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Article ; Online: RAS-associated Autoimmune Leukoproliferative Disease (RALD-KRAS) Consistent with the Clinical Diagnosis of Rosai-Dorfman Disease: A 15-year Follow-up.

Tang, Yu / Wang, Huakun / Zhao, Hongjun / Jin, Shijie / Wu, Junjiao

2024 Volume 44, Issue 5, Page(s) 123

MeSH term(s)	Humans ; Histiocytosis, Sinus/diagnosis ; Follow-Up Studies ; Female ; Male ; Mutation/genetics ; Autoimmune Diseases/diagnosis
Language	English
Publishing date	2024-05-17
Publishing country	Netherlands
Document type	Letter ; Case Reports ; Journal Article
ZDB-ID	779361-3
ISSN	1573-2592 ; 0271-9142
ISSN (online)	1573-2592
ISSN	0271-9142
DOI	10.1007/s10875-024-01728-3
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Article: Characterization of the circRNA Landscape in Interleukin-4 Induced Anti-Inflammatory Microglia.

Li, Chaoyi / Wang, Huakun / Tang, Yu / Wu, Junjiao

Biomedicines

2023 Volume 11, Issue 12

Abstract: Microglia are resident innate immune cells that play an essential role in the development and surveillance of the central nervous system as well as the shared pathogenesis of neurodegenerative diseases. Microglia rapidly respond to multiple inflammatory ... ...

Abstract	Microglia are resident innate immune cells that play an essential role in the development and surveillance of the central nervous system as well as the shared pathogenesis of neurodegenerative diseases. Microglia rapidly respond to multiple inflammatory stimuli and activate towards different phenotypes, such as pro-inflammatory and anti-inflammatory phenotypes. Cytokines, epigenetic and long non-coding RNA modulations have been shown to regulate microglial activation; however, the role of circRNAs in microglia-mediated neuroinflammation remains elusive. Here, we performed circRNA sequencing in IL-4-treated anti-inflammatory microglia and discovered 120 differentially expressed circRNAs. We systemically verified the identities of circRNAs by assays of PCR, RNase R treatment and fluorescent in situ hybridization (FISH), among others. We found that circAdgre1 promoted IL-4-induced anti-inflammatory responses and further conferred neuroprotective effects upon lipopolysaccharide (LPS) stimuli. Taken together, our results show that circRNAs might be possible therapeutic targets for microglia-mediated neuroinflammation and neurodegenerative diseases.
Language	English
Publishing date	2023-12-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11123239
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Article ; Online: Identification and characterization of novel genetic variants in the first Chinese family of mucopolysaccharidosis IIIC (Sanfilippo C syndrome).

Zhao, Hongjun / Wang, Lijing / Zhang, Mengfei / Wang, Huakun / Zhang, Sizhe / Wu, Junjiao / Tang, Yu

Journal of cellular and molecular medicine

2024 Volume 28, Issue 8, Page(s) e18307

Abstract: Mucopolysaccharidosis type IIIC (MPS IIIC) is one of inherited lysosomal storage disorders, caused by deficiencies in lysosomal hydrolases degrading acidic mucopolysaccharides. The gene responsible for MPS IIIC is HGSNAT, which encodes an enzyme that ... ...

Abstract	Mucopolysaccharidosis type IIIC (MPS IIIC) is one of inherited lysosomal storage disorders, caused by deficiencies in lysosomal hydrolases degrading acidic mucopolysaccharides. The gene responsible for MPS IIIC is HGSNAT, which encodes an enzyme that catalyses the acetylation of the terminal glucosamine residues of heparan sulfate. So far, few studies have focused on the genetic landscape of MPS IIIC in China, where IIIA and IIIB were the major subtypes. In this study, we utilized whole-exome sequencing (WES) to identify novel compound heterozygous variants in the HGSNAT gene from a Chinese patient with typical MPS IIIC symptoms: c.743G>A; p.Gly248Glu and c.1030C>T; p.Arg344Cys. We performed in silico analysis and experimental validation, which confirmed the deleterious pathogenic nature of both variants, as evidenced by the loss of HGSNAT activity and failure of lysosomal localization. To the best of our knowledge, the MPS IIIC is first confirmed by clinical, biochemical and molecular genetic findings in China. Our study thus expands the spectrum of MPS IIIC pathogenic variants, which is of importance to dissect the pathogenesis and to carry out clinical diagnosis of MPS IIIC. Moreover, this study helps to depict the natural history of Chinese MPS IIIC populations.
MeSH term(s)	Humans ; Mucopolysaccharidosis III/genetics ; Mucopolysaccharidoses/genetics ; Asian People/genetics ; Acetylation ; China ; Acetyltransferases
Chemical Substances	HGSNAT protein, human (EC 2.3.1.78) ; Acetyltransferases (EC 2.3.1.-)
Language	English
Publishing date	2024-04-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2074559-X
ISSN	1582-4934 ; 1582-4934 ; 1582-1838
ISSN (online)	1582-4934
ISSN	1582-4934 ; 1582-1838
DOI	10.1111/jcmm.18307
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Article ; Online: Citrulline inhibits LPS-induced pyroptosis of RAW264.7 macrophages through NF-κB signaling pathway.

