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  1. Article ; Online: The development, feasibility and credibility of intra-abdominal pressure measurement techniques: A scoping review.

    Li, ZhiRu / Wang, HuaFen / Lu, FangYan

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0297982

    Abstract: Aim: To provide a comprehensive overview on emerging direct and alternative methods for intra-abdominal pressure (IAP) measurement techniques.: Methods: This was a scoping review study following Arksey and Malley's framework. The PubMed, EMBASE, Web ... ...

    Abstract Aim: To provide a comprehensive overview on emerging direct and alternative methods for intra-abdominal pressure (IAP) measurement techniques.
    Methods: This was a scoping review study following Arksey and Malley's framework. The PubMed, EMBASE, Web of Science, EBSCO, Scopus and ProQuest databases were searched, and we only considered studies published from 2000 as we have extended the data from two previous reviews. Original studies that reported on the development, feasibility and credibility of IAP measurement techniques were included.
    Results: Forty-two of 9954 screened articles were included. IAP measurement techniques include three major categories: direct, indirect and less invasive measurement techniques. Agreement analyses were performed in most studies, and some explored the safety, time expenditure and reproducibility of IAP measurement techniques.
    Conclusions: Clinical data assessing the validation of new IAP measurement techniques or the reliability of established measurement techniques remain lacking. Considering the cost and invasiveness, direct measurement is not recommended as a routine method for IAP measurement and should be preserved for critically ill patients where standard techniques are contraindicated or could be inaccurate. The measurement accuracy, reliability and sensitivity of the transrectal and transfemoral vein methods remain insufficient and cannot be recommended as surrogate IAP measures. Transvesical measurement is the most widely used method, which is the potentially most easy applicable technique and can be used as a reliable method for continuous and intermittent IAP measurement. Wireless transvaginal method facilitates the quantitative IAP measurement during exercise and activity, which laying the foundations for monitoring IAP outside of the clinic environment, but the accuracy of this technique in measuring absolute IAP cannot be determined at present. Less invasive technology will become a new trend to measure IAP and has substantial potential to replace traditional IAP measurement technologies, but further validation and standardization are still needed. Medical professionals should choose appropriate measurement tools based on the advantages and disadvantages of each IAP technique in combination with assessing specific clinical situations.
    MeSH term(s) Humans ; Reproducibility of Results ; Feasibility Studies ; Critical Illness ; Technology ; Abdomen ; Intra-Abdominal Hypertension
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0297982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: An Integrative Model of In-Hospital and Out-of-Hospital Nursing Care for Non-Suicidal Self-Injury: A Narrative Review.

    Zhang, Ruili / Lai, Jianbo / Wang, Huafen

    Brain sciences

    2023  Volume 13, Issue 3

    Abstract: Background: Non-suicidal self-injury (NSSI) refers to the intentional and repeated physical trauma of an individual without explicit suicidal intent, which has negative effects on the physical and mental well-being of an individual, especially for ... ...

    Abstract Background: Non-suicidal self-injury (NSSI) refers to the intentional and repeated physical trauma of an individual without explicit suicidal intent, which has negative effects on the physical and mental well-being of an individual, especially for adolescents. Timely and accessible nursing care may play an important role in the survival and rehabilitation process of NSSI.
    Methods: In this review, we systematically discuss the nursing care of NSSI behavior and provide recommendations based on an integrated nursing model for NSSI management.
    Results: As reported in previous studies, a variety of factors can contribute to NSSI behavior, such as personality traits, current psychological status, history of mental illnesses, as well as family and social factors. In-hospital care is the most necessary and effective care during acute episodes of NSSI behavior. To effectively manage inpatients with NSSI behaviors, nurses should first understand the motivation of NSSI, and provide comprehensive and multi-level care through nurse-patient communication, individualized psychological care, and multidisciplinary cooperation with other professionals. While the purpose of out-of-hospital nursing is to reduce the frequency of NSSI behaviors by screening high-risk individuals, providing psychological support, promoting health education, and improving self-awareness.
    Conclusions: An integrative model of in-hospital and out-of-hospital nursing care can help improve the clinical management and long-term prognosis of patients with NSSI and minimize the risk of suicidal ideation or suicidal behavior.
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13030466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Monitoring and Management of Intra-abdominal Pressure in Critically Ill Children.

