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Article ; Online: Development of biological metal-organic frameworks designed for biomedical applications: from bio-sensing/bio-imaging to disease treatment.

Wang, Huai-Song / Wang, Yi-Hui / Ding, Ya

Nanoscale advances

2020 Volume 2, Issue 9, Page(s) 3788–3797

Abstract: Metal-organic frameworks (MOFs) are built using various organic ligands and metal ions (or clusters). With properties of high porosity, tunable chemical composition, and potential for post-synthetic modification, they have been applied in biomedicine, ... ...

Abstract	Metal-organic frameworks (MOFs) are built using various organic ligands and metal ions (or clusters). With properties of high porosity, tunable chemical composition, and potential for post-synthetic modification, they have been applied in biomedicine, especially in bio-sensing, bio-imaging, and drug delivery. Since organic ligands and metal centers (ions or clusters) in the structure of MOFs can directly influence the property, function, and performance of MOFs, strict screening of organic ligands and metal centers is necessary. Especially, to improve the application of MOFs in the field of biomedicine, biocompatible organic ligands with low toxicity are desirable. In recent years, biological metal-organic frameworks (bio-MOFs) with ideal biocompatibility and diverse functionality have attracted wide attention. Endogenous biomolecules, including nucleobases, amino acids, peptides, proteins, porphyrins and saccharides, are employed as frameworks for MOF construction. These biological ligands coordinate with diverse metal centers in different ways, leading to the structural diversity of bio-MOFs. In this review, we summarize the organic ligand selectivity in constructing different types of bio-MOFs and their influence in biomedical applications with attractive new functions.
Language	English
Publishing date	2020-07-31
Publishing country	England
Document type	Journal Article ; Review
ISSN	2516-0230
ISSN (online)	2516-0230
DOI	10.1039/d0na00557f
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Circulating tumor DNA analysis for tumor diagnosis.

Wang, Yi-Hui / Song, Zhen / Hu, Xin-Yuan / Wang, Huai-Song

Talanta

2021 Volume 228, Page(s) 122220

Abstract: Tumor is a kind of abnormal organism generated by the proliferation and differentiation of cells in the body under the action of various initiating and promoting factors, which seriously threatens human life and health. Tumorigenesis is a gradual process ...

Abstract	Tumor is a kind of abnormal organism generated by the proliferation and differentiation of cells in the body under the action of various initiating and promoting factors, which seriously threatens human life and health. Tumorigenesis is a gradual process that involves multistage reactions and the accumulation of mutations. Gene mutation usually occurs during tumorigenesis, and can be used for tumor diagnosis. Early diagnosis is the most effective way to improve the cure rate and reduce the mortality rate. Among the peripheral blood circulating tumor DNA (ctDNA), gene mutation in keeping with tumor cells can be detected, which can potentially replace tumor tissue section for early diagnosis. It has been considered as a liquid biopsy marker with good clinical application prospect. However, the high fragmentation and low concentration of ctDNA in blood result in the difficulty of tumor stage determination. Therefore, high sensitive and specific mutation detection methods have been developed to detect trace mutant ctDNA. At present, the approaches include digital PCR (dPCR), Bead, Emulsion, Amplification and Magnetic (BEAMing), Next Generation Sequencing (NGS), Amplification Refractory Mutation System (ARMS), etc. In this paper, the principle, characteristics, latest progress and application prospects of these methods are reviewed, which will facilitate researchers to choose appropriate ctDNA detection approaches.
MeSH term(s)	Biomarkers, Tumor/genetics ; Circulating Tumor DNA/genetics ; DNA, Neoplasm/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; Liquid Biopsy ; Mutation ; Neoplasms/diagnosis ; Neoplasms/genetics
Chemical Substances	Biomarkers, Tumor ; Circulating Tumor DNA ; DNA, Neoplasm
Language	English
Publishing date	2021-02-19
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2021.122220
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Article ; Online: Fluorescent intracellular imaging of reactive oxygen species and pH levels moderated by a hydrogenase mimic in living cells.

