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Article ; Online: Guanosine-Based Multidrug Strategy Delivery for Synergistic Anti-Inflammation.

Gao, Wei / Zhang, Di / Wang, Hongyue / Qiao, Renzhong / Li, Chao

ACS macro letters

2024 , Page(s) 260–265

Abstract: The development of codelivery approaches for combination therapy is of great significance, especially for natural products that need to be combined to achieve therapeutic effects. Targeted delivery of multiple drugs through a single carrier remains a ... ...

Abstract	The development of codelivery approaches for combination therapy is of great significance, especially for natural products that need to be combined to achieve therapeutic effects. Targeted delivery of multiple drugs through a single carrier remains a challenge. Here, a multi-drug-loaded hydrogel, incorporating quercetin, demethyleneberberine, and dencichine, based on a G
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ISSN	2161-1653
ISSN (online)	2161-1653
DOI	10.1021/acsmacrolett.3c00562
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Article ; Online: RESTRUCTURING THEORETICAL FRAMEWORK OF URBAN SUSTAINABILITY FROM THE HEALTH DIMENSION

Wang Hongyue / Inna Koblianska

Економіка та суспільство, Iss

2021 Volume 31

Abstract: The environmental crisis caused by rapid global urbanization has led to many public health problems, which has gradually become the new normal in the process of achieving sustainable urban development. This study aims to reveal the relationships between ... ...

Abstract	The environmental crisis caused by rapid global urbanization has led to many public health problems, which has gradually become the new normal in the process of achieving sustainable urban development. This study aims to reveal the relationships between health, environment, and urban sustainability from a multidisciplinary perspective. Based on the existing research dimensions of urban sustainable development, the necessity, rationality, and feasibility of introducing the health dimension are proposed, and the research framework of health and urban sustainability is integrated and reconstructed. It is pointed out that scholars and policy makers should take the urban environment as the platform, take the duality of health and sustainability as the starting point, reconstruct the research framework of urban sustainability based on the health dimension, and provide a new theoretical perspective for the realization of urban sustainable development under the new normal.
Keywords	health ; environment ; urban sustainability ; public health ; urban management ; Economics as a science ; HB71-74 ; Business ; HF5001-6182
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Helvetica Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Generation of a human embryonic stem cell line WAe009-A-79 carrying a long QT syndrome mutation in KCNQ1.

Wang, Hongyue / Guo, Tianwei / Lan, Feng

Stem cell research

2023 Volume 70, Page(s) 103119

Abstract: The voltage-gated potassium channel KvLQT1 encoded by KCNQ1 plays an important role in the repolarization of myocardial action potentials. KCNQ1 mutations can cause Long QT syndrome type 1 (LQT1), which is considered to be the most common causative gene ... ...

Abstract	The voltage-gated potassium channel KvLQT1 encoded by KCNQ1 plays an important role in the repolarization of myocardial action potentials. KCNQ1 mutations can cause Long QT syndrome type 1 (LQT1), which is considered to be the most common causative gene of LQT. In this study, we established a human embryonic stem cell line KCNQ1
MeSH term(s)	Humans ; KCNQ1 Potassium Channel/genetics ; KCNQ1 Potassium Channel/metabolism ; Human Embryonic Stem Cells/metabolism ; Long QT Syndrome/genetics ; Romano-Ward Syndrome/genetics ; Mutation/genetics ; Potassium Channels, Voltage-Gated/genetics ; KCNQ Potassium Channels/genetics
Chemical Substances	KCNQ1 Potassium Channel ; Potassium Channels, Voltage-Gated ; KCNQ Potassium Channels ; KCNQ1 protein, human
Language	English
Publishing date	2023-05-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2393143-7
ISSN	1876-7753 ; 1873-5061
ISSN (online)	1876-7753
ISSN	1873-5061
DOI	10.1016/j.scr.2023.103119
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Article ; Online: Key drivers of urban digital economy sustainable development

Wang Hongyue / Inna Koblianska / Zhang Zhengchuan / Yan Xiumin

Наукові горизонти, Vol 25, Iss 3, Pp 76-

The China case

2022 Volume 84

Abstract: Digitalisation is a modern social and economic reality. The search for efficient pathways to move towards high-quality digital communities’ sustainable development constitutes the scope of current urban research worldwide. Given the need to move towards ... ...

