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  1. Article: Influence of Laser Energy Density on Tribological Properties of AlSi10Mg Manufactured by Selective Laser Melting.

    Wang, Keqing

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 2

    Abstract: In recent years, much work related to the performance of AlSi10Mg manufactured by selective laser melting (SLM) has been extensively researched. However, the study of tribological performance caused by different laser energy densities is still ... ...

    Abstract In recent years, much work related to the performance of AlSi10Mg manufactured by selective laser melting (SLM) has been extensively researched. However, the study of tribological performance caused by different laser energy densities is still insufficient. This work concentrates on the relationship between the wear resistance and laser energy density of AlSi10Mg processed using SLM. Moreover, XRD characterization, density, surface roughness and microhardness were also examined since they are closely related to wear resistance. The results revealed that the XRD pattern of AlSi10Mg was mainly composed of the α-Al and Si phases under the conditions of different laser energy densities. In addition, the peak of Mg
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17020323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Grammar enhancement in EFL instruction: a reflection on the effects of self-evaluation, teacher support, and L2 grit.

    Wang, Kelu

    BMC psychology

    2024  Volume 12, Issue 1, Page(s) 15

    Abstract: Advancement in learning grammar and using it practically is one of the challenges of English as foreign learners (EFL) learners. Its progression may be expedited or slowed down by a variety of causes. Among the crucial factors, the possible effects of ... ...

    Abstract Advancement in learning grammar and using it practically is one of the challenges of English as foreign learners (EFL) learners. Its progression may be expedited or slowed down by a variety of causes. Among the crucial factors, the possible effects of self-evaluation, teacher support, and L2 grit were still untouched which is the target of the current research. In so doing, 86 EFL students at the intermediate level were divided into two groups (i.e., experimental group and control group). The students in the control group (CG) are exposed to normal education, whereas learners in experimental group (EG) get extra instruction to practice self-evaluation and L2 Grit. Moreover, the emphasis on the teacher's position as a facilitator and supporter was more prominent in the EG. Based on data screening which was completed via one-way ANCOVA, learners in EG were more successful in grammar assessment due to the treatment. Further research avenues and educational implications were elaborated upon.
    MeSH term(s) Humans ; Diagnostic Self Evaluation ; Educational Personnel ; Students ; Internationality ; Learning
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2705921-2
    ISSN 2050-7283 ; 2050-7283
    ISSN (online) 2050-7283
    ISSN 2050-7283
    DOI 10.1186/s40359-023-01504-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Visual Abstract of "Six Tips for Giving Good Health Care to Anyone With a Cervix".

    Wang, Kelly

    AMA journal of ethics

    2024  Volume 26, Issue 1, Page(s) E84–85

    Abstract: This visual abstract is based on an article from the February 2020 issue of the journal. ...

    Abstract This visual abstract is based on an article from the February 2020 issue of the journal.
    MeSH term(s) Female ; Humans ; Cervix Uteri ; Delivery of Health Care
    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Journal Article
    ISSN 2376-6980
    ISSN (online) 2376-6980
    DOI 10.1001/amajethics.2024.84
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  4. Article ; Online: Interval estimate of causal effect in summary data based Mendelian randomization in the presence of winner's curse.

    Wang, Kai

    Genetic epidemiology

    2024  Volume 48, Issue 2, Page(s) 74–84

    Abstract: This research focuses on the interval estimation of the causal effect of an exposure on an outcome using the summary data-based Mendelian randomization (SMR) method while accounting for the winner's curse caused by the selection of single nucleotide ... ...

    Abstract This research focuses on the interval estimation of the causal effect of an exposure on an outcome using the summary data-based Mendelian randomization (SMR) method while accounting for the winner's curse caused by the selection of single nucleotide polymorphism instruments. This issue is understudied and is important as the point estimate is biased. Since Fieller's theorem and its variations are not suitable for constructing a confidence interval, we use the box method. This box method is known to be conservative and thus provides a lower bound on the coverage level. To assess the performance of the box method, we use simulation studies and compare it with the support interval we proposed earlier and the Wald interval derived from the SMR method. All three methods are applied to a study of causal genes for Alzheimer's disease. Overall, the box method presents an alternative for constructing interval estimates for a causal effect while addressing the winner's curse issue.
    MeSH term(s) Humans ; Mendelian Randomization Analysis ; Models, Genetic ; Computer Simulation ; Polymorphism, Single Nucleotide ; Genome-Wide Association Study
    Language English
    Publishing date 2024-01-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605785-8
    ISSN 1098-2272 ; 0741-0395
    ISSN (online) 1098-2272
    ISSN 0741-0395
    DOI 10.1002/gepi.22545
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1969: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Revealing genomic secrets of archival FFPE samples.

    Wang, Kaile

    Nature reviews. Cancer

    2024  

    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062767-1
    ISSN 1474-1768 ; 1474-175X
    ISSN (online) 1474-1768
    ISSN 1474-175X
    DOI 10.1038/s41568-024-00686-7
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    Zs.A 5563: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MG 24: Show issues

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  6. Article ; Online: Support Interval for Two-Sample Summary Data-Based Mendelian Randomization.

    Wang, Kai

    Genes

    2023  Volume 14, Issue 1

    Abstract: The summary-data-based Mendelian randomization (SMR) method is gaining popularity in estimating the causal effect of an exposure on an outcome. In practice, the instrument SNP is often selected from the genome-wide association study (GWAS) on the ... ...

