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Article ; Online: Tumor-associated myeloid cells in cancer immunotherapy.

Cheng, Xinyu / Wang, Huilan / Wang, Zhongyu / Zhu, Bo / Long, Haixia

2023 Volume 16, Issue 1, Page(s) 71

Abstract: Tumor-associated myeloid cells (TAMCs) are among the most important immune cell populations in the tumor microenvironment, and play a significant role on the efficacy of immune checkpoint blockade. Understanding the origin of TAMCs was found to be the ... ...

Abstract	Tumor-associated myeloid cells (TAMCs) are among the most important immune cell populations in the tumor microenvironment, and play a significant role on the efficacy of immune checkpoint blockade. Understanding the origin of TAMCs was found to be the essential to determining their functional heterogeneity and, developing cancer immunotherapy strategies. While myeloid-biased differentiation in the bone marrow has been traditionally considered as the primary source of TAMCs, the abnormal differentiation of splenic hematopoietic stem and progenitor cells, erythroid progenitor cells, and B precursor cells in the spleen, as well as embryo-derived TAMCs, have been depicted as important origins of TAMCs. This review article provides an overview of the literature with a focus on the recent research progress evaluating the heterogeneity of TAMCs origins. Moreover, this review summarizes the major therapeutic strategies targeting TAMCs with heterogeneous sources, shedding light on their implications for cancer antitumor immunotherapies.
MeSH term(s)	Humans ; Neoplasms ; Myeloid Cells ; Immunotherapy ; Bone Marrow/pathology ; Hematopoietic Stem Cells ; Tumor Microenvironment
Language	English
Publishing date	2023-07-06
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2429631-4
ISSN	1756-8722 ; 1756-8722
ISSN (online)	1756-8722
ISSN	1756-8722
DOI	10.1186/s13045-023-01473-x
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Article ; Online: MicroRNA-423-5p Mediates Cocaine-Induced Smooth Muscle Cell Contraction by Targeting Cacna2d2.

Dykxhoorn, Derek M / Wang, Huilan / Da Fonseca Ferreira, Andrea / Wei, Jianqin / Dong, Chunming

International journal of molecular sciences

2023 Volume 24, Issue 7

Abstract: Cocaine abuse increases the risk of atherosclerotic cardiovascular disease (CVD) and causes acute coronary syndromes (ACS) and hypertension (HTN). Significant research has explored the role of the sympathetic nervous system mediating the cocaine effects ... ...

Abstract	Cocaine abuse increases the risk of atherosclerotic cardiovascular disease (CVD) and causes acute coronary syndromes (ACS) and hypertension (HTN). Significant research has explored the role of the sympathetic nervous system mediating the cocaine effects on the cardiovascular (CV) system. However, the response of the sympathetic nervous system alone is insufficient to completely account for the CV consequences seen in cocaine users. In this study, we examined the role of microRNAs (miRNAs) in mediating the effect of cocaine on the CV system. MiRNAs regulate many important biological processes and have been associated with both response to cocaine and CV disease development. Multiple miRNAs have altered expression in the CV system (CVS) upon cocaine exposure. To understand the molecular mechanisms underlying the cocaine response in the CV system, we studied the role of miRNA-423-5p and its target Cacna2d2 in the regulation of intracellular calcium concentration and SMC contractility, a critical factor in the modulation of blood pressure (BP). We used in vivo models to evaluate BP and aortic stiffness. In vitro, cocaine treatment decreased miR-423-5p expression and increased Cacna2d2 expression, which led to elevated intracellular calcium concentrations and increased SMC contractility. Overexpression of miR-423-5p, silencing of its target Cacna2d2, and treatment with a calcium channel blocker reversed the elevated SMC contractility caused by cocaine. In contrast, suppression of miR-423-5p increased the intracellular calcium concentration and SMC contractibility. In vivo, smooth muscle-specific overexpression of miR-423-5p ameliorated the increase in BP and aortic stiffness associated with cocaine use. Thus, miR-423-5p regulates SMC contraction by modulating Cacna2d2 expression increasing intracellular calcium concentrations. Modulation of the miR-423-5p-Cacna2d2-Calcium transport pathway may represent a novel therapeutic strategy to improve cocaine-induced HTN and aortic stiffness.
MeSH term(s)	Humans ; Cocaine/adverse effects ; Cocaine/metabolism ; Calcium/metabolism ; MicroRNAs/metabolism ; Atherosclerosis/metabolism ; Cocaine-Related Disorders/metabolism ; Myocytes, Smooth Muscle/metabolism ; Cell Proliferation ; Calcium Channels/metabolism
Chemical Substances	Cocaine (I5Y540LHVR) ; Calcium (SY7Q814VUP) ; MicroRNAs ; CACNA2D2 protein, human ; Calcium Channels ; MIRN423 microRNA, human
Language	English
Publishing date	2023-04-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24076584
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Article ; Online: The state-dependent impulsive control for a general predator-prey model.

Zhu, Xiaoxiao / Wang, Huilan / Ouyang, Zigen

Journal of biological dynamics

2021 Volume 16, Issue 1, Page(s) 354–372

Abstract: In this paper, a general predator-prey model with state-dependent impulse is considered. Based on the geometric analysis and Poincaré map or successor function, we construct three typical types of Bendixson domains to obtain some sufficient conditions ... ...

Abstract	In this paper, a general predator-prey model with state-dependent impulse is considered. Based on the geometric analysis and Poincaré map or successor function, we construct three typical types of Bendixson domains to obtain some sufficient conditions for the existence of order-1 periodic solutions. At the same time, the existing domains are discussed with respect to the system parameters. Moreover, the Analogue of Poincaré Criterion is used to obtain the asymptotic stability of the periodic solutions. Finally, to illustrate the results, an example is presented and some numerical simulations are carried out.
MeSH term(s)	Animals ; Models, Biological ; Population Dynamics ; Predatory Behavior
Language	English
Publishing date	2021-06-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2274786-2
ISSN	1751-3766 ; 1751-3758
ISSN (online)	1751-3766
ISSN	1751-3758
DOI	10.1080/17513758.2021.1937721
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Article ; Online: Subsequent strategies and underlying mechanism of acquired resistance to PD-1 axis inhibitors in advanced non-small cell lung cancer.

Wang, Huilan / Cheng, Xinyu / Yang, Fan / Chen, Lu / Zhang, Anmei / Zhong, Liangzhi / Long, Haixia / Zhu, Bo / Wang, Zhongyu

Chinese medical journal

2024 Volume 137, Issue 7, Page(s) 880–882

MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/drug therapy ; Programmed Cell Death 1 Receptor ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Drug Resistance, Neoplasm ; B7-H1 Antigen ; Protein Kinase Inhibitors/therapeutic use
Chemical Substances	Programmed Cell Death 1 Receptor ; Immune Checkpoint Inhibitors ; B7-H1 Antigen ; Protein Kinase Inhibitors
Language	English
Publishing date	2024-03-15
Publishing country	China
Document type	Journal Article
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000003015
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Zs.B 1207: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Relevance of small right-to-left shunt in contrast-enhanced transcranial Doppler in young and middle-aged patients with cryptogenic stroke: a report of two cases and literature review.

Cao, Liming / Huang, Xuming / Wang, Huilan

The International journal of neuroscience

2021 Volume 132, Issue 11, Page(s) 1118–1122

Abstract: Aim: The clinical relevance of small right-to-left shunt (RLS) in young patients with cryptogenic stroke is unknown. We aimed to analyze and understand the relationship between cryptogenic stroke and small RLS by studying specific cases.: Materials ... ...

Abstract	Aim: The clinical relevance of small right-to-left shunt (RLS) in young patients with cryptogenic stroke is unknown. We aimed to analyze and understand the relationship between cryptogenic stroke and small RLS by studying specific cases. Materials and methods: Clinical data from two cases of small RLS-related cryptogenic stroke in young patients were collected prospectively and analyzed. We followed up the patients for >1 year after discharge. Results: Case 1 Conclusion: We suspected that a small RLS may cause cryptogenic stroke. A small RLS in c-TCD in stroke patients may not be actually small, and c-TEE/c-TTE may be valuable in finding larger RLSs.
MeSH term(s)	Humans ; Middle Aged ; Male ; Hemiplegia/complications ; Ultrasonography, Doppler, Transcranial ; Foramen Ovale, Patent/complications ; Foramen Ovale, Patent/diagnostic imaging ; Brain Ischemia/complications ; Stroke/complications ; Stroke/diagnostic imaging ; Ischemic Stroke ; Cerebral Infarction/complications
Language	English
Publishing date	2021-01-05
Publishing country	England
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	3061-2
ISSN	1563-5279 ; 1543-5245 ; 0020-7454
ISSN (online)	1563-5279 ; 1543-5245
ISSN	0020-7454
DOI	10.1080/00207454.2020.1865345
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Zs.A 657: Show issues

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Article ; Online: Analysis of Macular Microperimetry Characteristics in Non-Arteritic Anterior Ischemic Optic Neuropathy.

Gong, Hongxia / Wang, Huilan / Zhou, Nan

Medical science monitor : international medical journal of experimental and clinical research

2020 Volume 26, Page(s) e928274

Abstract: BACKGROUND The aim of this study was to analyze the correlation of macular micro-field characteristics with vision and visual field in patients with non-arteritic anterior ischemic optic neuropathy. MATERIAL AND METHODS Retrospective case analysis was ... ...

Abstract	BACKGROUND The aim of this study was to analyze the correlation of macular micro-field characteristics with vision and visual field in patients with non-arteritic anterior ischemic optic neuropathy. MATERIAL AND METHODS Retrospective case analysis was performed. Fifty-eight NAION patients with 62 affected eyes were included in the study. In addition, 54 eyes not affected by NAION from 54 patients among the 58 patients were included as controls. All eyes underwent best corrected visual acuity (BCVA) test, slit lamp biomicroscopy, indirect ophthalmoscopy, visual field examination, and microperimetry. BCVA was converted into logarithm of minimum angle of resolution (LogMAR) for statistical analysis. There was no significant difference in age, sex, eye type, or intraocular pressure between the 2 groups. The macular integrity assessment (MAIA) instrument was used for microperimetry. Mean light sensitivity (microMS) in the 10° macular region and the fixation rates for macular fovea 2° and 4° were recorded. Spearman correlation analysis was performed. RESULTS The microMS values were significantly different between the control group and the affected eye group (t=-2.427, P=0.036). MicroMS was significantly correlated with logMAR BCVA (r=-0.802, P=-0.005) and with mean sensitivity (MS) and mean deviation (MD) (r=0.912, P=0.002; r=-0.905, P=0.002; P<0.05). MS and MD were not correlated with logMAR BCVA (r=-0.465, P=0.245; r=0.437, P=0.278). CONCLUSIONS The present study demonstrates that microMS of macular micro-visual field in NAION patients was significantly decreased at early stage, and was significantly correlated with and consistent with visual acuity and visual field.
MeSH term(s)	Female ; Humans ; Macula Lutea/diagnostic imaging ; Male ; Middle Aged ; Optic Neuropathy, Ischemic/diagnostic imaging ; Optic Neuropathy, Ischemic/physiopathology ; Visual Acuity ; Visual Field Tests ; Visual Fields
Language	English
Publishing date	2020-11-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.928274
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Zs.A 4924: Show issues

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Article ; Online: The expression of platelet-derived growth factor, epidermal growth factor, and insulin-like growth factor-II in patients with polycystic ovary syndrome and its correlation with pregnancy outcomes.

Gao, Jiefan / Song, Yangyang / Huang, Xiao / Wang, Donghui / Wang, Huilan

Annals of palliative medicine

2021 Volume 10, Issue 5, Page(s) 5671–5678

Abstract: Background: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder with complex pathogenesis. This study aimed to analyze the expression of platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and insulin-like ... ...

Abstract	Background: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder with complex pathogenesis. This study aimed to analyze the expression of platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and insulin-like growth factor-II (IGF-II) in patients with PCOS and its correlation with pregnancy outcomes. Methods: A total of 104 PCOS patients admitted to the Cangzhou Central Hospital from January 2015 to February 2018 were selected as the PCOS group, and 92 healthy pregnant women who received health examinations in the hospital during the same period were selected as the control group. Levels of PDGF, EGF, and IGF-II in serum were detected. The expression of PDGF, EGF, and IGF-II in different populations were compared. Age at pregnancy, body mass index (BMI), waist-to-hip ratio before pregnancy, parity, family history of hypertension, family history of diabetes, and serological indicators of pregnant women in the PCOS group were collected, such as follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), fasting insulin (INS), and free testosterone index (FTI). Multivariate logistic regression was used to analyze the risk factors that affect the pregnancy outcomes of PCOS patients. Results: The expression levels of PDGF, EGF, and IGF-II in the PCOS group were significantly higher than those in the control group (P<0.05). Among 76 pregnant PCOS patients, 34 cases had adverse pregnancy outcomes and 42 did not. Age at pregnancy, BMI before pregnancy, waist-to-hip ratio before pregnancy, LH, INS, FTI, PDGF, EGF, and IGF-II expression levels were positively correlated with the pregnancy outcome of PCOS patients (P<0.05). The BMI before pregnancy, waist-to-hip ratio before pregnancy, INS, FTI, and expression levels of PDGF, EGF, and IGF-II were revealed as independent risk factors that affect the pregnancy outcomes of PCOS patients (P<0.05). Conclusions: The expression levels of PDGF, EGF, and IGF-II are high in PCOS patients. The BMI, waist-to-hip ratio before pregnancy, INS, FTI, and the expression levels of PDGF, EGF, IGF-II are independent risk factors that affect the pregnancy outcomes of PCOS patients. Corresponding measures should be actively taken for PCOS patients with high-risk factors to improve both maternal and infant outcomes.
MeSH term(s)	Epidermal Growth Factor ; Female ; Humans ; Insulin-Like Growth Factor II ; Platelet-Derived Growth Factor ; Polycystic Ovary Syndrome ; Pregnancy ; Pregnancy Outcome
Chemical Substances	Platelet-Derived Growth Factor ; Epidermal Growth Factor (62229-50-9) ; Insulin-Like Growth Factor II (67763-97-7)
Language	English
Publishing date	2021-06-09
Publishing country	China
Document type	Journal Article
ZDB-ID	2828544-X
ISSN	2224-5839 ; 2224-5839
ISSN (online)	2224-5839
ISSN	2224-5839
DOI	10.21037/apm-21-1003
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Article ; Online: Associations Between Poor Oral Hygiene and Risk of Pancreatic Cancer: A Meta-analysis of Observational Studies.

Xu, Shuai / Wang, Hui-Lan / Xia, Chao / Lv, Jun / Zhang, Gang

Pancreas

2022 Volume 51, Issue 8, Page(s) 985–994

Abstract: Objectives: Epidemiological studies have reported the association of poor oral hygiene, especially periodontal disease, and tooth loss with the risk of pancreatic cancer (PC). However, these studies have yielded inconsistent results. Therefore, this ... ...

