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  1. Article: [Research progress on imagine diagnosis of limbal stem cell deficiency].

    Wang, L Y / Liang, Q F

    Zhonghua yan ke za zhi] Chinese journal of ophthalmology

    2023  Volume 59, Issue 8, Page(s) 673–676

    Abstract: Limbal stem cell deficiency (LSCD) is an ocular surface disease resulting from a reduction and/or dysfunction of limbal stem cells. The symptoms of LSCD are non-specific and can be difficult to distinguish from other ocular surface diseases through slit- ... ...

    Abstract Limbal stem cell deficiency (LSCD) is an ocular surface disease resulting from a reduction and/or dysfunction of limbal stem cells. The symptoms of LSCD are non-specific and can be difficult to distinguish from other ocular surface diseases through slit-lamp examination. Impression cytology is currently considered the gold standard for LSCD diagnosis; however,it is a qualitative method with low sensitivity. Nonetheless,emerging imaging techniques offer quantitative diagnosis and staging of LSCD. This review article examines four imaging methods and their associated parameters for diagnosing LSCD: optical coherence tomography,which measures corneal epithelial thickness; optical coherence tomography angiography,which detects corneal neovascularization;
    MeSH term(s) Humans ; Corneal Diseases/diagnosis ; Epithelium, Corneal ; Limbus Corneae ; Limbal Stem Cells ; Stem Cells ; Microscopy, Confocal ; Limbal Stem Cell Deficiency
    Language Chinese
    Publishing date 2023-08-08
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 604574-1
    ISSN 0412-4081
    ISSN 0412-4081
    DOI 10.3760/cma.j.cn112142-20220917-00459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Research progress on auxiliary indexes and methods of diagnosis and treatment of patent ductus arteriosus in preterm].

    Wang, L Y / Wang, B J / Gao, X Y

    Zhonghua er ke za zhi = Chinese journal of pediatrics

    2024  Volume 62, Issue 4, Page(s) 381–384

    MeSH term(s) Infant, Newborn ; Humans ; Ductus Arteriosus, Patent/diagnosis ; Ductus Arteriosus, Patent/therapy ; Infant, Premature ; Persistent Fetal Circulation Syndrome ; Ductus Arteriosus
    Language Chinese
    Publishing date 2024-03-25
    Publishing country China
    Document type Journal Article
    ZDB-ID 784523-6
    ISSN 0578-1310
    ISSN 0578-1310
    DOI 10.3760/cma.j.cn112140-20231216-00432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [An interpretation of global consensus on the diagnosis and management of limbal stem cell deficiency].

    Liang, Q F / Wang, L Y

    Zhonghua yan ke za zhi] Chinese journal of ophthalmology

    2021  Volume 57, Issue 2, Page(s) 95–99

    Abstract: Limbal stem cell deficiency is an ocular surface disease with the imbalance of corneal epithelial homeostasis caused by decrease of number or weakening of function of limbal stem cells. In 2019 and 2020, the international limbal stem cell deficiency ... ...

    Abstract Limbal stem cell deficiency is an ocular surface disease with the imbalance of corneal epithelial homeostasis caused by decrease of number or weakening of function of limbal stem cells. In 2019 and 2020, the international limbal stem cell deficiency working group developed and released the international consensus on the definition, classification, diagnosis, staging and management of limbal stem cell deficiency, which provided a standard protocol for related research and clinical diagnosis and treatment of limbal stem cell deficiency. In order to help Chinese ophthalmologists to properly understand its core components, there is a need to make in-depth interpretation to the key and difficult contents of the international consensus
    MeSH term(s) Consensus ; Corneal Diseases/diagnosis ; Corneal Diseases/therapy ; Epithelium, Corneal ; Humans ; Limbus Corneae ; Stem Cell Transplantation ; Stem Cells
    Language Chinese
    Publishing date 2021-02-02
    Publishing country China
    Document type Journal Article
    ZDB-ID 604574-1
    ISSN 0412-4081
    ISSN 0412-4081
    DOI 10.3760/cma.j.cn112142-20200816-00537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Eculizumab in patients with paroxysmal nocturnal hemoglobinuria: a real-world study in China].

    Wang, L Y / Hu, Q L / Chen, M / Yang, C / Han, B

    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

    2024  Volume 45, Issue 2, Page(s) 184–189

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Male ; Female ; Humans ; Middle Aged ; Aged ; Hemoglobinuria, Paroxysmal/drug therapy ; Hemoglobinuria ; Retrospective Studies ; Hemolysis ; China ; Thrombosis ; Antibodies, Monoclonal, Humanized
    Chemical Substances eculizumab (A3ULP0F556) ; Antibodies, Monoclonal, Humanized
    Language Chinese
    Publishing date 2024-04-11
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2997162-7
    ISSN 0253-2727 ; 0253-2727
    ISSN (online) 0253-2727
    ISSN 0253-2727
    DOI 10.3760/cma.j.cn121090-20231106-00250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Research progress on limbal stem cell transplantation].