Abstract	Digitalisation is a modern social and economic reality. The search for efficient pathways to move towards high-quality digital communities’ sustainable development constitutes the scope of current urban research worldwide. Given the need to move towards sustainable urban digitalisation, investigation of its critical influencing factors deserves special attention. However, quantitative empirical studies that avoid subjective judgement on the drivers of sustainable urban digitalisation are lacking. The purpose of this study is to fill this knowledge gap by outlining and quantifying the key factors affecting the sustainable development of the urban digital economy through entropy-TOPSIS modelling. The study takes China’s provinces and cities as an example due to China’s success in digital economy development. It is proposed to use the complex four-dimensional (scientific and technological innovation, economic growth, social development, information infrastructure) system involving 16 sub-indices to measure urban digital economy sustainability. Applying data from 31 Chinese provinces and cities for 2016-2019 and the entropy-TOPSIS model, the development of the technological innovations was found to be the most impacting factor on the urban digital economy sustainability path. The R&D staff engagement and expenditures, goods export and import, and e-commerce sales fuel the urban digital economy sustainability the most, while the number of students, public financial expenditures, and unemployment are the least significant. Results show that the urban digital economy is more a business-driven process than pushed by authorities. The gap between Chinese regions’ digital economy development was identified. This could be explained by the prevalence of conventional industries in several areas and the low level of their digitalisation and indicates the need to enhance interregional cooperation and partnership to promote sustainable development of the country under the digital economy paradigm. Despite China’s context, ...
Keywords	digitalisation ; entropy method ; sustainability ; topsis model ; urban development ; Agriculture ; S
Subject code	710
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Zhytomyr National Agroecological University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Retrospective Analysis of the Outcomes of Genetic Testing in Patients Suspected to Have Hereditary Hearing Loss or Deafness.

Bowden, Acacia / Hubbel, Alexandra / Smith, Lindsay / Wang, Hongyue / Fong, Chin-To

American journal of audiology

2024 , Page(s) 1–9

Abstract: Purpose: Uncorrected hearing loss can result in detrimental sequelae. Research addressing clinical presentation and genetic testing would inform clinical decision making.: Method: A retrospective chart review of 96 patients aged 1 month to 46 years ( ... ...

Abstract	Purpose: Uncorrected hearing loss can result in detrimental sequelae. Research addressing clinical presentation and genetic testing would inform clinical decision making. Method: A retrospective chart review of 96 patients aged 1 month to 46 years (median age = 6 years) diagnosed with hearing loss or deafness and who underwent genetic testing at University of Rochester Medical Center from 2011 to 2021. Chi-square and Fisher's exact tests examined the relationship between a diagnostic positive genetic test result and various characteristics of hearing loss, including congenital ( Results: Patients with sensorineural hearing loss (44.1%) had significantly more diagnostic positive results than those with mixed (0%) or conductive hearing loss (21.4%), Conclusions: Our study suggests a significant association between sensorineural type of hearing loss and a diagnostic positive genetic test result, while the presence of disabilities was significantly associated with a nondiagnostic genetic test result. Knowledge of these findings is critical for understanding the cause of the hearing loss, identifying other associated symptoms, and determining risk to family members.
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1162315-9
ISSN	1558-9137 ; 1059-0889
ISSN (online)	1558-9137
ISSN	1059-0889
DOI	10.1044/2023_AJA-23-00153
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Zs.A 3807: Show issues

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Article ; Online: Medication fill duration in pediatric hypertension: adherence, blood pressure control, and disparities.

McLaughlin, Meghan M / Gleber, Conrad D / Wang, Hongyue / Halterman, Jill S / Lande, Marc B

Pediatric nephrology (Berlin, Germany)

2024

Abstract: Background: Medication nonadherence is a barrier to hypertension control. The Centers for Disease Control and Prevention recommends prescribing 90-day fills for maintenance medications yet antihypertensives are often dispensed as 30-day fills. Our ... ...

