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Article ; Online: Triglyceride-lowering therapy for the prevention of cardiovascular events, stroke, and mortality in patients with diabetes: A meta-analysis of randomized controlled trials.

Yang, Xiu Hong / Tu, Qian Ming / Li, Li / Guo, Yong Ping / Wang, Nian Song / Jin, Hui Min

2023 , Page(s) 117187

Abstract: Background and aims: Triglyceride (TG)-lowering therapy is efficient for the prevention of cardiovascular disease (CVD) in the general population; however, for diabetic individuals, it is more controversial. The purpose of this study was to pool the ... ...

Abstract	Background and aims: Triglyceride (TG)-lowering therapy is efficient for the prevention of cardiovascular disease (CVD) in the general population; however, for diabetic individuals, it is more controversial. The purpose of this study was to pool the results from randomized controlled trials (RCTs) to clarify whether the lowering of TG is beneficial for the prevention of CVD events, stroke, and mortality in subjects with diabetes. Methods: MEDLINE, Web of Science, EMBASE, ClinicalTrials.gov, and the Cochrane Central Register for Controlled Trials were searched to identify the relevant literature. We included randomized controlled trials (RCTs) to assess the association of triglyceride-lowering therapy with the prevention of CVD events, stroke, and mortality in diabetic patients. Results: Overall, 19 studies were included in this meta-analysis. Compared with the control groups, TG lowering was associated with a decreased risk of CVD events (RR = 0.91, 95% CI 0.87-0.95, p = 0.000) and CVD mortality (RR = 0.93, 95% CI 0.86-1.00, p = 0.047). There was no significant correlation between TG-lowering therapy and the incidence of stroke and all-cause mortality (RR = 0.93, 95% CI 0.86-1.02, p = 0.129 and RR = 0.97, 95% CI 0.93-1.01, p = 0.107, respectively). Subgroup analysis showed that the decreased CVD risk resulting from TG-lowering therapy was independent of age, sex, region, duration of follow-up, degree of TG reduction and glycemic control. Conclusions: TG-lowering therapy is associated with a reduction in CVD events and cardiovascular-specific mortality, but not in stroke and all-cause mortality. Future large, multicenter RCTs will further confirm these conclusions.
Language	English
Publishing date	2023-07-13
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	80061-2
ISSN	1879-1484 ; 0021-9150
ISSN (online)	1879-1484
ISSN	0021-9150
DOI	10.1016/j.atherosclerosis.2023.117187
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Zs.A 226: Show issues

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Article ; Online: Effect of Sheng Xue Ning Tablets on Renal Anemia in Patients Subject to Maintenance Hemodialysis and Safety Evaluation: A Multi-setting Prospective Randomized Study.

Tang, Xiao-Jing / Rong, Shu / Mei, Chang-Lin / Ni, Zhao-Hui / Jiang, Geng-Ru / Yuan, Wei-Jie / Wang, Nian-Song / Guo, Zhi-Yong / Ma, Jun / Yan, Hai-Dong / ZHang, Li-Ming

Current medical science

2020 Volume 40, Issue 2, Page(s) 327–331

Abstract: This study compared Sheng Xue Ning (SXN) tablets with ferrous succinate (FS) tablets in terms of their efficacy for the treatment of iron-deficient renal anemia and safety in patients subject to maintenance hemodialysis (MHD). A total of 94 patients ... ...