    Wang, L Y / Liang, Q F

    Zhonghua yan ke za zhi] Chinese journal of ophthalmology

    2020  Volume 56, Issue 12, Page(s) 956–960

    Abstract: Limbal Stem Cell Deficiency (LSCD) is an ocular surface disease caused by the decrease of the quantity and dysfunction of limbal stem cell, which is characterized by conjunctivalization and other signs of epithelial dysfunction. For sever LSCD, surgery ... ...

    Abstract Limbal Stem Cell Deficiency (LSCD) is an ocular surface disease caused by the decrease of the quantity and dysfunction of limbal stem cell, which is characterized by conjunctivalization and other signs of epithelial dysfunction. For sever LSCD, surgery is the main treatment way. Recently, plenty of researches published the outcomes of different operation methods. This article summarized five major operations, including conjunctival limbal autograft (CLAU), simple limbal epithelial transplantation (SLET), limbal allograft, cultivated limbal stem cell transplantation (CLET) and cultivated oral mucosal epithelial transplantation (COMET).
    MeSH term(s) Cell Transplantation ; Corneal Diseases/surgery ; Corneal Transplantation ; Epithelium, Corneal ; Humans ; Limbus Corneae ; Stem Cell Transplantation ; Transplantation, Autologous
    Language Chinese
    Publishing date 2020-12-20
    Publishing country China
    Document type Journal Article
    ZDB-ID 604574-1
    ISSN 0412-4081
    ISSN 0412-4081
    DOI 10.3760/cma.j.cn112142-20201022-00526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Study on transcriptome characteristics of respiratory syncytial virus bronchiolitis in children by RNA sequencing].

    Wang, L Y / Le, Y S / Li, H Y / Liu, Z W / Weng, T T / Chen, X F / Liu, P N / Dong, L

    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

    2024  Volume 58, Issue 1, Page(s) 71–80

    Abstract: To explore the biological characteristics related to the pathogenesis and severity of respiratory syncytial virus (RSV) bronchiolitis by RNA sequencing of white blood cells in children with RSV bronchiolitis. This study is a case-control study. A total ... ...

    Abstract To explore the biological characteristics related to the pathogenesis and severity of respiratory syncytial virus (RSV) bronchiolitis by RNA sequencing of white blood cells in children with RSV bronchiolitis. This study is a case-control study. A total of 87 children diagnosed with bronchiolitis and RSV antigen positive and/or RSV nucleic acid positive in the pediatric respiratory department of the Second Affiliated Hospital of Wenzhou Medical University from October 2019 to April 2022 were selected as the case group. The case group was divided into three groups based on the condition: mild, moderate, and severe, and there were two groups according to the presence or absence of atopic symptoms: the atopic group and the non
    MeSH term(s) Child ; Humans ; Transcriptome ; Interleukin-10 ; Matrix Metalloproteinase 9 ; Case-Control Studies ; Sequence Analysis, RNA ; Respiratory Syncytial Virus Infections/genetics ; Receptors, Cytokine ; Viral Proteins ; Respiratory Syncytial Viruses ; Computational Biology/methods
    Chemical Substances Interleukin-10 (130068-27-8) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Receptors, Cytokine ; Viral Proteins
    Language Chinese
    Publishing date 2024-01-17
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 604575-3
    ISSN 0253-9624
    ISSN 0253-9624
    DOI 10.3760/cma.j.cn112150-20230126-00057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Early identification, diagnosis and treatment of COVID-19 related myocarditis, save more lives].

    Wang, L Y / Zhao, C X / Wang, F / Miao, K / Wang, D W

    Zhonghua xin xue guan bing za zhi

    2023  Volume 51, Page(s) 1–5

    Language Chinese
    Publishing date 2023-02-08
    Publishing country China
    Document type Journal Article
    ZDB-ID 603425-1
    ISSN 0253-3758
    ISSN 0253-3758
    DOI 10.3760/cma.j.cn112148-20230118-00036
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  8. Article: [Effect of REG3A on proliferation and invasion of glioma cells by regulating PI3K/Akt signaling pathway].