Yin, Li / Wei, Xiaomin / Zhang, Yanjun / Lu, Chengshu / Wang, Huakun

Immunity, inflammation and disease

2023 Volume 11, Issue 4, Page(s) e832

Abstract: Background: The aim of this study was to investigate the effect of citrulline on the pyroptosis of mouse macrophage RAW264.7 and the mechanism. We investigated the effect of citrulline on pyroptosis of RAW264.7 cell induced by lipopolysaccharide (LPS), ... ...

Abstract	Background: The aim of this study was to investigate the effect of citrulline on the pyroptosis of mouse macrophage RAW264.7 and the mechanism. We investigated the effect of citrulline on pyroptosis of RAW264.7 cell induced by lipopolysaccharide (LPS), and the modulation of nuclear factor-kappaB (NF-κB) signaling. Methods: Pyroptosis was evaluated using flow cytometry and caspase-1/sytox double staining. Cell counting kit-8 assay was performed to evaluate cell viability. Results: Citrulline promoted cell viability and inhibited the pyroptosis of RAW264.7 cell stimulated by LPS. Furthermore, citrulline inactivated NF-κb/p65 signaling pathway by suppressing p65 nuclear translocation induced by LPS. An NF-κb signaling pathway activator, betulinic acid, reversed the inhibition of pyroptosis induced by citrulline. Conclusion: Citrulline inhibited LPS-induced pyrophosis, which may be closely related to the inactivation of NF-κB/p65 signaling pathway.
MeSH term(s)	Animals ; Mice ; Citrulline/pharmacology ; Lipopolysaccharides/toxicity ; Macrophages/metabolism ; NF-kappa B/metabolism ; Pyroptosis ; Signal Transduction
Chemical Substances	Citrulline (29VT07BGDA) ; Lipopolysaccharides ; NF-kappa B
Language	English
Publishing date	2023-05-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2740382-8
ISSN	2050-4527 ; 2050-4527
ISSN (online)	2050-4527
ISSN	2050-4527
DOI	10.1002/iid3.832
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Article ; Online: Bioinspired Jumping Soft Actuators of the Liquid Crystal Elastomer Enabled by Photo-Mechanical Coupling.

Lei, Bing / Wen, Zhi-Yuan / Wang, Hua-Kun / Gao, Jing / Chen, Lu-Jian

ACS applied materials & interfaces

2023 Volume 16, Issue 1, Page(s) 1596–1604

Abstract: Jumping, a fundamental survival behavior observed in organisms, serves as a vital mechanism for adapting to the surrounding environment and overcoming significant obstacles within a given terrain. Here, we present a light-controlled soft jumping actuator ...

Abstract	Jumping, a fundamental survival behavior observed in organisms, serves as a vital mechanism for adapting to the surrounding environment and overcoming significant obstacles within a given terrain. Here, we present a light-controlled soft jumping actuator inspired by asphondylia, which employs a closed-loop structure and utilizes a liquid crystal elastomer (LCE). Photo-mechanical coupling highlights the significant influence of the light source on the actuator's jumping behavior. Manipulating the light intensity, the relative position of stimulus and light lock, and the concentration of disperse red 1 (DR1) allows precise control over both the maximum take-off velocity and jump height. Furthermore, tailoring the size of the LCE actuator offers a means of regulating jumping behavior. Upon exposure to 460 nm LED irradiation, our actuator achieves remarkable performance, with a maximum jumping height of 10 body length (BL) and take-off velocity of 62 BL/s. These actuators accumulate and rapidly release energy, enabling the effective transportation of microcargos across substantial distances. Our research yields valuable insights into the realm of soft robotics, underscoring the pivotal importance of photo-mechanical coupling in the field of soft robotics, thereby serving as a catalyst for inspiring continued exploration of agile and capable systems by prestoring elastic energy.
Language	English
Publishing date	2023-12-28
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c16530
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Article: Self-compatibility of ‘Zaohuang’ loquat is attributed to the lack of a 52 bp fragment in the S10-RNase promoter

Wu, Chao / Zhang, Ying / Wang, Huakun / Yan, Mengyao / Wang, Sanhong

Scientia horticulturae. 2022 July 27, v. 301

2022

Abstract: Loquat (Eriobotrya japonica Lindl.) is a typical gametophytic self-incompatible (GSI) subtropical evergreen fruit tree, but there are also some self-compatible varieties. In this study, the fruit set rate of ‘Zaohuang (S²S¹⁰)’ and ‘Baiyu (S²S¹⁰)’ loquats ...