Abstract	Objectives: Epidemiological studies have reported the association of poor oral hygiene, especially periodontal disease, and tooth loss with the risk of pancreatic cancer (PC). However, these studies have yielded inconsistent results. Therefore, this systematic review and meta-analysis aimed to investigate the relationship between oral disease and PC. Methods: We systematically searched the PubMed, Embase, and Cochrane Library databases for English literature since inception through May 2021. We used relative risks, hazard ratios, or odds ratios to measure the association between oral disease and PC. A fixed- or random-effects model was applied to evaluate pooled risk estimates, and sensitivity and subgroup analyses were performed to identify sources of heterogeneity and pooled estimation. Results: We identified 17 relevant observational studies involving 1,352,256 participants. Notably, oral disease correlated significantly with PC (hazard ratio [HR], 1.32; 95% confidence interval [CI], 1.13-1.54). In subgroup analyses, subjects with periodontal disease (HR, 1.38; 95% CI, 1.12-1.71) had a higher risk of developing PC than those with tooth loss (HR, 1.19; 95% CI, 0.97-1.46). Conclusions: The results suggest that subjects with oral disease may face a significant and independent risk of PC. However, the mechanisms linking oral disease and PC are uncertain, and additional investigations of this correlation are warranted.
MeSH term(s)	Humans ; Tooth Loss/epidemiology ; Oral Hygiene ; Periodontal Diseases/complications ; Periodontal Diseases/epidemiology ; Pancreatic Neoplasms/epidemiology ; Pancreatic Neoplasms
Language	English
Publishing date	2022-11-04
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632831-3
ISSN	1536-4828 ; 0885-3177
ISSN (online)	1536-4828
ISSN	0885-3177
DOI	10.1097/MPA.0000000000002143
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Zs.A 2160: Show issues

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Article: Curcumin Alleviates Hyperandrogenism and Promotes Follicular Proliferation in Polycystic Ovary Syndrome Rats: Insights on IRS1/PI3K/GLUT4 and PTEN Modulations.

Zheng, Luo / Chen, Pei-Fang / Dai, Wei-Chao / Zheng, Zhi-Qun / Wang, Hui-Lan

Chinese journal of integrative medicine

2022 Volume 28, Issue 12, Page(s) 1088–1095

Abstract: Objective: To explore the effect of curcumin on the insulin receptor substrate 1 (IRS1)/phosphatidylinositol-3-kinase (PI3K)/endometrial expression of glucose 4 (GLUT4) signalling pathway and its regulator, phosphatase and tensin homolog (PTEN), in a ... ...

Abstract	Objective: To explore the effect of curcumin on the insulin receptor substrate 1 (IRS1)/phosphatidylinositol-3-kinase (PI3K)/endometrial expression of glucose 4 (GLUT4) signalling pathway and its regulator, phosphatase and tensin homolog (PTEN), in a rat model of polycystic ovarian syndrome (PCOS). Methods: PCOS model was induced by letrozole intragastric administration. Sprague-Dawley rats were randomized into 4 groups according to a random number table: (1) control group; (2) PCOS group, which was subjected to PCOS and received vehicle; (3) curcumin group, which was subjected to PCOS and treated with curcumin (200 mg/kg for 2 weeks); and (4) curcumin+LY294002 group, which was subjected to PCOS, and treated with curcumin and LY294002 (a specific PI3K inhibitor). Serum hormone levels (17 β-estradiol, follicle stimulating hormone, luteinizing hormone, progesterone, and testosterone) were measured by enzyme linked immunosorbent assay, and insulin resistance (IR) was assessed using the homeostasis model assessment of IR. Ovarian tissues were stained with haematoxylin and eosin for pathological and apoptosis examination. Expression levels of key transcriptional regulators and downstream targets, including IRS1, PI3K, protein kinase B (AKT), GLUT4, and PTEN, were measured via reverse transcription polymerase chain reaction and Western blot, respectively. Results: The PCOS group showed impaired ovarian morphology and function. Compared with the PCOS group, curcumin treatment exerted ovarioprotective effects, down-regulated serum testosterone, restored IR, inhibited inflammatory cell infiltration in ovarian tissues, decreased IRS1, PI3K, and AKT expressions, and up-regulated GLUT4 and PTEN expressions in PCOS rats (P<0.05 or P<0.01). In contrast, IRS1, PI3K, AKT, and PTEN expression levels were not significantly different between PCOS and curcumin+LY294002 groups (P>0.05). Conclusion: The beneficial effects of curcumin on PCOS rats included the alteration of serum hormone levels and recovery of morphological ovarian lesions, in which, PTEN, a new target, may play a role in regulating the IRS1/PI3K/GLUT4 pathway.
MeSH term(s)	Animals ; Female ; Rats ; Cell Proliferation ; Curcumin/pharmacology ; Curcumin/therapeutic use ; Follicle Stimulating Hormone ; Glucose ; Hyperandrogenism ; Insulin Receptor Substrate Proteins/metabolism ; Insulin Resistance ; Ovarian Cysts ; Ovarian Neoplasms ; Phosphatidylinositol 3-Kinase/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Polycystic Ovary Syndrome/drug therapy ; Proto-Oncogene Proteins c-akt/metabolism ; Rats, Sprague-Dawley ; Testosterone
Chemical Substances	Curcumin (IT942ZTH98) ; Follicle Stimulating Hormone (9002-68-0) ; Glucose (IY9XDZ35W2) ; Insulin Receptor Substrate Proteins ; Irs1 protein, rat ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Pten protein, rat (EC 3.1.3.67) ; Testosterone (3XMK78S47O)
Language	English
Publishing date	2022-10-15
Publishing country	China
Document type	Journal Article
ZDB-ID	2171254-2
ISSN	1993-0402 ; 1672-0415
ISSN (online)	1993-0402
ISSN	1672-0415
DOI	10.1007/s11655-022-3582-z
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Zs.A 5823: Show issues

