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Article ; Online: Role of TRP Channels in Metabolism-Related Diseases.

Wu, Fengming / Bu, Siyuan / Wang, Hongmei

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: Metabolic syndrome (MetS), with its high prevalence and significant impact on cardiovascular disease, poses a substantial threat to human health. The early identification of pathological abnormalities related to MetS and prevention of the risk of ... ...

Abstract	Metabolic syndrome (MetS), with its high prevalence and significant impact on cardiovascular disease, poses a substantial threat to human health. The early identification of pathological abnormalities related to MetS and prevention of the risk of associated diseases is of paramount importance. Transient Receptor Potential (TRP) channels, a type of nonselective cation channel, are expressed in a variety of tissues and have been implicated in the onset and progression of numerous metabolism-related diseases. This study aims to review and discuss the expression and function of TRP channels in metabolism-related tissues and blood vessels, and to elucidate the interactions and mechanisms between TRP channels and metabolism-related diseases. A comprehensive literature search was conducted using keywords such as TRP channels, metabolic syndrome, pancreas, liver, oxidative stress, diabetes, hypertension, and atherosclerosis across various academic databases including PubMed, Google Scholar, Elsevier, Web of Science, and CNKI. Our review of the current research suggests that TRP channels may be involved in the development of metabolism-related diseases by regulating insulin secretion and release, lipid metabolism, vascular functional activity, oxidative stress, and inflammatory response. TRP channels, as nonselective cation channels, play pivotal roles in sensing various intra- and extracellular stimuli and regulating ion homeostasis by osmosis. They present potential new targets for the diagnosis or treatment of metabolism-related diseases.
MeSH term(s)	Humans ; Metabolic Syndrome ; Transient Receptor Potential Channels/genetics ; Metabolic Diseases ; Atherosclerosis ; Cations
Chemical Substances	Transient Receptor Potential Channels ; Cations
Language	English
Publishing date	2024-01-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25020692
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of stroke on the intestinal biota in diabetic mice and type 2 diabetic patient biota.

Qiao, Sen / Bu, Siyuan / Wang, Hongmei

Journal of applied microbiology

2024

Abstract: Aims: The intestinal biota, known for its colonization of the human intestine and its modulation of host pathophysiological responses through the immune and endocrine systems, has gained substantial interest in recent years due to its notable ... ...

Abstract	Aims: The intestinal biota, known for its colonization of the human intestine and its modulation of host pathophysiological responses through the immune and endocrine systems, has gained substantial interest in recent years due to its notable correlation with diabetes and stroke. Methods: In order to examine this association, a comparative study was conducted on the intestinal biota and blood samples obtained from mouse models and type 2 diabetic patients with and without stroke complications. Advanced techniques, such as high-throughput sequencing and enzyme-linked immunosorbent assay were employed to identify the differences in the intestinal biota and blood indices of mouse models and patients. Results: At the phylum level, the dominant gut bacteria identified in patients with diabetes mellitus and stroke were Firmicutes, Bacteroidetes, and Proteobacteria. It was noteworthy that the relative abundance of Bacteroides at the genus level was significantly diminished in the DB-PT group (photothrombotic diabetes mice) as compared to the DB group (diabetesmice). This result was consistent with observations in human samples. Additionally, significant variations were detected in lipid proteins, specifically APOA4, in diabetic patients with and without stroke. Conclusions: Stroke can diminish the abundance and diversity of intestinal biota, potentially correlating with lipid proteins in patients with diabetes.
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1358023-1
ISSN	1365-2672 ; 1364-5072
ISSN (online)	1365-2672
ISSN	1364-5072
DOI	10.1093/jambio/lxae015
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Zs.A 259: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Tegument protein UL3 of bovine herpesvirus 1 suppresses antiviral IFN-I signaling by targeting STING for autophagic degradation.

Sun, Fachao / Ma, Wenqing / Wang, Hongmei / He, Hongbin

Veterinary microbiology

2024 Volume 291, Page(s) 110031

Abstract: Bovine herpesvirus 1 (BoHV-1) is a highly contagious pathogen which causes infectious bovine rhinotracheitis in cattle worldwide. Although it has the ability to evade the host's antiviral innate immune response and establish persistent latent infections, ...

