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  1. Article: Effect of Humanistic Pain Management in Postpartum Women after Cesarean Delivery Based on Active Pain Assessment and Visual Analog Scale.

    Peng, Yan / Li, Li / Wang, Kehui / Zhang, Ran

    Alternative therapies in health and medicine

    2024  

    Abstract: Objective: To explore the effect of humanistic pain management based on active pain assessment and the visual analog scale in postpartum women after cesarean delivery.: Methods: We selected 100 postpartum women who underwent cesarean delivery in ... ...

    Abstract Objective: To explore the effect of humanistic pain management based on active pain assessment and the visual analog scale in postpartum women after cesarean delivery.
    Methods: We selected 100 postpartum women who underwent cesarean delivery in Xuzhou Maternity and Child Health Care Hospital from April to December 2021 and divided the postpartum women into a management group and a conventional group, with 50 cases in each group. The conventional group was given routine pain management, while the management group was given humanistic pain management based on active pain assessment and visual analog scale score. The quality of pain management, sleep quality, unhealthy emotion, maternal comfort, breastfeeding rates, and patient compliance in the 2 groups were compared.
    Results: The most severe degree of pain, the least degree of pain, the frequency of moderate and severe pain, and the influence of pain on sleep were lower in the management group than in the conventional group. The Pittsburgh Sleep Quality Index score was lower and the Self-Rating Anxiety Scale and the Self-Rating Depression Scale scores were higher in the management group than in the conventional group. In addition, the comfort scores for the second day and the third day after delivery were higher in the management group than in the conventional group. The breastfeeding rate and patient compliance were higher in the management group than in the conventional group.
    Conclusion: Humanistic pain management based on active pain assessment and the visual analog scale can improve the quality of maternal pain management, the quality of sleep, and maternal comfort, ameliorate maternal adverse emotions, and promote breastfeeding and patient compliance.
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4504: Show issues Location:
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  2. Article ; Online: The moderation of satisfaction with working conditions in the association between workload and mental health among healthcare workers collecting test samples in the post-COVID-19 era.

    Wang, Kehui / Yang, Bin / Wu, Cuiping / Zheng, Lianxue

    Frontiers in public health

    2023  Volume 11, Page(s) 1106299

    Abstract: Background: This study aimed to examine the associations between workload and satisfaction with working conditions and mental health (i.e., anxiety disorder, depression, and somatization) of healthcare workers collecting test samples during the local ... ...

    Abstract Background: This study aimed to examine the associations between workload and satisfaction with working conditions and mental health (i.e., anxiety disorder, depression, and somatization) of healthcare workers collecting test samples during the local outbreaks of COVID-19, and explore satisfaction with working conditions as a moderator of these relationships.
    Methods: A total of 1,349 participants were obtained via an online survey in Zhengzhou, Henan Province, China. Multivariate regression was used to assess the associations between workload and satisfaction with working conditions and anxiety disorder, depression, and somatization. The simple slope analysis and Johnson-Neyman technique were used to assess the effect value and change trend of the moderator.
    Results: The prevalence of anxiety disorder, depression, and somatization were 8.6, 6.9, and 19.2% of healthcare workers collecting test samples, respectively. High levels of workload were associated with an increased risk of an anxiety disorder (OR = 1.81, 95%CI = 1.17-2.78), depression (OR = 1.92, 95%CI = 1.19-3.10), and somatization (OR = 1.90, 95%CI = 1.40-2.57), while high satisfaction of working conditions was associated with a reduction in the risk of these outcomes, and ORs (95%CI) were 0.35 (0.20-0.64), 0.27 (0.13-0.56), and 0.32 (0.21-0.48), respectively. The findings also indicated that a weaker association between workload and anxiety disorder, as well as depression and somatization, has been reported in those with a high level of satisfaction with working conditions.
    Conclusion: Workload significantly increased the risk of healthcare workers suffering from psychological problems, while satisfaction with working conditions alleviated these negative effects, and effective resource support was crucial for healthcare workers.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Mental Health ; Workload ; Working Conditions ; Depression/epidemiology ; Health Personnel ; Personal Satisfaction
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1106299
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  3. Article: Inference in Functional Linear Quantile Regression.