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Article: Disruption of Aokap6 near the kojic acid gene cluster affects the growth and kojic acid production in Aspergillus oryzae

Chen, Ziming / Chen, Tianming / Wang, Huilan / Jiang, Conghua / Liu, Yixue / Wu, Xinyu / Li, Yuzhen / Zeng, Bin / Zhang, Zhe

World journal of microbiology & biotechnology. 2022 Oct., v. 38, no. 10

2022

Abstract: The kojic acid gene cluster of Aspergillus oryzae plays a key role in kojic acid synthesis. Although the kojic acid gene cluster has been found in 2010, there is little information on the function of the genes located near the kojic acid gene cluster of ... ...

Abstract	The kojic acid gene cluster of Aspergillus oryzae plays a key role in kojic acid synthesis. Although the kojic acid gene cluster has been found in 2010, there is little information on the function of the genes located near the kojic acid gene cluster of A. oryzae and whether these genes affect the kojic acid gene cluster containing kojA, kojR and kojT. Here, Aokap6 near the kojic acid gene cluster of A. oryzae was identified and characterized. The Aokap6 disrupted mutants were constructed by the CRISPR/Cas9 system, which exhibited increased mycelium growth and conidial formation. Disruption of Aokap6 enhanced the tolerance to cell wall, oxidative and heat stress but not osmotic stress. Deletion of Aokap6 repressed kojic acid production, together with the reduced expression of kojA, kojR and kojT. Meanwhile, knockout of kojA, kojR and kojT led to the declined expression of Aokap6, indicating that Aokap6 is required for kojic acid production in coordination with kojA, kojR and kojT. Furthermore, overexpression of kojA, kojR and kojT had no effects on the transcript level of Aokap6, and overexpression of kojA in Aokap6 deletion strain could rescue the reduced yield of kojic acid, suggesting that Aokap6 is involved in kojic acid synthesis acting upstream of kojA. These findings provide new insight for the further understanding of kojic acid gene cluster and kojic acid production in A. oryzae.
Keywords	Aspergillus oryzae ; CRISPR-Cas systems ; biotechnology ; cell walls ; conidia ; heat stress ; kojic acid ; microbiology ; multigene family ; mycelium ; osmotic stress
Language	English
Dates of publication	2022-10
Size	p. 175.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	1499109-3
ISSN	1573-0972 ; 0959-3993
ISSN (online)	1573-0972
ISSN	0959-3993
DOI	10.1007/s11274-022-03361-x
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