    Li, ZhiRu / Wang, HuaFen / Lu, FangYan

    Critical care nurse

    2023  Volume 43, Issue 3, Page(s) 44–51

    Abstract: Background: Intra-abdominal hypertension is a comorbid condition in critically ill children, is an independent predictor of mortality, and has harmful effects on multiple organ systems through renal, pulmonary or hemodynamic damage. Intra-abdominal ... ...

    Abstract Background: Intra-abdominal hypertension is a comorbid condition in critically ill children, is an independent predictor of mortality, and has harmful effects on multiple organ systems through renal, pulmonary or hemodynamic damage. Intra-abdominal pressure monitoring is widely used in clinical practice because it is a safe, accurate, inexpensive, and rapid method for the clinical diagnosis of intra-abdominal hypertension.
    Objective: To improve pediatric critical care nurses' understanding of and ability to perform intra-abdominal pressure monitoring and provide a reference for standardizing intra-abdominal pressure monitoring in clinical practice.
    Methods: A literature review was performed using the following keywords: intra-abdominal pressure, bladder pressure, vesicular pressure, measurement, monitoring, critically ill children, pediatric intensive care, pediatric, and children. Four hundred fifty-four articles were initially identified and screened; 24 were included.
    Results: The monitoring and management of intra-abdominal pressure should include appropriate and clinically proven intra-abdominal pressure measurement techniques, appropriate patients, the proper frequency of measurement, and a repeatable intra-abdominal pressure measurement method.
    Conclusions: Knowledge of intra-abdominal pressure monitoring in critically ill children enhances the ability of nurses in clinical practice to accurately measure intra-abdominal pressure to improve the timeliness and accuracy of clinical identification of intra-abdominal hypertension and guide decompression interventions.
    MeSH term(s) Humans ; Child ; Intra-Abdominal Hypertension/diagnosis ; Intra-Abdominal Hypertension/therapy ; Critical Illness/therapy ; Critical Care ; Hemodynamics
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 632663-8
    ISSN 1940-8250 ; 0279-5442
    ISSN (online) 1940-8250
    ISSN 0279-5442
    DOI 10.4037/ccn2023545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mania in a Patient With Pituitrin-Associated Hyponatremia.

    Zhang, Ruili / Li, Shaoli / Lai, Jianbo / Wang, Huafen

    Journal of clinical psychopharmacology

    2022  Volume 42, Issue 2, Page(s) 219–221

    MeSH term(s) Humans ; Hyponatremia/chemically induced ; Hyponatremia/diagnosis ; Mania ; Pituitary Hormones, Posterior
    Chemical Substances Pituitary Hormones, Posterior
    Language English
    Publishing date 2022-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604631-9
    ISSN 1533-712X ; 0271-0749
    ISSN (online) 1533-712X
    ISSN 0271-0749
    DOI 10.1097/JCP.0000000000001511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Gene set enrichment analysis identifies immune subtypes of kidney renal clear cell carcinoma with significantly different molecular and clinical properties.

    Chen, Zuobing / Cao, Wenxiu / Luo, Jiangti / Abdelrahman, Zeinab / Lu, Qiqi / Wang, Huafen / Wang, Xiaosheng

    Frontiers in immunology

    2023  Volume 14, Page(s) 1191365

    Abstract: Background: Kidney renal clear cell carcinoma (KIRC) is the most prevalent renal malignancy, marked by a high abundance of tumor-infiltrating lymphocytes (TILs) and an unfavorable prognosis upon metastasis. Numerous studies have demonstrated that KIRC ... ...

