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  1. Article ; Online: Re: Stereotactic Ablative Body Radiotherapy for Primary Kidney Cancer (TROG 15.03 FASTRACK II): A Non-randomised Phase 2 Trial.

    Jiang, Aimin / Liu, Ying / Cai, Chen / Luo, Peng / Wang, Linhui

    European urology

    2024  

    Language English
    Publishing date 2024-04-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2024.04.003
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    Zs.A 1247: Show issues Location:
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    Zs.MO 294: Show issues

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  2. Article ; Online: Re: CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma.

    Jiang, Aimin / Liu, Ying / Lin, Anqi / Luo, Peng / Wang, Linhui

    European urology

    2024  

    Language English
    Publishing date 2024-05-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2024.04.020
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 294: Show issues

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  3. Article ; Online: Urological surgical robot in China: state of the art and future prospect.

    Jiang, Aimin / Liu, Ying / Cai, Chen / Luo, Peng / Wang, Linhui

    International journal of surgery (London, England)

    2024  

    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000001377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6502: Show issues Location:
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  4. Article ; Online: A commentary on "Predicting recurrence and survival in patients with non-metastatic renal-cell carcinoma after nephrectomy: a prospective population-based study with multicenter validation".

    Jiang, Aimin / Luo, Peng / Chen, Chenxin / Cai, Chen / Wang, Linhui

    International journal of surgery (London, England)

    2024  

    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000001349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6502: Show issues Location:
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  5. Article ; Online: Re: Multi-omic Profiling of Clear Cell Renal Cell Carcinoma Identifies Metabolic Reprogramming Associated with Disease Progression.

    Jiang, Aimin / Qu, Le / Cai, Chen / Luo, Peng / Wang, Linhui

    European urology

    2024  

    Language English
    Publishing date 2024-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2024.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1247: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 294: Show issues

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  6. Article: The Review of Hybridization of Transition Metal-Based Chalcogenides for Lithium-Ion Battery Anodes.

    Wang, Lin-Hui / Ren, Long-Long / Qin, Yu-Feng

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 12

    Abstract: Transition metal chalcogenides as potential anodes for lithium-ion batteries have been widely investigated. For practical application, the drawbacks of low conductivity and volume expansion should be further overcome. Besides the two conventional methods ...

    Abstract Transition metal chalcogenides as potential anodes for lithium-ion batteries have been widely investigated. For practical application, the drawbacks of low conductivity and volume expansion should be further overcome. Besides the two conventional methods of nanostructure design and the doping of carbon-based materials, the component hybridization of transition metal-based chalcogenides can effectively enhance the electrochemical performance owing to the synergetic effect. Hybridization could promote the advantages of each chalcogenide and suppress the disadvantages of each chalcogenide to some extent. In this review, we focus on the four different types of component hybridization and the excellent electrochemical performance that originated from hybridization. The exciting problems of hybridization and the possibility of studying structural hybridization were also discussed. The binary and ternary transition metal-based chalcogenides are more promising to be used as future anodes of lithium-ion batteries for their excellent electrochemical performance originating from the synergetic effect.
    Language English
    Publishing date 2023-06-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16124448
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  7. Article: Editorial: Establishment of marker models for molecular typing of renal cell carcinoma.

    Jiang, Aimin / Zapała, Łukasz / Qu, Le / Wang, Linhui

    Frontiers in oncology

    2023  Volume 13, Page(s) 1236980

    Language English
    Publishing date 2023-07-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1236980
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  8. Article ; Online: Identification of fatty acid metabolism-based molecular subtypes and prognostic signature to predict immune landscape and guide clinical drug treatment in renal clear cell carcinoma.

    Wang, Linhui / Shen, Junlin / Wang, Yutao / Bi, Jianbin

    International immunopharmacology

    2023  Volume 116, Page(s) 109735

    Abstract: Three subtypes of samples were generated based on genes involved in fatty acid metabolism in The Cancer Genome Atlas (TCGA)-RCC patients using a non-negative matrix factorization (NMF) algorithm. 32 co-expressed modules were identified using WCGNA. We ... ...

