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Article: B细胞激活因子及其靶向药物与炎症性肠病的研究进展.

Li, Lin / Liu, Hai-Yan / Wang, Li-Jun

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

2024 Volume 26, Issue 3, Page(s) 315–320

Abstract: B-cell activating factor (BAFF), a critical regulator of B cells, is involved in various autoimmune diseases. Inflammatory bowel disease (IBD) is a group of chronic and recurrent intestinal inflammatory disorders with unclear etiology, and its global ... ...

Title translation	Research advances on B-cell activating factor and its targeted agents in inflammatory bowel disease.
Abstract	B-cell activating factor (BAFF), a critical regulator of B cells, is involved in various autoimmune diseases. Inflammatory bowel disease (IBD) is a group of chronic and recurrent intestinal inflammatory disorders with unclear etiology, and its global incidence has been increasing in recent years. Abnormal immune responses triggered by multiple factors are closely related to the pathogenesis of IBD. Previous studies have confirmed the association of B-cell abnormal activation and increased production of autoantibodies with the development of ulcerative colitis. However, the involvement of BAFF in the mechanisms of IBD remains unclear. This review summarizes the potential role of BAFF in the pathogenesis of IBD and provides an overview of targeted therapies on BAFF in IBD, aiming to contribute insights for targeted treatments of IBD.
MeSH term(s)	Humans ; B-Cell Activating Factor/metabolism ; B-Lymphocytes ; Colitis, Ulcerative/complications ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/etiology
Chemical Substances	B-Cell Activating Factor
Language	Chinese
Publishing date	2024-04-01
Publishing country	China
Document type	Review ; English Abstract ; Journal Article
ISSN	1008-8830
ISSN	1008-8830
DOI	10.7499/j.issn.1008-8830.2309126
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Article ; Online: Antifungal activity and mechanism of oxanthromicin against Verticillium dahliae.

Wang, Li-Jun / Wen, Feng / Li, Li-Xia / Xia, Zhan-Feng

Archives of microbiology

2024 Volume 206, Issue 2, Page(s) 83

Abstract: Oxanthromicin is an anthranone-type natural product isolated from Streptomyces sp. TRM 15522, which exhibits antifungal activity. However, the underlying mechanisms remain unclear. This study, therefore, aimed at investigating the mode of action of ... ...

Abstract	Oxanthromicin is an anthranone-type natural product isolated from Streptomyces sp. TRM 15522, which exhibits antifungal activity. However, the underlying mechanisms remain unclear. This study, therefore, aimed at investigating the mode of action of oxanthromicin against the phytopathogen Verticillium dahliae. We found that oxanthromicin substantially suppressed spore germination and mycelial growth in V. dahliae. Further, electron microscopy and staining with propidium iodide and Rhodamine 123 indicated that oxanthromicin causes cell membrane damage and induces changes in mitochondrial membrane potential. These findings suggest that oxanthromicin exhibits its antifungal activity by damaging fungal cell membranes. This discovery could potentially facilitate the development of oxanthromicin as a biological pesticide.
MeSH term(s)	Antifungal Agents/pharmacology ; Antifungal Agents/metabolism ; Verticillium ; Ascomycota ; Plant Diseases/microbiology ; Anthraquinones
Chemical Substances	Antifungal Agents ; oxanthromicin (90614-51-0) ; Anthraquinones
Language	English
Publishing date	2024-01-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-023-03815-2
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Article ; Online: Tailoring 3D-printed high internal phase emulsion-rice starch gels: Role of amylose in rheology and bioactive stability.

Zheng, Lu-Yao / Li, Dong / Wang, Li-Jun / Wang, Yong

Carbohydrate polymers

2024 Volume 331, Page(s) 121891

Abstract: This study investigated the properties of 3D-printed high internal phase emulsion (HIPE)-rice starch gels, specially tailored for personalized nutrition by co-encapsulating resveratrol and β-carotene. We examined the influence of amylose content on ... ...

