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  1. Article ; Online: Using an Isogenic Human Pluripotent Stem Cell Model for Better Understanding Neurodevelopmental Defects in Fragile X Syndrome.

    Wang, Jun Yi

    Biological psychiatry

    2020  Volume 88, Issue 6, Page(s) e25–e27

    MeSH term(s) Fragile X Mental Retardation Protein/genetics ; Fragile X Syndrome/genetics ; Humans ; Pluripotent Stem Cells
    Chemical Substances Fragile X Mental Retardation Protein (139135-51-6)
    Language English
    Publishing date 2020-08-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2020.07.008
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    Zs.A 720: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Breakthrough in efficient cloning and activation of large cryptic biosynthetic gene clusters from high GC actinobacteria.

    Wang, Jun-Yi / Li, Bing-Zhi

    Synthetic and systems biotechnology

    2022  Volume 7, Issue 4, Page(s) 1064–1065

    Language English
    Publishing date 2022-06-22
    Publishing country China
    Document type Journal Article
    ISSN 2405-805X
    ISSN (online) 2405-805X
    DOI 10.1016/j.synbio.2022.06.006
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  3. Article ; Online: Double charge transfer processes enable a green multiple resonance-induced thermally activated delayed fluorescence emitter for an efficient narrowband OLED.

    Luo, Xu-Feng / Shen, Liangjun / Wang, Jun-Yi / Xiao, Xunwen

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 5, Page(s) 574–577

    Abstract: Benefitting from short-range charge transfer (SR-CT) and through-space charge transfer (TSCT) effects, an efficient green narrowband emitter, BNDCN, was developed. Owing to the synergistic effect of double CT processes, a BNDCN-based organic light- ... ...

    Abstract Benefitting from short-range charge transfer (SR-CT) and through-space charge transfer (TSCT) effects, an efficient green narrowband emitter, BNDCN, was developed. Owing to the synergistic effect of double CT processes, a BNDCN-based organic light-emitting diode showed a high external quantum efficiency of 32.3%.
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc05684h
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  4. Article: [

    Zhang, Lei / Wang, Jun-Yi / He, Xiang / Wu, Min / Li, Guo-Ping / Vincent, Kam-Wai-Wong

    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

    2024  Volume 46, Issue 1, Page(s) 1–10

    Abstract: Objective To investigate the impact ... ...

    Abstract Objective To investigate the impact of
    MeSH term(s) Humans ; Animals ; Mice ; Endothelial Cells ; Pseudomonas aeruginosa ; Calcium ; Pseudomonas Infections ; Transcription Factors ; Lung ; Pneumonia ; Lactates ; RNA, Messenger
    Chemical Substances Calcium (SY7Q814VUP) ; Transcription Factors ; Lactates ; RNA, Messenger
    Language Chinese
    Publishing date 2024-03-04
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 604853-5
    ISSN 1000-503X
    ISSN 1000-503X
    DOI 10.3881/j.issn.1000-503X.15831
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  5. Article ; Online: Artificial neural network applied to fragile X-associated tremor/ataxia syndrome stage diagnosis based on peripheral mitochondrial bioenergetics and brain imaging outcomes.

    Giulivi, Cecilia / Wang, Jun Yi / Hagerman, Randi J

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 21382

    Abstract: No proven prognosis is available for the neurodegenerative disorder fragile X-associated tremor/ataxia syndrome (FXTAS). Artificial neural network analyses (ANN) were used to predict FXTAS progression using data from 127 adults (noncarriers and FMR1 ... ...

    Abstract No proven prognosis is available for the neurodegenerative disorder fragile X-associated tremor/ataxia syndrome (FXTAS). Artificial neural network analyses (ANN) were used to predict FXTAS progression using data from 127 adults (noncarriers and FMR1 premutation carriers with and without FXTAS) with five outcomes from brain MRI imaging and 22 peripheral bioenergetic outcomes from two cell types. Diagnosis accuracy by ANN predictions ranged from 41.7 to 86.3% (depending on the algorithm used), and those misclassified usually presented a higher FXTAS stage. ANN prediction of FXTAS stages was based on a combination of two imaging findings (white matter hyperintensity and whole-brain volumes adjusted for intracranial volume) and four bioenergetic outcomes. Those at Stage 3 vs. 0-2 showed lower mitochondrial mass, higher oxidative stress, and an altered electron transfer consistent with mitochondrial unfolded protein response activation. Those at Stages 4-5 vs. 3 had higher oxidative stress and glycerol-3-phosphate-linked ATP production, suggesting that targeting mGPDH activity may prevent a worse prognosis. This was confirmed by the bioenergetic improvement of inhibiting mGPDH with metformin in affected fibroblasts. ANN supports the prospect of an unbiased molecular definition in diagnosing FXTAS stages while identifying potential targets for personalized medicine.
    Language English
    Publishing date 2022-12-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-25615-2
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  6. Article: Middle thyroid vein tumor thrombus in metastatic papillary thyroid microcarcinoma: A case report and review of literature.