Abstract	This study compared Sheng Xue Ning (SXN) tablets with ferrous succinate (FS) tablets in terms of their efficacy for the treatment of iron-deficient renal anemia and safety in patients subject to maintenance hemodialysis (MHD). A total of 94 patients undergoing MHD were randomly assigned to an experiment group (receiving oral SXN tablets, SXN group) and a control group (orally given FS tablets, FS group) and followed up for 12 weeks. Erythropoietin (EPO) was used in both groups. The efficacy was assessed by detecting the subsequent changes in hemoglobin (Hb), serum iron (SI), SF and transferrin saturation (TSAT). At the 12th week, Hb and TSAT levels in both groups were significantly increased compared to those in the screening period (P<0.05). However, no significant difference in Hb and TSAT was found between the two groups. The average weekly EPO dosage used was lower in SXN group than in FS group (P<0.05) at the 10th week and the 12th week. Our study showed that SXN tablets can effectively ameliorate renal anemia and keep iron metabolism stable in MHD patients, and its efficacy is virtually close to that of FS tablets. Meanwhile, SXN tablets can reduce the dosage of EPO and have a good safety profile.
MeSH term(s)	Administration, Oral ; Adult ; Aged ; Anemia/drug therapy ; Anemia/etiology ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/therapeutic use ; Female ; Ferrous Compounds/administration & dosage ; Ferrous Compounds/therapeutic use ; Hemoglobins/analysis ; Humans ; Iron/blood ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Prospective Studies ; Renal Dialysis/adverse effects ; Tablets ; Treatment Outcome ; Young Adult
Chemical Substances	Drugs, Chinese Herbal ; Ferrous Compounds ; Hemoglobins ; Tablets ; shengxuening ; ferrous succinate (818ZYK7N91) ; Iron (E1UOL152H7)
Language	English
Publishing date	2020-04-26
Publishing country	China
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2931065-9
ISSN	2523-899X ; 2096-5230
ISSN (online)	2523-899X
ISSN	2096-5230
DOI	10.1007/s11596-020-2179-z
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Article ; Online: Visceral muscle dysmotility syndrome in systemic lupus erythematosus: case report and review of the literature.

Chen, Yu Qiang / Xue, Qing / Wang, Nian Song

Rheumatology international

2011 Volume 32, Issue 6, Page(s) 1701–1703

Abstract: Intestinal pseudo-obstruction (IPO) is not uncommon in systemic lupus erythematosus (SLE), and IPO in SLE has an apparent association with ureterohydronephrosis. However, hepatobiliary dilatation without mechanical obstruction presenting together with ... ...

Abstract	Intestinal pseudo-obstruction (IPO) is not uncommon in systemic lupus erythematosus (SLE), and IPO in SLE has an apparent association with ureterohydronephrosis. However, hepatobiliary dilatation without mechanical obstruction presenting together with IPO and ureterohydronephrosis is much more scarce in SLE. Here, we named this rare triad of IPO, ureterohydronephrosis, and biliary tract dilatation as visceral muscle dysmotility syndrome (VMDS). It always imitates an acute abdomen and is even life-threatening if treated incorrectly. To diagnose a VMDS, infections and mechanical obstructions should be ruled out carefully. Here, we report a 24-year-old Chinese woman with SLE who presented of VMDS that associated with corticoids tapering induced SLE flare. In this case, early vigorous immunosuppressive treatment conquered the triad timely and thus yielded a good outcome.
MeSH term(s)	Adrenal Cortex Hormones/administration & dosage ; Biliary Tract/pathology ; Cholangiopancreatography, Magnetic Resonance ; Dilatation, Pathologic ; Drug Administration Schedule ; Female ; Gastrointestinal Motility ; Humans ; Hydronephrosis/etiology ; Immunosuppressive Agents/administration & dosage ; Intestinal Pseudo-Obstruction/diagnosis ; Intestinal Pseudo-Obstruction/drug therapy ; Intestinal Pseudo-Obstruction/etiology ; Intestinal Pseudo-Obstruction/physiopathology ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy ; Syndrome ; Tomography, X-Ray Computed ; Treatment Outcome ; Ureteral Diseases/etiology ; Young Adult
Chemical Substances	Adrenal Cortex Hormones ; Immunosuppressive Agents
Language	English
Publishing date	2011-03-24
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-011-1856-4
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Zs.A 1639: Show issues

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Article ; Online: Pregnancy-related Acute Kidney Injury and a Review of the Literature in China.

Liu, Yu-mei / Bao, Hong-da / Jiang, Zhen-zhen / Huang, Ya-juan / Wang, Nian-song

Internal medicine (Tokyo, Japan)

2015 Volume 54, Issue 14, Page(s) 1695–1703

Abstract: Objective: To determine the incidence, causes and prognosis of pregnancy-related acute kidney injury (PR-AKI) in Chinese women.: Methods: From July 2004 to February 2013, 18,589 women of Han ethnicity who attended the Obstetrics and Nephrology ... ...

Abstract	Objective: To determine the incidence, causes and prognosis of pregnancy-related acute kidney injury (PR-AKI) in Chinese women. Methods: From July 2004 to February 2013, 18,589 women of Han ethnicity who attended the Obstetrics and Nephrology Department of our tertiary hospital were investigated, and individuals meeting the PR-AKI criteria were included in the analysis. The WanFang, Chinese Science Journal, Chinese Knowledge, MEDLINE, EMBASE and Cochrane library databases were searched, and literature describing PR-AKI diagnoses with Chinese women as study subjects and a sample size of ≥5 were included. Results: The incidence of PR-AKI was 0.1183% (22/18,589). Hemorrhagic shock (31.8%) and pre-eclampsia (severe, 18.2%) were the two most common causes of PR-AKI. Twelve women recovered completely, six women displayed persistent proteinuria and four women had an increased serum creatinine level at discharge. There were no cases of death. Twenty women demonstrated adverse pregnancy outcomes (90.9%), including eight cases of stillbirth (36.4%). In our literature review, 29 of 4,076 articles were included, and the incidence of PR-AKI in China was found to range from 0.02% to 1.84%. Pregnancy hypertension (49.2%) and postpartum hemorrhage (13.8%) were found to be the most common causes of PR-AKI in China. The prognosis improved in 81.9% of the patients, the renal function deteriorated in 4.5% of the patients and 13.6% of the patients died. The rate of stillbirth was 27.0%. Conclusion: The maternal condition after active treatment was good, whereas the pregnancy outcomes were generally poor. Although the incidence of PR-AKI was relatively low, this finding is noteworthy. Further studies are thus warranted to improve maternal-fetal outcomes.
MeSH term(s)	Acute Kidney Injury/diagnosis ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Adult ; China/epidemiology ; Female ; Humans ; Incidence ; Kidney/pathology ; Pregnancy ; Pregnancy Complications/diagnosis ; Pregnancy Complications/epidemiology ; Pregnancy Outcome ; Prevalence ; Prognosis ; Proteinuria/complications ; Retrospective Studies
Language	English
Publishing date	2015
Publishing country	Japan
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.54.3870
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Zs.A 240: Show issues

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Article ; Online: Human urine-derived stem cells contribute to the repair of ischemic acute kidney injury in rats.

Tian, Shou-Fu / Jiang, Zhen-Zhen / Liu, Yu-Mei / Niu, Xin / Hu, Bin / Guo, Shang-Chun / Wang, Nian-Song / Wang, Yang

Molecular medicine reports

2017 Volume 16, Issue 4, Page(s) 5541–5548

Abstract: Acute kidney injury (AKI) is a clinical syndrome associated with high rates of morbidity and mortality. It has previously been reported that stem cells may be considered a potential therapeutic strategy for the treatment of AKI. The present study aimed ... ...