Abstract	This study investigated the properties of 3D-printed high internal phase emulsion (HIPE)-rice starch gels, specially tailored for personalized nutrition by co-encapsulating resveratrol and β-carotene. We examined the influence of amylose content on various parameters, including functional groups, linear and nonlinear rheology, printed precision and microstructural stability. Additionally, we assessed the protective efficacy and release in vitro digestion of these gels on the encapsulated bioactive components. Compared to HIPE, HIPE-starch gels differently impacted by amylose content in starches. Low-level amylose weakened the network structure, attributed to amylose mainly responsible for gel formation and weak hydrogen bond interaction between the surface-active molecules and amylose due to gelatinized starch granules rupturing the protein network. Oppositely, high-level amylose led to denser, more gel-like structures with enhanced mechanical strength and reversible deformation resistance, making them suitable for 3D printing. Furthermore, 3D-printed gels with high-level amylose demonstrated well-defined structures, smooth surfaces, stable printing and less dimension deviation. They were also regarded as effective entrapping and delivery systems for resveratrol and β-carotene, protecting them against degradation from environment and damage under the erosion of digestive fluid. Overall, this research offers a straightforward strategy for creating reduced-fat HIPE gels that serve as the carrier for personalized nutraceutical foods.
MeSH term(s)	Amylose/chemistry ; Oryza/chemistry ; Emulsions ; beta Carotene ; Resveratrol ; Starch/chemistry ; Gels/chemistry ; Rheology
Chemical Substances	Amylose (9005-82-7) ; Emulsions ; beta Carotene (01YAE03M7J) ; Resveratrol (Q369O8926L) ; Starch (9005-25-8) ; Gels
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2024.121891
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Article ; Online: Probiotics combined with Budesonide and Ipratropium bromide for chronic obstructive pulmonary disease: A retrospective analysis.

Chen, Chen / Wu, LingBo / Wang, LiJun / Tang, XinHeng

Medicine

2024 Volume 103, Issue 10, Page(s) e37309

Abstract: To explore the effect of probiotics combined with budesonide and ipratropium bromide in the treatment of chronic obstructive pulmonary disease (COPD) on lung function and gut microbiota. This was a retrospective study of prospectively collected clinical ... ...

Abstract	To explore the effect of probiotics combined with budesonide and ipratropium bromide in the treatment of chronic obstructive pulmonary disease (COPD) on lung function and gut microbiota. This was a retrospective study of prospectively collected clinical data of 118 patients with COPD admitted to our hospital between January 2020 and December 2022. According to the treatment records, 59 patients received budesonide and irpratropium bromide (control group), and 59 patients received probiotics combined with budesonide and irpratropium bromide (observation group). The lung function, inflammatory factor levels, airway remodeling, and gut microbiota before and after treatment were compared between the 2 groups. After treatment, FVC, MMEF, PEF, and FEV1 in the 2 groups were higher than before treatment, and the values in the observation group were higher than those in the control group (P < .05). After treatment, the serum levels of TNF-α, IL-6, and PCT in the 2 groups were lower than before treatment, and the levels in the observation group were lower than those in the control group (P < .05). After treatment, the levels of serum MMP-9, VEGF, basic fibroblast growth factor, and NGF in the 2 groups were lower than before treatment, and the levels in the observation group were lower than those in the control group (P < .05). After treatment, the levels of lactobacilli and bifidobacteria in the 2 groups increased compared to those before treatment, and the observation group had a higher level, while the levels of Enterobacteriaceae and Enterococcus were lower in the observation group than those before treatment (P < .05). Based on budesonide and irpratropium bromide, probiotic treatment of COPD is more conducive to reducing the degree of inflammatory reactions, inhibiting airway remodeling, regulating the level of gut microbiota, and promoting the recovery of lung function.
MeSH term(s)	Humans ; Budesonide/therapeutic use ; Ipratropium/therapeutic use ; Retrospective Studies ; Airway Remodeling ; Bromides/therapeutic use ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Bronchodilator Agents/therapeutic use
Chemical Substances	Budesonide (51333-22-3) ; Ipratropium (GR88G0I6UL) ; Bromides ; Bronchodilator Agents
Language	English
Publishing date	2024-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037309
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Article ; Online: Rheological properties and micro distribution of amorphous poly alpha olefin /styrene-butadiene rubber composite modified asphalt

WANG Li-jun / LIU Ke-yan

Hecheng xiangjiao gongye, Vol 45, Iss 1, Pp 29-

2022 Volume 34

Abstract: In order to improve the high temperature performance of styrene-butadiene rubber （SBR）modified asphalt, amorphous poly alpha olefin （APAO） was selected as the modifier, and APAO/SBR composites modified asphalt with good high and low temperature ... ...

Abstract	In order to improve the high temperature performance of styrene-butadiene rubber （SBR）modified asphalt, amorphous poly alpha olefin （APAO） was selected as the modifier, and APAO/SBR composites modified asphalt with good high and low temperature performance and rheological properties were prepared. The high, medium and low tempe-rature rheological properties of APAO/SBR composites modified asphalts with different amount APAO were studied. Fluorescence electron microscope was used to observe the distribution of polymers in the asphalt to reflect the rheological properties from the microscopic view. The results showed that the addition of APAO reduced the non-recoverable creep compliance and temperature sensitivity of asphalt in high temperature areas, and increased the softening point, rutting resistance factor, elastic recovery rate and fatigue fai-lure loading times of asphalt, indicating that APAO increased the high temperature performance and fatigue resistance of asphalt. Although APAO had a negative effect on the low-temperature creep stiffness modulus （S） and creep rate （m） of asphalt, the amount of APAO was not more than 5% (mass fraction, the same below) based on K （S/m）. The low temperature performance of the index was still better than that of styrene-butadiene-styrene block copolymer modified asphalt. Considering all properties, it was recommen-ded to use APAO amount of 5%, under which APAO and SBR compatibility was better.
Keywords	styrene-butadiene rubber ; amorphous poly alpha olefin ; composite modified asphalt ; rheological property ; fluorescence microscope ; Organic chemistry ; QD241-441 ; Chemical engineering ; TP155-156 ; Chemicals: Manufacture ; use ; etc ; TP200-248
Subject code	621
Language	Chinese
Publishing date	2022-01-01T00:00:00Z
Publisher	Editorial Office of China Synthetic Rubber Industry
Document type	Article ; Online
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Article ; Online: Green, tough, and heat-resistant: A GDL-induced strategy for starch-alginate hydrogels.

Su, Chun-Yan / Li, Dong / Sun, Weihong / Wang, Li-Jun / Wang, Yong

Food chemistry

2024 Volume 449, Page(s) 139188

Abstract: Hydrogels fabricated by non-covalent interaction garnered significant attention for their eco-friendly and robust mechanical attributes, and are often used in food, medicine and other fields. Although starch-alginate hydrogels exhibit high adhesion and ... ...

Abstract	Hydrogels fabricated by non-covalent interaction garnered significant attention for their eco-friendly and robust mechanical attributes, and are often used in food, medicine and other fields. Although starch-alginate hydrogels exhibit high adhesion and are environmentally sustainable, their applications are limited due to their low elasticity and hardness. Addressing this challenge, we introduce a solvent-induced strategy using glucolactone (GDL) to fabricate hydrogels with enhanced strength and thermal resilience. Utilizing corn starch with varying amylose contents, sodium alginate and calcium carbonate to prepare a double network structure. This GDL-induced hydrogel outperforms most previous starch-based hydrogels in mechanical robustness and thermal stability. Typical starch-alginate hydrogel had a homogeneous network structure and exhibited a high tensile stress of 407.57 KPa, and a high enthalpy value of 1857.67 J/g. This investigation furnishes a facile yet effective method for the synthesis of hydrogels with superior mechanical and thermal properties, thereby broadening the design landscape for starch-based hydrogels.
MeSH term(s)	Hydrogels/chemistry ; Starch/chemistry ; Alginates/chemistry ; Hot Temperature ; Tensile Strength ; Green Chemistry Technology
Chemical Substances	Hydrogels ; Starch (9005-25-8) ; Alginates
Language	English
Publishing date	2024-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.139188
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Article ; Online: Association of lncRNA THRIL, HOTAIR genes variations and expression levels with pulmonary tuberculosis.