    Abstract Background: Kidney renal clear cell carcinoma (KIRC) is the most prevalent renal malignancy, marked by a high abundance of tumor-infiltrating lymphocytes (TILs) and an unfavorable prognosis upon metastasis. Numerous studies have demonstrated that KIRC possesses a tumor microenvironment that is highly heterogeneous, and this is associated with significant variations in the effectiveness of most first-line drugs administered to KIRC patients. Therefore, it is crucial to classify KIRC based on the tumor microenvironment, although these subtyping techniques are still inadequate.
    Methods: By applying gene set enrichment scores of 28 immune signatures, we conducted a hierarchical clustering of KIRC and determined its immune subtypes. In addition, we conducted a comprehensive exploration of the molecular and clinical features of these subtypes, including survival prognosis, proliferation, stemness, angiogenesis, tumor microenvironment, genome instability, intratumor heterogeneity, and pathway enrichment.
    Results: Through cluster analysis, two immune subtypes of KIRC were identified and termed Immunity-High (Immunity-H) and Immunity-Low (Immunity-L). This clustering outcome was consistent in four independent KIRC cohorts. The subtype Immunity-H exhibited elevated levels of TILs, tumor aneuploidy, homologous recombination deficiency, stemness, and proliferation potential, along with a poorer prognosis for survival. Despite this, the Immunity-L subtype demonstrated elevated intratumor heterogeneity and a stronger angiogenesis signature in contrast to Immunity-H. According to the results of pathway enrichment analysis, the Immunity-H subtype was found to be highly enriched in immunological, oncogenic, and metabolic pathways, whereas the Immunity-L subtype was highly enriched in angiogenic, neuroactive ligand-receptor interaction, and PPAR pathways.
    Conclusions: Based on the enrichment of immune signatures in the tumor microenvironment, KIRC can be categorized into two immune subtypes. The two subtypes demonstrate considerably distinct molecular and clinical features. In KIRC, an increase in immune infiltration is linked to a poor prognosis. Patients with Immunity-H KIRC may exhibit active responses to PPAR and immune checkpoint inhibitors, whereas patients with Immunity-L may manifest favorable responses to anti-angiogenic agents and immune checkpoint inhibitors. The immunological classification provides molecular insights into KIRC immunity, as well as clinical implications for the management of this disease.
    MeSH term(s) Humans ; Immune Checkpoint Inhibitors ; Peroxisome Proliferator-Activated Receptors ; Carcinoma, Renal Cell/genetics ; Kidney Neoplasms/genetics ; Kidney ; Tumor Microenvironment/genetics
    Chemical Substances Immune Checkpoint Inhibitors ; Peroxisome Proliferator-Activated Receptors
    Language English
    Publishing date 2023-06-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1191365
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The experiences of adolescent solid organ transplantation recipients, parents, and healthcare professionals in healthcare transition: A qualitative systematic review.

    Li, Zhi Ru / Wang, HuaFen / Lu, FangYan / Dong, Li / Wu, JingYun

    Journal of pediatric nursing

    2023  Volume 71, Page(s) e154–e164

    Abstract: Problem: The transition from paediatric-centred to adult healthcare services in adolescent solid organ transplantation recipients is a period of increased risk and vulnerability, the issues related to healthcare transition have become key concerns to ... ...

    Abstract Problem: The transition from paediatric-centred to adult healthcare services in adolescent solid organ transplantation recipients is a period of increased risk and vulnerability, the issues related to healthcare transition have become key concerns to the healthcare community.
    Eligibility criteria: Qualitative studies of any design and qualitative components of mixed method studies that explored the experiences of healthcare transition among adolescent solid organ transplant recipients, parents, and healthcare professionals were included.
    Sample: Nine articles were finalised and included in the review.
    Methods: A systematic review of qualitative studies was conducted. Databases searched were Scopus, PsycINFO, EMBASE, Web of Science, PubMed, CINAHL and ProQuest Dissertations and Theses. Studies published between the inception of respective database and December 2022 inclusive were considered. A three-step inductive thematic synthesis method outlined by Thomas and Harden was used to form descriptive themes and the 10-item Joanna Briggs Institute Critical Appraisal Checklist was utilised to appraise the quality of included articles.
    Results: Two hundred and twenty studies were screened, and 9 studies published between 2013 and 2022 were included. Five analytical themes were generated: 'the struggle of being an adolescent with a transplant'; 'perceptions of transition'; 'the role of parents'; 'lack of transition readiness' and 'the need for better support'.
    Conclusions: Adolescent solid organ transplant recipients, parents, and healthcare professionals faced multiple challenges in the healthcare transition.
    Implications: Future interventions and health policies should provide targeted intervention strategies that address the barriers present in the healthcare transition to facilitate the optimization of the youth healthcare transition.
    MeSH term(s) Adult ; Humans ; Child ; Adolescent ; Transition to Adult Care ; Health Personnel ; Parents ; Qualitative Research ; Delivery of Health Care ; Organ Transplantation
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 632731-x
    ISSN 1532-8449 ; 0882-5963
    ISSN (online) 1532-8449
    ISSN 0882-5963
    DOI 10.1016/j.pedn.2023.05.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Parents' experience of children's transitions from intensive care unit after liver transplantation: A qualitative study.

