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  1. Article ; Online: Statistical Methods for Disease Risk Prediction with Genotype Data.

    Xia, Xiaoxuan / Zhang, Yexian / Wei, Yingying / Wang, Maggie Haitian

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2629, Page(s) 331–347

    Abstract: Single-nucleotide polymorphism (SNP) is the basic unit to understand the heritability of complex traits. One attractive application of the susceptible SNPs is to construct prediction models for assessing disease risk. Here, we introduce prediction ... ...

    Abstract Single-nucleotide polymorphism (SNP) is the basic unit to understand the heritability of complex traits. One attractive application of the susceptible SNPs is to construct prediction models for assessing disease risk. Here, we introduce prediction methods for human traits using SNPs data, including the polygenic risk score (PRS), linear mixed models (LMMs), penalized regressions, and methods for controlling population stratification.
    MeSH term(s) Humans ; Genome-Wide Association Study/methods ; Genotype ; Phenotype ; Risk Factors ; Multifactorial Inheritance ; Polymorphism, Single Nucleotide ; Genetic Predisposition to Disease
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2986-4_15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: W-Test for Genetic Epistasis Testing.

    Sun, Rui / Weng, Haoyi / Wang, Maggie Haitian

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2212, Page(s) 45–53

    Abstract: The genetic epistasis effect has been widely acknowledged as an essential contributor to genetic variation in complex diseases. In this chapter, we introduce a powerful and efficient statistical method, called W-test, for genetic epistasis testing. A ... ...

    Abstract The genetic epistasis effect has been widely acknowledged as an essential contributor to genetic variation in complex diseases. In this chapter, we introduce a powerful and efficient statistical method, called W-test, for genetic epistasis testing. A wtest R package is developed for the implementation of the W-test method, which provides various functions to measure the main effect, pairwise interaction, higher-order interaction, and cis-regulation of SNP-CpG pairs in genetic and epigenetic data. It allows flexible stagewise and exhaustive association testing as well as diagnostic checking on the probability distributions in a user-friendly interface. The wtest package is available in CRAN at https://CRAN.R-project.org/package=wtest .
    MeSH term(s) Algorithms ; Computational Biology/methods ; CpG Islands ; DNA Methylation ; Datasets as Topic ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/genetics ; Epistasis, Genetic ; Genetic Testing ; Genotype ; Humans ; Polymorphism, Single Nucleotide ; Probability ; Sample Size ; Software
    Language English
    Publishing date 2020-08-17
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0947-7_4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Author Correction: MircoRNA-145 promotes activation of hepatic stellate cells via targeting krüppel-like factor 4.

    Men, Ruoting / Wen, Maoyao / Zhao, Mingyue / Dan, Xuelian / Yang, Zongze / Wu, Wenchao / Wang, Maggie Haitian / Liu, Xiaojing / Yang, Li

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 9593

    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-36674-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Emergency Department Use Across Income Groups Following an Increase in Cost-Sharing.

    Wu, Yushan / Wang, Dorothy Yingxuan / Zhao, Shi / Wang, Maggie Haitian / Wong, Eliza Lai-Yi / Yeoh, Eng-Kiong

    JAMA network open

    2023  Volume 6, Issue 8, Page(s) e2329577

    Abstract: Importance: To encourage the appropriate utilization of emergency care, cost-sharing for emergency care was increased from HK$100 (US $12.8) to HK$180 (US $23.1) per visit in June 2017 in all public hospitals in Hong Kong. However, there are concerns ... ...

    Abstract Importance: To encourage the appropriate utilization of emergency care, cost-sharing for emergency care was increased from HK$100 (US $12.8) to HK$180 (US $23.1) per visit in June 2017 in all public hospitals in Hong Kong. However, there are concerns that this increase could deter appropriate emergency department (ED) visits and be associated with income-related disparities.
    Objective: To examine changes in ED visits after the fee increase.
    Design, setting, and participants: This retrospective cohort study used administrative data from June 2015 to May 2019 from all public hospitals in Hong Kong. Participants included all Hong Kong residents aged 64 years and younger, categorized into low-income, middle-income, and high-income groups according to the median household income in their district of residence. Data analysis was performed from May to June 2023.
    Main outcomes and measures: The primary outcome was the ED visit rate per 100 000 people per month, categorized into 3 severity levels (emergency, urgent, and nonurgent). Secondary outcomes include general outpatient (GOP) visit rate, emergency admission rate, and in-hospital mortality rate per month at public hospitals. Segmented regression analyses were used to estimate changes in the level and slope of outcome variables before and after the fee increase.
    Results: This study included a total of 5 441 679 ED patients (2 606 332 male patients [47.9%]; 2 108 933 patients [38.5%] aged 45-64 years), with 2 930 662 patients (1 407 885 male patients [48.0%]; 1 111 804 patients [37.9%] aged 45-64 years) from the period before the fee increase. The fee increase was associated with an 8.0% (95% CI, 7.1%-9.0%) immediate reduction in ED visits after June 2017, including a 5.9% (95% CI, 3.3%-8.5%) reduction in urgent visits and an 8.9% (95% CI, 8.0%-9.8%) reduction in nonurgent visits. In addition, a 5.7% (95% CI, 4.7%-6.8%) reduction of emergency admissions was found, whereas no significant changes were observed in in-hospital mortality. Specifically, a statistically significant increase in GOP visits (4.1%; 95% CI, 0.9%-7.2%) was found within the low-income group, but this association became insignificant after controlling for the social security group, who were exempted from payment, as a control.
    Conclusions and relevance: In this cohort study, the fee increase was not associated with changes in ED visits for emergency conditions, but there was a negative and significant association with both urgent and nonurgent conditions across all income groups. Considering the marginal increase in public GOP services, further study is warranted to examine strategies to protect low-income people from avoiding necessary care.
    MeSH term(s) Humans ; Male ; Cohort Studies ; Retrospective Studies ; Emergency Service, Hospital ; Income ; Emergency Medical Services
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.29577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Response to 'Mortality, length-of-stay, bloodstream and respiratory viral infections in a pediatric intensivecare unit: comment on data sparsity.

