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  1. Article ; Online: Investigation on the hospital-acquired pressure injury prevalence and incidence rate in patients.

    Fu, Xiaojun / Wang, Jingnan / Zhou, Mingqin / Wang, Chunying

    Asian journal of surgery

    2024  

    Language English
    Publishing date 2024-04-10
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.03.156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: In Vivo Fibroblast Activation of Systemic Sarcoidosis: A

    Wang, Jingnan / Huo, Li / Lin, Lu / Niu, Na / Li, Xiang

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 8

    Abstract: A 47-year-old female with cardiac dysfunction and lymphadenopathy ... ...

    Abstract A 47-year-old female with cardiac dysfunction and lymphadenopathy underwent
    Language English
    Publishing date 2023-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13081450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Benign Metastasizing Leiomyoma: Is "Wait and Watch" Strategy Feasible?

    Liu, Yixuan / Li, Dong / Li, Xueqing / Wang, Jingnan / Wang, Jigang

    Reproductive sciences (Thousand Oaks, Calif.)

    2023  Volume 30, Issue 12, Page(s) 3568–3577

    Abstract: Benign metastasizing leiomyoma (BML) is a rare disease that affects women with a history of uterine leiomyoma. The aim of this study is to investigate the clinical characteristics and outcome patterns. We collected 385 cases from previous reports indexed ...

    Abstract Benign metastasizing leiomyoma (BML) is a rare disease that affects women with a history of uterine leiomyoma. The aim of this study is to investigate the clinical characteristics and outcome patterns. We collected 385 cases from previous reports indexed in PubMed and Google Scholar and made a thorough review. All relevant clinical parameters were carefully reviewed, including age at diagnosis, clinical presentations, course of disease, medical history, imaging, molecular tests, treatment, and outcomes. Univariate survival analysis was performed to investigate the effects of treatment strategies on outcomes. The mean age at diagnosis was 46.2 years. The most common site for the metastasis was lung, and followed by abdomen/pelvis/retroperitoneum, bone, lymph nodes, and heart. The medical histories and molecular alterations were non-specific, and the pathogenesis was still unclear. Due to its unresectable nature, hormone deprivation treatment, including oophorectomy and hormone drugs, is the most effective strategy to reduce or delay tumor progression. The present study may provide a useful consultation for diagnosing and managing BMLs.
    MeSH term(s) Female ; Humans ; Middle Aged ; Uterine Neoplasms/therapy ; Uterine Neoplasms/pathology ; Lung Neoplasms/diagnosis ; Lung Neoplasms/secondary ; Lung Neoplasms/therapy ; Leiomyoma/pathology ; Lung ; Hormones
    Chemical Substances Hormones
    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2276411-2
    ISSN 1933-7205 ; 1933-7191
    ISSN (online) 1933-7205
    ISSN 1933-7191
    DOI 10.1007/s43032-023-01314-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4113: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: A dynamic view of environmental regulation influence mechanism on manufacturing agglomeration-a case study of the Yangtze River Delta city cluster

    An, Min / Wang, Jingnan / An, Hui / Zhang, Jiaqi / Huang, Jin

    Environ Sci Pollut Res. 2023 Jan., v. 30, no. 3 p.6643-6657

    2023  

    Abstract: Rapid development and agglomeration of manufacturing industries in China inevitably lead to serious environmental pollution problems. The government restrains development of manufacturing industries through environmental regulation policies, but this may ...

    Abstract Rapid development and agglomeration of manufacturing industries in China inevitably lead to serious environmental pollution problems. The government restrains development of manufacturing industries through environmental regulation policies, but this may affect manufacturing industries agglomeration. Therefore, studying the impact of environmental regulation (ER) on manufacturing agglomeration (MA) is a critical prerequisite for the sustainability of China’s manufacturing industry. Based on the panel data of 41 cities in Yangtze River Delta (YRD) region of China from 2003 to 2017, this paper explores the threshold effect of ER on MA using a panel threshold model and analyzes the heterogeneity impact of ER on MA in different regions and analyzes the dynamic mechanism and contribution of each influencing factor on MA using a panel vector autoregressive model. The results show that (1) there is a double threshold effect of ER on MA, showing an inverted “U”-shaped effect of rising and then falling; there are threshold effects of ER on MA based on foreign direct investment (FDI) and economic development level (EDL). The effect of ER on MA has the threshold effect under different FDI and EDL level, in which the effect based on FDI shows an inverted “U” shape relationship of rising and then falling; the effect based on EDL shows a growing trend. (2) There are 29 cities in YRD region in the “weak regulation” or “strong regulation” stage, both of which are not conducive to MA. (3) ER has a facilitating effect on MA, but with the extension of forecast period, this facilitating effect turns into an inhibiting effect. MA is mainly influenced by itself and transportation conditions (TC). Our study can provide some insights for improving the ecological environment and promoting the development of manufacturing clusters in YRD region.
    Keywords case studies ; economic development ; environmental law ; foreign direct investment ; industry ; pollution ; river deltas ; threshold models ; transportation ; China ; Yangtze River
    Language English
    Dates of publication 2023-01
    Size p. 6643-6657.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-22596-7
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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  5. Article ; Online: Reduced the Food Effect and Enhanced the Oral Bioavailability of Ivacaftor by Self-Nanoemulsifying Drug Delivery System (SNEDDS) Using a New Oil Phase.