    Wu, Jingyun / Lu, Fangyan / Li, Zhiru / Dai, Yanhong / Wang, Yan / Bao, Ruijie / Rao, Yuxin / Wang, Huafen

    Intensive & critical care nursing

    2024  Volume 83, Page(s) 103698

    Abstract: Objective: The aim of this study was to understand parents' perspectives on caring for children who underwent liver transplantation in the intensive care unit transition period and to provide a reference for the development of targeted intervention ... ...

    Abstract Objective: The aim of this study was to understand parents' perspectives on caring for children who underwent liver transplantation in the intensive care unit transition period and to provide a reference for the development of targeted intervention strategies.
    Methods: Thirteen parents of children who underwent liver transplantation at a tertiary hospital in Hangzhou, Zhejiang Province were chosen for in-depth semi-structured interviews via purposive sampling. The interview data were analyzed and summarized via content analysis.
    Findings: Three themes were extracted, including a period of separation and suffering (being apart from child is tough, chilling atmosphere, and limited family access); being an overwhelming caregiver (hope coupled with worry, conflict of roles, and existential care dilemmas); and facing a new normal: searching for information and support (information on medical conditions, post-discharge care assistance, educational support, and peer support).
    Conclusion: For parents whose child underwent liver transplantation, the transition period from the intensive care unit to the general ward is challenging. Parents are burdened with several caregiving responsibilities and require a variety of information and support. It is advised that nurses should offer sufficient information and suitable educational approaches to enhance these parents' capacity to care for their children and assist children and their parents in making a smooth transition.
    Implications for clinical practice: This study highlights parents' perspectives on caring for children with liver transplants transferred from the intensive care unit to a general ward. Transitional care is strenuous, evoking different feelings before and after transfer. The health care professionals should focus on the needs and challenges faced by parents who are caring for children with liver transplants during the intensive care unit transition period. To achieve this, it is critical to establish a supportive environment and provide suitable information and education for parents to enhance their caregiving abilities.
    Language English
    Publishing date 2024-04-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1105892-4
    ISSN 1532-4036 ; 0964-3397
    ISSN (online) 1532-4036
    ISSN 0964-3397
    DOI 10.1016/j.iccn.2024.103698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Novel Monomethoxy Poly(Ethylene Glycol) Modified Hydroxylated Tung Oil for Drug Delivery.

    Wang, Huafen / He, Huanhuan / Zhang, Jiaxiang / Liu, Juntao / Zhuang, Yuwei / Yin, Yuanyuan / Ren, Zhiyong / Fu, Yang / He, Suqin

    Polymers

    2023  Volume 15, Issue 3

    Abstract: Novel monomethoxy poly(ethylene glycol) ( ...

    Abstract Novel monomethoxy poly(ethylene glycol) (
    Language English
    Publishing date 2023-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15030564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Mental health outcome and resilience among aiding Wuhan nurses: One year after the COVID-19 outbreak in China.

    Zhang, Ruili / Lai, Jianbo / Wang, Ying / Huang, Jinwen / Hu, Shaohua / Wang, Huafen

    Journal of affective disorders

    2021  Volume 297, Page(s) 348–352

    Abstract: Objective: This study aimed to explore whether aiding Wuhan experience of nurses was associated with adverse mental health outcome one year after the COVID-19 outbreak in China.: Methods: In this study, 100 nurses with and 100 nurses without aiding ... ...