    Li, Meng / Wang, Kehui / Maity, Arnab / Staicu, Ana-Maria

    Journal of multivariate analysis

    2022  Volume 190

    Abstract: In this paper, we study statistical inference in functional quantile regression for scalar response and a functional covariate. Specifically, we consider a functional linear quantile regression model where the effect of the covariate on the quantile of ... ...

    Abstract In this paper, we study statistical inference in functional quantile regression for scalar response and a functional covariate. Specifically, we consider a functional linear quantile regression model where the effect of the covariate on the quantile of the response is modeled through the inner product between the functional covariate and an unknown smooth regression parameter function that varies with the level of quantile. The objective is to test that the regression parameter is constant across several quantile levels of interest. The parameter function is estimated by combining ideas from functional principal component analysis and quantile regression. An adjusted Wald testing procedure is proposed for this hypothesis of interest, and its chi-square asymptotic null distribution is derived. The testing procedure is investigated numerically in simulations involving sparse and noisy functional covariates and in a capital bike share data application. The proposed approach is easy to implement and the R code is published online at https://github.com/xylimeng/fQR-testing.
    Language English
    Publishing date 2022-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1469773-7
    ISSN 0047-259X
    ISSN 0047-259X
    DOI 10.1016/j.jmva.2022.104985
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  4. Article ; Online: CENP-I directly targets centromeric DNA to support CENP-A deposition and centromere maintenance.

    Hu, Liqiao / Zhao, Congcong / Liu, Mingjie / Liu, Shuaiyu / Ye, Jingjing / Wang, Kehui / Shi, Jinyun / Tian, Wei / He, Xiaojing

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 11, Page(s) e2219170120

    Abstract: The enrichment of histone H3 variant CENP-A is the epigenetic mark of centromere and initiates the assembly of the kinetochore at centromere. The kinetochore is a multi-subunit complex that ensures accurate attachment of microtubule centromere and ... ...

    Abstract The enrichment of histone H3 variant CENP-A is the epigenetic mark of centromere and initiates the assembly of the kinetochore at centromere. The kinetochore is a multi-subunit complex that ensures accurate attachment of microtubule centromere and faithful segregation of sister chromatids during mitosis. As a subunit of kinetochore, CENP-I localization at centromere also depends on CENP-A. However, whether and how CENP-I regulates CENP-A deposition and centromere identity remains unclear. Here, we identified that CENP-I directly interacts with the centromeric DNA and preferentially recognizes AT-rich elements of DNA via a consecutive DNA-binding surface formed by conserved charged residues at the end of N-terminal HEAT repeats. The DNA binding-deficient mutants of CENP-I retained the interaction with CENP-H/K and CENP-M, but significantly diminished the centromeric localization of CENP-I and chromosome alignment in mitosis. Moreover, the DNA binding of CENP-I is required for the centromeric loading of newly synthesized CENP-A. CENP-I stabilizes CENP-A nucleosomes upon binding to nucleosomal DNA instead of histones. These findings unveiled the molecular mechanism of how CENP-I promotes and stabilizes CENP-A deposition and would be insightful for understanding the dynamic interplay of centromere and kinetochore during cell cycle.
    MeSH term(s) Centromere Protein A/genetics ; Centromere Protein A/metabolism ; Chromosomal Proteins, Non-Histone/metabolism ; Centromere/genetics ; Centromere/metabolism ; Histones/genetics ; Histones/metabolism ; Nucleosomes/genetics ; DNA/genetics ; Mitosis ; Autoantigens/metabolism
    Chemical Substances Centromere Protein A ; Chromosomal Proteins, Non-Histone ; Histones ; Nucleosomes ; DNA (9007-49-2) ; Autoantigens
    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2219170120
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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  5. Article ; Online: The relationship between management and control indexes of distribution network construction based on Apriori algorithm

    Yang Zhuo / Yu Jinxiong / Li Huitao / Zheng Zhicong / Wang Lili / Wang Kehui / Pan Zhaolun / Sun Huijun

    E3S Web of Conferences, Vol 237, p

    2021  Volume 02002

    Abstract: There are a large number of distribution network construction projects with different types, and a large number of complex data relationships are generated in the construction process. This paper combs the key management and control indicators of ... ...

