Zhang, Min-Na / Wen, Xin / Yang, Xiao-Zhong

    Clinics and research in hepatology and gastroenterology

    2021  Volume 45, Issue 2, Page(s) 101629

    MeSH term(s) Colitis/chemically induced ; Humans ; Succinates
    Chemical Substances Succinates ; itaconic acid (Q4516562YH)
    Language English
    Publishing date 2021-02-08
    Publishing country France
    Document type Letter
    ZDB-ID 2594333-9
    ISSN 2210-741X ; 2210-7401
    ISSN (online) 2210-741X
    ISSN 2210-7401
    DOI 10.1016/j.clinre.2021.101629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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