    Gui, Yan / Wang, Jun-Yi / Wei, Xu-Dong

    World journal of clinical cases

    2022  Volume 10, Issue 10, Page(s) 3213–3221

    Abstract: Background: Although papillary thyroid microcarcinoma (PTMC) is not considered a threatening tumor, in some cases, it can be aggressive. Metastatic thrombosis of papillary thyroid carcinoma, follicular thyroid carcinoma, Hürthle cell carcinoma, poorly ... ...

    Abstract Background: Although papillary thyroid microcarcinoma (PTMC) is not considered a threatening tumor, in some cases, it can be aggressive. Metastatic thrombosis of papillary thyroid carcinoma, follicular thyroid carcinoma, Hürthle cell carcinoma, poorly differentiated thyroid carcinoma and anaplastic thyroid carcinoma have been reported in the literature, but there have been no reports about PTMC.
    Case summary: A 45-year-old woman presented with a thyroid mass and thrombosis in a middle thyroid vein during a physical examination. She had no symptoms, and the physical examination showed no positive signs. Subsequent ultrasonography-guided fine-needle aspiration biopsy results indicated an atypical lesion of ambiguous significance, with some actively growing cells (TBSRTC III) and the BRAF
    Conclusion: Middle thyroid vein tumor thrombus is an extremely rare condition in PTMC, but it does exist. Lobectomy and thromboembolectomy may be an option for patients with thrombi in the middle vein of the thyroid, and we strongly suggest close follow-up of these patients.
    Language English
    Publishing date 2022-05-11
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v10.i10.3213
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  7. Article: Electroless Plating of High-Performance Composite Pd Membranes with EDTA-Free Bath.

    Wang, Jun-Yi / Chi, Yen-Hsun / Huang, Jin-Hua

    Materials (Basel, Switzerland)

    2021  Volume 14, Issue 17

    Abstract: High-performance composite Pd membranes were successfully fabricated using electroless plating with an EDTA-free bath. The plating started with employing the one-time addition of hydrazine. In the experiment, the hydrazine concentrations and plating bath ...

    Abstract High-performance composite Pd membranes were successfully fabricated using electroless plating with an EDTA-free bath. The plating started with employing the one-time addition of hydrazine. In the experiment, the hydrazine concentrations and plating bath volumes were systematically varied to optimize the plating. The optimum composite Pd membrane tube showed high H
    Language English
    Publishing date 2021-08-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma14174894
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  8. Article ; Online: Meta-analysis of the survival rate and postoperative infection rate of primary and secondary implants after vascularized fibula transplantation for reconstruction of jaw defects.

    Liu, Yi-Bo / Wu, Di / Wang, Jun-Yi / Lun, Xiao-Han / Dai, Wei

    International journal of implant dentistry

    2023  Volume 9, Issue 1, Page(s) 51

    Abstract: Objectives: Vascularized fibula flap transplantation is the most effective and common method to repair the jaw defects. In addition, implantation is the first choice to restore dentition on the graft fibula. Implants are usually implanted at least 6 ... ...

    Abstract Objectives: Vascularized fibula flap transplantation is the most effective and common method to repair the jaw defects. In addition, implantation is the first choice to restore dentition on the graft fibula. Implants are usually implanted at least 6 months after fibula transplantation. Primary implantation of implants during surgery can restore the dentition earlier, but whether this method can achieve the same restorative effect as secondary implantation is still uncertain. This article aims to compare the survival rate and complications between primary and secondary implantation through meta-analysis.
    Methods: This meta-analysis was conducted according to PRISMA protocol and the Cochrane Handbook of Systematic Reviews of Interventions. According to the inclusion and exclusion criteria, we selected the PubMed, Embase, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), Chinese BioMedical Literature Database (CBM) according to established inclusion and exclusion criteria. The Newcastle-Ottawa Scale (NOS) was used to assess the quality of the included studies. Meta-analysis was conducted to compare the survival rate and postoperative infection rate of primary and secondary implantation.
    Results: Seven studies were involved in our research, involving 186 patients. Five of the studies detailed implant success in 106 patients (primary implantation 50, secondary implantation 56), and four studies documented infection after implantation in 117 patients (primary implantation 52, secondary implantation 65); the survival rate of the primary implantation was 93.3%, and the incidence of postoperative infection was 17.3%. The survival rate of the secondary implantation was 93.4%, and 23.1% had postoperative infection. Meta-analysis showed that there was no significant difference in the survival rate between primary implantation and secondary implantation, OR = 0.813 (95% CI 0.383-1.725, P = 0.589 > 0.05), and there was no significant difference in the incidence of postoperative infection, OR = 0.614 (95% CI 0.239-1.581, P = 0.312 > 0.05).
    Conclusions: Based on the results of this study, the research found no significant difference in the survival rate or infection rates between primary and secondary implantation. After appropriate indications selection, primary implantation can be used to reconstruct the dentition with less waiting time, reduce the impact of radiotherapy, and bring a higher quality of life for patients.
    MeSH term(s) Humans ; Survival Rate ; Fibula/surgery ; Quality of Life ; Dental Implants/adverse effects ; Postoperative Complications/epidemiology ; Ketamine
    Chemical Substances Dental Implants ; Ketamine (690G0D6V8H)
    Language English
    Publishing date 2023-12-18
    Publishing country Germany
    Document type Meta-Analysis ; Journal Article ; Review
    ISSN 2198-4034
    ISSN (online) 2198-4034
    DOI 10.1186/s40729-023-00514-x
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  9. Article: A postmortem MRI study of cerebrovascular disease and iron content at end-stage of fragile X-associated tremor/ataxia syndrome.