    Hon, Kam Lun / Wang, Maggie Haitian

    Journal of critical care

    2017  Volume 41, Page(s) 334

    Language English
    Publishing date 2017-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2017.07.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Genetic Test, Risk Prediction, and Counseling.

    Wang, Maggie Haitian / Weng, Haoyi

    Advances in experimental medicine and biology

    2017  Volume 1005, Page(s) 21–46

    Abstract: Advancement in technology has nurtured the new era of genetic tests for personalized medicine. In this chapter, we will introduce the current development, challenges, and the outlook of genetic test, disease risk prediction, and genetic counseling. In ... ...

    Abstract Advancement in technology has nurtured the new era of genetic tests for personalized medicine. In this chapter, we will introduce the current development, challenges, and the outlook of genetic test, disease risk prediction, and genetic counseling. In the first section, we will present the success cases in the areas of molecular classification of tumors, pharmacogenomics, and Mendelian disorders, and the challenges of genetic tests implementations. In the second section, common methods for genetic risk prediction models and evaluation measures will be introduced, as well as challenges in feature reliability, risk model stability, and clinical utility. In the final section, key components of genetic counseling will be introduced, covering individual communications, psychosocial concerns, risk assessments, and follow-ups. Current evidences have shown a promising future for genetic testing and risk prediction; we expect that the advancement of analytical methods, technology, integration of omics data, and the increasing clinical implementation and regulation will continue to pave the way for precision medicine in future.
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-10-5717-5_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Association of spirometric restriction with mortality in the silicotics: a cohort study.

    Yang, Shuyuan / Chan, Chi Kuen / Wang, Maggie Haitian / Leung, Chi Chiu / Tai, Lai Bun / Tse, Lap Ah

    BMC pulmonary medicine

    2023  Volume 23, Issue 1, Page(s) 327

    Abstract: Background: Restrictive spirometry pattern (RSP), defined as reduced forced vital capacity (FVC) in absence of airflow obstruction (AFO), is associated with increased risk of mortality in general population. However, evidence in the patients with ... ...

    Abstract Background: Restrictive spirometry pattern (RSP), defined as reduced forced vital capacity (FVC) in absence of airflow obstruction (AFO), is associated with increased risk of mortality in general population. However, evidence in the patients with silicosis is limited. This study was aimed to investigate the relationship between RSP and the risk of death in a silicotic cohort.
    Method: This retrospective cohort study used data from the Pneumoconiosis Clinic, Hong Kong Department of Health that containing 4315 patients aged 18-80 years and diagnosed with silicosis during 1981-2019, with a follow-up till 31 December 2019. Spirometry was carried out at the diagnostic examination of silicosis. Lung function categories were classified as normal spirometry (FEV
    Results: Among the 4315 patients enrolled in the study, the prevalence of RSP was 24.1% (n = 1038), including 11.0% (n = 473) with RSP only and 13.1% (n = 565) with mixed RSP and AFO. During the follow-up period, a total of 2399 (55.6%) deaths were observed. Compared with the silicotics with normal spirometry, those with RSP only had significantly increased risk of all-cause mortality (HR = 1.63, 95% CI 1.44-1.85) and respiratory-related mortality (HR = 1.56, 95% CI 1.31-1.85). Notably, a higher risk of mortality was observed in silicotics with mixed ventilatory defects of both RSP and AFO (all-cause mortality: HR = 2.22, 95% CI 1.95-2.52; respiratory-related mortality: HR = 2.59, 95% CI 2.18-3.07) than in those with RSP only.
    Conclusion: RSP is significantly associated with increased risk of all-cause and respiratory-related mortality in the silicotics, and patients with mixed restrictive and obstructive ventilatory defect have higher risk of mortality than those with single RSP or AFO. These findings emphasize the importance of recognizing RSP in the occupational settings, especially for the silicotic patients with mixed ventilatory defect.
    MeSH term(s) Humans ; Cohort Studies ; Retrospective Studies ; Spirometry ; Silicosis ; Body Mass Index
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-023-02622-1
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  8. Article: Extra cup of tea intake associated with increased risk of Alzheimer's disease: Genetic insights from Mendelian randomization.

