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Article ; Online: Combination Treatment of Cervical Cancer Using Folate-Decorated, pH-Sensitive, Carboplatin and Paclitaxel Co-Loaded Lipid-Polymer Hybrid Nanoparticles.

Wang, Junjian

2020 Volume 14, Page(s) 823–832

Abstract: Purpose: Cervical cancer is one of the most common causes of death among women globally. Combinations of cisplatin, paclitaxel, bevacizumab, carboplatin, topotecan, and gemcitabine are recommended as first-line therapies.: Methods: This study focuses ...

Abstract	Purpose: Cervical cancer is one of the most common causes of death among women globally. Combinations of cisplatin, paclitaxel, bevacizumab, carboplatin, topotecan, and gemcitabine are recommended as first-line therapies. Methods: This study focuses on the development of folate-decorated, pH-sensitive lipid-polymer hybrid nanoparticles (LPNs). Loading carboplatin (CBP) and paclitaxel (PTX), LPNs were expected to combine the therapeutic effects of CBP and PTX, thus show synergistic ability on cervical cancer. Results: FA-CBP/PTX-LPNs showed the sizes of 169.9 ± 5.6 nm, with a narrow size distribution of 0.151 ± 0.023. FA-CBP/PTX-LPNs exhibited pH-responsive drug release, high cellular uptake efficiency (66.7 ± 3.1%), and prominent cell inhibition capacity (23 ± 1.1%). In vivo tumor distribution and tumor inhibition efficiency of FA-CBP/PTX-LPNs was the highest, with no obvious body weight lost. Conclusion: High tumor distribution and remarkable antitumor efficiency obtained using in vitro as well as in vivo models further proved the FA-CBP/PTX-LPNs is a promising tool for cervical cancer therapy.
MeSH term(s)	Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacology ; Carboplatin/administration & dosage ; Carboplatin/pharmacology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Combined Modality Therapy ; Dose-Response Relationship, Drug ; Drug Liberation ; Drug Screening Assays, Antitumor ; Female ; Folic Acid/administration & dosage ; Folic Acid/pharmacology ; HeLa Cells ; Humans ; Hydrogen-Ion Concentration ; Ligands ; Lipids/chemistry ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Structure ; Nanoparticles/administration & dosage ; Nanoparticles/chemistry ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/pathology ; Paclitaxel/administration & dosage ; Paclitaxel/pharmacology ; Polymers/chemistry ; Structure-Activity Relationship ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/pathology
Chemical Substances	Antineoplastic Agents ; Ligands ; Lipids ; Polymers ; Folic Acid (935E97BOY8) ; Carboplatin (BG3F62OND5) ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2020-02-26
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S235098
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A commentary on "Portal vein thrombosis and liver transplantation: management, matching, and outcomes: a retrospective multicenter cohort study".

Wang, Junjian / Ye, Xiaoang / Chen, Hongyu

International journal of surgery (London, England)

2024

Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1097/JS9.0000000000001485
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reassessing the Quantum Yield and Reactivity of Triplet-State Dissolved Organic Matter via Global Kinetic Modeling.

Du, Penghui / Tang, Kexin / Yang, Biwei / Mo, Xiaohan / Wang, Junjian

Environmental science & technology

2024 Volume 58, Issue 13, Page(s) 5856–5865

Abstract: Measuring the quantum yield and reactivity of triplet-state dissolved organic matter ( ...

Abstract	Measuring the quantum yield and reactivity of triplet-state dissolved organic matter (
MeSH term(s)	Dissolved Organic Matter ; Photochemical Processes ; Photochemistry ; Photolysis
Chemical Substances	Dissolved Organic Matter
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.4c00214
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Article ; Online: Heat Hazard Control in High-Temperature Tunnels: Experimental Study of Coupled Cooling with Ventilation and Partial Insulation for Synergistic Geothermal Extraction.

Wang, Junjian / Li, Zijun / Li, Gang / Xu, Yu

International journal of environmental research and public health

2023 Volume 20, Issue 3

Abstract: The problem of heat hazard in tunnel engineering has seriously affected the normal work of personnel and machinery. After combining the heat hazard control method of controlling the energy source and blocking the energy transfer, a technical scheme of ... ...