    Abstract There are a large number of distribution network construction projects with different types, and a large number of complex data relationships are generated in the construction process. This paper combs the key management and control indicators of distribution network construction projects, and constructs the management and control index system of each stage of the project. Based on Apriori algorithm, this paper studies the relationship between the key management and control indicators, and provides reference for the management and control of distribution network construction.
    Keywords Environmental sciences ; GE1-350
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Multi-omics analysis of an in vitro photoaging model and protective effect of umbilical cord mesenchymal stem cell-conditioned medium.

    Zou, Xiaocang / Zou, Dayang / Li, Linhao / Yu, Renfeng / Li, XianHuang / Du, Xingyue / Guo, JinPeng / Wang, KeHui / Liu, Wei

    Stem cell research & therapy

    2022  Volume 13, Issue 1, Page(s) 435

    Abstract: Background: Skin ageing caused by long-term ultraviolet (UV) irradiation is a complex biological process that involves multiple signalling pathways. Stem cell-conditioned media is believed to have anti-ageing effects on the skin. The purpose of this ... ...

    Abstract Background: Skin ageing caused by long-term ultraviolet (UV) irradiation is a complex biological process that involves multiple signalling pathways. Stem cell-conditioned media is believed to have anti-ageing effects on the skin. The purpose of this study was to explore the biological effects of UVB irradiation and anti-photoaging effects of human umbilical cord mesenchymal stem cell-conditioned medium (hUC-MSC-CM) on HaCaT cells using multi-omics analysis with a novel cellular photoaging model.
    Methods: A cellular model of photoaging was constructed by irradiating serum-starved HaCaT cells with 20 mJ/cm
    Results: The results of the multi-omics analysis revealed that UVB irradiation affected various biological functions of cells, including cell proliferation and the cell cycle, and induced a senescence-associated secretory phenotype. hUC-MSC-CM treatment reduced cell apoptosis, inhibited G1 phase arrest in the cell cycle, reduced the production of reactive oxygen species, and promoted cell motility. The qRT-PCR results indicated that MYC, IL-8, FGF-1, and EREG were key genes involved in the anti-photoaging effects of hUC-MSC-CM. The western blotting results demonstrated that C-FOS, C-JUN, TGFβ, p53, FGF-1, and cyclin A2 were key proteins involved in the anti-photoaging effects of hUC-MSC-CM.
    Conclusion: Serum-starved HaCaT cells irradiated with 20 mJ/cm
    MeSH term(s) Culture Media, Conditioned/metabolism ; Culture Media, Conditioned/pharmacology ; Fibroblast Growth Factor 1/metabolism ; Humans ; Mesenchymal Stem Cells/metabolism ; Skin Aging ; Umbilical Cord
    Chemical Substances Culture Media, Conditioned ; Fibroblast Growth Factor 1 (104781-85-3)
    Language English
    Publishing date 2022-09-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2548671-8
    ISSN 1757-6512 ; 1757-6512
    ISSN (online) 1757-6512
    ISSN 1757-6512
    DOI 10.1186/s13287-022-03137-y
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  7. Article ; Online: Ser68 phosphoregulation is essential for CENP-A deposition, centromere function and viability in mice.

    Liu, Yuting / Wang, Kehui / Huang, Li / Zhao, Jicheng / Chen, Xinpeng / Wu, Qiang / Yu, Zhouliang / Li, Guohong

    Science China. Life sciences

    2022  Volume 65, Issue 9, Page(s) 1881–1889

    Abstract: Centromere identity is defined by nucleosomes containing CENP-A, a histone H3 variant. The deposition of CENP-A at centromeres is tightly regulated in a cell-cycle-dependent manner. We previously reported that the spatiotemporal control of centromeric ... ...

