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  1. Article: [Interpretation of the 2020 American society of colon and rectal surgeons clinical practice guidelines for the management of rectal cancer].

    Wang, J P

    Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

    2020  Volume 24, Issue 1, Page(s) 27–34

    Abstract: Located in the pelvic cavity and contiguous to the anal sphincter complex and urogenital organs, the rectum has more intricate anatomical features compared with the colon. Consequently, the treatment of rectal cancer involves more consideration, ... ...

    Abstract Located in the pelvic cavity and contiguous to the anal sphincter complex and urogenital organs, the rectum has more intricate anatomical features compared with the colon. Consequently, the treatment of rectal cancer involves more consideration, including pelvic radiation, lateral lymph node dissection, transanal access, postoperative function, sphincter preservation, and nonoperative management. Based on the last set of American society of colon and rectal surgeons (ASCRS) practice parameters for the management of rectal cancer published in 2013, the 2020 guidelines present evidence-based updates for both long-existing and emerging controversies on surgical management of rectal cancer. These updates include the indication for local resection, lymph node dissection for radical proctectomy, minimally invasive surgery, the "watch and wait" strategy for patients with clinical complete response, and prevention of anastomotic leak. Meanwhile, the guidelines recommend a risk-stratified approach for perioperative therapies for non-metastatic disease, and an individualized multimodality treatment based on treatment intent for synchronous metastatic disease.
    MeSH term(s) Humans ; Lymph Node Excision ; Neoplasms, Multiple Primary/surgery ; Neoplasms, Multiple Primary/therapy ; Practice Guidelines as Topic ; Proctectomy ; Rectal Neoplasms/surgery ; Rectal Neoplasms/therapy ; Rectum/surgery ; United States
    Language Chinese
    Publishing date 2020-12-24
    Publishing country China
    Document type Journal Article
    ISSN 1671-0274
    ISSN 1671-0274
    DOI 10.3760/cma.j.cn.441530-20201218-00664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Identification of ferroptosis-related genes for the prediction of prognosis and chemotherapy benefit of gastric cancer.

    Zheng, J-J / Wang, J-P

    European review for medical and pharmacological sciences

    2022  Volume 26, Issue 18, Page(s) 6754–6763

    Abstract: Objective: As a newly reported programmed cell death, ferroptosis plays a crucial role in tumor progression. We aimed to comprehensively analyze the prognostic value of ferroptosis-related genes and identify the genes for the prediction of prognosis and ...

    Abstract Objective: As a newly reported programmed cell death, ferroptosis plays a crucial role in tumor progression. We aimed to comprehensively analyze the prognostic value of ferroptosis-related genes and identify the genes for the prediction of prognosis and chemotherapy benefit of gastric cancer (GC) patients.
    Materials and methods: Public microarray data and corresponding clinical information of GC were downloaded from GEO databases. Patients in GSE66229 were randomly separated into discovery and internal validation at a ratio of 2:1. GSE15459 was set as the external validation set. LASSO Cox regression model was performed to identify the most significant prognostic ferroptosis-related genes.
    Results: Twenty ferroptosis-related genes were finally identified to establish the predictive signature. In the discovery data set, the signature could divide patients into low- and high-risk groups with significantly different overall survival (HR: 2.11, 95% CI: 1.40-3.17, p<0.001). These results were successfully validated in the internal validation cohort (HR 2.04, 95% CI 1.18-3.52; p=0.008) and external validation cohort (HR 4.87, 95% CI 2.99-7.93; p=0.008). Survival ROC at 5-year revealed a remarkably higher predictive ability of the ferroptosis classifier (AUC=0.835) compared with other clinical features in predicting prognosis. Further GSEA analysis showed that samples of high risk were related to several established tumor invasion and metastatic signaling pathways. Further experiments revealed that VLDLR and GCH1 were two newly identified genes associated with chemotherapy sensitivity in GC.
    Conclusions: The developed ferroptosis gene-set based prognostic signature indicated superior prognostic and predictive value, suggesting new possibilities for individualized treatment of GC patients.
    MeSH term(s) Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Ferroptosis/genetics ; Humans ; Prognosis ; Proportional Hazards Models ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/genetics
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2022-11-07
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202209_29774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [A case of gastric glomus tumor].

