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  1. Article ; Online: Transition-Metal-Doped SiP

    Wang, Kelvin / Luo, Xuan

    ACS omega

    2022  Volume 7, Issue 41, Page(s) 36848–36855

    Abstract: Two-dimensional materials have exhibited great potential in mitigating climate change through sensing and capturing carbon dioxide. The interaction of ... ...

    Abstract Two-dimensional materials have exhibited great potential in mitigating climate change through sensing and capturing carbon dioxide. The interaction of CO
    Language English
    Publishing date 2022-10-07
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c05532
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  2. Article ; Online: A Novel 0.1 mm 3D Laser Imaging Technology for Pavement Safety Measurement.

    Yang, Guangwei / Wang, Kelvin C P / Li, Joshua Q / Wang, Guolong

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 20

    Abstract: Traditionally, pavement safety performance in terms of texture, friction, and hydroplaning speed are measured separately via different devices with various limitations. This study explores the feasibility of using a novel 0.1 mm 3D Safety Sensor for ... ...

    Abstract Traditionally, pavement safety performance in terms of texture, friction, and hydroplaning speed are measured separately via different devices with various limitations. This study explores the feasibility of using a novel 0.1 mm 3D Safety Sensor for pavement safety evaluation in a non-contact and continuous manner with a single hardware sensor. The 0.1 mm 3D images were collected for pavement safety measurement from 12 asphalt concrete (AC) and Portland cement concrete (PCC) field sites with various texture characteristics. The results indicate that the Safety Sensor was able to measure pavement texture data as traditional devices do with better repeatability. Moreover, pavement friction numbers can be estimated using 0.1 mm 3D data via the proposed 3D texture parameters with good accuracy using an artificial neural network, especially for asphalt pavement. Lastly, a case study of pavement hydroplaning speed prediction was performed using the Safety Sensor. The results demonstrate the potential of using ultra high-resolution 3D imaging to measure pavement safety, including texture, friction, and hydroplaning, in a non-contact, continuous, and accurate manner.
    MeSH term(s) Imaging, Three-Dimensional ; Hydrocarbons ; Lasers ; Technology
    Chemical Substances asphalt (8052-42-4) ; Hydrocarbons
    Language English
    Publishing date 2022-10-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22208038
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  3. Article ; Online: Size-Controlled Synthesis of Gold Nanoparticles Tethering Antimicrobial Peptides with Potent Broad-Spectrum Antimicrobial and Antibiofilm Activities.

    Rajchakit, Urawadee / Lamba, Saurabh / Wang, Kelvin / Lyons, Nikita / Lu, Jun / Swift, Simon / Pletzer, Daniel / Sarojini, Vijayalekshmi

    Molecular pharmaceutics

    2024  Volume 21, Issue 2, Page(s) 596–608

    Abstract: New antimicrobials are urgently needed to combat the rising global health concern of antibiotic resistance. Antimicrobial peptides (AMPs) are one of the leading candidates as new antimicrobials since they target bacterial membranes and are therefore less ...

    Abstract New antimicrobials are urgently needed to combat the rising global health concern of antibiotic resistance. Antimicrobial peptides (AMPs) are one of the leading candidates as new antimicrobials since they target bacterial membranes and are therefore less prone to bacterial resistance. However, poor enzymatic stability, high production costs, and toxicity are drawbacks that limit their clinical use. Conjugation of AMPs to gold nanoparticles (NPs) may help to improve enzymatic stability and, thus, their overall antimicrobial efficiency. We did a one-pot synthesis of size-controlled (10 nm) gold NPs selectively conjugated to lipopeptides and determined their antibacterial activity. The conjugates exhibited potent (0.13-1.25 μM) antimicrobial activity against clinical isolates, including Gram-positive methicillin-resistant
    MeSH term(s) Rats ; Animals ; Methicillin-Resistant Staphylococcus aureus ; Staphylococcus aureus ; Gold/chemistry ; Antimicrobial Peptides ; Escherichia coli ; Metal Nanoparticles/chemistry ; Microbial Sensitivity Tests ; Anti-Infective Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Biofilms ; Mammals
    Chemical Substances Gold (7440-57-5) ; Antimicrobial Peptides ; Anti-Infective Agents ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.3c00734
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6250: Show issues Location:
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  4. Article ; Online: Author's response to "Comment on Fan et al. (2023) 'Text messaging interventions for breastfeeding outcomes: A systematic review and meta-analysis'".