Abstract	Bovine herpesvirus 1 (BoHV-1) is a highly contagious pathogen which causes infectious bovine rhinotracheitis in cattle worldwide. Although it has the ability to evade the host's antiviral innate immune response and establish persistent latent infections, the mechanisms are not fully understood, especially the function of the tegument protein to escape innate immunity and participate in viral replication. In this study, we showed that overexpression of tegument protein UL3 facilitates BoHV-1 replication and suppresses the expression of type-I interferon (IFN-I) and IFN-stimulated genes. Then, STING was identified as the target by which UL3 inhibits the IFN-I signaling pathway, and STING was degraded through the UL3-induced autophagy pathway. Furthermore, overexpression of UL3 promotes the expression of the autophagy-related protein ATG101, thereby inducing autophagy. Further study showed that UL3 enhances the interaction between ATG101 and STING, and then the degradation of STING was reversed following ATG101 silencing in UL3-overexpressing cells during BoHV-1 infection. Our research results demonstrate a novel function of UL3 in regulating host's antiviral response and provide a potential mechanism for BoHV-1 immune evasion.
MeSH term(s)	Animals ; Cattle ; Antiviral Agents ; Autophagy ; Herpesvirus 1, Bovine/genetics ; Herpesvirus 1, Bovine/metabolism ; Immunity, Innate/genetics ; Virus Replication/genetics ; Interferon Type I/metabolism ; Membrane Proteins/metabolism ; Herpesviridae Infections/metabolism ; Herpesviridae Infections/veterinary ; Viral Proteins/metabolism
Chemical Substances	Antiviral Agents ; Interferon Type I ; Membrane Proteins ; Viral Proteins
Language	English
Publishing date	2024-02-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2024.110031
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Zs.A 2917: Show issues

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Article ; Online: Ferroptosis in antitumor therapy: Unraveling regulatory mechanisms and immunogenic potential.

Zhang, Ting / Zeng, Xiaoping / Zeng, Erming / Wang, Hongmei

International immunopharmacology

2024 Volume 134, Page(s) 112203

Abstract: Ferroptosis, a recently discovered form of non-apoptotic cell death, has the potential to revolutionize anti-tumor therapy. This review highlights the regulatory mechanisms and immunogenic properties of ferroptosis, and how it can enhance the ... ...

Abstract	Ferroptosis, a recently discovered form of non-apoptotic cell death, has the potential to revolutionize anti-tumor therapy. This review highlights the regulatory mechanisms and immunogenic properties of ferroptosis, and how it can enhance the effectiveness of radio and immunotherapies in overcoming tumor resistance. However, tumor metabolism and the impact of ferroptosis on the tumor microenvironment present challenges in completely realizing its therapeutic potential. A deeper understanding of the effects of ferroptosis on tumor cells and their associated immune cells is essential for developing more effective tumor treatment strategies. This review offers a comprehensive overview of the relationship between ferroptosis and tumor immunity, and sheds new light on its application in tumor immunotherapy.
Language	English
Publishing date	2024-05-04
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2024.112203
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Zs.A 5408: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Multi-focus image fusion algorithm based on focus detection in spatial and NSCT domain.

Wang, Hongmei

PloS one

2018 Volume 13, Issue 9, Page(s) e0204225

Abstract: Multi-focus image fusion is an effective approach to obtain the all-in-focus image. Focus detection is the key issue of multi-focus image fusion. Aiming at the shortcoming of spatial domain and transform domain algorithms for multi-focus image fusion, a ... ...

Abstract	Multi-focus image fusion is an effective approach to obtain the all-in-focus image. Focus detection is the key issue of multi-focus image fusion. Aiming at the shortcoming of spatial domain and transform domain algorithms for multi-focus image fusion, a novel multi-focus image fusion algorithm is proposed by combing focus detection in spatial domain and non-subsampled contourlet transform (NSCT) domain. At first, the focused pixels are detected by the sum-modified-Laplacian algorithm in spatial domain. At the same time, the focus detection method is proposed in NSCT domain, namely by MPCNN and voting fusion methods for high-frequency subbands of NSCT. Then, the morphological operation is utilized to correct the focus detection results in spatial domain and NSCT domain. At last, synthesis of detection results is implemented and the fused image can be obtained. Experimental results verified that the proposed algorithm outperformed some state-of-the-art fusion algorithms in terms of both subjective observation and objective evaluations.
MeSH term(s)	Algorithms ; Image Interpretation, Computer-Assisted/methods ; Image Processing, Computer-Assisted/methods ; Neural Networks (Computer)
Language	English
Publishing date	2018-09-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0204225
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Article: Combating antimicrobial resistance with cefiderocol for complicated infections involving the urinary tract.