Abstract	Loquat (Eriobotrya japonica Lindl.) is a typical gametophytic self-incompatible (GSI) subtropical evergreen fruit tree, but there are also some self-compatible varieties. In this study, the fruit set rate of ‘Zaohuang (S²S¹⁰)’ and ‘Baiyu (S²S¹⁰)’ loquats were investigated after self-pollination and cross-pollination, respectively. The analysis demonstrated that ‘Zaohuang’ (‘ZH’) was self-compatible (SC) and ‘Baiyu’ (‘BY’) was self-incompatible (SI), while they were cross-compatible. The expression levels of S-RNase in the pistils of ‘ZH’ and ‘BY’ were analyzed by qPCR, indicating that the expression of S²-RNase was similar in the two cultivars, but the expression of S¹⁰-RNase in the pistils of ‘ZH’ was significantly lower than that in ‘BY’. In addition, cloning of the full-length open reading frame (ORF) sequence and promoter of S¹⁰-RNase in ‘ZH’ and ‘BY’ by TAIL-PCR showed that the full-length ORF sequence of S¹⁰-RNase was completely consistent in two loquat cultivars. However, the promoter of S¹⁰-RNase in ‘ZH’ (ZH-S¹⁰-RNase-P) lacks 52 bp fragment comparing with that in ‘BY’ (BY-S¹⁰-RNase-P). The deletion fragment was located at 1755 bp upstream to the start code ATG of S¹⁰-RNase, containing a TGACG-motif and a CGTCA-motif. To detect the activities of ZH-S¹⁰-RNase-P and BY-S¹⁰-RNase-P, we constructed ZH-S¹⁰-RNase-P::GFP and BY-S¹⁰-RNase-P::GFP plasmids and introduced them into tobacco pistils by transient expression method. The fluorescence of GFP was much lower in ZH-S¹⁰-RNase-P::GFP transformed tobacco pistils than that in BY-S¹⁰-RNase-P::GFP transformed pistils. These results indicated that the 52 bp deletion in the promoter of S¹⁰-RNase results in reducing the expression of S¹⁰-RNase and eventually leads to self-compatibility of ‘ZH’ loquat. Our research provided a new direction for screening loquat SC varieties with S¹⁰-RNase promoter.
Keywords	Eriobotrya japonica ; cross pollination ; cultivars ; fluorescence ; fruit set ; fruit trees ; gametophytes ; loquats ; pistil ; plasmids ; ribonucleases ; self-pollination ; tobacco
Language	English
Dates of publication	2022-0727
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	185557-8
ISSN	0304-4238
ISSN	0304-4238
DOI	10.1016/j.scienta.2022.111093
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The heterogeneity of microglial activation and its epigenetic and non-coding RNA regulations in the immunopathogenesis of neurodegenerative diseases

Li, Chaoyi / Ren, Jie / Zhang, Mengfei / Wang, Huakun / Yi, Fang / Wu, Junjiao / Tang, Yu

Cell. Mol. Life Sci.. 2022 Oct., v. 79, no. 10 p.511-511

2022

Abstract: Microglia are resident immune cells in the brain and play a central role in the development and surveillance of the nervous system. Extensive gliosis is a common pathological feature of several neurodegenerative diseases, such as Alzheimer's disease (AD), ...

Abstract	Microglia are resident immune cells in the brain and play a central role in the development and surveillance of the nervous system. Extensive gliosis is a common pathological feature of several neurodegenerative diseases, such as Alzheimer's disease (AD), the most common cause of dementia. Microglia can respond to multiple inflammatory insults and later transform into different phenotypes, such as pro- and anti-inflammatory phenotypes, thereby exerting different functions. In recent years, an increasing number of studies based on both traditional bulk sequencing and novel single-cell/nuclear sequencing and multi-omics analysis, have shown that microglial phenotypes are highly heterogeneous and dynamic, depending on the severity and stage of the disease as well as the particular inflammatory milieu. Thus, redirecting microglial activation to beneficial and neuroprotective phenotypes promises to halt the progression of neurodegenerative diseases. To this end, an increasing number of studies have focused on unraveling heterogeneous microglial phenotypes and their underlying molecular mechanisms, including those due to epigenetic and non-coding RNA modulations. In this review, we summarize the epigenetic mechanisms in the form of DNA and histone modifications, as well as the general non-coding RNA regulations that modulate microglial activation during immunopathogenesis of neurodegenerative diseases and discuss promising research approaches in the microglial era.
Keywords	Alzheimer disease ; DNA ; brain ; epigenetics ; histones ; monitoring ; multiomics ; neuroglia ; non-coding RNA
Language	English
Dates of publication	2022-10
Size	p. 511.
Publishing place	Springer International Publishing
Document type	Article ; Online
Note	Review
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-022-04536-3
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Article: Mitigating CO2 emission in pulverized coal-fired power plant via co-firing ammonia: A simulation study of flue gas streams and exergy efficiency