    Miao, Yanfei / Zhao, Shihua / Zuo, Jian / Sun, Jiqin / Wang, Jingnan

    Drug design, development and therapy

    2022  Volume 16, Page(s) 1531–1546

    Abstract: Purpose: The purpose of this work was to develop an ivacaftor self-nanoemulsion drug delivery system (IVA-SNEDDS) using the newly developed double headed miscellaneous lipid (DHML) as oil phase to reduce the food effect and inter-individual absorption ... ...

    Abstract Purpose: The purpose of this work was to develop an ivacaftor self-nanoemulsion drug delivery system (IVA-SNEDDS) using the newly developed double headed miscellaneous lipid (DHML) as oil phase to reduce the food effect and inter-individual absorption variability of IVA.
    Methods: The lipids with the greatest solubility to IVA were selected as the oil phase of IVA-SNEDDS by saturation solubility method. Then, among different surfactants and co-surfactants, those with good emulsifying ability for the selected oil phase were selected, and the proportion of surfactant and co-surfactant was further selected by pseudo-ternary phase diagram. The prepared IVA-SNEDDS were screened and evaluated in vitro and in beagle dogs.
    Results: The optimized IVA-SNEDDS formulation consisting of DHML, Tween 80, and Transcutol HP with the weight ratio of 2:2:1 was physically stable and it was easy to disperse in water, pH 1.2 hydrochloric acid and pH 6.8 phosphate buffer solution, and generated a fine homogeneous nanoemulsion, with mean globule size less than 75 nm regardless of dilution ratio. In vitro drug release studies showed that the drug in IVA-SNEDDS could be completely released in a short time, while the drug release in IVA-suspension was less than 1% at 60 min. In vivo, using IVA-suspension (Fed) as a reference, the relative oral bioavailability of IVA-suspension (Fasted), IVA-SNEDDS (Fasted), and IVA-SNEDDS (Fed) were 23.35%, 153.63%, and 149.89%, respectively. This showed that IVA-SNEDDS could eliminate the positive food effect, improve the oral bioavailability, and reduce the IVA absorption difference between individuals.
    Conclusion: As the oil phase of SNEDDS, DHML can significantly improve the drug solubility and drug loading of IVA-SNEDDS. Moreover, DHML was easily emulsified and can effectively form a nanoemulsion in vivo and in vitro. The prepared IVA-SNEDDS can reduce the inter-individual absorption variability of IVA, eliminate its food effect and improve its oral bioavailability.
    MeSH term(s) Aminophenols ; Animals ; Biological Availability ; Dogs ; Drug Delivery Systems/methods ; Emulsions ; Nanoparticles ; Particle Size ; Quinolones ; Surface-Active Agents ; Suspensions
    Chemical Substances Aminophenols ; Emulsions ; Quinolones ; Surface-Active Agents ; Suspensions ; ivacaftor (1Y740ILL1Z)
    Language English
    Publishing date 2022-05-23
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2451346-5
    ISSN 1177-8881 ; 1177-8881
    ISSN (online) 1177-8881
    ISSN 1177-8881
    DOI 10.2147/DDDT.S356967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Direct Electrochemical Synthesis of Acetamide from CO

    Wang, Jingnan / Li, Sha / Liu, Qiang / Zhao, Kaiheng / Yang, Yongan / Wang, Xi

    ACS applied materials & interfaces

    2023  Volume 15, Issue 46, Page(s) 53436–53445

    Abstract: The electrochemical conversion of carbon dioxide into value-added compounds not only paves the way toward a sustainable society but also unlocks the potential for electrocatalytic synthesis of amides through the introduction of N atoms. However, it also ... ...

    Abstract The electrochemical conversion of carbon dioxide into value-added compounds not only paves the way toward a sustainable society but also unlocks the potential for electrocatalytic synthesis of amides through the introduction of N atoms. However, it also poses one of the greatest challenges in catalysis: achieving simultaneous completion of C-C coupling and C-N coupling. Here, we have meticulously investigated the catalytic prowess of Cu-based single-atom alloys in facilitating the electrochemical synthesis of acetamide from CO
    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c11097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Engineering Spin States of Isolated Copper Species in a Metal-Organic Framework Improves Urea Electrosynthesis.

    Gao, Yuhang / Wang, Jingnan / Yang, Yijun / Wang, Jian / Zhang, Chuang / Wang, Xi / Yao, Jiannian

    Nano-micro letters

    2023  Volume 15, Issue 1, Page(s) 158

    Abstract: The catalytic activities are generally believed to be relevant to the electronic states of their active center, but understanding this relationship is usually difficult. Here, we design two types of catalysts for electrocatalytic urea via a coordination ... ...