Wang, Hongmei / Palasik, Brittany N

Therapeutic advances in urology

2022 Volume 14, Page(s) 17562872211065570

Abstract: Cefiderocol is a unique siderophore cephalosporin antimicrobial agent that has shown promise in treating complicated urinary tract infections (cUTI). Urinary tract infections are commonly diagnosed infections with risk increasing with age and prevalence ... ...

Abstract	Cefiderocol is a unique siderophore cephalosporin antimicrobial agent that has shown promise in treating complicated urinary tract infections (cUTI). Urinary tract infections are commonly diagnosed infections with risk increasing with age and prevalence more common in women. cUTI poses a risk of recurrence and is more likely to be associated with antibiotic-resistant bacteria. The Food and Drug Administration approved cefiderocol for use as a last-line option in the treatment of cUTI including pyelonephritis. Cefiderocol has activity against all forms of carbapenemases due to its ability to overcome the mechanisms of carbapenemase resistance. Because of this, resistance to cefiderocol is unlikely to occur. Studies show cefiderocol is well tolerated among younger patients and patients greater than 65 years of age, the latter making up most of the study population. Renal dose adjustments are recommended. Dose adjustment in the presence of hepatic impairment is not recommended, as hepatic clearance represents a minor elimination pathway for cefiderocol. The ability of cefiderocol to overcome multiple resistance mechanisms makes it a novel choice in combating multidrug-resistant bacteria in the treatment of cUTI.
Language	English
Publishing date	2022-01-31
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2492591-3
ISSN	1756-2880 ; 1756-2872
ISSN (online)	1756-2880
ISSN	1756-2872
DOI	10.1177/17562872211065570
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Article ; Online: Development Strategy of Intelligent Digital Library without Human Service in the Era of "Internet +".

Wang, Hongmei / Ding, Jian

publication RETRACTED

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 7892738

Abstract: Internet technology has a great impact on the application and development of libraries. In order to provide users with more convenient and efficient services, this paper puts forward the development strategy of unmanned intelligent digital libraries in ... ...

Abstract	Internet technology has a great impact on the application and development of libraries. In order to provide users with more convenient and efficient services, this paper puts forward the development strategy of unmanned intelligent digital libraries in the era of "Internet +." Design by IntelliSense module, network transmission module, data storage and analysis module, and intelligent service module of no wisdom digital library service mode, IntelliSense module using RFID technology, close range wireless communication technology, and other Internet technologies to collect the wisdom of unmanned services of all kinds of information in the digital library; use network transmission module of the wireless LAN network, Internet technology such as RFID network to transmit information collected to store in a data storage and analysis module; and at the same time using
MeSH term(s)	Humans ; Libraries, Digital ; Wireless Technology ; Information Storage and Retrieval ; Internet ; Intelligence
Language	English
Publishing date	2022-10-10
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/7892738
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Article ; Online: English Long and Short Sentence Translation and Recognition Method Based on Deep GLR Model.

Wang, Hongmei / Zhao, Changhan

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 3119477

Abstract: The translation recognition of English long and short sentence information is an important issue to obtain the focus and core of English articles. Based on the deep GLR model, this paper constructs a method framework for English long and short sentence ... ...

Abstract	The translation recognition of English long and short sentence information is an important issue to obtain the focus and core of English articles. Based on the deep GLR model, this paper constructs a method framework for English long and short sentence translation and recognition, using different embedding layer parameter initialization methods and using multi-layer computing methods in the sentence decoder. The initial corpus text is segmented and tagged with part-of-speech, then, the part-of-speech tag is appropriately corrected to reduce ambiguity, and then it is manually syntactically tagged. In the simulation process, the English long and short sentence summary and translation components are designed and developed, which can accurately and efficiently obtain the key information of English long and short sentences. The experimental results show that the English long and short sentence translation and recognition method of the deep GLR model improves the accuracy of the model parameters. In terms of model structure, the deep GLR value can be improved by 70.77% by reproducing the multi-layer representation fusion of semantic translation; in terms of data enhancement, the deep GLR value can be increased by 70.35% by means of "back translation," and the improved model is effective. It promotes the translation and recognition generalization ability of English long and short sentences.
MeSH term(s)	Language ; Recognition, Psychology ; Semantics ; Speech Perception ; Translations
Language	English
Publishing date	2022-06-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/3119477
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Article ; Online: Prognostic factors in extensive-stage small cell lung cancer patients with organ-specific metastasis: unveiling commonalities and disparities.