    Abstract Three subtypes of samples were generated based on genes involved in fatty acid metabolism in The Cancer Genome Atlas (TCGA)-RCC patients using a non-negative matrix factorization (NMF) algorithm. 32 co-expressed modules were identified using WCGNA. We constructed a four-gene signature in our training set using least absolute shrinkage selection operator regression analysis and verified it in our testing and overall sets. A relevant study analysis in clinical trials was conducted, which showed the model had good stability and potential application value for predicting outcomes. We analyzed the immune microenvironment using MCPcounter, CIBERSORT, quanTIseq, TIMER and ESTIMATE algorithms, and the result indicated risk was positively related to T cells, B-lineage, and fibroblasts and negatively correlated with monocytic lineage, myeloid dendritic cells, neutrophils, and endothelial cells, and CPT1B was positively related to T cells, CD8 + T cells, Cytotoxic lymphocytes and NK cells, and negatively correlated with myeloid dendritic cells, fibroblasts, endothelial cells. Tumor mutation burden was positively related to risk score and the expression of CPT1B using the R packages corrplot, circlize. Through the R package pRRophetic, drug sensitivity tests showed that the low-risk score group would benefit more from sunitinib and less from pazopanib, sorafenib, temsirolimus, gemcitabine and doxorubicin than the high-risk score group. We performed the relevant basic assay validation for CPT1B, and the proliferation ability of RCC cells was inhibited after the knockdown of protein expression of CPT1B. In conclusion, we established a four-gene model that can predict outcomes of RCC with potential applications in diagnosis and treatment.
    MeSH term(s) Humans ; Prognosis ; Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/genetics ; Endothelial Cells ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/genetics ; Fatty Acids ; Tumor Microenvironment
    Chemical Substances Fatty Acids
    Language English
    Publishing date 2023-01-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.109735
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    Zs.A 5408: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Bioinformatics analysis and experimental validation of cuproptosis-related lncRNA LINC02154 in clear cell renal cell carcinoma.

    Shen, Junlin / Wang, Linhui / Bi, Jianbin

    BMC cancer

    2023  Volume 23, Issue 1, Page(s) 160

    Abstract: Background: Clear cell renal cell carcinoma (ccRCC) is common in urinary system tumors. Cuproptosis is a non-apoptotic cell death pathway. Copper binds to fatty acylated mitochondrial proteins and activates various forms of cell death. LncRNA LINC02154 ... ...

    Abstract Background: Clear cell renal cell carcinoma (ccRCC) is common in urinary system tumors. Cuproptosis is a non-apoptotic cell death pathway. Copper binds to fatty acylated mitochondrial proteins and activates various forms of cell death. LncRNA LINC02154 is significantly highly expressed in cells and tissues of many types of tumors, and the risk signature of LINC02154 in some tumors has been validated for effectiveness.
    Methods: We constructed a risk prognostic signature by obtaining differentially expressed long noncoding RNAs (lncRNAs) associated with ccRCC outcomes and cuproptosis from The Cancer Genome Atlas (TCGA). We used TCGA to construct training and testing sets to analyze the risk signature and the impact of LINC02154, and we performed relevant survival analyses. Tumor mutational burdens were analyzed in different LINC02154 expression groups and risk score groups. We next analyzed the immune microenvironment of LINC20154. We performed LINC20154-related drug sensitivity analyses. We also investigated the cellular function of LINC02154 in the ACHN cell line and performed CCK-8 assay, EdU, wound-healing assay, and Transwell assay. The essential genes FDX1 and DLST of cuproptosis were detected by western blot.
    Results: We demonstrated that LINC02154's impact on outcomes was statistically significant. We also demonstrated the association of different ages, genders, stages, and grades with LINC02154 and risk models. The results showed a significant difference in tumor mutation burden between the groups, which was closely related to clinical prognosis. We found differences in immune cells among groups with different levels of LINC02154 expression and significant differences in immune function, immunotherapeutic positive markers, and critical steps of the immune cycle. The sensitivity analysis showed that differential expression of LINC02154 discriminated between sensitivity to axitinib, doxorubicin, gemcitabine, pazopanib, sorafenib, sunitinib, and temsirolimus. This difference was also present in the high-risk group and low-risk group. We demonstrated that the proliferation and migration of t ACHN cells in the LINC02154 knockdown group were inhibited. The western blot results showed that the knockdown of LINC02154 significantly affected the expression of FDX1 and DLST, critical genes of cuproptosis.
    Conclusion: Finally, we demonstrated that LINC02154 and our constructed risk signature could predict outcomes and have potential clinical value.
    MeSH term(s) Female ; Humans ; Male ; Apoptosis/genetics ; Carcinoma, Renal Cell/genetics ; Computational Biology ; Copper ; Kidney Neoplasms/genetics ; RNA, Long Noncoding/genetics ; Tumor Microenvironment
    Chemical Substances Copper (789U1901C5) ; RNA, Long Noncoding
    Language English
    Publishing date 2023-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-023-10639-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Association of thymidine kinase-1 with prostate cancer.

    Jiang, Changyi / Zhou, Wenting / Wang, Linhui / Ke, Changxing

    Asian journal of surgery

    2023  Volume 47, Issue 2, Page(s) 1302–1303

    MeSH term(s) Male ; Humans ; Thymidine Kinase ; Prostatic Neoplasms
    Chemical Substances Thymidine Kinase (EC 2.7.1.21)
    Language English
    Publishing date 2023-12-21
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.12.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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