Hu, Xin-Yuan / Li, Jia-Jing / Yang, Zi-Wei / Zhang, Jun / Wang, Huai-Song

Journal of pharmaceutical analysis

2022 Volume 12, Issue 5, Page(s) 801–807

Abstract: The catalytic generation of ... ...

Abstract	The catalytic generation of H
Language	English
Publishing date	2022-05-28
Publishing country	China
Document type	Journal Article
ZDB-ID	2630174-X
ISSN	2214-0883 ; 2095-1779
ISSN (online)	2214-0883
ISSN	2095-1779
DOI	10.1016/j.jpha.2022.05.007
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Article ; Online: Cancer drug resistance related microRNAs: recent advances in detection methods.

Hu, Xin-Yuan / Song, Zhen / Yang, Zi-Wei / Li, Jia-Jing / Liu, Jing / Wang, Huai-Song

The Analyst

2022 Volume 147, Issue 12, Page(s) 2615–2632

Abstract: Drug resistance is a significant factor that hinders the success of cancer chemotherapy. The widely recognized mechanisms of drug resistance include changes to cell proliferation, cycle/apoptosis, drug metabolism/transport, DNA damage and the epithelial ... ...

Abstract	Drug resistance is a significant factor that hinders the success of cancer chemotherapy. The widely recognized mechanisms of drug resistance include changes to cell proliferation, cycle/apoptosis, drug metabolism/transport, DNA damage and the epithelial to mesenchymal transition. MicroRNAs (miRNAs), short non-coding RNAs with lengths of approximately 19-25 nucleotides, are related to cancer drug resistance, which is regulated by the aforementioned mechanisms. Based on the importance of miRNAs in regulating drug resistance, it is also necessary to take appropriate miRNA detection methods into consideration. To date, a number of advanced miRNA detection methods with high specificity and sensitivity have been developed, such as isothermal amplification-based methods, nanomaterial-based methods, chromatography-based methods, mass spectrometry-based methods and so on. Herein, biogenesis of miRNAs, the relationship between miRNAs and cancer drug resistance, and miRNA detection methods are introduced and discussed to facilitate the development of non-invasive diagnosis and inhibition of cancer drug resistance.
MeSH term(s)	Apoptosis ; Drug Resistance, Neoplasm/genetics ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; MicroRNAs/genetics ; Neoplasms/diagnosis ; Neoplasms/drug therapy ; Neoplasms/genetics
Chemical Substances	MicroRNAs
Language	English
Publishing date	2022-06-13
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d2an00171c
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Article: Development of fluorescent and luminescent probes for reactive oxygen species

Wang, Huai-Song

Trends in analytical chemistry. 2016 Dec., v. 85

2016

Abstract: Reactive oxygen species (ROS) are chemically reactive molecules that can mediate a wide variety of biological processes. The imbalance of these reactive intermediates in the metabolism will result in the phenomenon known as oxidative stress. Therefore, a ...

Abstract	Reactive oxygen species (ROS) are chemically reactive molecules that can mediate a wide variety of biological processes. The imbalance of these reactive intermediates in the metabolism will result in the phenomenon known as oxidative stress. Therefore, a great number of approaches have been developed for measuring ROS in biological systems. Due to their reactive and transient nature, the ROS are generally difficult to determine. Fluorescent and luminescent probes for monitoring ROS have shown advantages such as high sensitivity, selectivity, as well as real-time imaging, which can yield visible information about the ROS. The recent progress in preparing ROS probes (including small organic molecules, metal complexes or nanomaterials) for detecting and imaging of ROS production in living cells or whole organisms were summarized in this review. The design strategies and ROS sensing mechanisms of these functional probes were described.
Keywords	fluorescence ; image analysis ; metabolism ; monitoring ; nanomaterials ; oxidative stress ; reactive oxygen species
Language	English
Dates of publication	2016-12
Size	p. 181-202.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2014041-1
ISSN	0165-9936
ISSN	0165-9936
DOI	10.1016/j.trac.2016.09.006
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Visual and Electrochemical Detection of let-7a: A Tumor Suppressor and Biomarker.