    Fan, Yingwei / Li, Junyan / Wong, Janet Yuen Ha / Fong, Daniel Yee Tak / Wang, Kelvin Man Ping / Lok, Kris Yuet Wan

    International journal of nursing studies

    2024  Volume 154, Page(s) 104746

    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 80148-3
    ISSN 1873-491X ; 0020-7489
    ISSN (online) 1873-491X
    ISSN 0020-7489
    DOI 10.1016/j.ijnurstu.2024.104746
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 130: Show issues Location:
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  5. Article ; Online: Bioactive Components and Anticancer Activities of Spray-Dried New Zealand Tamarillo Powder.

    Liu, Qian / Hamid, Nazimah / Liu, Ye / Kam, Rothman / Kantono, Kevin / Wang, Kelvin / Lu, Jun

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 9

    Abstract: Tamarillo fruit contains many phytochemicals that have beneficial therapeutic and nutritional properties. Spray-drying is widely used to preserve fruit puree in powder form. However, to obtain high-quality fruit powder, the optimisation of spray-drying ... ...

    Abstract Tamarillo fruit contains many phytochemicals that have beneficial therapeutic and nutritional properties. Spray-drying is widely used to preserve fruit puree in powder form. However, to obtain high-quality fruit powder, the optimisation of spray-drying conditions is necessary, as a high drying temperature can damage sensitive bioactive compounds. This study investigated the effects of spray-drying on the microstructure, polyphenolics, total flavonoids, total carotenoids, antioxidant activity, and anticancer capacity of tamarillo powder. Response surface methodology (RSM) was used to optimise the spray-drying process to produce tamarillo powder. The independent variables were inlet drying temperature (120-160 °C), flow rate (1-5 g/mL), and maltodextrin concentration (0-10%). These variables influenced the microstructural attributes, bioactive components, and cytotoxicity of the spray-dried tamarillo powder. The increase in polyphenols and antioxidant activities were favoured under high-temperature spray drying conditions and a low carrier concentration. The optimised spray-drying conditions for producing tamarillo powder with high antioxidant and anticancer activities, high yield, and stable bioactive compounds were found to be at 146.8 °C inlet temperature, and a flow rate of 1.76 g/mL.
    MeSH term(s) Antioxidants/chemistry ; Antioxidants/pharmacology ; Desiccation/methods ; New Zealand ; Powders/chemistry ; Spray Drying
    Chemical Substances Antioxidants ; Powders
    Language English
    Publishing date 2022-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27092687
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  6. Article ; Online: Metabolite profiling identifies chemical markers associated with the cytotoxic properties of roasted fermented avocado seeds.

    Zhao, Zhiyu / Hamid, Nazimah / Gutierrez-Maddox, Noemi / Kam, Rothman / Kantono, Kevin / Wang, Kelvin / Young, Tim / Le, Thao T / Lu, Jun

    Food research international (Ottawa, Ont.)

    2023  Volume 172, Page(s) 113131

    Abstract: Studies have demonstrated avocado seeds are a good source of bioactive compounds. This study investigated the effects of roasting on the metabolites and anticancer activities of fermented avocado seeds. All three anti-cancer activities of fermented ... ...

    Abstract Studies have demonstrated avocado seeds are a good source of bioactive compounds. This study investigated the effects of roasting on the metabolites and anticancer activities of fermented avocado seeds. All three anti-cancer activities of fermented avocado seeds were higher at lower roasting temperature and time. The best inhibition effect was found against Hep G2 followed by the MDA-MB-231 and MCF-7 cancer cell lines. Untargeted metabolite profiling using gas chromatography-mass spectrometry resulted in identification of 208 metabolites. In total, 41 metabolites identified had VIP values more than 1 using PLS-R that were related to anticancer activities. All amino acids and most sugars were higher at lower roasting temperature and positively correlated to anticancer activity. The roasting conditions for optimal antioxidant and anticancer activities were determined to be 121 °C for 9 min. Findings showed that fermented avocado seed powder has the potential to become a functional food ingredient with beneficial bioctive properties.
    MeSH term(s) Persea ; Antineoplastic Agents ; Amino Acids ; Antioxidants/pharmacology ; Seeds
    Chemical Substances Antineoplastic Agents ; Amino Acids ; Antioxidants
    Language English
    Publishing date 2023-06-25
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1111695-x
    ISSN 1873-7145 ; 0963-9969
    ISSN (online) 1873-7145
    ISSN 0963-9969
    DOI 10.1016/j.foodres.2023.113131
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    In stock of ZB MED Bonn / Germany

    Z 2972: Show issues

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  7. Article ; Online: Text messaging interventions for breastfeeding outcomes: A systematic review and meta-analysis.

    Fan, Yingwei / Li, Junyan / Wong, Janet Yuen Ha / Fong, Daniel Yee Tak / Wang, Kelvin Man Ping / Lok, Kris Yuet Wan

    International journal of nursing studies

    2023  Volume 150, Page(s) 104647

    Abstract: Background: Given the health benefits of breastfeeding for infants and mothers, breastfeeding has become a significant public health issue. The global growth of mobile phone usage has created new options for breastfeeding promotion, including text ... ...

    Abstract Background: Given the health benefits of breastfeeding for infants and mothers, breastfeeding has become a significant public health issue. The global growth of mobile phone usage has created new options for breastfeeding promotion, including text messaging.
    Objective: We aimed to evaluate the efficacy of text messaging interventions on breastfeeding outcomes and to identify the efficacy moderators of such interventions.
    Methods: Ten electronic databases were searched from the inception of the databases to 5 July 2023. Studies were included if they used randomized controlled trials or quasi-experimental designs to evaluate the effect of text messaging interventions on breastfeeding outcomes. Two reviewers screened the included studies, assessed the risk of bias, and extracted the data. Pooled results were obtained by the random-effects model, and subgroup analyses were conducted on intervention characteristics to identify potential moderators. The protocol of this study was registered on PROSPERO (ID: CRD42022371311).
    Results: Sixteen studies were included. Text messaging interventions could improve the exclusive breastfeeding rate (at <3 months: OR = 2.04; 95 % CI: 1.60-2.60, P < 0.001; at 3-6 months: OR = 1.66; 95 % CI: 1.18-2.33, P = 0.004; at ≥6 months: OR = 2.13; 95 % CI: 1.47-3.08, P < 0.001), and the breastfeeding self-efficacy (SMD = 0.30, 95 % CI: 0.14-0.45, P < 0.001). Text messaging interventions that covered antenatal and postnatal periods, delivered weekly were most effective in improving the exclusive breastfeeding rate.
    Conclusions: Text messaging interventions may improve breastfeeding practice compared with no or general health information. We suggest text messaging conducted from the pre- to postnatal periods in a weekly manner can effectively increase exclusive breastfeeding rates and breastfeeding self-efficacy. Further studies should investigate the relation between new theories (such as the health action process approach and the theory of message-framing) and efficacy of breastfeeding interventions, using text components.
    MeSH term(s) Female ; Humans ; Pregnancy ; Breast Feeding ; Cell Phone ; Mothers ; Reminder Systems ; Text Messaging
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 80148-3
    ISSN 1873-491X ; 0020-7489
    ISSN (online) 1873-491X
    ISSN 0020-7489
    DOI 10.1016/j.ijnurstu.2023.104647
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 130: Show issues Location:
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  8. Article: Renal hyperparathyroidism- a risk factor in the development of encapsulating peritoneal sclerosis.

    Moinuddin, Zia / Wang, Kelvin / Fullwood, Catherine / Wiredu, Elizabeth / Hutchison, Alastair / Vardhan, Anand / Herrick, Sarah E / Summers, Angela / Augustine, Titus / van Dellen, David

    Frontiers in endocrinology

    2024  Volume 15, Page(s) 1282925

    Abstract: Background: Encapsulating peritoneal sclerosis (EPS) is a rare complication of prolonged peritoneal dialysis (PD) exposure, characterised by peritoneal thickening, calcification, and fibrosis ultimately presenting with life-threatening bowel obstruction. ...