Abstract	Acute kidney injury (AKI) is a clinical syndrome associated with high rates of morbidity and mortality. It has previously been reported that stem cells may be considered a potential therapeutic strategy for the treatment of AKI. The present study aimed to determine whether administration of urine‑derived stem cells (USCs) to rats with ischemia/reperfusion (I/R)‑induced AKI could improve renal function. USCs were isolated and cultured from 8 healthy men. Subsequently, USCs transduced with green fluorescent protein were mixed with hydrogel and were injected into rats with renal I/R injury. Renal tubular injury, proliferation and apoptosis were detected in the I/R model. Hematoxylin and eosin staining was used to detect the morphological of kidney injury. Immunohistochemistry and TUNEL kits used to evaluate the proliferation and apoptosis of the I/R model. The results demonstrated that USCs could be detected in the tubular epithelial lining of the rats and administration of USCs was able to improve renal function in the I/R model. The USCs‑treated group exhibited significantly reduced serum creatinine and blood urea nitrogen levels, decreased tubular injury score, an increased number of proliferating cells and a decreased number of apoptotic cells. Compared with the control group, the mRNA expression levels of the anti‑inflammatory factors interleukin (IL)‑10 and transforming growth factor‑β1 were significantly upregulated, whereas the expression levels of the proinflammatory factors interferon‑γ and IL‑1β were significantly reduced in the USCs‑treated group. These findings suggested that USCs may promote kidney repair and improve function following ischemic AKI, which may be useful in treating human kidney disease.
Language	English
Publishing date	2017-10
Publishing country	Greece
Document type	Journal Article
ISSN	1791-3004
ISSN (online)	1791-3004
DOI	10.3892/mmr.2017.7240
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Article: A Clinical Multicenter Randomized Controlled Study on JianpiQinghua Decoction in Treating Stage 3 Chronic Kidney Disease with A Syndrome Type of Dampness-heat due to Spleen Deficiency.

Yu, Ke-Na / Ni, Zhao-Hui / Wang, Nian-Song / Peng, Wen / Wang, Yi / Zhang, Chang-Ming / He, Li-Qun

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

2016 Volume 38, Issue 6, Page(s) 686–695

Abstract: Objective To evaluate the clinical effectiveness of JianpiQinghua decoction in treating stage 3 chronic kidney disease (CKD3) with syndrome type of dampness-heat due to spleen deficiency. Methods A multicenter, randomized, controlled, prospective, double- ...

Abstract	Objective To evaluate the clinical effectiveness of JianpiQinghua decoction in treating stage 3 chronic kidney disease (CKD3) with syndrome type of dampness-heat due to spleen deficiency. Methods A multicenter, randomized, controlled, prospective, double-blind, and double-simulation study was undertaken. A total of 270 CKD3 patients with syndrome type of dampness-heat due to spleen deficiency from the outpatient departments of six general hospitals were randomly divided into telmisartan+analog traditional Chinese medicine (TA) group, traditional Chinese medicine+analog telmisartan (TCMA) group, and telmisartan+traditional Chinese medicine (TTCM) group, in which the corresponding treatment was applied in addition to basic treatment. Six months later, changes in the traditional Chinese medicine (TCM) clinical symptom scores and renal functions before and after treatment were compared among these three groups. Results Of these 270 CKD3 patients who had been enrolled in this study, 30 cases lost to follow-up. The baseline data were comparable among these three groups. After treatment, the TCM clinical symptom scores of both syndrome of spleen-qi deficiency and dampness-heat in TA group were significantly higher than those in TCMA group and TTCM group (P<0.001). With the treatment time prolonged, the TCM clinical symptom scores showed similar descending trends in TCMA group and TTCM group but were different from that in TA group. After treatment, abnormal creatinine rate decreased (P=0.003), and these three treatments and their interactions with each visit had no effect on serum urea nitrogen value (P=0.270, P=0.520); with prolonged treatment, the estimated glomerular filtration rates in three groups tended to be relatively stable after the first rise. The liver function and abnormal serum potassium rate were not statistically significant before and after treatment (P>0.05). Conclusions JianpiQinghua decoction can improve clinical symptoms of TCM in CKD3 patients with syndrome type of dampness-heat due to spleen deficiency and thus improve the quality of life and prognosis. The clinical efficacy of JianpiQinghua decoction alone or combined with telmisartan is superior to telmisartan monotherapy.
MeSH term(s)	Benzimidazoles/therapeutic use ; Benzoates/therapeutic use ; Double-Blind Method ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Medicine, Chinese Traditional ; Phytotherapy ; Prospective Studies ; Quality of Life ; Renal Insufficiency, Chronic/drug therapy
Chemical Substances	Benzimidazoles ; Benzoates ; Drugs, Chinese Herbal ; telmisartan (U5SYW473RQ)
Language	English
Publishing date	2016-12-20
Publishing country	China
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	604853-5
ISSN	1000-503X
ISSN	1000-503X
DOI	10.3881/j.issn.1000-503X.2016.06.010
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Zs.B 2554: Show issues

