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  1. Article ; Online: MP Allosterically Activates AMPK to Enhance ABCA1 Stability by Retarding the Calpain-Mediated Degradation Pathway.

    Li, Hui / Wang, Mingchao / Qu, Kai / Xu, Ruiming / Zhu, Haibo

    International journal of molecular sciences

    2023  Volume 24, Issue 24

    Abstract: It is widely recognized that macrophage cholesterol efflux mediated by the ATP-binding cassette transporter A1 (ABCA1) constitutes the initial and rate-limiting step of reverse cholesterol transport (RCT), displaying a negative correlation with the ... ...

    Abstract It is widely recognized that macrophage cholesterol efflux mediated by the ATP-binding cassette transporter A1 (ABCA1) constitutes the initial and rate-limiting step of reverse cholesterol transport (RCT), displaying a negative correlation with the development of atherosclerosis. Although the transcriptional regulation of ABCA1 has been extensively studied in previous research, the impact of post-translational regulation on its expression remains to be elucidated. In this study, we report an AMP-activated protein kinase (AMPK) agonist called ((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-((3-hydroxyphenyl) amino)-9H-purin-9-yl) tetrahydrofuran-2-yl) methyl dihydrogen phosphate (MP), which enhances ABCA1 expression through post-translational regulation rather than transcriptional regulation. By integrating the findings of multiple experiments, it is confirmed that MP directly binds to AMPK with a moderate binding affinity, subsequently triggering its allosteric activation. Further investigations conducted on macrophages unveil a novel mechanism through which MP modulates ABCA1 expression. Specifically, MP downregulates the Cav1.2 channel to obstruct the influx of extracellular Ca
    MeSH term(s) Calpain/metabolism ; AMP-Activated Protein Kinases/metabolism ; Cholesterol/metabolism ; Macrophages/metabolism ; Proteolysis ; ATP Binding Cassette Transporter 1/genetics ; ATP Binding Cassette Transporter 1/metabolism
    Chemical Substances Calpain (EC 3.4.22.-) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Cholesterol (97C5T2UQ7J) ; ATP Binding Cassette Transporter 1
    Language English
    Publishing date 2023-12-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242417280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction to "Strategy for Microscale Extraction and Proteome Profiling of Peripheral Blood Mononuclear Cells".

    Yang, Li / Weng, Shuang / Qian, Xiaohong / Wang, Mingchao / Ying, Wantao

    Analytical chemistry

    2023  Volume 95, Issue 32, Page(s) 12192

    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c03282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Local delivery of doxorubicin prodrug via lipid nanocapsule-based hydrogel for the treatment of glioblastoma.

    Wang, Mingchao / Bergès, Raphaël / Malfanti, Alessio / Préat, Véronique / Bastiancich, Chiara

    Drug delivery and translational research

    2023  

    Abstract: Glioblastoma (GBM) recurrences appear in most cases around the resection cavity borders and arise from residual GBM cells that cannot be removed by surgery. Here, we propose a novel treatment that combines the advantages of nanomedicine and local drug ... ...

    Abstract Glioblastoma (GBM) recurrences appear in most cases around the resection cavity borders and arise from residual GBM cells that cannot be removed by surgery. Here, we propose a novel treatment that combines the advantages of nanomedicine and local drug delivery to target these infiltrating GBM cells. We developed an injectable lipid nanocapsule (LNC)-based formulation loaded with lauroyl-doxorubicin prodrug (DOXC
    Language English
    Publishing date 2023-10-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2590155-2
    ISSN 2190-3948 ; 2190-393X
    ISSN (online) 2190-3948
    ISSN 2190-393X
    DOI 10.1007/s13346-023-01456-y
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  4. Article ; Online: Correction: Two-dimensional conjugated metal-organic frameworks (2D

    Wang, Mingchao / Dong, Renhao / Feng, Xinliang

    Chemical Society reviews

    2022  Volume 51, Issue 2, Page(s) 793–794

    Abstract: Correction for 'Two-dimensional conjugated metal-organic frameworks ( ... ...