    Abstract Background: Encapsulating peritoneal sclerosis (EPS) is a rare complication of prolonged peritoneal dialysis (PD) exposure, characterised by peritoneal thickening, calcification, and fibrosis ultimately presenting with life-threatening bowel obstruction. The presence or role of peritoneal calcification in the pathogenesis of EPS is poorly characterised. We hypothesise that significantly aberrant bone mineral metabolism in patients on PD can cause peritoneal calcification which may trigger the development of EPS. We compared the temporal evolution of bone mineral markers during PD in EPS patients with non-EPS long-term PD controls.
    Methods: Linear mixed model and logistic regression analysis were used to compare four-monthly serum levels of calcium, phosphate, parathyroid hormone, and alkaline phosphatase (ALP) over the duration of PD exposure in 46 EPS and 46 controls (PD, non-EPS) patients.
    Results: EPS patients had higher mean calcium (2.51 vs. 2.41 mmol/L) and ALP (248.00 vs. 111.13 IU/L) levels compared with controls (p=0.01 and p<0.001 respectively, maximum likelihood estimation). Logistic regression analysis demonstrated that high serum calcium and phosphate levels during PD were associated with a 4.5 and 2.9 fold increase in the risk of developing EPS respectively.
    Conclusion: High levels of calcium and phosphate in patients on PD were identified to be risk factors for EPS development. Possible reasons for this may be an imbalance of pro-calcifying factors and calcification inhibitors promoting peritoneal calcification which increases peritoneal stiffness. Mechanical alterations may trigger, unregulated fibrosis and subsequent development of EPS. Improved management of secondary hyperparathyroidism during PD may ultimately diminish the EPS risk.
    MeSH term(s) Humans ; Peritoneal Fibrosis/etiology ; Calcium ; Risk Factors ; Calcinosis/etiology ; Hyperparathyroidism ; Minerals ; Phosphates
    Chemical Substances Calcium (SY7Q814VUP) ; Minerals ; Phosphates
    Language English
    Publishing date 2024-03-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2024.1282925
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  9. Article: Study of Pavement Micro- and Macro-Texture Evolution Due to Traffic Polishing Using 3D Areal Parameters.

    Zou, Yiwen / Yang, Guangwei / Huang, Wanqing / Lu, Yang / Qiu, Yanjun / Wang, Kelvin C P

    Materials (Basel, Switzerland)

    2021  Volume 14, Issue 19

    Abstract: Pavement micro- and macro-texture have significant effects on roadway friction and driving safety. The influence of traffic polish on pavement texture has been investigated in many laboratory studies. This paper conducts field evaluation of pavement ... ...

    Abstract Pavement micro- and macro-texture have significant effects on roadway friction and driving safety. The influence of traffic polish on pavement texture has been investigated in many laboratory studies. This paper conducts field evaluation of pavement micro- and macro-texture under actual traffic polishing using three-dimensional (3D) areal parameters. A portable high-resolution 3D laser scanner measured pavement texture from a field site in 2018, 2019, and 2020. Then, the 3D texture data was decomposed to micro- and macro-texture using Fourier transform and Butterworth filter methods. Twenty 3D areal parameters from five categories, including height, spatial, hybrid, function, and feature parameters, were calculated to characterize pavement micro- and macro-texture. The results demonstrate that the 3D areal parameters provide an alternative to comprehensively characterize the evolution of pavement texture under traffic polish from different aspects.
    Language English
    Publishing date 2021-10-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma14195769
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  10. Article ; Online: Lane Marking Detection and Reconstruction with Line-Scan Imaging Data.

    Li, Lin / Luo, Wenting / Wang, Kelvin C P

    Sensors (Basel, Switzerland)

    2018  Volume 18, Issue 5

    Abstract: ... ...

    Abstract A
    Language English
    Publishing date 2018-05-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s18051635
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