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  1. Article ; Online: A review on Zika vaccine development.

    Peng, Zhe-Yu / Yang, Song / Lu, Hong-Zheng / Wang, Lin-Min / Li, Ni / Zhang, Hai-Ting / Xing, Si-Yu / Du, Yi-Nan / Deng, Sheng-Qun

    Pathogens and disease

    2024  Volume 82

    Abstract: Zika virus (ZIKV), which belongs to the Flavivirus family, is mainly transmitted via the bite of Aedes mosquitoes. In newborns, ZIKV infection can cause severe symptoms such as microcephaly, while in adults, it can lead to Guillain‒Barré syndrome (GBS). ... ...

    Abstract Zika virus (ZIKV), which belongs to the Flavivirus family, is mainly transmitted via the bite of Aedes mosquitoes. In newborns, ZIKV infection can cause severe symptoms such as microcephaly, while in adults, it can lead to Guillain‒Barré syndrome (GBS). Due to the lack of specific therapeutic methods against ZIKV, the development of a safe and effective vaccine is extremely important. Several potential ZIKV vaccines, such as live attenuated, inactivated, nucleic acid, viral vector, and recombinant subunit vaccines, have demonstrated promising outcomes in clinical trials involving human participants. Therefore, in this review, the recent developmental progress, advantages and disadvantages of these five vaccine types are examined, and practical recommendations for future development are provided.
    MeSH term(s) Infant, Newborn ; Animals ; Adult ; Humans ; Zika Virus ; Zika Virus Infection/prevention & control ; Mosquito Vectors ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 2049-632X
    ISSN (online) 2049-632X
    DOI 10.1093/femspd/ftad036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mosquito Repellents: Efficacy Tests of Commercial Skin-Applied Products in China.

    Peng, Zhe-Yu / He, Mu-Zi / Zhou, Ling-Yan / Wu, Xin-Yu / Wang, Lin-Min / Li, Ni / Deng, Sheng-Qun

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 17

    Abstract: As a prevention tool for mosquito-borne diseases, mosquito repellents have received substantial attention. To make a convincing recommendation for repellent products to Chinese consumers, we compared the protection time (landing time and probing time) of ...

    Abstract As a prevention tool for mosquito-borne diseases, mosquito repellents have received substantial attention. To make a convincing recommendation for repellent products to Chinese consumers, we compared the protection time (landing time and probing time) of the 26 best-selling commercial repellents in the Chinese market in a controlled laboratory environment. The data were analyzed by one-way ANOVA. Meanwhile, prices and favorable rates of repellents are also taken into consideration. In our study, N, N-diethyl-m-toluamide (DEET)-based products provided the longest protection time (0.5-3.88 h landing time and/or 1-5.63 h probing time) and lower prices (13.9-21.9 yuan) than other components (ethyl butylacetylaminopropionate (IR3535), picaridin, and botanical. Among the 26 selected products, only 17 repellents showed repellency, and the best repellent was Green Jungle (15% DEET), with a mean (±SD) landing and/or probing time of 3.88 ± 1.65 h and/or 5.63 ± 0.36 h. For botanicals, only ICE King, OMNIbaby, and Ren He showed a little repellency. Autan (20% picaridin) performed best in the picaridin group. Run Ben (7% IR3535) stood out from the IR3535 group. In conclusion, DEET repellent is highly recommended to consumers. The combination of botanicals and synthesized chemicals is a new prospect for eco-friendly repellents.
    MeSH term(s) Animals ; China ; DEET/pharmacology ; Insect Repellents/pharmacology ; Male ; Skin
    Chemical Substances Insect Repellents ; DEET (134-62-3)
    Language English
    Publishing date 2022-08-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27175534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The sex pheromone heptacosane enhances the mating competitiveness of sterile Aedes aegypti males.

    Wang, Lin-Min / Li, Ni / Zhang, Mao / Tang, Qi / Lu, Hong-Zheng / Zhou, Qing-Ya / Niu, Jia-Xuan / Xiao, Liang / Peng, Zhe-Yu / Zhang, Chao / Liu, Miao / Wang, Duo-Quan / Deng, Sheng-Qun

    Parasites & vectors

    2023  Volume 16, Issue 1, Page(s) 102

    Abstract: Background: Aedes aegypti is a vector that transmits various viral diseases, including dengue and Zika. The radiation-based sterile insect technique (SIT) has a limited effect on mosquito control because of the difficulty in irradiating males without ... ...