Abstract	Background: Medication nonadherence is a barrier to hypertension control. The Centers for Disease Control and Prevention recommends prescribing 90-day fills for maintenance medications yet antihypertensives are often dispensed as 30-day fills. Our objectives were to examine how often patients receive 30-day supplies of medication despite prescriptions for longer duration and to examine the effect of medication fill duration on adherence and hypertension control. Methods: We conducted a retrospective cohort study of pediatric patients with hypertension over a 3-year period. For each patient, days prescribed per fill were compared to days dispensed per fill using pharmacy reports and insurance claim data. Proportion of Days Covered (PDC) was calculated to estimate adherence. Hypertension control was determined by provider assessment of control and blood pressure measurement at the final visit. Results: Final cohort included 449 patients. A total of 70% had at least one prescription for ≥ 90 days but only 37% had at least one dispense for ≥ 90 days. There was no difference in the likelihood of being prescribed a 90-day fill by insurance type (public vs. private); however, patients with public insurance were less likely to be dispensed a 90-day fill (OR = 0.068, p < 0.001). Patients who received 90-day fills had better adherence (median PDC 77.5% vs. 58.1%, p < 0.001) and were more likely to have hypertension control based on provider assessment. Conclusions: Longer fill duration is associated with improved adherence and hypertension control. Patients with public insurance are markedly less likely to be dispensed 90-day fills, a modifiable barrier to improving adherence.
Language	English
Publishing date	2024-04-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-024-06363-z
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Zs.A 2196: Show issues

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Article ; Online: A modified extended Morrow procedure to relieve symptoms of the patient with Danon disease: a case report.

Wu, Dongdong / Yang, Kai / Wang, Hongyue / Zhang, Jing / Li, Shoujun

European heart journal. Case reports

2023 Volume 7, Issue 8, Page(s) ytad352

Language	English
Publishing date	2023-07-26
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytad352
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Article ; Online: Stabilization effects of saccharides in protein formulations: A review of sucrose, trehalose, cyclodextrins and dextrans.

Li, Jinghan / Wang, Hongyue / Wang, Lushan / Yu, Dongyue / Zhang, Xiangrong

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2023 Volume 192, Page(s) 106625

Abstract: Saccharides are a popular group of stabilizers in liquid, frozen and freeze dried protein formulations. The current work reviewed the stabilization mechanisms of three groups of saccharides: (i) Disaccharides, specifically sucrose and trehalose; (ii) ... ...

Abstract	Saccharides are a popular group of stabilizers in liquid, frozen and freeze dried protein formulations. The current work reviewed the stabilization mechanisms of three groups of saccharides: (i) Disaccharides, specifically sucrose and trehalose; (ii) cyclodextrins (CDs), a class of cyclic oligosaccharides; and (iii) dextrans, a class of polysaccharides. Compared to sucrose, trehalose exhibits a more pronounced preferential exclusion effect in liquid protein formulations, due to its stronger interaction with water molecules. However, trehalose obtains higher phase separation and crystallization propensity in frozen solutions, resulting in the loss of its stabilization function. In lyophilized formulations, sucrose has a higher crystallization propensity. Besides, its glass matrix is less homogeneous than that of trehalose, thus undermining its lyoprotectant function. Nevertheless, the hygroscopic nature of trehalose may result in high water absorption upon storage. Among all the CDs, the β form is believed to have stronger interactions with proteins than the α- and γ-CDs. However, the stabilization effect, brought about by CD-protein interactions, is case-by-case - in some examples, such interactions can promote protein destabilization. The stabilization effect of hydroxypropyl-β-cyclodextrin (HPβCD) has been extensively studied. Due to its amphiphilic nature, it can act as a surface-active agent in preventing interfacial stresses. Besides, it is a dual functional excipient in freeze dried formulations, acting as an amorphous bulking agent and lyoprotectant. Finally, dextrans, when combined with sucrose or trehalose, can be used to produce stable freeze dried protein formulations. A strong stabilization effect can be realized by low molecular weight dextrans. However, the terminal glucose in dextrans yields protein glycation, which warrants extra caution during formulation development.
MeSH term(s)	Trehalose/chemistry ; Sucrose/chemistry ; Cyclodextrins/chemistry ; Dextrans/chemistry ; Excipients/chemistry ; Water/chemistry ; Freeze Drying
Chemical Substances	Trehalose (B8WCK70T7I) ; Sucrose (57-50-1) ; Cyclodextrins ; Dextrans ; Excipients ; Water (059QF0KO0R)
Language	English
Publishing date	2023-11-02
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1154366-8
ISSN	1879-0720 ; 0928-0987
ISSN (online)	1879-0720
ISSN	0928-0987
DOI	10.1016/j.ejps.2023.106625
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Zs.A 3705: Show issues

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Article ; Online: Promoting effects of calponin 3 on the growth of diffuse large B‑cell lymphoma cells.