    Abstract Correction for 'Two-dimensional conjugated metal-organic frameworks (2D
    Language English
    Publishing date 2022-01-24
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/d2cs90005j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Two-dimensional conjugated metal-organic frameworks (2D

    Wang, Mingchao / Dong, Renhao / Feng, Xinliang

    Chemical Society reviews

    2021  Volume 50, Issue 4, Page(s) 2764–2793

    Abstract: The 21st century has seen a reinvention of how modern electronics impact our daily lives; silicon-electronics and organic electronics are currently at the core of modern electronics. Recent advances have demonstrated that conductive metal-organic ... ...

    Abstract The 21st century has seen a reinvention of how modern electronics impact our daily lives; silicon-electronics and organic electronics are currently at the core of modern electronics. Recent advances have demonstrated that conductive metal-organic frameworks (MOFs), as another unique class of electronic materials, are emerging to provide additional possibility for multifunctional electronic devices that brings us "MOFtronics". Typically, two-dimensional conjugated MOFs (2D c-MOFs) are a novel class of layer-stacked MOFs with in-plane extended π-conjugation that exhibit unique properties such as intrinsic porosity, crystallinity, stability, and electrical conductivity as well as tailorable band gaps. Benefiting from their unique features and high conductivity, 2D c-MOFs have displayed great potential for multiple high-performance (opto)electronic, magnetic, and energy devices. In this review article, we introduce the chemical and synthetic methodologies of 2D c-MOFs, intrinsic influences on their electronic structures and charge transport properties, as well as multifunctional applications of this class of materials for MOFtronics and potential power sources for MOFtronics. We highlight the benefits and limitations of thus-far developed 2D c-MOFs from synthesis to function and offer our perspectives in regard to the challenges to be addressed.
    Language English
    Publishing date 2021-01-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/d0cs01160f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Effect of Different Diluents and Curing Agents on the Performance of Epoxy Resin-Based Intumescent Flame-Retardant Coatings.

    Yang, Xukun / Wan, Yange / Yang, Nan / Hou, Yilin / Chen, Dantong / Liu, Jiachen / Cai, Guoshuai / Wang, Mingchao

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 2

    Abstract: The epoxy resin-based (ESB) intumescent flame-retardant coatings were modified with 1,4-butanediol diglycidyl ether (14BDDE) and butyl glycidyl ether (BGE) as diluents and T403 and 4,4'-diaminodiphenylmethane (DDM) as curing agents, respectively. The ... ...

    Abstract The epoxy resin-based (ESB) intumescent flame-retardant coatings were modified with 1,4-butanediol diglycidyl ether (14BDDE) and butyl glycidyl ether (BGE) as diluents and T403 and 4,4'-diaminodiphenylmethane (DDM) as curing agents, respectively. The effects of different diluents and curing agents on the flame-retardant and mechanical properties, as well as the composition evolution of the coatings, were investigated by using large-plate combustion, the limiting oxygen index (LOI), vertical combustion, a cone calorimeter, X-ray diffraction, FTIR analysis, a N
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17020348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Strategy for Microscale Extraction and Proteome Profiling of Peripheral Blood Mononuclear Cells.

    Yang, Li / Weng, Shuang / Qian, Xiaohong / Wang, Mingchao / Ying, Wantao

    Analytical chemistry

    2022  Volume 94, Issue 25, Page(s) 8827–8832

    Abstract: Peripheral blood mononuclear cells (PBMCs) play vital roles in physiological and pathological processes and represent a rich source for disease monitoring. Typical molecular profiling on PBMCs involves the sorting of cell subsets and thus requires a ... ...

    Abstract Peripheral blood mononuclear cells (PBMCs) play vital roles in physiological and pathological processes and represent a rich source for disease monitoring. Typical molecular profiling on PBMCs involves the sorting of cell subsets and thus requires a large volume of peripheral blood (PB), which impedes the clinical practicability of omics tools in PBMC measurements. It would be clinically invaluable to develop a convenient approach for preparing PBMCs from small volumes of PB and for deep proteome profiling of PBMCs. To this end, here, we designed an apparatus (PBMC-mCap) for microscale enrichment and proteome analysis of PBMCs, which pushed the needed PB volume from the normal 2 mL or higher to 100 μL or lower, comparable to the volume of a drop of finger blood. A PBMC-specific mass spectra library containing 8869 proteins and 121,956 peptides was further built, which, in combination with the optimized data-independent acquisition strategy, helped to identify 6000 and 6500 proteins from PBMCs with 100 μL and 1 mL of PB as initial materials, respectively. Further application of the strategy for PBMC proteomes revealed a steady difference between gender (male vs female) and upon stimulus (COVID-19 vaccination). For the latter, we observed differentially expressed genes and pathways involving the activation of immune cells, including the NF-κB pathway, inflammation response, and antiviral response. Our strategy for the proteome analysis of microscale PBMCs may provide a convenient clinical toolkit for disease diagnosis and healthy state monitoring.
    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Female ; Humans ; Leukocytes, Mononuclear ; Male ; Mass Spectrometry ; Proteome/metabolism
    Chemical Substances COVID-19 Vaccines ; Proteome
    Language English
    Publishing date 2022-06-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.1c05365
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Two-Dimensional Conjugated Metal-Organic Frameworks for Electrocatalysis: Opportunities and Challenges.