    Zhang, Y / Yang, Y F / Wang, J P

    Zhonghua nei ke za zhi

    2023  Volume 62, Issue 12, Page(s) 1476–1478

    MeSH term(s) Humans ; Glomus Tumor/pathology ; Stomach Neoplasms/pathology
    Language Chinese
    Publishing date 2023-10-31
    Publishing country China
    Document type Case Reports ; Journal Article
    ZDB-ID 754223-9
    ISSN 0578-1426
    ISSN 0578-1426
    DOI 10.3760/cma.j.cn112138-20221220-00945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Bowel preparation before elective surgery for colorectal cancer].

    Dou, R X / Zhou, Z L / Wang, J P

    Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

    2022  Volume 25, Issue 7, Page(s) 645–647

    Abstract: For elective surgery of colorectal cancer, current evidence supports preoperative mechanical bowel preparation combined with oral antibiotics. Meanwhile, for patients with varied degrees of intestinal stenosis, individualized protocol is required to ... ...

    Abstract For elective surgery of colorectal cancer, current evidence supports preoperative mechanical bowel preparation combined with oral antibiotics. Meanwhile, for patients with varied degrees of intestinal stenosis, individualized protocol is required to avoid adverse events. We hereby summarize recent high-quality evidences and updates of guidelines and consensus, and recommend stratified bowel preparation based on the clinical practice of our institute as follows. (1) For patients with unimpaired oral intake, whose tumor can be passed by colonoscopy, mechanical bowel preparation and oral antibiotics are given. (2) For patients without symptoms of bowel obstruction but with impaired oral intake or incomplete colonoscopy due to tumor-related stenosis, small-dosage laxative is given for several days before surgery, and oral antibiotics the day before surgery. (3) For patients with bowel obstruction, mechanical bowel preparation or enema is not indicated. We proposed this evidence-based, individualized protocol for preoperative bowel preparation for the reference of our colleagues, in the hope of improving perioperative outcomes and reducing adverse events.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Colorectal Neoplasms/drug therapy ; Constriction, Pathologic/etiology ; Elective Surgical Procedures/adverse effects ; Humans ; Preoperative Care/methods ; Surgical Wound Infection/etiology
    Chemical Substances Anti-Bacterial Agents
    Language Chinese
    Publishing date 2022-07-18
    Publishing country China
    Document type Journal Article
    ISSN 1671-0274
    ISSN 1671-0274
    DOI 10.3760/cma.j.cn441530-20220221-00056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Comparison among different flushing media for intracoronary imaging with optical coherence tomography].

    Li, B / Li, Z B / Wang, J P / Zhao, L / Wang, Z H / Wu, J D / Liu, B

    Zhonghua xin xue guan bing za zhi

    2024  Volume 52, Issue 2, Page(s) 144–149

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Male ; Middle Aged ; Aged ; Tomography, Optical Coherence/methods ; Percutaneous Coronary Intervention/methods ; Coronary Angiography ; Prospective Studies ; Stents ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/pathology ; Treatment Outcome ; Coronary Artery Disease/pathology ; Predictive Value of Tests
    Language Chinese
    Publishing date 2024-02-07
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 603425-1
    ISSN 0253-3758
    ISSN 0253-3758
    DOI 10.3760/cma.j.cn112148-20231030-00396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Application of Bayesian calculation to determine logic-tree weights for ground motion prediction equations: Seismological case studies in Taiwan

    Wang, J.P. / Lin, Yen-Hui

    Engineering geology. 2021 Dec. 05, v. 294

    2021  

    Abstract: This paper presents a new application of the Bayesian approach to objectively determine logic-tree weights for ground motion prediction equations (GMPEs) used in seismic hazard analysis. This is a considerable improvement over the current practice based ... ...

    Abstract This paper presents a new application of the Bayesian approach to objectively determine logic-tree weights for ground motion prediction equations (GMPEs) used in seismic hazard analysis. This is a considerable improvement over the current practice based on subjective judgment to determine the logic-tree weights for GMPEs. To demonstrate the feasibility of this Bayesian application, case studies at three sites in Taiwan were conducted. The results demonstrate that the logic-tree weights for three Next Generation Attenuation GMPEs can be determined in an objective and repeatable manner using this Bayesian calculation, which is based on the difference between predicted and observed peak ground accelerations.
    Keywords Bayesian theory ; geophysics ; hazard characterization ; prediction ; Taiwan
    Language English
    Dates of publication 2021-1205
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 0013-7952
    DOI 10.1016/j.enggeo.2021.106347
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: First Report of Green Mold Disease Caused by Penicillium ochrochloron on Medicinal Plant Pseudostellaria heterophylla in China

    Xiao, R. F. / Chen, Y. P. / Chen, M. C. / Liu, X. / Wang, J. P. / Liu, B.