    Quan, Y C / Wang, L Y / Wang, Z Y / Gao, W / Che, F Y

    Zhonghua zhong liu za zhi [Chinese journal of oncology

    2023  Volume 45, Issue 8, Page(s) 642–650

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Glioma/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Kinase Inhibitors ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Messenger/metabolism ; Signal Transduction ; Vimentin/metabolism
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Protein Kinase Inhibitors ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; RNA, Messenger ; Vimentin ; REG3A protein, human
    Language Chinese
    Publishing date 2023-08-14
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 603424-x
    ISSN 0253-3766
    ISSN 0253-3766
    DOI 10.3760/cma.j.cn112152-20220210-00086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Risk perception for fractures and its related factors among family caregivers of underage patients with osteogenesis imperfecta in China: A cross-sectional study.

    Wang, M / Wang, L L / Zhong, Y P / Wang, X Y / Wang, L Y / Shi, T / Yang, L J / Ji, J

    Journal of pediatric nursing

    2024  Volume 77, Page(s) 81–88

    Abstract: Purpose: To describe the level of risk perception for fractures among family caregivers of children diagnosed with osteogenesis imperfecta, and explore the related factors.: Design and methods: This was a cross-sectional survey study. A self- ... ...

    Abstract Purpose: To describe the level of risk perception for fractures among family caregivers of children diagnosed with osteogenesis imperfecta, and explore the related factors.
    Design and methods: This was a cross-sectional survey study. A self-administered questionnaire on family caregivers' perception of fracture risk of underage patients with osteogenesis imperfecta was used. The study was performed in mainland China from May to December 2022, with 127 family caregivers of patients aged 3-17. Stepwise backwards multivariable linear regression analysis was undertaken to examine risk factors for caregivers' risk perception of fractures.
    Results: A total of 16.54% of caregivers had a higher level of risk perception for fractures of patients. The caregiver's educational level, the family members, the patient's self-care ability, fracture times in the past year, and whether or not they had received community services were associated with the caregiver's risk perception for fracture.
    Conclusions: Patients with osteogenesis imperfecta will eventually leave the medical system and receive more support from themselves or family caregivers instead of health personnel. These findings should be incorporated into the prevention and health education of fractures in caregivers of underage patients with osteogenesis imperfecta to help develop effective risk communication strategies and induce caregivers to implement appropriate protective behaviors.
    Practice implications: It is important to evaluate the risk perception for fractures and its related factors among family caregivers of underage patients with osteogenesis imperfecta. Identifying these factors can help healthcare providers to screen caregivers with high perceived level of fracture risk in a quicker and earlier way. This study provides evidence for the establishment of interventions to balance caregivers' risk perception and patient socialization.
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632731-x
    ISSN 1532-8449 ; 0882-5963
    ISSN (online) 1532-8449
    ISSN 0882-5963
    DOI 10.1016/j.pedn.2024.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Value of magnetic resonance imaging in assessment of iron deposition among patients with hepatic alveolar echinococcosis: a preliminary evaluation].

    Wang, L Y / Bao, H H / Kang, Y L

    Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control

    2020  Volume 32, Issue 1, Page(s) 94–96

    Abstract: Objective: To assess the value of MRI combined with serum ferritin analysis in measurement of hepatic iron deposition among patients with hepatic alveolar echinococcosis.: Methods: A total of 96 patients with definitive diagnosis of hepatic alveolar ... ...

    Abstract Objective: To assess the value of MRI combined with serum ferritin analysis in measurement of hepatic iron deposition among patients with hepatic alveolar echinococcosis.
    Methods: A total of 96 patients with definitive diagnosis of hepatic alveolar echinococcosis and 30 healthy volunteers were enrolled and underwent routine 1.5T MR scanning, and all laboratory examination data were captured. The liver-to-muscle signal intensity ratio, serum ferritin level and liver functions were analyzed.
    Results: The liver-to-muscle signal intensity ratio was (1.95 ± 0.57) in patients with hepatic alveolar echinococcosis and (2.22 ± 0.28) in healthy volunteers (
    Conclusions: Abnormal iron deposition is detected in the liver of patients with hepatic alveolar echinococcosis, and serum ferritin level may be helpful for the identification of abnormal iron deposition in the liver of patients with hepatic alveolar echinococcosis. The liver-to-muscle signal intensity ratio measured by MRI may be a non-invasive approached used to assess the hepatic iron deposition in patients with hepatic alveolar echinococcosis.
    MeSH term(s) Echinococcosis, Hepatic/blood ; Echinococcosis, Hepatic/diagnostic imaging ; Ferritins/blood ; Humans ; Iron/metabolism ; Liver/diagnostic imaging ; Magnetic Resonance Imaging
    Chemical Substances Ferritins (9007-73-2) ; Iron (E1UOL152H7)
    Language Chinese
    Publishing date 2020-03-16
    Publishing country China
    Document type Journal Article
    ISSN 1005-6661
    ISSN 1005-6661
    DOI 10.16250/j.32.1374.2019108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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