Xu, Yishu / Wang, Huakun / Liu, Xiaowei / Zhu, Jingji / Xu, Jingying / Xu, Minghou

Energy conversion and management. 2022 Mar. 15, v. 256

2022

Abstract: Coal-fired power plants are one of the major sources of CO₂ emission, and the novel application of directly co-firing the carbon-free fuel ammonia into the coal-fired power plants is emerging as a promising method of CO₂ emission reduction. In this study, ...

Abstract	Coal-fired power plants are one of the major sources of CO₂ emission, and the novel application of directly co-firing the carbon-free fuel ammonia into the coal-fired power plants is emerging as a promising method of CO₂ emission reduction. In this study, simulations of the boiler system of a 600 MWₑ coal-fired power plant unit were performed in both coal-fired condition and ammonia-coal co-firing conditions, and the impacts of ammonia co-firing on the emission and thermal properties of flue gas, exergy loss, and exergy efficiency were analyzed. Two co-firing scenarios (identical adiabatic flame temperature scenario and identical excess air coefficient scenario) were compared, both assuming that the total heating value of the fuel into the furnace kept unchanged with different ammonia co-firing ratios (5%, 10%, 15%, 20% on heating value basis). The results showed that CO₂ emission was effectively reduced by 24.08 t/h for every 5% increase in the ammonia co-firing ratio. The amount of total flue gas was also reduced while both the content and the emission rate of H₂O were increased with ammonia co-firing. Consequently, the specific heat capacity of flue gas increased and further changed its temperature distribution profile. Compared with the coal-fired base case, the exergy loss in the furnace under the ammonia co-firing conditions increased continuously as the ammonia co-firing ratio increased, suggesting that the irreversible loss of the ammonia combustion process was greater than that of coal. By contrast, the exergy loss of heat exchangers and fans decreased in ammonia co-firing conditions. Finally, the exergy efficiency of the boiler system was only slightly reduced (53.82% vs. 53.27%–53.22%) in ammonia co-firing conditions, showing that co-firing ammonia in coal-fired power plant would not significantly deteriorate the thermal economy.
Keywords	administrative management ; air ; ammonia ; carbon dioxide ; coal ; combustion ; exergy ; flue gas ; furnaces ; heat ; power plants ; specific heat ; temperature
Language	English
Dates of publication	2022-0315
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2000891-0
ISSN	0196-8904
ISSN	0196-8904
DOI	10.1016/j.enconman.2022.115328
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Article: Using artificial neural network in predicting the key fruit quality of loquat.

Huang, Xiao / Wang, Huakun / Qu, Shenchun / Luo, Wenjie / Gao, Zhihong

Food science & nutrition

2021 Volume 9, Issue 3, Page(s) 1780–1791

Abstract: The formation and regulation of loquat fruit quality have always been an important research field to improve fruit quality, commodities, and market value. Fruit size, soluble solids content, and titratable acid content represent the most important ... ...

Abstract	The formation and regulation of loquat fruit quality have always been an important research field to improve fruit quality, commodities, and market value. Fruit size, soluble solids content, and titratable acid content represent the most important quality factors in loquat. Mineral nutrients in abundance or deficiency are among the most important key factor that affect fruit quality. In the present study, we use artificial neural network (ANN) to explore the effects of mineral nutrients in soil and leaves on the key fruit quality of loquat. The results show that the ANN model with the structure of 12-12-1 can predict the single fruit weight with the highest accuracy (
Language	English
Publishing date	2021-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703010-6
ISSN	2048-7177
ISSN	2048-7177
DOI	10.1002/fsn3.2166
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Article: The Double-Faceted Role of Leucine-Rich Repeat Kinase 2 in the Immunopathogenesis of Parkinson's Disease.

Zhang, Mengfei / Li, Chaoyi / Ren, Jie / Wang, Huakun / Yi, Fang / Wu, Junjiao / Tang, Yu

Frontiers in aging neuroscience

2022 Volume 14, Page(s) 909303

Abstract: Leucine-rich repeat kinase ... ...

Abstract	Leucine-rich repeat kinase 2
Language	English
Publishing date	2022-05-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2022.909303
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