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Article ; Online: Proteus Takayasu's arteritis with unusual intracranial granulomatosis as initial manifestation.

Chen, Yu Qiang / Wang, Yuan / Wang, Feng / Wang, Nian Song

Rheumatology international

2010 Volume 32, Issue 7, Page(s) 2185–2188

Abstract: Takayasu's arteritis (TA) is an inflammatory vasculitis of aorta and its branches, its low incidence limited our recognition to this entity. We sometimes can confuse this disease with polyarteritis nodosa and other vasculitis when no conventional "big ... ...

Abstract	Takayasu's arteritis (TA) is an inflammatory vasculitis of aorta and its branches, its low incidence limited our recognition to this entity. We sometimes can confuse this disease with polyarteritis nodosa and other vasculitis when no conventional "big artery" involved in TA cases. Here we report a 26-year-old man with Takayasu's arteritis who presented with a provisional intracranial granulomatosis first and then saccular aneurysms between celiac trunk and arteria hepatica communis and many other proteus manifestations, which is seldom described before.
MeSH term(s)	Adult ; Aneurysm/diagnosis ; Aneurysm/diagnostic imaging ; Aneurysm/microbiology ; Anticoagulants/therapeutic use ; Celiac Artery/diagnostic imaging ; Celiac Artery/drug effects ; Celiac Artery/microbiology ; Cerebrovascular Disorders/diagnosis ; Cerebrovascular Disorders/diagnostic imaging ; Cerebrovascular Disorders/drug therapy ; Cerebrovascular Disorders/microbiology ; Dexamethasone/therapeutic use ; Fever/diagnosis ; Fever/drug therapy ; Fever/microbiology ; Glucocorticoids/therapeutic use ; Granuloma/diagnosis ; Granuloma/diagnostic imaging ; Granuloma/drug therapy ; Granuloma/microbiology ; Headache/diagnosis ; Headache/diagnostic imaging ; Headache/microbiology ; Humans ; Male ; Proteus Infections/diagnosis ; Proteus Infections/diagnostic imaging ; Proteus Infections/drug therapy ; Radiography ; Takayasu Arteritis/diagnosis ; Takayasu Arteritis/diagnostic imaging ; Takayasu Arteritis/drug therapy ; Treatment Outcome
Chemical Substances	Anticoagulants ; Glucocorticoids ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2010-03-31
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-010-1432-3
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Zs.A 1639: Show issues

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Article: Transplantation of induced pluripotent stem cell-derived renal stem cells improved acute kidney injury.

Li, Qing / Tian, Shou-Fu / Guo, Ye / Niu, Xin / Hu, Bin / Guo, Shang-Chun / Wang, Nian-Song / Wang, Yang

Cell & bioscience

2015 Volume 5, Page(s) 45

Abstract: Background: Acute kidney injury (AKI) is a severe disease with high morbidity and mortality. Methods that promote repair of the injured kidney have been extensively investigated. Cell-based therapy with mesenchymal stem cells or renal progenitor cells ( ... ...