Song, Zhen / Zhang, Qiang-Yan / Li, Jia-Jing / Su, Jing-Lian / Liu, Yuan-Hua / Yang, Gong-Jun / Wang, Huai-Song

Journal of medicinal chemistry

2023 Volume 66, Issue 11, Page(s) 7605–7614

Abstract: Let-7a, a type of low-expressed microRNAs in cancer cells, has been investigated as a promising biomarker and therapeutic target for tumor suppression. Developing simple and sensitive detection methods for let-7a is important for cancer diagnosis and ... ...

Abstract	Let-7a, a type of low-expressed microRNAs in cancer cells, has been investigated as a promising biomarker and therapeutic target for tumor suppression. Developing simple and sensitive detection methods for let-7a is important for cancer diagnosis and treatment. In this work, the hybridization chain reaction (HCR) was initiated by let-7a via two hairpin primers (H1 and H2). After the HCR, the remaining hairpin H1 was further detected by lateral flow assay (LFA) and electrochemical impedance spectroscopy. For LFA, biotin-modified H1(bio-H1) and free H2 were used for HCR. With the decrease of let-7a concentration, the color of T line gradually increased. As for electrochemical methods, the H1'-AuNP-modified electrode was used for detection of bio-H1 based on the difference of impedance (Δ
MeSH term(s)	Nucleic Acid Hybridization/methods ; MicroRNAs ; Biotin ; Biomarkers ; Electrochemical Techniques
Chemical Substances	MicroRNAs ; Biotin (6SO6U10H04) ; Biomarkers
Language	English
Publishing date	2023-05-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.3c00499
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Article: Circulating tumor DNA analysis for tumor diagnosis

Wang, Yi-Hui / Song, Zhen / Hu, Xin-Yuan / Wang, Huai-Song

Talanta. 2021 June 01, v. 228

2021

Abstract	Tumor is a kind of abnormal organism generated by the proliferation and differentiation of cells in the body under the action of various initiating and promoting factors, which seriously threatens human life and health. Tumorigenesis is a gradual process that involves multistage reactions and the accumulation of mutations. Gene mutation usually occurs during tumorigenesis, and can be used for tumor diagnosis. Early diagnosis is the most effective way to improve the cure rate and reduce the mortality rate. Among the peripheral blood circulating tumor DNA (ctDNA), gene mutation in keeping with tumor cells can be detected, which can potentially replace tumor tissue section for early diagnosis. It has been considered as a liquid biopsy marker with good clinical application prospect. However, the high fragmentation and low concentration of ctDNA in blood result in the difficulty of tumor stage determination. Therefore, high sensitive and specific mutation detection methods have been developed to detect trace mutant ctDNA. At present, the approaches include digital PCR (dPCR), Bead, Emulsion, Amplification and Magnetic (BEAMing), Next Generation Sequencing (NGS), Amplification Refractory Mutation System (ARMS), etc. In this paper, the principle, characteristics, latest progress and application prospects of these methods are reviewed, which will facilitate researchers to choose appropriate ctDNA detection approaches.
Keywords	DNA ; biopsy ; blood ; carcinogenesis ; early diagnosis ; emulsions ; genes ; humans ; magnetism ; mortality ; mutants ; mutation ; neoplasms
Language	English
Dates of publication	2021-0601
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2021.122220
Database	NAL-Catalogue (AGRICOLA)

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Article: Surface functionalized biomimetic bioreactors enable the targeted starvation-chemotherapy to glioma

Ke, Ruifang / Zhen, Xueyan / Wang, Huai-Song / Li, Linhao / Wang, Hongying / Wang, Sicen / Xie, Xiaoyu

Journal of colloid and interface science. 2022 Mar., v. 609

2022

Abstract: Altering the glucose supply and the metabolic pathways would be an intriguing strategy in starvation therapy toward cancers. Nevertheless, starvation therapy alone could be inadequate to eliminate tumor cells completely. Herein, a multifunctional ... ...