Xing, Xiaojing / Liu, Meichen / Wang, Xuguang / Guo, Qianxue / Wang, Hongyue

Oncology reports

2023 Volume 49, Issue 2

Abstract: Diffuse large B‑cell lymphoma (DLBCL) is one of the most common types of lymphoma. Calponin 3 (CNN3) is a thin filament‑associated protein previously known to regulate smooth muscle contraction. Recent evidence illustrates its involvement in ... ...

Abstract	Diffuse large B‑cell lymphoma (DLBCL) is one of the most common types of lymphoma. Calponin 3 (CNN3) is a thin filament‑associated protein previously known to regulate smooth muscle contraction. Recent evidence illustrates its involvement in carcinogenesis; however, its roles in DLBCL remain unknown. CNN3 was found to be highly expressed in DLBCL specimens according to the online Gene Expression Profiling Interactive Analysis data. The aim of the present study was to investigate the roles of CNN3 in the progression of DLBCL.
MeSH term(s)	Animals ; Mice ; Cell Line, Tumor ; Mice, Nude ; Cell Proliferation/genetics ; Lymphoma, Large B-Cell, Diffuse/pathology ; Gene Expression Regulation, Neoplastic ; Calponins
Language	English
Publishing date	2023-01-20
Publishing country	Greece
Document type	Journal Article
ZDB-ID	1222484-4
ISSN	1791-2431 ; 1021-335X
ISSN (online)	1791-2431
ISSN	1021-335X
DOI	10.3892/or.2023.8483
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Zs.A 4213: Show issues

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Article ; Online: Ras interacting protein 1 facilitated proliferation and invasion of diffuse large B-cell lymphoma cells.

Xing, Xiaojing / Wang, Xuguang / Liu, Meichen / Guo, Qianxue / Wang, Hongyue

Cancer biology & therapy

2023 Volume 24, Issue 1, Page(s) 2193114

Abstract: A GTPase binding protein, Ras interacting protein 1 (RASIP1), has been reported with a tumor-promoting role in lung cancer cells, and its role in lymphoma remains unknown. The analysis of medical databank shows that RASIP1 is upregulated in diffuse large ...

Abstract	A GTPase binding protein, Ras interacting protein 1 (RASIP1), has been reported with a tumor-promoting role in lung cancer cells, and its role in lymphoma remains unknown. The analysis of medical databank shows that RASIP1 is upregulated in diffuse large B-cell lymphoma (DLBCL) specimens. In this article, we demonstrated that RASIP1 is highly expressed in DLBCL cell lines, compared with primary B cells. The gain- and loss-of-function experiments were performed to investigate the effects of RASIP1 on DLBCL cells. CCK-8, flow cytometry, western blot, and transwell assays demonstrated that silence of RASIP1 inhibited proliferation, cell cycle transition, and invasion and induced significant apoptosis in DLBCL cells, and ectopic expression of RASIP1 played opposite roles. Xenograft results revealed that RASIP1 facilitated the growth of DLBCL cells
MeSH term(s)	Humans ; Apoptosis ; Carrier Proteins/metabolism ; Cell Cycle ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Lymphoma, Large B-Cell, Diffuse/pathology ; Intracellular Signaling Peptides and Proteins/metabolism
Chemical Substances	Carrier Proteins ; RASIP1 protein, human ; Intracellular Signaling Peptides and Proteins
Language	English
Publishing date	2023-03-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2146305-0
ISSN	1555-8576 ; 1538-4047
ISSN (online)	1555-8576
ISSN	1538-4047
DOI	10.1080/15384047.2023.2193114
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Zs.A 5887: Show issues

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