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  1. AU="Wang, Peter H"
  2. AU="Preto, Jordane"
  3. AU="Pierce, Shaketha"
  4. AU="Sankar, Jishnu"
  5. AU="Yahagi, Naohisa"
  6. AU=Pinho Juliana
  7. AU="Brennan, Anna"
  8. AU="Lee, Theresa M"
  9. AU="Chunqing Ou"
  10. AU="Gwynn, Simon"
  11. AU="Holper, Sarah"
  12. AU="Haider, Farag Ibrahim"
  13. AU="Rice, Jordin L"
  14. AU="Gong, Xingguo"
  15. AU=Rother Magdalena B.
  16. AU="Petrov, Ksenia"
  17. AU="Rijneveld, R"
  18. AU=Lopez-Martinez Briceida
  19. AU=Astone Pia
  20. AU="Amaral, V"

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  1. Artikel ; Online: Reciprocal transmission of activating and inhibitory signals and cell fate in regenerating T cells.

    Wang, Peter H / Washburn, Robert S / Mariuzza, Dylan L / Lin, Wen-Hsuan W / Gill, Amanda L / Ahmed, Rafi / Reiner, Steven L

    Cell reports

    2023  Band 42, Heft 10, Seite(n) 113155

    Abstract: The ability of activated progenitor T cells to self-renew while producing differentiated effector cell descendants may underlie immunological memory and persistent responses to ongoing infection. The nature of stem-like T cells responding to cancer and ... ...

    Abstract The ability of activated progenitor T cells to self-renew while producing differentiated effector cell descendants may underlie immunological memory and persistent responses to ongoing infection. The nature of stem-like T cells responding to cancer and during treatment with immunotherapy is not clear. The subcellular organization of dividing progenitor CD8
    Mesh-Begriff(e) Mice ; Animals ; CD8-Positive T-Lymphocytes ; Phosphatidylinositol 3-Kinases ; Cell Differentiation ; Stem Cells ; Signal Transduction
    Chemische Substanzen Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
    Sprache Englisch
    Erscheinungsdatum 2023-09-26
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.113155
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Cutting Edge: Promoting T Cell Factor 1

    Wang, Peter H / Washburn, Robert / Maniar, Rohan / Mu, Michael / Ringham, Olivia / Kratchmarov, Radomir / Henick, Brian S / Reiner, Steven L

    Journal of immunology (Baltimore, Md. : 1950)

    2022  Band 209, Heft 4, Seite(n) 660–664

    Abstract: Immune checkpoint blockade is limited by resistance to treatment, with many patients not achieving durable antitumor responses. Self-renewing (T cell factor ... ...

    Abstract Immune checkpoint blockade is limited by resistance to treatment, with many patients not achieving durable antitumor responses. Self-renewing (T cell factor 1
    Mesh-Begriff(e) Animals ; CD8-Positive T-Lymphocytes ; Cell Death ; Immunotherapy ; Mice ; Neoplasms ; Phosphatidylinositol 3-Kinases ; T Cell Transcription Factor 1
    Chemische Substanzen T Cell Transcription Factor 1
    Sprache Englisch
    Erscheinungsdatum 2022-07-29
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2200317
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors.

    Gill, Amanda L / Wang, Peter H / Lee, Judong / Hudson, William H / Ando, Satomi / Araki, Koichi / Hu, Yinghong / Wieland, Andreas / Im, Sejin / Gavora, Autumn / Medina, Christopher B / Freeman, Gordon J / Hashimoto, Masao / Reiner, Steven L / Ahmed, Rafi

    Science immunology

    2023  Band 8, Heft 86, Seite(n) eadg0539

    Abstract: ... PD- ... ...

    Abstract PD-1
    Mesh-Begriff(e) Humans ; Animals ; Mice ; Programmed Cell Death 1 Receptor ; CD8-Positive T-Lymphocytes ; Antibodies ; Cell Differentiation ; Disease Models, Animal
    Chemische Substanzen Programmed Cell Death 1 Receptor ; Antibodies
    Sprache Englisch
    Erscheinungsdatum 2023-08-25
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.adg0539
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Self-Renewing CD8+ T-cell Abundance in Blood Associates with Response to Immunotherapy.

    Maniar, Rohan / Wang, Peter H / Washburn, Robert S / Kratchmarov, Radomir / Coley, Shana M / Saqi, Anjali / Pan, Samuel S / Hu, Jianhua / Shu, Catherine A / Rizvi, Naiyer A / Henick, Brian S / Reiner, Steven L

    Cancer immunology research

    2022  Band 11, Heft 2, Seite(n) 164–170

    Abstract: Treatment with immune checkpoint blockade (ICB) often fails to elicit durable antitumor immunity. Recent studies suggest that ICB does not restore potency to terminally dysfunctional T cells, but instead drives proliferation and differentiation of self- ... ...

    Abstract Treatment with immune checkpoint blockade (ICB) often fails to elicit durable antitumor immunity. