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Article: Dopaminergic signaling regulates microglial surveillance and adolescent plasticity in the frontal cortex.

Stowell, Rianne / Wang, Kuan Hong

bioRxiv : the preprint server for biology

2024

Abstract: Adolescence is a sensitive period for frontal cortical development and cognitive maturation. The dopaminergic (DA) mesofrontal circuit is particularly malleable in response to changes in adolescent experience and DA activity. However, the cellular ... ...

Abstract	Adolescence is a sensitive period for frontal cortical development and cognitive maturation. The dopaminergic (DA) mesofrontal circuit is particularly malleable in response to changes in adolescent experience and DA activity. However, the cellular mechanisms engaged in this plasticity remain unexplored. Here, we report that microglia, the innate immune cells of the brain, are uniquely sensitive to adolescent mesofrontal DA signaling. Longitudinal
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.08.584167
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Article ; Online: Prior actions influence cost-benefit-related decision-making during mouse foraging behaviours.

Dylda, Evelyn / Wang, Kuan Hong

The European journal of neuroscience

2022 Volume 56, Issue 2, Page(s) 3861–3874

Abstract: Food foraging is essential for the fitness of animals. Previous studies have suggested that optimal foraging strategies involve a cost-benefit analysis comparing reward versus effort to guide action choices. Little is known how prior experience with ... ...

Abstract	Food foraging is essential for the fitness of animals. Previous studies have suggested that optimal foraging strategies involve a cost-benefit analysis comparing reward versus effort to guide action choices. Little is known how prior experience with different actions to obtain rewards may affect subsequent foraging choices. Here, we report a sunflower seed foraging test to investigate how effort and prior actions influence decision-making in laboratory mice. Sunflower seeds are a natural food favourite for mice, and mice spend effort to peel the hard shells to obtain the seeds. In our test, peeled and unpeeled sunflower seeds were placed at different ends of a Y-maze. Mice were free to explore the maze and make foraging decisions. Naïve mice were more likely to choose peeled seeds requiring low effort versus unpeeled seeds requiring high effort. Furthermore, mice with prior seed peeling experience significantly reduced preference for peeled seeds during the subsequent Y-maze foraging test, compared with mice pre-exposed to peeled seeds only. This experience-dependent shift in foraging choice was associated with reduced seed peeling time and improved motor skills with practice, and predictable on a trial-by-trial basis by a probabilistic decision-making model with the amount of peeled and unpeeled seeds consumed as inputs. Together, these results suggest that laboratory mice make rational foraging choices based on effort estimation and moreover, prior actions to obtain reward alter effort estimation and decision-making through motor skill learning. This naturalist behavioural task may be applied to dissect neural mechanisms in adaptive decision-making during foraging.
MeSH term(s)	Animals ; Choice Behavior ; Cost-Benefit Analysis ; Decision Making ; Maze Learning ; Mice ; Reward
Language	English
Publishing date	2022-05-26
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645180-9
ISSN	1460-9568 ; 0953-816X
ISSN (online)	1460-9568
ISSN	0953-816X
DOI	10.1111/ejn.15689
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Article ; Online: An ethologically motivated neurobiology of primate visually-guided reach-to-grasp behavior.

Mitchell, Jude F / Wang, Kuan Hong / Batista, Aaron P / Miller, Cory T

Current opinion in neurobiology

2024 Volume 86, Page(s) 102872

Abstract: The precision of primate visually guided reaching likely evolved to meet the many challenges faced by living in arboreal environments, yet much of what we know about the underlying primate brain organization derives from a set of highly constrained ... ...