Abstract	Altering the glucose supply and the metabolic pathways would be an intriguing strategy in starvation therapy toward cancers. Nevertheless, starvation therapy alone could be inadequate to eliminate tumor cells completely. Herein, a multifunctional bioreactor was fabricated for synergistic starvation-chemotherapy through embedding glucose oxidase (GOx) and doxorubicin (DOX) in the tumor targeting ligands (RGD) modified red blood cell membrane camouflaged metal-organic framework (MOF) nanoparticle (denoted as RGD-mGZD). Owing to the remarkable biointerfacing property, the designed RGD-mGZD could not only possess enhanced blood retention time inherited from red blood cells, but also preferentially target the tumor site after the modification with RGD peptide. Once the bioreactor reached the desired region, GOx promptly consumed the intratumoral glucose and oxygen to starve cancer cells for robust starvation therapy. More importantly, the aggravated acidic microenvironment at the tumor region was found to induce the decomposition of the MOF structure, thus triggering the release of DOX for reinforced chemotherapy. This bioreactor would further prompt the development of synergistic patterns toward cancer treatment in a spatiotemporally controlled manner.
Keywords	biomimetics ; bioreactors ; cancer therapy ; coordination polymers ; doxorubicin ; drug therapy ; erythrocyte membrane ; glioma ; glucose ; glucose oxidase ; ligands ; oxygen ; peptides ; starvation
Language	English
Dates of publication	2022-03
Size	p. 307-319.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2021.12.009
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Lanthanide Complexes for Tumor Diagnosis and Therapy by Targeting Sialic Acid.

Wang, Jia-Li / Hu, Xin-Yuan / Han, Cheng-Gang / Hou, Shao-Yuan / Wang, Huai-Song / Zheng, Feng

ACS nano

2022 Volume 16, Issue 9, Page(s) 14827–14837

Abstract: Sialic acid (SA) is overexpressed on cell membranes of tumor cells, and increased serum SA concentration has been observed in tumor-bearing patients. Herein, a series of lanthanide-containing bimetallic complexes (TDA-M-Lns) for targeting SA were ... ...

Abstract	Sialic acid (SA) is overexpressed on cell membranes of tumor cells, and increased serum SA concentration has been observed in tumor-bearing patients. Herein, a series of lanthanide-containing bimetallic complexes (TDA-M-Lns) for targeting SA were prepared via coordination among luminescent lanthanide ions (Ln
MeSH term(s)	Animals ; Ions ; Lanthanoid Series Elements ; Ligands ; Luminescence ; Mice ; N-Acetylneuraminic Acid
Chemical Substances	Ions ; Lanthanoid Series Elements ; Ligands ; N-Acetylneuraminic Acid (GZP2782OP0)
Language	English
Publishing date	2022-08-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.2c05715
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Article ; Online: Emerging enantiomeric resolution materials with homochiral nano-fabrications.

Wang, Huai-Song / Wei, Ji-Ping

Nanoscale

2015 Volume 7, Issue 28, Page(s) 11815–11832

Abstract: The major scientific challenge of enantiomeric separation is to develop simple, rapid, and sensitive routine analytical methods. Generally, enantio-resolution is still based on "three-point interaction" theory, which indicates that homochiral sites are ... ...

Abstract	The major scientific challenge of enantiomeric separation is to develop simple, rapid, and sensitive routine analytical methods. Generally, enantio-resolution is still based on "three-point interaction" theory, which indicates that homochiral sites are needed for enantio-selective interaction. However, in recent years, advanced materials with precise homochiral fabrication at the nanoscale have been synthesized, and have shown great potential in development of high-throughput enantio-resolution methods. This tutorial review summarizes fabrication and applications of homochiral materials for enantio-selective recognition and separation. These materials, which include intrinsic and restructured chiral metal surfaces, plasmonic nanostructures, coordination polymers, organic polymer sensors, and molecularly imprinted polymers, have been applied as sensors or chiral stationary phases (CSPs) for efficient enantio-resolution.
Language	English
Publishing date	2015-07-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/c5nr03048j
Database	MEDical Literature Analysis and Retrieval System OnLINE

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