    Abstract Background: Aedes aegypti is a vector that transmits various viral diseases, including dengue and Zika. The radiation-based sterile insect technique (SIT) has a limited effect on mosquito control because of the difficulty in irradiating males without reducing their mating competitiveness. In this study, the insect sex pheromone heptacosane was applied to Ae. aegypti males to investigate whether it could enhance the mating competitiveness of irradiated males.
    Methods: Heptacosane was smeared on the abdomens of Ae. aegypti males that were allowed to mate with untreated virgin females. The insemination rate was used to assess the attractiveness of heptacosane-treated males to females. The pupae were irradiated with different doses of X-rays and γ-rays, and the emergence, survival time, egg number, and hatch rate were detected to find the optimal dose of X-ray and γ-ray radiation. The males irradiated at the optimal dose were smeared with heptacosane, released in different ratios with untreated males, and mated with females. The effect of heptacosane on the mating competitiveness of irradiated mosquitoes was then evaluated by the hatch rate, induced sterility, and mating competitiveness index.
    Results: Applying heptacosane to Ae. aegypti males significantly increased the insemination rate of females by 20%. Pupal radiation did not affect egg number but significantly reduced survival time and hatch rate. The emergence of the pupae was not affected by X-ray radiation but was affected by γ-ray radiation. Pupae exposed to 60 Gy X-rays and 40 Gy γ-rays were selected for subsequent experiments. After 60 Gy X-ray irradiation or 40 Gy γ-ray irradiation, the average hatch rate was less than 0.1%, and the average survival time was more than 15 days. Moreover, at the same release ratio, the hatch rate of the irradiated group perfumed with heptacosane was lower than that of the group without heptacosane. Conversely, the male sterility and male mating competitiveness index were significantly increased due to the use of heptacosane.
    Conclusions: The sex pheromone heptacosane enhanced the interaction between Ae. aegypti males and females. Perfuming males irradiated by X-rays or γ-rays with heptacosane led to a significant increase in mating competitiveness. This study provided a new idea for improving the application effect of SIT.
    MeSH term(s) Animals ; Female ; Humans ; Male ; Aedes/radiation effects ; Sex Attractants/pharmacology ; Mosquito Vectors/radiation effects ; Infertility, Male ; Reproduction ; Pupa/radiation effects ; Sexual Behavior, Animal/radiation effects ; Zika Virus ; Zika Virus Infection
    Chemical Substances Sex Attractants
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2409480-8
    ISSN 1756-3305 ; 1756-3305
    ISSN (online) 1756-3305
    ISSN 1756-3305
    DOI 10.1186/s13071-023-05711-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction: The sex pheromone heptacosane enhances the mating competitiveness of sterile Aedes aegypti males.

    Wang, Lin-Min / Li, Ni / Zhang, Mao / Tang, Qi / Lu, Hong-Zheng / Zhou, Qing-Ya / Niu, Jia-Xuan / Xiao, Liang / Peng, Zhe-Yu / Zhang, Chao / Liu, Miao / Wang, Duo-Quan / Deng, Sheng-Qun

    Parasites & vectors

    2023  Volume 16, Issue 1, Page(s) 452

    Language English
    Publishing date 2023-12-11
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2409480-8
    ISSN 1756-3305 ; 1756-3305
    ISSN (online) 1756-3305
    ISSN 1756-3305
    DOI 10.1186/s13071-023-06078-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Sterility of

    Wang, Lin-Min / Li, Ni / Ren, Cui-Ping / Peng, Zhe-Yu / Lu, Hong-Zheng / Li, Dong / Wu, Xin-Yu / Zhou, Zi-Xin / Deng, Jian-Yi / Zheng, Zi-Han / Wang, Ruo-Qing / Du, Yi-Nan / Wang, Duo-Quan / Deng, Sheng-Qun

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 1

    Abstract: ... The ... ...

    Abstract The mosquito
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12010102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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