Abstract	Background: Acute kidney injury (AKI) is a severe disease with high morbidity and mortality. Methods that promote repair of the injured kidney have been extensively investigated. Cell-based therapy with mesenchymal stem cells or renal progenitor cells (RPCs) resident in the kidney has appeared to be an effective strategy for the treatment of AKI. Embryonic stem cells or induced pluripotent stem cells (iPSCs) are also utilized for AKI recovery. However, the therapeutic effect of iPSC-derived RPCs for AKI has yet to be determined. Methods: In this study, we induced iPSCs differentiation into RPCs using a nephrogenic cocktail of factors combined with the renal epithelial cell growth medium. We then established the rat ischemia-reperfusion injury (IR) model and transplanted the iPSC-derived RPCs into the injured rats in combination with the hydrogel. Next, we examined the renal function-related markers and renal histology to assess the therapeutic effect of the injected cells. Moreover, we investigated the mechanism by which iPSC-derived RPCs affect AKI caused by IR. Results: We showed that the differentiation efficiency of iPSCs to RPCs increased when cultured with renal epithelial cell growth medium after stimulation with a nephrogenic cocktail of factors. The transplantation of iPSC-derived RPCs decreased the levels of biomarkers indicative of renal injury and attenuated the necrosis and apoptosis of renal tissues, but resulted in the up-regulation of renal tubules formation, cell proliferation, and the expression of pro-renal factors. Conclusion: Our results revealed that iPSC-derived RPCs can protect AKI rat from renal function impairment and severe tubular injury by up-regulating the renal tubules formation, promoting cell proliferation, reducing apoptosis, and regulating the microenvironment in the injured kidney.
Language	English
Publishing date	2015-08-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2593367-X
ISSN	2045-3701
ISSN	2045-3701
DOI	10.1186/s13578-015-0040-z
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Article: [Volatile oil of Magnolia biondii inhibits expressions of P-selectin protein in serum and renal tissue of rats with diabetic nephropathy].

Sun, Xue-Peng / Wang, Nian-Song / Xue, Qin / Wang, Feng

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine

2008 Volume 6, Issue 5, Page(s) 524–529

Abstract: Objective: To investigate the protection mechanism of volatile oil of Magnolia biondii Pamp. (VOMBP) against diabetic nephropathy in rats by observing its effects on level of soluble P-selectin (sP-selectin) in serum and expression of P-selectin in ... ...

Abstract	Objective: To investigate the protection mechanism of volatile oil of Magnolia biondii Pamp. (VOMBP) against diabetic nephropathy in rats by observing its effects on level of soluble P-selectin (sP-selectin) in serum and expression of P-selectin in renal tissue. Methods: Fifty SD rats were randomly divided into normal control group, untreated group, and low-, medium- and high-dose VOMBP-treated group. Diabetic nephropathy was induced in rats by intraperitoneal injection of 1% streptozotocin. Before and the 1st day, 4th, 8th and 12th week after the induction, random blood glucose (RBG) and 24-hour urinary micro-albumin were detected in different groups. At the 12th week, the rats were sacrificed to collect the blood samples and renal tissues. The contents of blood urea nitrogen (BUN) and serum creatinine (SCr) were detected and the pathological change in renal tissues was observed by light microscope; the level of sP-selectin was detected by enzyme-linked immunosorbent assay and the expression of P-selectin protein in renal tissues was measured by immunohistochemical method. Results: Compared with the normal control group, RBG, 24-hour urinary micro-albumin, the contents of BUN, sP-selectin in serum and expression of P-selectin protein in renal tissue in the untreated group were significantly increased (P<0.01), the content of SCr was significantly decreased (P<0.01), and pathological change of renal tissues was also obvious. Compared with the untreated group, 24-hour urinary micro-albumin, the level of sP-selectin in serum and expression P-selectin protein in renal tissue of the three VOMBP-treated groups were all significantly decreased (P<0.01), and pathological change was lessened too. However, there were no significant differences among the three VOMBP-treated groups (P>0.05). Conclusion: VOMBP can protect the kidney in rats with diabetic nephropathy by inhibiting the expressions of P-selectin protein in serum and in renal tissue.
MeSH term(s)	Animals ; Diabetes Mellitus, Experimental/drug therapy ; Diabetic Nephropathies/drug therapy ; Diabetic Nephropathies/metabolism ; Down-Regulation ; Kidney/metabolism ; Magnolia/chemistry ; Male ; Oils, Volatile/isolation & purification ; Oils, Volatile/therapeutic use ; P-Selectin/blood ; P-Selectin/metabolism ; Phytotherapy ; Random Allocation ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Oils, Volatile ; P-Selectin
Language	Chinese
Publishing date	2008-05
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2229154-4
ISSN	1672-1977
ISSN	1672-1977
DOI	10.3736/jcim20080518
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Zs.A 6322: Show issues