Wu, Yuanli / Zhang, Jing / Zhou, Weiying / Yuan, Zhongzhen / Wang, Hongmei

Journal of cancer research and clinical oncology

2024 Volume 150, Issue 2, Page(s) 74

Abstract: Background: This study aimed to identify shared and distinct prognostic factors related to organ-specific metastases (liver, lung, bone, and brain) in extensive-stage small cell lung cancer (ES-SCLC) patients, then construct nomograms for survival ... ...

Abstract	Background: This study aimed to identify shared and distinct prognostic factors related to organ-specific metastases (liver, lung, bone, and brain) in extensive-stage small cell lung cancer (ES-SCLC) patients, then construct nomograms for survival prediction. Methods: Patient data for ES-SCLC were from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2019. Kaplan-Meier analysis was applied to estimate overall survival (OS), and Cox regression was used to identify prognostic factors. A Venn diagram was utilized to distinguish common and unique prognostic factors among the variables assessed. These identified prognostic factors were used to formulate a nomogram, and its predictive accuracy and reliability were evaluated using C-indexes, calibration curves, and receiver operating characteristic (ROC) curves. Results: A total of 24,507 patients diagnosed with ES-SCLC exhibiting metastases to the liver, lung, bone, and brain were included. The 6-month, 1-year, and 2-year OS rates were 46.1%, 19.7%, and 5.0%, respectively. Patients with liver metastasis demonstrated the most unfavorable prognosis, with a 1-year OS rate of 14.5%, while those with brain metastasis had a significantly better prognosis with a 1-year OS rate of 21.6%. The study identified seven common factors associated with a poor prognosis in ES-SCLC patients with organ-specific metastases: older age, male sex, unmarried status, higher T stage, presence of other metastases, and combination radiotherapy and chemotherapy. Furthermore, specific prognostic factors were identified for patients with metastasis to the liver, bone, and brain, including paired tumors, lack of surgical treatment at the primary site, and household income, respectively. To facilitate prognostic predictions, four nomograms were developed and subsequently validated. The performance of these nomograms was assessed using calibration curves, C-indexes, and the area under the curve (AUC), all of which consistently indicated good predictive accuracy and reliability. Conclusions: Patients diagnosed with ES-SCLC with organ-specific metastases revealed shared and distinct prognostic factors. The nomograms developed from these factors demonstrated good performance and can serve valuable clinical tools to predict the prognosis of ES-SCLC patients with organ-specific metastases.
MeSH term(s)	Humans ; Male ; Small Cell Lung Carcinoma/therapy ; Prognosis ; Lung Neoplasms/therapy ; Reproducibility of Results ; Liver ; Nomograms ; SEER Program
Language	English
Publishing date	2024-02-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-024-05621-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Uh III Zs.10: Show issues

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bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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Article ; Online: Shaping the immune-suppressive microenvironment on tumor-associated myeloid cells through tumor-derived exosomes.

Wang, Hongmei / Liu, Shanshan / Zhan, Jianhao / Liang, Yuqing / Zeng, Xiaoping

International journal of cancer

2024 Volume 154, Issue 12, Page(s) 2031–2042

Abstract: Tumor-associated myeloid cells (TAMCs) play a crucial role in orchestrating the dynamics of the tumor immune microenvironment. This heterogeneous population encompasses myeloid-derived suppressor cells, tumor-associated macrophages and dendritic cells, ... ...

Abstract	Tumor-associated myeloid cells (TAMCs) play a crucial role in orchestrating the dynamics of the tumor immune microenvironment. This heterogeneous population encompasses myeloid-derived suppressor cells, tumor-associated macrophages and dendritic cells, all of which contribute to the establishment of an immunosuppressive milieu that fosters tumor progression. Tumor-derived exosomes (TEXs), small extracellular vesicles secreted by tumor cells, have emerged as central mediators in intercellular communication within the tumor microenvironment. In this comprehensive review, we explore the intricate mechanisms through which TEXs modulate immune-suppressive effects on TAMCs and their profound implications in cancer progression. We delve into the multifaceted ways in which TEXs influence TAMC functions, subsequently affecting tumor immune evasion. Furthermore, we elucidate various therapeutic strategies aimed at targeting TEX-mediated immune suppression, with the ultimate goal of bolstering antitumor immunity.
MeSH term(s)	Humans ; Exosomes/pathology ; Neoplasms/pathology ; Immunosuppression Therapy ; Myeloid Cells ; Myeloid-Derived Suppressor Cells ; Tumor Microenvironment
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.34921
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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