Abstract	The problem of heat hazard in tunnel engineering has seriously affected the normal work of personnel and machinery. After combining the heat hazard control method of controlling the energy source and blocking the energy transfer, a technical scheme of precise thermal insulation at the working face in concert with geothermal energy extraction is proposed, forming a coupled cooling method of ventilation and partial thermal insulation. By building a scaled model test platform, the temperature field of the working area was analyzed, and the effect of factors, such as with or without a thermal insulation layer, ventilation velocity, and surrounding rock temperature on the cooling limit, was discussed. The feasibility of extracting energy and enhancing cooling through the heat exchange layer was judged. The results show that the partial thermal insulation can effectively weaken the heat dissipation of the surrounding rock and enhance the ventilation and cooling effect, which can reduce the average ventilation limit temperature of the working area by 1.6 °C. The addition of the heat exchange layer can further improve the tunnel environment on the basis of partial insulation, making the cooling limit temperature drop by another 3.1 °C, and the heat exchange layer can work for one year to extract geothermal energy 4.5 × 10
MeSH term(s)	Humans ; Body Temperature Regulation ; Cold Temperature ; Hot Temperature ; Temperature ; Occupational Health
Language	English
Publishing date	2023-01-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20031941
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Article ; Online: Monthly dietary shifts in the jellyfish Nemopilema nomurai in Liaodong Bay, China.

Wang, Junjian / Wang, Yantao / Tao, Zhencheng / Li, Chaolun

Marine pollution bulletin

2023 Volume 193, Page(s) 115115

Abstract: Nemopilema nomurai is a frequently bloomed species in the China seas. Their feeding organ has an ontogenetic change when they grow up, but whether their diet changes along with it is unclear. A 5-month study on N. nomurai was conducted in Liaodong Bay, ... ...

Abstract	Nemopilema nomurai is a frequently bloomed species in the China seas. Their feeding organ has an ontogenetic change when they grow up, but whether their diet changes along with it is unclear. A 5-month study on N. nomurai was conducted in Liaodong Bay, China to clarify the dietary shift and feeding effect of N. nomurai. Fatty acid biomarkers revealed the proportion of carnivorous food in the diet of N. nomurai decreased when their bell diameter increased. The isotope data revealed a similar story with δ
MeSH term(s)	Animals ; Bays ; Cnidaria ; Scyphozoa ; Oceans and Seas ; Diet
Language	English
Publishing date	2023-06-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2023.115115
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Article ; Online: A bibliometric study on carbon cycling in vegetated blue carbon ecosystems.

Yin, Shuo / Wang, Junjian / Zeng, Hui

Environmental science and pollution research international

2023 Volume 30, Issue 30, Page(s) 74691–74708

Abstract: Understanding carbon cycling in blue carbon ecosystems is key to sequestrating more carbon in these ecosystems to mitigate climate change. However, limited information is available on the basic characteristics of publications, research hotspots, research ...

Abstract	Understanding carbon cycling in blue carbon ecosystems is key to sequestrating more carbon in these ecosystems to mitigate climate change. However, limited information is available on the basic characteristics of publications, research hotspots, research frontiers, and the evolution of topics related to carbon cycling in different blue carbon ecosystems. Here, we conducted bibliometric analysis on carbon cycling in salt marsh, mangrove, and seagrass ecosystems. The results showed that interest in this field has dramatically increased with time, particularly for mangroves. The USA has substantially contributed to the research on all ecosystems. Research hotspots for salt marshes were sedimentation process, carbon sequestration, carbon emissions, lateral carbon exchange, litter decomposition, plant carbon fixation, and carbon sources. In addition, biomass estimation by allometric equations was a hotspot for mangroves, and carbonate cycling and ocean acidification were hotspots for seagrasses. Topics involving energy flow, such as productivity, food webs, and decomposition, were the predominant areas a decade ago. Current research frontiers mainly concentrated on climate change and carbon sequestration for all ecosystems, while methane emission was a common frontier for mangroves and salt marshes. Ecosystem-specific research frontiers included mangrove encroachment for salt marshes, ocean acidification for seagrasses, and aboveground biomass estimation and restoration for mangroves. Future research should expand estimates of lateral carbon exchange and carbonate burial and strengthen the exploration of the impacts of climate change and restoration on blue carbon. Overall, this study provides the research status of carbon cycling in vegetated blue carbon ecosystems, which favors knowledge exchanges for future research.
MeSH term(s)	Ecosystem ; Carbon ; Hydrogen-Ion Concentration ; Seawater ; Wetlands ; Carbon Sequestration
Chemical Substances	Carbon (7440-44-0)
Language	English
Publishing date	2023-05-27
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-27816-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pulmonary metastasectomy for recurrent metastatic ovarian cancer.