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Article ; Online: Abelmoschus manihot - a traditional Chinese medicine versus losartan potassium for treating IgA nephropathy: study protocol for a randomized controlled trial.

Li, Ping / Chen, Yi-Zhi / Lin, Hong-Li / Ni, Zhao-Hui / Zhan, Yong-Li / Wang, Rong / Yang, Hong-Tao / Fang, Jing-Ai / Wang, Nian-Song / Li, Wen-Ge / Sun, Xue-Feng / Chen, Xiang-Mei

Trials

2017 Volume 18, Issue 1, Page(s) 170

Abstract: Background: IgA nephropathy (IgAN) is one of the most common primary glomerular diseases worldwide, but effective therapy remains limited and many patients progress to end-stage renal disease (ESRD). Only angiotensin-converting enzyme inhibitors (ACE-I)/ ...

Abstract	Background: IgA nephropathy (IgAN) is one of the most common primary glomerular diseases worldwide, but effective therapy remains limited and many patients progress to end-stage renal disease (ESRD). Only angiotensin-converting enzyme inhibitors (ACE-I)/angiotensin-receptor blockers (ARB) show a high level of evidence (1B level) of being of value in the treatment for IgAN according to the 2012 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. However, traditional Chinese medicine has raised attention in kidney disease research. Abelmoschus manihot, a single medicament of traditional Chinese medicine has shown therapeutic effects in primary glomerular disease according to the randomized controlled clinical trial that we have completed. Here, we conduct a new study to assess the efficacy and safety of Abelmoschus manihot in IgAN. Also, this study is currently the largest double-blind, randomized controlled registered clinical research for the treatment of IgAN. Methods: We will conduct a multicenter, prospective, double-blind, double-dummy randomized controlled study. The study is designed as a noninferiority clinical trial. Approximately 1600 biopsy-proven IgAN patients will be enrolled at 100 centers in China and followed up for as long as 48 weeks. IgAN patients will be randomized assigned to the Abelmoschus manihot group (in the form of a huangkui capsule, 2.5 g, three times per day) and the losartan potassium group (losartan potassium, 100 mg/d). The primary outcome is the change in 24-h proteinuria from baseline after 48 weeks of treatment. Change in estimated glomerular filtration rate (eGFR) from baseline after 48 weeks of treatment, the incidence of endpoint events (proteinuria ≥3.5 g/24 h, the doubling of serum creatinine, or receiving blood purification treatment) are the secondary outcomes. Twenty-four-hour proteinuria and eGFR are measured at 0, 4, 12, 24, 36 and 48 weeks. Discussion: This study will be of sufficient size and scope to evaluate the efficacy and safety of Abelmoschus manihot compared to losartan potassium in treating patients with IgAN. The results of this study may provide a new, effective and safe treatment strategy for IgAN. Trial registration: ClinicalTrials.gov, identifier: NCT02231125 . Registered on 30 August 2014.
Language	English
Publishing date	2017-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1468-6708
ISSN (online)	1745-6215 ; 1468-6694
ISSN	1468-6708
DOI	10.1186/s13063-016-1774-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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