Abstract	The precision of primate visually guided reaching likely evolved to meet the many challenges faced by living in arboreal environments, yet much of what we know about the underlying primate brain organization derives from a set of highly constrained experimental paradigms. Here we review the role of vision to guide natural reach-to-grasp movements in marmoset monkey prey capture to illustrate the breadth and diversity of these behaviors in ethological contexts, the fast predictive nature of these movements [1,2], and the advantages of this particular primate model to investigate the underlying neural mechanisms in more naturalistic contexts [3]. In addition to their amenability to freely-moving neural recording methods for investigating the neural basis of dynamic ethological behaviors [4,5], marmosets have a smooth neocortical surface that facilitates imaging and array recordings [6,7] in all areas in the primate fronto-parietal network [8,9]. Together, this model organism offers novel opportunities to study the real-world interplay between primate vision and reach-to-grasp dynamics using ethologically motivated neuroscientific experimental designs.
Language	English
Publishing date	2024-04-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1078046-4
ISSN	1873-6882 ; 0959-4388
ISSN (online)	1873-6882
ISSN	0959-4388
DOI	10.1016/j.conb.2024.102872
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Article ; Online: Fast prediction in marmoset reach-to-grasp movements for dynamic prey.

Shaw, Luke / Wang, Kuan Hong / Mitchell, Jude

Current biology : CB

2023 Volume 33, Issue 12, Page(s) 2557–2565.e4

Abstract: Primates have evolved sophisticated, visually guided reaching behaviors for interacting with dynamic objects, such as insects, during foraging. ...

Abstract	Primates have evolved sophisticated, visually guided reaching behaviors for interacting with dynamic objects, such as insects, during foraging.
MeSH term(s)	Animals ; Callithrix ; Psychomotor Performance ; Movement ; Hand ; Vision, Ocular
Language	English
Publishing date	2023-06-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2023.05.032
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Article ; Online: Can Emotional Well-Being Maintain Health and Prevent Suicide in Later Life? A National Priority for Research.

Conwell, Yeates / Lin, Feng Vankee / Wang, Kuan Hong

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

2023 Volume 31, Issue 6, Page(s) 425–427

MeSH term(s)	Humans ; Suicide/psychology ; Emotions
Language	English
Publishing date	2023-01-25
Publishing country	England
Document type	Editorial ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	1278145-9
ISSN	1545-7214 ; 1064-7481
ISSN (online)	1545-7214
ISSN	1064-7481
DOI	10.1016/j.jagp.2023.01.008
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Article ; Online: New horizons in emotional well-being and brain aging: Potential lessons from cross-species research.

Lin, Feng Vankee / Zuo, Yi / Conwell, Yeates / Wang, Kuan Hong

International journal of geriatric psychiatry

2023 Volume 38, Issue 6, Page(s) e5936

MeSH term(s)	Humans ; Emotions ; Brain ; Aging/psychology
Language	English
Publishing date	2023-06-01
Publishing country	England
Document type	Editorial ; Research Support, N.I.H., Extramural
ZDB-ID	806736-3
ISSN	1099-1166 ; 0885-6230
ISSN (online)	1099-1166
ISSN	0885-6230
DOI	10.1002/gps.5936
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Article ; Online: Cholecystokinin facilitates motor skill learning by modulating neuroplasticity in the motor cortex.

Li, Hao / Feng, Jingyu / Chen, Mengying / Xin, Min / Chen, Xi / Liu, Wenhao / Wang, Liping / Wang, Kuan Hong / He, Jufang

eLife

2024 Volume 13

Abstract: Cholecystokinin (CCK) is an essential modulator for neuroplasticity in sensory and emotional domains. Here, we investigated the role of CCK in motor learning using a single pellet reaching task in mice. Mice with a knockout ... ...

Abstract	Cholecystokinin (CCK) is an essential modulator for neuroplasticity in sensory and emotional domains. Here, we investigated the role of CCK in motor learning using a single pellet reaching task in mice. Mice with a knockout of
MeSH term(s)	Animals ; Motor Cortex/physiology ; Motor Cortex/metabolism ; Motor Cortex/drug effects ; Cholecystokinin/metabolism ; Cholecystokinin/pharmacology ; Neuronal Plasticity/physiology ; Neuronal Plasticity/drug effects ; Mice ; Motor Skills/physiology ; Learning/physiology ; Mice, Knockout ; Male
Chemical Substances	Cholecystokinin (9011-97-6)
Language	English
Publishing date	2024-05-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.83897
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Article ; Online: Comparative anatomical analysis of dopamine systems in Mus musculus and Peromyscus californicus.