    Abstract Centromere identity is defined by nucleosomes containing CENP-A, a histone H3 variant. The deposition of CENP-A at centromeres is tightly regulated in a cell-cycle-dependent manner. We previously reported that the spatiotemporal control of centromeric CENP-A incorporation is mediated by the phosphorylation of CENP-A Ser68. However, a recent report argued that Ser68 phosphoregulation is dispensable for accurate CENP-A loading. Here, we report that the substitution of Ser68 of endogenous CENP-A with either Gln68 or Glu68 severely impairs CENP-A deposition and cell viability. We also find that mice harboring the corresponding mutations are lethal. Together, these results indicate that the dynamic phosphorylation of Ser68 ensures cell-cycle-dependent CENP-A deposition and cell viability.
    MeSH term(s) Animals ; Autoantigens/metabolism ; Cell Cycle ; Centromere/genetics ; Centromere/metabolism ; Centromere Protein A/genetics ; Centromere Protein A/metabolism ; Histones/genetics ; Histones/metabolism ; Mice ; Nucleosomes
    Chemical Substances Autoantigens ; Centromere Protein A ; Histones ; Nucleosomes
    Language English
    Publishing date 2022-04-01
    Publishing country China
    Document type Journal Article
    ZDB-ID 2546732-3
    ISSN 1869-1889 ; 1674-7305
    ISSN (online) 1869-1889
    ISSN 1674-7305
    DOI 10.1007/s11427-021-2077-1
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  8. Article ; Online: Ser68 Phosphorylation Ensures Accurate Cell-Cycle-Dependent CENP-A Deposition at Centromeres.

    Wang, Kehui / Yu, Zhouliang / Liu, Yuting / Li, Guohong

    Developmental cell

    2017  Volume 40, Issue 1, Page(s) 5–6

    Language English
    Publishing date 2017-01-09
    Publishing country United States
    Document type Letter
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2016.12.015
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    Zs.MG 76: Show issues

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  9. Article: [Development of Portable Bowel Sound Monitor].

    Wei, Ziran / Zhang, Xin / Hu, Zunqi / Jiang, Guocheng / Wang, Kehui / Cai, Qingping

    Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation

    2019  Volume 43, Issue 6, Page(s) 418–421

    Abstract: This paper designs and implements a low power portable bowel sound monitor, which adopts bone conduction transducer to collect bowel sound continuously for long time and transmit to phone by Bluetooth. Then the phone application can record, play and ... ...

    Abstract This paper designs and implements a low power portable bowel sound monitor, which adopts bone conduction transducer to collect bowel sound continuously for long time and transmit to phone by Bluetooth. Then the phone application can record, play and analyse the bowel sound digital data in real time. This paper also designs an experiment to collect bowel sound from healthy people and patients with intestinal obstruction. It is verified by clinicians that this monitor can accurately record and preserve the bowel sound of the detected people, and is not disturbed by the external environment.
    MeSH term(s) Humans ; Intestinal Obstruction ; Monitoring, Physiologic
    Language Chinese
    Publishing date 2019-12-18
    Publishing country China
    Document type Journal Article
    ISSN 1671-7104
    ISSN 1671-7104
    DOI 10.3969/j.issn.1671-7104.2019.06.007
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  10. Article ; Online: Coffee consumption and risk of hypertension: a systematic review and dose-response meta-analysis of cohort studies.

    Xie, Chen / Cui, Lingling / Zhu, Jicun / Wang, Kehui / Sun, Nan / Sun, Changqing

    Journal of human hypertension

    2018  Volume 32, Issue 2, Page(s) 83–93

    Abstract: Some debates exist regarding the association of coffee consumption with hypertension risk. We performed a meta-analysis including dose-response analysis aimed to derive a more quantitatively precise estimation of this association. PubMed and Embase were ... ...

    Abstract Some debates exist regarding the association of coffee consumption with hypertension risk. We performed a meta-analysis including dose-response analysis aimed to derive a more quantitatively precise estimation of this association. PubMed and Embase were searched for cohort studies published up to 18 July 2017. Fixed-effects generalized least-squares regression models were used to assess the quantitative association between coffee consumption and hypertension risk across studies. Restricted cubic spline was used to model the dose-response association. We identified eight articles (10 studies) investigating the risk of hypertension with the level of coffee consumption, including 243,869 individuals and 58,094 incident cases of hypertension. We found no evidence of a nonlinear dose-response association of coffee consumption and hypertension (P
    MeSH term(s) Coffee ; Cohort Studies ; Dose-Response Relationship, Drug ; Humans ; Hypertension/etiology
    Chemical Substances Coffee
    Language English
    Publishing date 2018-01-04
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 639472-3
    ISSN 1476-5527 ; 0950-9240
    ISSN (online) 1476-5527
    ISSN 0950-9240
    DOI 10.1038/s41371-017-0007-0
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