    Abstract Objective: This study aimed to explore whether aiding Wuhan experience of nurses was associated with adverse mental health outcome one year after the COVID-19 outbreak in China.
    Methods: In this study, 100 nurses with and 100 nurses without aiding Wuhan experience a year ago were enrolled from February 1, 2021 to March 31, 2021 in Zhejiang Province, China. Depression, anxiety, insomnia, distress and psychological resilience of participants was assessed and analyzed.
    Results: A total of 100 participants from 112 aiding Wuhan nurses completed the survey, with a response rate of 89.3%. Another 100 nurses from the same hospitals without aiding Wuhan experience were enrolled as controls. In both groups, a considerable proportion of participants reported symptoms of depression (46.0% for the aiding Wuhan group vs. 49.0% for the controls, similarly hereinafter), anxiety (40.0% vs. 38.0%), and PTSD (61.0% vs. 56.0%). Aiding Wuhan nurses were more likely to suffer from insomnia (41.0% vs. 29.0%, P = 0.041). Multivariable logistic regression analysis showed that aiding Wuhan experience was not associated with depression (adjusted OR (AOR) 0.22; 95%CI, 0.05-1.01), anxiety (AOR 0.53; 95%CI, 0.12-2.43), insomnia (AOR 1.52; 95%CI, 0.76-3.02), PTSD (AOR 0.50; 95%CI, 0.19-1.34), or resilience (AOR 1.59; 95%CI, 0.78-3.26). Resilience was negatively correlated with depression, anxiety, insomnia, and PTSD.
    Conclusions: This survey indicated that aiding Wuhan experience a year ago did not cause additional adverse mental health outcomes in nurses, expect for insomnia. The psychological status of nurses in general calls for more attention.
    MeSH term(s) Anxiety/epidemiology ; COVID-19 ; China/epidemiology ; Cross-Sectional Studies ; Depression/epidemiology ; Disease Outbreaks ; Humans ; Mental Health ; Outcome Assessment, Health Care ; SARS-CoV-2 ; Surveys and Questionnaires
    Language English
    Publishing date 2021-10-25
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2021.10.050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Qualitative study on working experience of COVID-19 care nurses].

    Wang, Jinying / He, Jiangjuan / Zhu, Jianmei / Qiu, Jiangying / Wang, Huafen / Xu, Hongzhen

    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

    2020  Volume 49, Issue 4, Page(s) 480–486

    Abstract: Objective: To study the working experience of COVID-19 care nurses.: Methods: Twenty two nurses taking care of COVID-19 patients were interviewed by means of descriptive phenomenology. All the data were transcribed and recorded, and then processed ... ...

    Abstract Objective: To study the working experience of COVID-19 care nurses.
    Methods: Twenty two nurses taking care of COVID-19 patients were interviewed by means of descriptive phenomenology. All the data were transcribed and recorded, and then processed into WORD documents. The Colaizzi 7 footwork was used to classify, encode, establish nodes and extract themes based on Nvivo11.0 software.
    Results: Two main themes were extracted: one is the positive feelings of nurses, including the sense of professional mission and pride, the sense of achievement and happiness, the improvement of self-worth and ability, the powerful support system and the power of role models; the other is the negative experience of nurses, including the worry and anxiety at work, the lack of experience and trust, the difficulty of work, and the inconvenience of isolating life.
    Conclusions: s While fully affirming the work value of nurses, it is necessary for the society, hospitals and patients to give extensive and continuous support, care and respect to nurses, so as to stimulate their working enthusiasm and sense of professional achievement. Hospital managers need to implement all kinds of security work, meet the safety needs of nurses, pay attention to the physical and mental health of nurses, strengthen the training of nursing talents for critical and severe diseases and infectious diseases, improve the allocation of human resources, and enhance the ability of material allocation and reserve for major health events, so as to make adequate preparations for coping with public health events in the future.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Hospitals/statistics & numerical data ; Humans ; Nurses/statistics & numerical data ; Pandemics ; Pneumonia, Viral ; Qualitative Research ; SARS-CoV-2 ; Workplace/statistics & numerical data
    Keywords covid19
    Language Chinese
    Publishing date 2020-11-03
    Publishing country China
    Document type Journal Article
    ISSN 1008-9292
    ISSN 1008-9292
    DOI 10.3785/j.issn.1008-9292.2020.08.07
    Database MEDical Literature Analysis and Retrieval System OnLINE

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