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Article: [Emphasizing precision minimally invasive corneal surgery].

Wang, L L

Zhonghua yan ke za zhi] Chinese journal of ophthalmology

2023 Volume 59, Issue 10, Page(s) 775–778

Abstract: In recent years, precision minimally invasive surgery has emerged as a significant developmental direction within the field of ophthalmology, bringing about revolutionary changes in the treatment of corneal diseases. Employing cutting-edge techniques and ...

Abstract	In recent years, precision minimally invasive surgery has emerged as a significant developmental direction within the field of ophthalmology, bringing about revolutionary changes in the treatment of corneal diseases. Employing cutting-edge techniques and surgical methods, corneal surgeries have achieved greater precision and safety. In cases such as immune-mediated corneal diseases, it remains crucial to underscore the enhancement of vision through minimally invasive surgical approaches, thereby avoiding potential irreversible complications that surgery might induce. This article aims to assist readers in comprehending the profound impact of precision minimally invasive surgery on the treatment of corneal diseases, and calls upon medical professionals and researchers to continually explore and refine the realm of precision minimally invasive corneal surgery, fostering its further advancement.
MeSH term(s)	Humans ; Minimally Invasive Surgical Procedures/methods ; Corneal Diseases/surgery
Language	Chinese
Publishing date	2023-10-05
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	604574-1
ISSN	0412-4081
ISSN	0412-4081
DOI	10.3760/cma.j.cn112142-20230808-00028
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Article: [Effect of clonal hematopoiesis in remission on hematopoiesis recovery in patients with NPM1 mutated acute myeloid leukemia after chemotherapy].

Wang, L L / Chen, S N

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

2023 Volume 44, Issue 10, Page(s) 845–850

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Female ; Humans ; Male ; Middle Aged ; Clonal Hematopoiesis ; Hematopoiesis ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Mutation ; Nucleophosmin ; Prognosis ; Retrospective Studies ; Adolescent ; Young Adult ; Adult ; Aged
Chemical Substances	Nucleophosmin (117896-08-9)
Language	Chinese
Publishing date	2023-11-15
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2997162-7
ISSN	0253-2727 ; 0253-2727
ISSN (online)	0253-2727
ISSN	0253-2727
DOI	10.3760/cma.j.issn.0253-2727.2023.10.009
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Article ; Online: Clinical efficacy and adverse reactions analysis of PD-1/PD-L1 inhibitors in advanced esophageal squamous cell carcinoma.

Wang, L-L / Xie, Y-X / Liu, Y

European review for medical and pharmacological sciences

2024 Volume 28, Issue 2, Page(s) 659–667

Abstract: Objective: The aim of this study was to investigate the clinical efficacy and associated adverse reactions of Programmed Death Receptor-1 (PD-1)/PD-L1 inhibitors in the management of patients with advanced esophageal squamous cell carcinoma (ESCC).: ... ...

Abstract	Objective: The aim of this study was to investigate the clinical efficacy and associated adverse reactions of Programmed Death Receptor-1 (PD-1)/PD-L1 inhibitors in the management of patients with advanced esophageal squamous cell carcinoma (ESCC). Patients and methods: In this retrospective study, 54 patients with advanced ESCC treated with PD-1/PD-L1 inhibitors in our hospital from January 2021 to January 2023 were identified as the research subjects. Using propensity score matching at a 1:1 ratio, patients only receiving chemotherapy were recruited as controls. The clinical effectiveness of PD-1/PD-L1 was evaluated by comparing the objective response rate (ORR) and disease control rate (DCR). Progression-free survival (PFS) and overall survival (OS) were analyzed for treatment outcome assessments. Adverse events (AEs) between the two groups were recorded and compared. Results: Patients treated with PD-1/PD-L1 inhibitors had a higher rate of ORR (33.33%) and disease control (85.19%), compared to controls with an objective response rate of 20.37% and a disease control rate of 59.26%. The two groups showed similar ORR results, while the incorporation of PD-1/PD-L1 inhibitors resulted in significantly increased DCR when compared to the controls. The median OS was 22 months (95% CI: 1,629 months) for the control group and 31 months (95% CI: 28NA) for the study group, suggesting OS benefits offered by PD-1/PD-L1 inhibitor treatment (HR=0.479, 95% CI: 0.284, 0.809). The median PFS was 15 months (95% CI: 1,223 months) for the control group and 23 months (95% CI: 1,926) for the study group, indicating more PFS benefits provided by PD-1/PD-L1 inhibitors (HR=0.662, 95% CI: 0.436, 1.005). Adverse events and their severity were recorded during patient follow-up, and no grade 5 adverse events were reported in either group. The incidence of grade 3 or higher adverse events between the two groups was similar, while PD-1/PD-L1 inhibitors appeared to significantly reduce the incidence of gastrointestinal reactions in patients. Conclusions: PD-1/PD-L1 inhibitors integrated with chemotherapy provide significant benefits in the management of patients with advanced ESCC without increasing adverse events.
MeSH term(s)	Humans ; B7-H1 Antigen ; Esophageal Neoplasms/drug therapy ; Esophageal Squamous Cell Carcinoma/drug therapy ; Immune Checkpoint Inhibitors/adverse effects ; Immune Checkpoint Inhibitors/therapeutic use ; Programmed Cell Death 1 Receptor ; Retrospective Studies ; Treatment Outcome
Chemical Substances	B7-H1 Antigen ; Immune Checkpoint Inhibitors ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2024-02-02
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202401_35062
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Article: [Correlation and clinical significance of VISTA expression and cervical squamous cell carcinoma].