Wang, Li-Jun / Li, Rui / Zhang, Tian-Ping / Li, Hong-Miao

BMC medical genomics

2023 Volume 16, Issue 1, Page(s) 326

Abstract: Background: Long non-coding RNA (lncRNA) has been implicated in the pathogenesis of pulmonary tuberculosis (PTB). This study aims to investigate the involvement of lncRNA THRIL and HOTAIR gene single nucleotide polymorphisms (SNPs) and their expression ... ...

Abstract	Background: Long non-coding RNA (lncRNA) has been implicated in the pathogenesis of pulmonary tuberculosis (PTB). This study aims to investigate the involvement of lncRNA THRIL and HOTAIR gene single nucleotide polymorphisms (SNPs) and their expression levels in PTB susceptibility. Methods: A total of 456 PTB patients and 464 healthy controls participated in our study. we genotyped six SNPs of THRIL and HOTAIR genes using an improved multiple ligase detection reaction (iMLDR). Additionally, real-time reverse-transcriptase polymerase chain reaction was employed to detect the expression levels of THRIL and HOTAIR in peripheral blood mononuclear cells (PBMC) from 78 PTB patients and 84 healthy controls. Results: No significant differences in allele and genotype frequencies were observed for THRIL rs1055472, rs11058000, and HOTAIR rs12427129, rs1899663, rs4759314, and rs7958904 polymorphisms between PTB patients and healthy controls (all P > 0.05). Moreover, genotype frequencies of all SNPs did not show any association with PTB susceptibility in the dominant-recessive model. However, the frequencies of rs7958904 CC genotype and C allele in the HOTAIR gene were significantly correlated with leukopenia in PTB patients. Furthermore, the expression levels of the HOTAIR gene were significantly elevated in PTB patients compared to controls. Conclusions: Our study indicates that THRIL and HOTAIR gene SNPs might not contribute to PTB susceptibility, while the level of HOTAIR was increased in PTB patients.
MeSH term(s)	Humans ; Alleles ; Case-Control Studies ; Genetic Predisposition to Disease ; Genotype ; Leukocytes, Mononuclear ; Polymorphism, Single Nucleotide ; RNA, Long Noncoding/genetics
Chemical Substances	RNA, Long Noncoding ; HOTAIR long untranslated RNA, human
Language	English
Publishing date	2023-12-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2411865-5
ISSN	1755-8794 ; 1755-8794
ISSN (online)	1755-8794
ISSN	1755-8794
DOI	10.1186/s12920-023-01770-x
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Article ; Online: Carboxymethyl chitosan/polyvinyl alcohol double network hydrogels prepared by freeze-thawing and calcium chloride cross-linking for efficient dye adsorption.

Zhang, Kai-Yan / Li, Dong / Wang, Yong / Wang, Li-Jun

International journal of biological macromolecules

2023 Volume 253, Issue Pt 3, Page(s) 126897

Abstract: The discharge of dye wastewater resulting from rapid industrial development has become a serious environmental concern. Therefore, there is a pressing need to develop efficient methods and technologies for the removal of dye pollutants. This study ... ...

Abstract	The discharge of dye wastewater resulting from rapid industrial development has become a serious environmental concern. Therefore, there is a pressing need to develop efficient methods and technologies for the removal of dye pollutants. This study introduced a double network hydrogel, with varying carboxymethyl chitosan (CMCS) contents and polyvinyl alcohol (PVA), employing a combination of freeze- thawing and calcium chloride cross-linking. The investigation focused on the rheological properties of the hydrogels and their removal ability of acidic blue 93 (AB). The results showed that the strength and viscoelastic modulus of composite hydrogels were positively correlated with the CMCS content, and all composite hydrogels exhibited the typical weak strain overshoot behavior. The pore size of the gel initially decreased and then increased, with the densest pores observed at 4 wt% CMCS, showing the optimal removal ability for AB. The adsorption process followed pseudo second-order kinetic model, dominated by external diffusion, and exhibited inhomogeneous multilayer adsorption. This study unveils the potential of CMCS/PVA gels as adsorbents, offering inspirations for the design and development of polyvinyl alcohol-based gels for applications in the food industry.
MeSH term(s)	Chitosan ; Calcium Chloride ; Polyvinyl Alcohol ; Adsorption ; Hydrogels
Chemical Substances	Chitosan (9012-76-4) ; Calcium Chloride (M4I0D6VV5M) ; polyvinyl alcohol hydrogel ; Polyvinyl Alcohol (9002-89-5) ; Hydrogels
Language	English
Publishing date	2023-09-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.126897
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Article ; Online: Curdlan/sodium carboxymethylcellulose composite adsorbents: A biodegradable solution for organic dye removal from water.