Cheng, Feng / Wang, Junjian / Chen, Qixun / Zhu, Jianqing

The journal of obstetrics and gynaecology research

2023 Volume 49, Issue 12, Page(s) 2905–2909

Abstract: Aim: The prognosis of patients with ovarian cancer with lung metastasis is poor; data on pulmonary metastasectomy for such patients are lacking. This study aimed to determine the safety and feasibility of pulmonary resection as part of cytoreductive ... ...

Abstract	Aim: The prognosis of patients with ovarian cancer with lung metastasis is poor; data on pulmonary metastasectomy for such patients are lacking. This study aimed to determine the safety and feasibility of pulmonary resection as part of cytoreductive surgery for recurrent metastatic ovarian cancer. Methods: Medical records of patients with ovarian cancer, who underwent pulmonary resection for lung metastasis in our hospital from April 2012 to February 2022, were retrospectively reviewed. Results: Ten patients were included (median age, 53 years). Five patients had metastatic disease limited to the lungs. Additional surgeries included diaphragm resection, partial hepatectomy, para-aortic lymph node dissection, and cytoreduction. We achieved complete cytoreduction for all patients without severe complications, and the 30-day mortality was zero. After a median follow-up of 23 months, four of the patients experienced recurrence. One patient recurred 9 months after the operation and was lost to follow-up at 17 months, two died at 68 and 26 months respectively, one is alive with disease (23 months), and six are alive without recurrence, among whom two have survived for 56 and 124 months. Conclusions: Pulmonary resection for recurrent metastatic ovarian cancer seems safe and feasible, with long-term survival observed in certain patients. Pulmonary metastasectomy can be performed as part of the debulking surgery for selected patients with relapsed metastatic ovarian cancer. Both the patient lost to follow-up and the one who died at 26 months, had two lung metastatic nodules and did not receive postoperative chemotherapy, which might have led to relatively poor prognosis.
MeSH term(s)	Humans ; Female ; Middle Aged ; Metastasectomy ; Retrospective Studies ; Neoplasm Recurrence, Local/surgery ; Neoplasm Recurrence, Local/pathology ; Ovarian Neoplasms/pathology ; Carcinoma, Ovarian Epithelial ; Lung Neoplasms/surgery ; Lung Neoplasms/secondary
Language	English
Publishing date	2023-10-09
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1327307-3
ISSN	1447-0756 ; 1341-8076
ISSN (online)	1447-0756
ISSN	1341-8076
DOI	10.1111/jog.15809
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Article ; Online: 2H-Phosphindole-Enabled Dearomatization and [4+2] Cycloaddition of (Hetero)Arenes.

Luo, Haotian / Wang, Junjian / Tian, Rongqiang / Duan, Zheng

Chemistry (Weinheim an der Bergstrasse, Germany)

2023 Volume 29, Issue 54, Page(s) e202301898

Abstract: The heavier main group multiple bonds offer an effective tool for small molecule activation. Transient 2H-phosphinidole working as a reactive phosphadiene system undergoes phospha-Diels-Alder reaction with a wide range of non-activated aromatic ... ...