Li, L / Wang, L L / Zhou, J Y

Zhonghua zhong liu za zhi [Chinese journal of oncology

2023 Volume 45, Issue 5, Page(s) 396–401

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Female ; Humans ; Carcinoma, Squamous Cell/pathology ; Clinical Relevance ; Neoplasm Staging ; Prognosis ; Uterine Cervical Dysplasia/pathology ; Uterine Cervical Neoplasms/pathology ; Uterine Cervicitis/pathology
Chemical Substances	VSIR protein, human
Language	Chinese
Publishing date	2023-05-15
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	603424-x
ISSN	0253-3766
ISSN	0253-3766
DOI	10.3760/cma.j.cn112152-20211020-00772
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Article: [The research advances of graphene and its derivatives in regulating the fate of neural stem cells].

He, X Z / Wu, W / Wang, L L

Zhonghua yan ke za zhi] Chinese journal of ophthalmology

2023 Volume 59, Issue 2, Page(s) 146–149

Abstract: As a new class of nanomaterials, graphene and its derivatives have excellent mechanical, electrical and optical properties, which are widely used in various fields. In recent years, more and more scholars have linked it to stem cell research. Their ... ...

Abstract	As a new class of nanomaterials, graphene and its derivatives have excellent mechanical, electrical and optical properties, which are widely used in various fields. In recent years, more and more scholars have linked it to stem cell research. Their effects on stem cell proliferation, differentiation can not be underestimated. Here we review the regulation of graphene and its derivatives on the fate of neural stem cells, hoping that more ophthalmologists will invest in this research and provide a new way for neurodegenerative diseases in ophthalmology.
MeSH term(s)	Humans ; Biocompatible Materials ; Graphite/pharmacology ; Neural Stem Cells/physiology ; Cell Differentiation/physiology ; Nanostructures
Chemical Substances	Biocompatible Materials ; Graphite (7782-42-5)
Language	Chinese
Publishing date	2023-02-02
Publishing country	China
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	604574-1
ISSN	0412-4081
ISSN	0412-4081
DOI	10.3760/cma.j.cn112142-20220930-00474
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Article: [Analysis of early diagnosis and prevention techniques for occupational pneumoconiosis based on patent perspectives in China's coal industry].

Wang, J / Shi, H D / Wang, P / Wu, Y G / Wang, L L / Song, Z L

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases

2024 Volume 41, Issue 12, Page(s) 948–955

Abstract: Occupational pneumoconiosis in the coal industry is an occupational disease that seriously endangers coal miners' health. Early diagnosis and prevention techniques are significant in controlling its incidence rate and reducing its harm. This article ... ...

Abstract	Occupational pneumoconiosis in the coal industry is an occupational disease that seriously endangers coal miners' health. Early diagnosis and prevention techniques are significant in controlling its incidence rate and reducing its harm. This article takes the patent data related to the early diagnosis and prevention of occupational pneumoconiosis in the coal industry, published from 1985 to 2021, as the research object. It uses tools such as the Derwent Data Analyzer (DDA) software, the Patyee Database, and the PatSnap Database to analyze the technological development trend and characteristics in this field from aspects of growth trend, primary patent holders, IPC classification layout, value, and research and development hotspots. The results show that the number of patent applications in this field indicates a rapid growth trend, mainly in the hands of Shandong Energy Group Co. Ltd., Shandong University of Science and Technology, China University of Mining and Technology, and other institutions or enterprises. Patent technology mainly involves spray dust reduction, dust removal fans, dust masks, and other aspects with high patent value and innovation ability. This article provides a new perspective and reference for preventing, diagnosing, and treating occupational pneumoconiosis in the coal industry.
MeSH term(s)	Humans ; Coal Industry ; Pneumoconiosis/diagnosis ; Pneumoconiosis/prevention & control ; Early Diagnosis ; Dust ; China
Chemical Substances	Dust
Language	Chinese
Publishing date	2024-01-09
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1050900-8
ISSN	1001-9391
ISSN	1001-9391
DOI	10.3760/cma.j.cn121094-20230106-00008
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Article: [Analysis of phenotype and pathogenic variant in a case of Heimler syndrome].