    Plant Disease. 2023 June 01, v. 107, no. 6 p.1946-

    2023  

    Abstract: Pseudostellaria heterophylla is one of the Chinese herbal medicines with high medicinal and economic values. From 2019 to 2021, postharvest green mold disease was observed with an incidence of 2 to 5% on the tuberous roots of the harvested P. ... ...

    Abstract Pseudostellaria heterophylla is one of the Chinese herbal medicines with high medicinal and economic values. From 2019 to 2021, postharvest green mold disease was observed with an incidence of 2 to 5% on the tuberous roots of the harvested P. heterophylla at eight locations in Zherong county, Fujian Province, China. The symptoms were as follows: white mycelial growth on the tuberous root surfaces initially, then green mold layers forming, and finally the tuberous roots decaying. To identify the causal agent, a total of 20 symptomatic tuberous roots were collected. Small pieces (5 × 5 mm) were treated by surface disinfestation with 75% ethanol and 1% NaOCl, and then rinsed three times with sterile distilled water. These treated pieces were transferred onto potato dextrose agar (PDA) and incubated at 25°C in the dark for 7 days. Twenty pure cultures were obtained by the single-spore isolation method. Colonies on PDA medium initially appeared as white mycelium that developed grayish-green conidia with white margins. Mycelium was septate and colorless. Conidiophores were predominantly monoverticillate, occasionally biverticillate. Stipes was long and slender. Phialides were ampulliform to almost cylindrical with collula, 11.25 (7.80 to 23.50) μm long (n = 50). Conidia were smooth walled and pale green, with globose to ellipsoidal shape, 2.75 (2.37 to 3.27) × 2.47 (2.18 to 3.13) μm (n = 50). Based on these morphological characteristics, the isolates matched the description of the genus Penicillium. Genomic DNA from two representative isolates (FJAT-32578 and FJAT-32579) was extracted with a fungal genomic DNA extraction kit. The rDNA ITS region and partial β-tubulin gene (BenA) were amplified using the primers ITS1/ITS4 (White et al. 1990) and Bt2a/Bt2b (Glass and Donaldson 1995), respectively. The sequences of isolates FJAT-32578 and FJAT-32579 were deposited in GenBank (ITS, OM920986 and OM920987; BenA, OM953825 and OM953826). All sequences showed above 99% similarity to Penicillium ochrochloron type strain CBS357.48 (ITS, NR111509; BenA, GU981672). In multilocus phylogenetic analysis (ITS + BenA), the two isolates from this study clustered together with other strains of P. ochrochloron with 100% bootstrap support. The two isolates were thus identified as P. ochrochloron based on both morphological and molecular characteristics. Pathogenicity tests were conducted in triplicate by inoculating the aseptic wounds with 10 μl of conidial suspension (1 × 10⁶ conidia/ml) of the two isolates in each healthy tuberous root (cv. Zheshen No.1). The experiment was conducted twice. All the inoculated tuberous roots were placed in sterilized Petri dishes with moistened filter paper and incubated at 25 ± 2°C. Fifteen days after inoculation, all inoculated tuberous roots demonstrated the same symptoms as those observed in the field conditions. The reisolated fungi from the artificially infected tuberous roots were confirmed as P. ochrochloron using the method described above, whereas the control tuberous roots treated with sterile water did not develop symptoms, fulfilling Koch’s postulates. To our knowledge, this is the first report of P. ochrochloron causing green mold disease on P. heterophylla in China, which would be a potentially new threat to the medicinal plant.
    Keywords DNA ; Penicillium ; conidia ; conidiophores ; culture media ; disinfestation ; ethanol ; fungi ; genes ; isolation techniques ; medicinal plants ; mycelium ; pathogenicity ; phylogeny ; China ; green mold disease ; morphological and molecular characteristics ; pathogenicity tests ; Penicillium ochrochloron ; Pseudostellaria heterophylla
    Language English
    Dates of publication 2023-0601
    Publishing place The American Phytopathological Society
    Document type Article ; Online
    ZDB-ID 754182-x
    ISSN 0191-2917
    ISSN 0191-2917
    DOI 10.1094/PDIS-09-22-2237-PDN
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Correlations between pore water pressure development in sandy soil and CAV-based ground motion intensity measures

    Tsai, Chi-Chin / Wang, J.P. / Huang, Tsai-Yu / Sung, Chia-Ying

    Engineering geology. 2022 July 05,

    2022  

    Abstract: This study investigated the respective correlation coefficients between pore water pressure (PWP) development in sandy soil and 41 CAV-based (cumulative absolute velocity) ground motion intensity measures and peak ground acceleration (PGA). Based on 720 ... ...