    Zhong, Haixia / Wang, Mingchao / Chen, Guangbo / Dong, Renhao / Feng, Xinliang

    ACS nano

    2022  Volume 16, Issue 2, Page(s) 1759–1780

    Abstract: A highly effective electrocatalyst is the central component of advanced electrochemical energy conversion. Recently, two-dimensional conjugated metal-organic frameworks (2D c-MOFs) have emerged as a class of promising electrocatalysts because of their ... ...

    Abstract A highly effective electrocatalyst is the central component of advanced electrochemical energy conversion. Recently, two-dimensional conjugated metal-organic frameworks (2D c-MOFs) have emerged as a class of promising electrocatalysts because of their advantages including 2D layered structure with high in-plane conjugation, intrinsic electrical conductivity, permanent pores, large surface area, chemical stability, and structural diversity. In this Review, we summarize the recent advances of 2D c-MOF electrocatalysts for electrochemical energy conversion. First, we introduce the chemical design principles and synthetic strategies of the reported 2D c-MOFs, as well as the functional design for the electrocatalysis. Subsequently, we present the representative 2D c-MOF electrocatalysts in various electrochemical reactions, such as hydrogen/oxygen evolution, and reduction reactions of oxygen, carbon dioxide, and nitrogen. We highlight the strategies for the structural design and property tuning of 2D c-MOF electrocatalysts to boost the catalytic performance, and we offer our perspectives in regard to the challenges to be overcome.
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.1c10544
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: High Emissivity MoSi

    Yang, Xukun / Wan, Yange / Li, Jiancun / Liu, Jiachen / Wang, Mingchao / Tao, Xin

    Materials (Basel, Switzerland)

    2023  Volume 17, Issue 1

    Abstract: High emissivity coatings with sol as the binder have the advantages of room temperature curing, good thermal shock resistance, and high emissivity; however, only silica sol has been used in the current systems. In this study, aluminum sol was used as the ...

    Abstract High emissivity coatings with sol as the binder have the advantages of room temperature curing, good thermal shock resistance, and high emissivity; however, only silica sol has been used in the current systems. In this study, aluminum sol was used as the binder for the first time, and MoSi
    Language English
    Publishing date 2023-12-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17010220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Combining Machine Learning and Molecular Dynamics to Predict Mechanical Properties and Microstructural Evolution of FeNiCrCoCu High-Entropy Alloys.

    Yu, Jingui / Yu, Faping / Fu, Qiang / Zhao, Gang / Gong, Caiyun / Wang, Mingchao / Zhang, Qiaoxin

    Nanomaterials (Basel, Switzerland)

    2023  Volume 13, Issue 6

    Abstract: Compared with traditional alloys, high-entropy alloys have better mechanical properties and corrosion resistance. However, their mechanical properties and microstructural evolution behavior are unclear due to their complex composition. Machine learning ... ...

    Abstract Compared with traditional alloys, high-entropy alloys have better mechanical properties and corrosion resistance. However, their mechanical properties and microstructural evolution behavior are unclear due to their complex composition. Machine learning has powerful data processing and analysis capabilities, that provides technical advantages for in-depth study of the mechanical properties of high-entropy alloys. Thus, we combined machine learning and molecular dynamics to predict the mechanical properties of FeNiCrCoCu high-entropy alloys. The optimal multiple linear regression machine learning algorithm predicts that the optimal composition is Fe
    Language English
    Publishing date 2023-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano13060968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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