    Abstract The catalytic activities are generally believed to be relevant to the electronic states of their active center, but understanding this relationship is usually difficult. Here, we design two types of catalysts for electrocatalytic urea via a coordination strategy in a metal-organic frameworks: Cu
    Language English
    Publishing date 2023-06-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2642093-4
    ISSN 2150-5551 ; 2150-5551
    ISSN (online) 2150-5551
    ISSN 2150-5551
    DOI 10.1007/s40820-023-01127-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A quantitative clinical evaluation of simultaneous reconstruction of attenuation and activity in time-of-flight PET.

    Zhang, Haiqiong / Wang, Jingnan / Li, Nan / Zhang, Yue / Cui, Jie / Huo, Li / Zhang, Hui

    BMC medical imaging

    2023  Volume 23, Issue 1, Page(s) 35

    Abstract: Background: The maximum likelihood activity and attenuation (MLAA) reconstruction algorithm has been proposed to jointly estimate tracer activity and attenuation at the same time, and proven to be a promising solution to the CT attenuation correction ( ... ...

    Abstract Background: The maximum likelihood activity and attenuation (MLAA) reconstruction algorithm has been proposed to jointly estimate tracer activity and attenuation at the same time, and proven to be a promising solution to the CT attenuation correction (CT-AC) artifacts in PET images. This study aimed to perform a quantitative evaluation and clinical validation of the MLAA method.
    Methods: A uniform cylinder phantom filled with
    Results: In quantitative analysis, SUVs in patient's organ ROIs between two methods showed R
    Conclusions: PET images reconstructed using MLAA are clinically acceptable in terms of image quality as well as quantification and it is a useful tool in clinical practice, especially when CT-AC may cause respiration motion and metal artifacts. Moreover, this study also provides technical reference and data support for the future iteration and development of PET reconstruction technology of SUV accurate quantification.
    MeSH term(s) Humans ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography ; Retrospective Studies ; Liver/diagnostic imaging ; Algorithms ; Polymers
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Polymers
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2061975-3
    ISSN 1471-2342 ; 1471-2342
    ISSN (online) 1471-2342
    ISSN 1471-2342
    DOI 10.1186/s12880-023-00987-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Author Correction: Identification of MyoD-Responsive Transcripts Reveals a Novel Long Non-coding RNA (lncRNA-AK143003) that Negatively Regulates Myoblast Differentiation.

    Guo, Yiwen / Wang, Jingnan / Zhu, Mingfei / Zeng, Rui / Xu, Zaiyan / Li, Guoliang / Zuo, Bo

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 1937

    Language English
    Publishing date 2023-02-02
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-28986-2
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  10. Article ; Online: Anaplastic and poorly differentiated thyroid carcinomas: genetic evidence of high-grade transformation from differentiated thyroid carcinoma.

    Gu, Haiyan / Wang, Jingnan / Ran, Wenwen / Li, Guangqi / Hu, Shasha / Zhao, Han / Wang, Xiaonan / Wang, Jigang

    The journal of pathology. Clinical research

    2024  Volume 10, Issue 2, Page(s) e356

    Abstract: Anaplastic thyroid carcinoma (ATC) is the most advanced and aggressive thyroid cancer, and poorly differentiated thyroid carcinoma (PDTC) lacks anaplastic histology but has lost architectural and cytologic differentiation. Only a few studies have focused ...

    Abstract Anaplastic thyroid carcinoma (ATC) is the most advanced and aggressive thyroid cancer, and poorly differentiated thyroid carcinoma (PDTC) lacks anaplastic histology but has lost architectural and cytologic differentiation. Only a few studies have focused on the genetic relationship between the two advanced carcinomas and coexisting differentiated thyroid carcinomas (DTCs). In the present study, we investigated clinicopathologic features and genetic profiles in 57 ATC and PDTC samples, among which 33 cases had concomitant DTC components or DTC history. We performed immunohistochemistry for BRAF V600E, p53, and PD-L1 expression, Sanger sequencing for TERT promoter and RAS mutations, and fluorescence in situ hybridization for ALK and RET rearrangements. We found that ATCs and PDTCs shared similar gene alterations to their coexisting DTCs, and most DTCs were aggressive subtypes harboring frequent TERT promoter mutations. A significantly higher proportion of ATCs expressed p53 and PD-L1, and a lower proportion expressed PAX-8 and TTF-1, than the coexisting DTCs. Our findings provide more reliable evidence that ATCs and PDTCs are derived from DTCs.
    MeSH term(s) Humans ; B7-H1 Antigen ; In Situ Hybridization, Fluorescence ; Tumor Suppressor Protein p53/genetics ; Thyroid Neoplasms/genetics ; Adenocarcinoma ; Ehlers-Danlos Syndrome ; Proline/analogs & derivatives ; Thiocarbamates
    Chemical Substances B7-H1 Antigen ; prolinedithiocarbamate (135467-92-4) ; Tumor Suppressor Protein p53 ; Proline (9DLQ4CIU6V) ; Thiocarbamates
    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2814357-7
    ISSN 2056-4538 ; 2056-4538
    ISSN (online) 2056-4538
    ISSN 2056-4538
    DOI 10.1002/cjp2.356
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