    Abstract This study investigated the respective correlation coefficients between pore water pressure (PWP) development in sandy soil and 41 CAV-based (cumulative absolute velocity) ground motion intensity measures and peak ground acceleration (PGA). Based on 720 site response analyses using DEEPSOIL with 120 (real) strong ground motions and the (real) borehole data (e.g., soil unit weight, shear-wave velocity) at six sites, the result shows that cutoff CAVs with cutoff acceleration of 0.02–0.04 g are better correlated with PWP developments in sandy soil than the (original) CAV without cutoff acceleration. It also shows that PGA is poorly correlated with PWP developments, having the lowest correlation coefficient among the 42 intensity measures.
    Keywords engineering ; engineers ; geology ; sandy soils
    Language English
    Dates of publication 2022-0705
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ISSN 0013-7952
    DOI 10.1016/j.enggeo.2022.106785
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: [Dilemma and strategy in surgery of chronic radiation intestinal injury].

    Ma, T H / Wang, H / Wang, J P

    Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

    2020  Volume 23, Issue 8, Page(s) 728–733

    Abstract: Chronic radiation intestinal injury denotes the repeated and prolonged damage of intestine caused by radiotherapy to pelvic malignancy, which usually occurs after three months of radiotherapy. Surgical intervention is indicated when the progressive ... ...

    Abstract Chronic radiation intestinal injury denotes the repeated and prolonged damage of intestine caused by radiotherapy to pelvic malignancy, which usually occurs after three months of radiotherapy. Surgical intervention is indicated when the progressive intestinal injury leads to the development of massive intestinal hemorrhage, obstruction, perforation, fistula and other late complications. However, there is no consensus on the surgical procedures. We illustrate the dilemma in surgical treatment from the points of pathological mechanism and the frequent sites of radiation intestinal injury. Meanwhile, we discuss the surgical alternatives of radiation intestinal injury based on the literature and our experience. The pathological mechanism of chronic radiation injury is progressive occlusive arteritis and parenchymal fibrosis. The frequently involved sites are distal ileum, sigmoid colon and rectum based on the radiotherapy region. The morbidity and mortality are high in surgery of chronic radiation injury due to poor ability of tissue healing, pelvic fibrosis, multiple organ damage, and poor physical condition. Definitive intestinal resection is one of the most common surgical procedures. Extended resection of diseased bowel to ensure that there is no radiation damage in at least one end of the anastomotic bowels is the key to decrease the risk of complications related to anastomotic sites.
    MeSH term(s) Anastomosis, Surgical ; Chronic Disease ; Humans ; Ileum ; Intestinal Diseases/surgery ; Radiation Injuries/surgery ; Rectum
    Language Chinese
    Publishing date 2020-08-06
    Publishing country China
    Document type Journal Article
    ISSN 1671-0274
    ISSN 1671-0274
    DOI 10.3760/cma.j.cn.441530-20200521-00296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Clinical value of capsule endoscopy in small intestinal diseases].

    Zhao, K / Yang, Y F / Wang, J P

    Zhonghua nei ke za zhi

    2020  Volume 59, Issue 2, Page(s) 124–128

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Capsule Endoscopy ; Crohn Disease/diagnosis ; Crohn Disease/epidemiology ; Endoscopy, Gastrointestinal/methods ; Female ; Gastrointestinal Hemorrhage/diagnosis ; Gastrointestinal Hemorrhage/epidemiology ; Humans ; Intestinal Diseases/diagnosis ; Intestinal Diseases/epidemiology ; Intestine, Small/pathology ; Male
    Language Chinese
    Publishing date 2020-02-16
    Publishing country China
    Document type Journal Article
    ZDB-ID 754223-9
    ISSN 0578-1426
    ISSN 0578-1426
    DOI 10.3760/cma.j.issn.0578-1426.2020.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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