    Sun, Yuxuan / Liang, Zixin / Xia, Xiaoxuan / Wang, Maggie Haitian / Zhu, Chengming / Pan, Yihang / Sun, Rui

    Frontiers in nutrition

    2023  Volume 10, Page(s) 1052281

    Abstract: Background: Observational studies report inconclusive effects of tea consumption on the risk of Alzheimer's disease (AD), and the mechanisms are unclear. This study aims to investigate the effects of genetically predicted tea intake (cups of tea ... ...

    Abstract Background: Observational studies report inconclusive effects of tea consumption on the risk of Alzheimer's disease (AD), and the mechanisms are unclear. This study aims to investigate the effects of genetically predicted tea intake (cups of tea consumed per day) on AD, brain volume, and cerebral small vessel disease (CSVD) using the two-sample Mendelian randomization (MR) method.
    Methods: Summary statistics of tea intake were obtained from UK Biobank (
    Results: In the primary MR analysis, tea intake significantly increased the risk of AD using two different methods (OR
    Conclusion: This study revealed a potential causal association between per extra cup of tea and an increased risk of AD. Genetically predicted tea intake was associated with a decreased brain volume of gray matter and the right hippocampus, which indicates that over-drinking tea might lead to a decline in language and memory functions. Our results shed light on a novel possible mechanism of tea intake to increase the risk of AD by reducing brain volume.
    Language English
    Publishing date 2023-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1052281
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  9. Article ; Online: Immune modulation by rural exposures and allergy protection.

    Xing, Yuhan / Tsang, Miranda Sin-Man / Yang, Zhaowei / Wang, Maggie Haitian / Pivniouk, Vadim / Leung, Agnes Sze-Yin / Leung, Ting-Fan / Roponen, Marjut / Schaub, Bianca / Vercelli, Donata / Wong, Chun-Kwok / Li, Jing / Wong, Gary Wing-Kin

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2024  Volume 35, Issue 2, Page(s) e14086

    Abstract: Background: Growing up on traditional farms protects children from the development of asthma and allergies. However, we have identified distinct asthma-protective factors, such as poultry exposure. This study aims to examine the biological effect of ... ...

    Abstract Background: Growing up on traditional farms protects children from the development of asthma and allergies. However, we have identified distinct asthma-protective factors, such as poultry exposure. This study aims to examine the biological effect of rural exposure in China.
    Methods: We recruited 67 rural children (7.4 ± 0.9 years) and 79 urban children (6.8 ± 0.6 years). Depending on the personal history of exposure to domestic poultry (DP), rural children were further divided into those with DP exposure (DP
    Results: There was a stepwise increase in the percentage of eosinophils (%) from rural DP
    Conclusions: Immune responses of rural children were dampened compared to urban children and those exposed to DP had further downregulated immune responsiveness. DP dust extracts ameliorated Th2-driven allergic airway inflammation in mice. Determining active protective components in the rural environment may provide directions for the development of primary prevention of asthma.
    MeSH term(s) Child ; Humans ; Animals ; Mice ; Lipopolysaccharides/adverse effects ; Hypersensitivity ; Asthma ; Allergens ; Cytokines/metabolism ; Dust ; Inflammation ; Disease Models, Animal ; Immunity ; Mice, Inbred BALB C ; Ovalbumin/adverse effects
    Chemical Substances Lipopolysaccharides ; Allergens ; Cytokines ; Dust ; Ovalbumin (9006-59-1)
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.14086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Statistical methods for genome-wide association studies.

    Wang, Maggie Haitian / Cordell, Heather J / Van Steen, Kristel

    Seminars in cancer biology

    2018  Volume 55, Page(s) 53–60

    Abstract: Genome-wide association studies (GWAS) detect common genetic variants associated with complex disorders. With their comprehensive coverage of common single nucleotide polymorphisms and comparatively low cost, GWAS are an attractive tool in the clinical ... ...

    Abstract Genome-wide association studies (GWAS) detect common genetic variants associated with complex disorders. With their comprehensive coverage of common single nucleotide polymorphisms and comparatively low cost, GWAS are an attractive tool in the clinical and commercial genetic testing. This review introduces the pipeline of statistical methods used in GWAS analysis, from data quality control, association tests, population structure control, interaction effects and results visualization, through to post-GWAS validation methods and related issues.
    MeSH term(s) Genetic Testing/statistics & numerical data ; Genome-Wide Association Study/statistics & numerical data ; Genotype ; Humans ; Phenotype ; Polymorphism, Single Nucleotide/genetics
    Language English
    Publishing date 2018-05-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2018.04.008
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