Buck, Justin / Manion, Matthew T C / Zhang, Wenyu / Glasper, Erica R / Wang, Kuan Hong

Brain structure & function

2022 Volume 227, Issue 6, Page(s) 2219–2227

Abstract: Dopamine plays important roles in motivational and social behaviors in mammals, and it has been implicated in several human neurological and psychiatric disorders. Rodents are used extensively as experimental models to study dopamine function in health ... ...

Abstract	Dopamine plays important roles in motivational and social behaviors in mammals, and it has been implicated in several human neurological and psychiatric disorders. Rodents are used extensively as experimental models to study dopamine function in health and disease. However, interspecies differences of dopamine systems remain incompletely characterized. Here, we assessed whether the commonly referenced anatomical organization of dopamine systems in Mus musculus differs from another rodent species, Peromyscus californicus, which exhibits unique social behaviors such as biparental care. We applied tyrosine hydroxylase immunofluorescence labeling and high-throughput microscopy to establish whole-brain maps of dopamine systems in P. californicus. By comparing these maps to those from M. musculus, we identified unexpected anatomical similarity and difference between these two species. A sex difference in dopamine neurons at the anteroventral periventricular nucleus of hypothalamus, which has been implicated in regulating the maternal behaviors of the uniparental M. musculus, is similarly present in the biparental P. californicus. In contrast, major interspecies differences from M. musculus are found in the ventral midbrain and striatum of P. californicus, including the expansion of midbrain dopamine neurons into the ventral substantia nigra and the presence of an internal capsule-like white matter tract that demarcates a dorsomedial area from the rest of the striatum. These features identified in P. californicus resemble the anatomical organization of the primate brain more closely compared to those in M. musculus. Our findings suggest that P. californicus is a unique model organism for studying the evolution of dopamine systems in mammals and the disorders of dopamine systems.
MeSH term(s)	Animals ; Dopamine ; Dopaminergic Neurons ; Female ; Humans ; Male ; Mice ; Peromyscus/physiology ; Sex Characteristics ; Social Behavior
Chemical Substances	Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2022-05-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2273162-3
ISSN	1863-2661 ; 1863-2653
ISSN (online)	1863-2661
ISSN	1863-2653
DOI	10.1007/s00429-022-02497-8
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Article ; Online: Assessing the integrity of auditory sensory memory processing in CLN3 disease (Juvenile Neuronal Ceroid Lipofuscinosis (Batten disease)): an auditory evoked potential study of the duration-evoked mismatch negativity (MMN).

Brima, Tufikameni / Freedman, Edward G / Prinsloo, Kevin D / Augustine, Erika F / Adams, Heather R / Wang, Kuan Hong / Mink, Jonathan W / Shaw, Luke H / Mantel, Emma P / Foxe, John J

Journal of neurodevelopmental disorders

2024 Volume 16, Issue 1, Page(s) 3

Abstract: Background: We interrogated auditory sensory memory capabilities in individuals with CLN3 disease (juvenile neuronal ceroid lipofuscinosis), specifically for the feature of "duration" processing. Given decrements in auditory processing abilities ... ...