Cui, Congli / Li, Dong / Wang, Li-Jun / Wang, Yong

Carbohydrate polymers

2023 Volume 328, Page(s) 121737

Abstract: Composite adsorbent comprised of curdlan (CURD) and sodium carboxymethylcellulose (CMC) were fabricated through a single-step heating process, targeting the removal of methylene blue (MB) from wastewater. The CURD/CMC composite adsorbents had a honeycomb ...

Abstract	Composite adsorbent comprised of curdlan (CURD) and sodium carboxymethylcellulose (CMC) were fabricated through a single-step heating process, targeting the removal of methylene blue (MB) from wastewater. The CURD/CMC composite adsorbents had a honeycomb porous structure. The integration of CMC not only increased the storage modulus of the CURD/CMC composite hydrogels but also affected the thermal stability and swelling behavior of the composite adsorbents in different pH solutions. Specifically, the addition of 1.2 % CMC increased the peak temperature (184.73 °C) of CURD/CMC composite adsorbent melting by 5.99 °C compared to CURD adsorbent. The addition of CMC improved the swelling ratio of the composite adsorbent at pH 3,7, and 12 with swelling ratio up to 918.07 %. The synergistic interaction between CURD and CMC led to an enhanced adsorption capacity of the aerogel for MB, achieving a maximum adsorption capability of 385.85 mg/g. Adsorption isotherm assessments further demonstrated that the Langmuir isotherm model well fitted the adsorption data of the composite adsorbent on MB. Collectively, these findings underscore the potential of the developed biodegradable adsorbents as promising adsorbents for efficiently eliminating organic dyes from water.
Language	English
Publishing date	2023-12-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2023.121737
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Article ; Online: LncRNA IGBP1-AS1 targets miR-150-5p to increase ZEB1 expression in nasopharyngeal carcinoma.

Wang, Li-Jun / Wang, Yan-Sheng / Zhao, Ying

Translational cancer research

2022 Volume 11, Issue 3, Page(s) 530–537

Abstract: Background: Nasopharyngeal carcinoma (NPC), which is a form of cancer arising from the epithelium of the nasopharynx, remains highly prevalent, particularly in Southeast Asia and Southern China. Dysregulated long non-coding RNAs (lncRNAs) are involved ... ...

Abstract	Background: Nasopharyngeal carcinoma (NPC), which is a form of cancer arising from the epithelium of the nasopharynx, remains highly prevalent, particularly in Southeast Asia and Southern China. Dysregulated long non-coding RNAs (lncRNAs) are involved in several malignancies, including the growth and aggression of tumors. LncRNA IGBP1-AS1 plays an important role in the advancement of breast cancer, but its role in NPC has not yet been explored. Methods: LncRNA IGBP1-AS1 levels in human NPC samples compared with their matched adjacent normal tissues by quantitative reverse transcription polymerase chain reaction (qRT-PCR). The proliferation alteration of NPC cells was tested Results: In the study, we found that IGBP1-AS1 was found to be significantly upregulated in the NPC samples and cell lines. The knockdown of IGBP1-AS1 impeded Conclusions: The progression of NPC tumors is facilitated by lncRNA IGBP1-AS1 via miR-150-5p and regulates ZEB1 expression.
Language	English
Publishing date	2022-03-09
Publishing country	China
Document type	Journal Article
ZDB-ID	2901601-0
ISSN	2219-6803 ; 2218-676X
ISSN (online)	2219-6803
ISSN	2218-676X
DOI	10.21037/tcr-22-291
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