    Wang, Jun Yi / Sonico, Gerard J / Salcedo-Arellano, Maria Jimena / Hagerman, Randi J / Martínez-Cerdeño, Verónica

    Research square

    2023  

    Abstract: Brain changes at end-stage of fragile X-associated tremor/ataxia syndrome (FXTAS) are largely unknown due to mobility impairment. We conducted a postmortem MRI study of FXTAS to quantify cerebrovascular disease, brain atrophy, and iron content and ... ...

    Abstract Brain changes at end-stage of fragile X-associated tremor/ataxia syndrome (FXTAS) are largely unknown due to mobility impairment. We conducted a postmortem MRI study of FXTAS to quantify cerebrovascular disease, brain atrophy, and iron content and examined their relationships using principal component analysis (PCA). Intracranial hemorrhage (ICH) was observed in 4/17 FXTAS cases among which one was confirmed by histologic staining. Compared with seven control brains, FXTAS cases showed higher ratings of T2-hyperintensities (indicating cerebral small vessel disease) in the cerebellum, globus pallidus, and frontoparietal white matter and significant atrophy in cerebellar white matter, red nucleus, and dentate nucleus. PCA of FXTAS cases revealed negative associations of T2-hyperintensity ratings with anatomic volumes and iron content in the white matter, hippocampus, and amygdala, that were independent from highly correlated number of regions with ICH and iron content in subcortical nuclei. Post hoc analysis confirmed PCA findings and further revealed increased iron content in the white matter, hippocampus, and amygdala in FXTAS cases than controls after adjusting for T2-hyperintensity ratings. These findings indicate that both ischemic and hemorrhagic brain damage may occur in FXTAS, with the former marked by demyelination/iron depletion and atrophy and the latter, ICH and iron accumulation in basal ganglia.
    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-2440612/v1
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  10. Article ; Online: A Postmortem MRI Study of Cerebrovascular Disease and Iron Content at End-Stage of Fragile X-Associated Tremor/Ataxia Syndrome.

    Wang, Jun Yi / Sonico, Gerard J / Salcedo-Arellano, Maria Jimena / Hagerman, Randi J / Martinez-Cerdeno, Veronica

    Cells

    2023  Volume 12, Issue 14

    Abstract: Brain changes at the end-stage of fragile X-associated tremor/ataxia syndrome (FXTAS) are largely unknown due to mobility impairment. We conducted a postmortem MRI study of FXTAS to quantify cerebrovascular disease, brain atrophy and iron content, and ... ...

    Abstract Brain changes at the end-stage of fragile X-associated tremor/ataxia syndrome (FXTAS) are largely unknown due to mobility impairment. We conducted a postmortem MRI study of FXTAS to quantify cerebrovascular disease, brain atrophy and iron content, and examined their relationships using principal component analysis (PCA). Intracranial hemorrhage (ICH) was observed in 4/17 FXTAS cases, among which one was confirmed by histologic staining. Compared with seven control brains, FXTAS cases showed higher ratings of T2-hyperintensities (indicating cerebral small vessel disease) in the cerebellum, globus pallidus and frontoparietal white matter, and significant atrophy in the cerebellar white matter, red nucleus and dentate nucleus. PCA of FXTAS cases revealed negative associations of T2-hyperintensity ratings with anatomic volumes and iron content in the white matter, hippocampus and amygdala, that were independent from a highly correlated number of regions with ICH and iron content in subcortical nuclei. Post-hoc analysis confirmed PCA findings and further revealed increased iron content in the white matter, hippocampus and amygdala in FXTAS cases compared to controls, after adjusting for T2-hyperintensity ratings. These findings indicate that both ischemic and hemorrhagic brain damage may occur in FXTAS, with the former being marked by demyelination/iron depletion and atrophy, and the latter by ICH and iron accumulation in basal ganglia.
    MeSH term(s) Humans ; Tremor/diagnostic imaging ; Tremor/pathology ; Iron ; Ataxia/diagnostic imaging ; Ataxia/pathology ; Fragile X Syndrome/diagnostic imaging ; Fragile X Syndrome/pathology ; Magnetic Resonance Imaging ; Cerebrovascular Disorders ; Atrophy
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2023-07-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12141898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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