    Abstract The summary-data-based Mendelian randomization (SMR) method is gaining popularity in estimating the causal effect of an exposure on an outcome. In practice, the instrument SNP is often selected from the genome-wide association study (GWAS) on the exposure but no correction is made for such selection in downstream analysis, leading to a biased estimate of the effect size and invalid inference. We address this issue by using the likelihood derived from the sampling distribution of the estimated SNP effects in the exposure GWAS and the outcome GWAS. This likelihood takes into account how the instrument SNPs are selected. Since the effective sample size is 1, the asymptotic theory does not apply. We use a support for a profile likelihood as an interval estimate of the causal effect. Simulation studies indicate that this support has robust coverage while the confidence interval implied by the SMR method has lower-than-nominal coverage. Furthermore, the variance of the two-stage least squares estimate of the causal effect is shown to be the same as the variance used for SMR for one-sample data when there is no selection.
    MeSH term(s) Genome-Wide Association Study ; Mendelian Randomization Analysis/methods ; Causality ; Computer Simulation ; Sample Size
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14010211
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  7. Article ; Online: Cr

    Wang, Kai

    Journal of computational chemistry

    2023  Volume 44, Issue 19, Page(s) 1667–1672

    Abstract: In this work, we investigated the structural evolution, electronic and magnetic properties of ... ...

    Abstract In this work, we investigated the structural evolution, electronic and magnetic properties of Cr
    MeSH term(s) Algorithms ; Cluster Analysis ; Electronics ; Isomerism
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1479181-X
    ISSN 1096-987X ; 0192-8651
    ISSN (online) 1096-987X
    ISSN 0192-8651
    DOI 10.1002/jcc.27117
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  8. Article ; Online: Anatomy and ultrasonic evaluation of superficial circumflex iliac artery flap vessels.

    Wang, Kunju

    Minerva surgery

    2023  

    Language English
    Publishing date 2023-12-13
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3067899-7
    ISSN 2724-5438
    ISSN (online) 2724-5438
    DOI 10.23736/S2724-5691.23.10164-X
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    Zs.A 25: Show issues Location:
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  9. Article ; Online: GPDOCK: highly accurate docking strategy for metalloproteins based on geometric probability.

    Wang, Kai

    Briefings in bioinformatics

    2023  Volume 24, Issue 1

    Abstract: Accurately predicting the interaction modes for metalloproteins remains extremely challenging in structure-based drug design and mechanism analysis of enzymatic catalysis due to the complexity of metal coordination in metalloproteins. Here, we report a ... ...

    Abstract Accurately predicting the interaction modes for metalloproteins remains extremely challenging in structure-based drug design and mechanism analysis of enzymatic catalysis due to the complexity of metal coordination in metalloproteins. Here, we report a docking method for metalloproteins based on geometric probability (GPDOCK) with unprecedented accuracy. The docking tests of 10 common metal ions with 9360 metalloprotein-ligand complexes demonstrate that GPDOCK has an accuracy of 94.3% in predicting binding pose. What is more, it can accurately realize the docking of metalloproteins with ligand when one or two water molecules are engaged in the metal ion coordination. Since GPDOCK only depends on the three-dimensional structure of metalloprotein and ligand, structure-based machine learning model is employed for the scoring of binding poses, which significantly improves computational efficiency. The proposed docking strategy can be an effective and efficient tool for drug design and further study of binding mechanism of metalloproteins. The manual of GPDOCK and the code for the logistical regression model used to re-rank the docking results are available at https://github.com/wangkai-zhku/GPDOCK.git.
    MeSH term(s) Metalloproteins/chemistry ; Metalloproteins/metabolism ; Protein Binding ; Ligands ; Machine Learning ; Catalysis ; Molecular Docking Simulation ; Binding Sites
    Chemical Substances Metalloproteins ; Ligands
    Language English
    Publishing date 2023-01-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2068142-2
    ISSN 1477-4054 ; 1467-5463
    ISSN (online) 1477-4054
    ISSN 1467-5463
    DOI 10.1093/bib/bbac620
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    Zs.A 6262: Show issues Location:
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  10. Article: [Membrane anatomy in right colon cancer: definition and identification of mesocolic completeness].

    Luo, B / Wang, K

    Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

    2023  Volume 26, Issue 7, Page(s) 639–643

    Abstract: Complete mesocolic excision (CME) and D3 resection of right colon cancer have been widely implemented, but the definition and identification of the completeness of the mesentery have not been fully agreed, especially the dorsal and medial borders. In ... ...

    Abstract Complete mesocolic excision (CME) and D3 resection of right colon cancer have been widely implemented, but the definition and identification of the completeness of the mesentery have not been fully agreed, especially the dorsal and medial borders. In this paper, we proposed the dorsal fascia of the colonic mesentery as the dorsal border of the mesocolon and the line connecting the roots of the ileocolic artery and the middle colic artery (ICA-MCA line) as the medial border of the CME by systematically studying the relationship between the mesentery and the mesenteric bed from the theory of membrane anatomy, combined with surgical experience and in-depth review of ontogenetic anatomy. We also proposed the visible "superior mesenteric vein notch" and "middle colic artery triangle" on surgical specimens as identifiers of mesocolic completeness.
    MeSH term(s) Humans ; Mesocolon/surgery ; Lymph Node Excision ; Colectomy ; Laparoscopy ; Colonic Neoplasms/surgery
    Language Chinese
    Publishing date 2023-08-15
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1671-0274
    ISSN 1671-0274
    DOI 10.3760/cma.j.cn441530-20230409-00109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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