Abstract	Background: We interrogated auditory sensory memory capabilities in individuals with CLN3 disease (juvenile neuronal ceroid lipofuscinosis), specifically for the feature of "duration" processing. Given decrements in auditory processing abilities associated with later-stage CLN3 disease, we hypothesized that the duration-evoked mismatch negativity (MMN) of the event related potential (ERP) would be a marker of progressively atypical cortical processing in this population, with potential applicability as a brain-based biomarker in clinical trials. Methods: We employed three stimulation rates (fast: 450 ms, medium: 900 ms, slow: 1800 ms), allowing for assessment of the sustainability of the auditory sensory memory trace. The robustness of MMN directly relates to the rate at which the regularly occurring stimulus stream is presented. As presentation rate slows, robustness of the sensory memory trace diminishes. By manipulating presentation rate, the strength of the sensory memory trace is parametrically varied, providing greater sensitivity to detect auditory cortical dysfunction. A secondary hypothesis was that duration-evoked MMN abnormalities in CLN3 disease would be more severe at slower presentation rates, resulting from greater demand on the sensory memory system. Results: Data from individuals with CLN3 disease (N = 21; range 6-28 years of age) showed robust MMN responses (i.e., intact auditory sensory memory processes) at the medium stimulation rate. However, at the fastest rate, MMN was significantly reduced, and at the slowest rate, MMN was not detectable in CLN3 disease relative to neurotypical controls (N = 41; ages 6-26 years). Conclusions: Results reveal emerging insufficiencies in this critical auditory perceptual system in individuals with CLN3 disease.
MeSH term(s)	Humans ; Neuronal Ceroid-Lipofuscinoses/complications ; Auditory Perception ; Evoked Potentials, Auditory ; Memory ; Brain ; Membrane Glycoproteins ; Molecular Chaperones
Chemical Substances	CLN3 protein, human ; Membrane Glycoproteins ; Molecular Chaperones
Language	English
Publishing date	2024-01-06
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2487174-6
ISSN	1866-1955 ; 1866-1955
ISSN (online)	1866-1955
ISSN	1866-1955
DOI	10.1186/s11689-023-09515-8
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Article ; Online: Effect of short-term high temperature on the accumulation of glucosinolates in Brassica rapa.

Rao, Shuai-Qi / Chen, Xiao-Qi / Wang, Kuan-Hong / Zhu, Zhu-Jun / Yang, Jing / Zhu, Biao

Plant physiology and biochemistry : PPB

2021 Volume 161, Page(s) 222–233

Abstract: Glucosinolates, an important class of secondary metabolites in cruciferous vegetables, play a crucial role in protecting plants from stress-related damage. The mechanism of glucosinolate synthesis under short-term high temperature stress has not been ... ...

Abstract	Glucosinolates, an important class of secondary metabolites in cruciferous vegetables, play a crucial role in protecting plants from stress-related damage. The mechanism of glucosinolate synthesis under short-term high temperature stress has not been sufficiently studied. In this work, we investigated the changes in transcription factors, synthetic genes, and related metabolites involved in glucosinolate synthesis by pakchoi seedlings under short-term high temperature stress (40 °C for 8 h). Short-term high temperature stress inhibited the primary sulfur assimilation and the contents of methionine, cysteine and glutathione. The contents of aliphatic and indolic glucosinolates were increased by short-term high temperature stress, whereas the content of 4-methoxy-glucobrassicin increased significantly. During the stress period, the transcript level of glucosinolate related MYB transcription factors had been basically significantly up-regulated, whereas the transcript level of aliphatic and indolic glucosinolate synthetic genes were predominantly up-regulated and down-regulated respectively. In the early recovery period, primary sulfur assimilation up-regulated rapidly, and decreased during the late recovery process. The glucosinolate content and synthesis gene expression act similar to the primary sulfur assimilation, a short up-regulated in early recovery, then all go down at 40 and 48 h after short-term high temperature treatment.
MeSH term(s)	Brassica rapa/genetics ; Glucosinolates ; Seedlings ; Temperature ; Transcription Factors
Chemical Substances	Glucosinolates ; Transcription Factors
Language	English
Publishing date	2021-02-16
Publishing country	France
Document type	Journal Article
ZDB-ID	742978-2
ISSN	1873-2690 ; 0981-9428
ISSN (online)	1873-2690
ISSN	0981-9428
DOI	10.1016/j.plaphy.2021.02.013
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