Abstract	The heavier main group multiple bonds offer an effective tool for small molecule activation. Transient 2H-phosphinidole working as a reactive phosphadiene system undergoes phospha-Diels-Alder reaction with a wide range of non-activated aromatic carbocycles and heterocycles, including naphthalene, anthracene, phenanthrene, furan, thiophene, pyrrole, pyridine, and benzo-fused heterocycles, affording concise access to a range of polycyclic fused rings feature with phosphorus at the bridgehead. These results demonstrate that non-activated (hetero)arenes are capable of acting as 2π systems in [4+2] cycloaddition with highly reactive 2H-phosphindole complex.
Language	English
Publishing date	2023-08-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202301898
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Monthly dietary shifts in the jellyfish Nemopilema nomurai in Liaodong Bay, China

Wang, Junjian / Wang, Yantao / Tao, Zhencheng / Li, Chaolun

Marine Pollution Bulletin. 2023 Aug., v. 193 p.115115-

2023

Abstract	Nemopilema nomurai is a frequently bloomed species in the China seas. Their feeding organ has an ontogenetic change when they grow up, but whether their diet changes along with it is unclear. A 5-month study on N. nomurai was conducted in Liaodong Bay, China to clarify the dietary shift and feeding effect of N. nomurai. Fatty acid biomarkers revealed the proportion of carnivorous food in the diet of N. nomurai decreased when their bell diameter increased. The isotope data revealed a similar story with δ¹⁵N dropping which indicated a decreased trophic level. The diet composition was dominated (74 %) by zooplankton >200 μm in May and then decreased to <32 % in July. In contrast, the proportion of particulate organic matter increased from <35 % to 68 %. This study revealed a monthly shift in the diet of N. nomurai and contributed to knowledge of trophic interactions between plankton and N. nomurai.
Keywords	Scyphozoa ; biomarkers ; carnivores ; diet ; fatty acids ; isotopes ; marine pollution ; ontogeny ; particulate organic matter ; trophic levels ; zooplankton ; China ; Nemopilema nomurai ; Distribution ; Stable isotopes
Language	English
Dates of publication	2023-08
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2023.115115
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Rhizosheath: Distinct features and environmental functions

Mo, Xiaohan / Wang, Mengke / Zeng, Hui / Wang, Junjian

Geoderma. 2023 July, v. 435 p.116500-

2023

Abstract: Interactions between plant roots and the surrounding soils are crucial for plant growth and soil health. The rhizosheath, which is the sheath-like soil that is tightly attached to the plant root surface, is increasingly acknowledged to exhibit distinct ... ...

Abstract	Interactions between plant roots and the surrounding soils are crucial for plant growth and soil health. The rhizosheath, which is the sheath-like soil that is tightly attached to the plant root surface, is increasingly acknowledged to exhibit distinct features and critical environmental functions for soil, plants, and microbes. However, the differences between the terms "rhizosheath" and "rhizosphere soil" remain ambiguous across the literature, and not all features and functions of rhizosheaths have reached a consensus. Here, we summarize the terminology, methodology, formation mechanisms, and findings of the features and functions of rhizosheaths via an integrated and quantitative approach. First, we propose a comprehensive framework for the terminology of different rhizosphere compartments, which allows for consistent definitions and improved comparability across studies. We also summarize the current knowledge of the mechanisms underlying rhizosheath formation. Moreover, by collecting evidence from the literature, we highlight the distinct physical, chemical, and microbial features of rhizosheath soils, such as 66% higher water content, 34% higher soil organic carbon, 56% higher water-extractable organic carbon, and 71% higher microbial biomass nitrogen in rhizosheath soils than those in other rhizosphere counterparts. We further discuss how these features lead to the environmental and biogeochemical functions of rhizosheaths, including sand fixation, soil aggregation, water and nutrient uptake, carbon dynamics, and microbial colonization. We highlight the significance of these functions from micro- to ecosystem-scale. Finally, we propose future research perspectives to better understand and harness the environmental benefits of rhizosheaths.
Keywords	microbial colonization ; microbial nitrogen ; nutrient uptake ; plant growth ; quantitative analysis ; rhizosphere ; roots ; sand ; soil ; soil aggregation ; soil organic carbon ; soil quality ; terminology ; water content ; Environmental stress ; Rhizosphere biogeochemistry ; Root−soil interface ; Sandy soil
Language	English
Dates of publication	2023-07
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	281080-3
ISSN	1872-6259 ; 0016-7061
ISSN (online)	1872-6259
ISSN	0016-7061
DOI	10.1016/j.geoderma.2023.116500
Database	NAL-Catalogue (AGRICOLA)

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