Zuo, B / Wang, L L / Mao, L / Xu, G E / Sun, S P / Lu, W

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery

2024 Volume 59, Issue 3, Page(s) 249–252

MeSH term(s)	Humans ; Phenotype ; Mutation ; Amelogenesis Imperfecta/genetics ; Hearing Loss, Sensorineural/genetics ; Nails, Malformed
Language	Chinese
Publishing date	2024-04-01
Publishing country	China
Document type	Case Reports ; Journal Article
ZDB-ID	2195655-8
ISSN	1673-0860
ISSN	1673-0860
DOI	10.3760/cma.j.cn115330-20240117-00033
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Article: [Limbal stem cell-sparing lamellar keratoplasty for advanced keratoglobus in a patient with osteogenesis imperfecta: a case report].

Li, K X / Wang, Q / Li, X Q / Wang, L L

Zhonghua yan ke za zhi] Chinese journal of ophthalmology

2023 Volume 59, Issue 4, Page(s) 302–304

Abstract: This 15-year-old male patient has been diagnosed with osteogenesis imperfecta through genetic testing after birth and has poor vision. His full corneas in both eyes are unevenly thinned and bulging in a spherical shape, with the right eye being more ... ...

Abstract	This 15-year-old male patient has been diagnosed with osteogenesis imperfecta through genetic testing after birth and has poor vision. His full corneas in both eyes are unevenly thinned and bulging in a spherical shape, with the right eye being more severe. He underwent a limbal stem cell-sparing lamellar keratoplasty in the right eye, resulting in improved vision with a corrected visual acuity of 0.5, a decrease in corneal curvature, and a significant increase in corneal thickness. The surgery had a satisfactory outcome. The condition of the left eye is progressing and will require further surgical treatment.
MeSH term(s)	Male ; Humans ; Adolescent ; Keratoconus/surgery ; Corneal Diseases/surgery ; Limbal Stem Cells ; Osteogenesis Imperfecta/surgery ; Visual Acuity ; Corneal Transplantation
Language	Chinese
Publishing date	2023-04-03
Publishing country	China
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604574-1
ISSN	0412-4081
ISSN	0412-4081
DOI	10.3760/cma.j.cn112142-20220731-00369
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Article: [The research progress of mesenchymal stem cell induction and differentiation into corneal tissue].

Liu, J J / Wang, L L / Huang, Y F

Zhonghua yan ke za zhi] Chinese journal of ophthalmology

2022 Volume 58, Issue 6, Page(s) 461–466

Abstract: Keratopathy is one of the most important blinding eye diseases in the world. Corneal opacity caused by keratopathy can seriously damage visual function. For example, corneal ulcer can lead to perforation and even loss of the eyeball. Although corneal ... ...

Abstract	Keratopathy is one of the most important blinding eye diseases in the world. Corneal opacity caused by keratopathy can seriously damage visual function. For example, corneal ulcer can lead to perforation and even loss of the eyeball. Although corneal transplantation is a routine treatment in clinical practice, there are not only a serious shortage of corneal donors in our country, but also various complications after keratoplasty that can not be avoided. In recent years, with the rapid development of regenerative medicine, it has been found that mesenchymal stem cells can differentiate into a variety of functional cells including corneal tissue under suitable induction conditions, which has a broad prospect of clinical application. This finding provides new ideas and methods for the treatment of keratopathy and corneal blindness in many aspects. This article reviews the research status of induction methods of mesenchymal stem cells in various specialties, particularly in the corneal subspecialty.
MeSH term(s)	Blindness/surgery ; Cornea ; Corneal Diseases/surgery ; Corneal Opacity/surgery ; Corneal Transplantation/adverse effects ; Humans ; Mesenchymal Stem Cells
Language	Chinese
Publishing date	2022-06-13
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	604574-1
ISSN	0412-4081
ISSN	0412-4081
DOI	10.3760/cma.j.cn112142-20210629-00300
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Article: [Problems and challenges in the development of keratoprosthesis surgery in China].

Wang, L L / Huang, Y F

Zhonghua yan ke za zhi] Chinese journal of ophthalmology

2020 Volume 56, Issue 10, Page(s) 730–734

Abstract: Keratoprosthesis implantation as an effective therapeutic method has been a treatment strategy in end-stage corneal blindness, contributing to restore vision and reduce the prevalence of blindness, but it has been restricted because of its high surgical ... ...

Abstract	Keratoprosthesis implantation as an effective therapeutic method has been a treatment strategy in end-stage corneal blindness, contributing to restore vision and reduce the prevalence of blindness, but it has been restricted because of its high surgical technique and devastating complications. There are a large number of patients with corneal blindness in China, and the rate of high-risk or end-stage corneal blindness is high. It is of great significance to improve the understanding of the indications and contraindications of different kinds of keratoprostheses, as well as relevant technologies and knowledge, cope with the problems and challenges in the development period, and conduct safe and efficient clinical applications and related research, so that the technology of keratoprosthesis implantation in our country can go to the world steadily.
MeSH term(s)	China ; Cornea/surgery ; Corneal Diseases/surgery ; Humans ; Prostheses and Implants ; Prosthesis Implantation
Language	Chinese
Publishing date	2020-10-15
Publishing country	China
Document type	Journal Article
ZDB-ID	604574-1
ISSN	0412-4081
ISSN	0412-4081
DOI	10.3760/cma.j.cn112142-20200321-00212
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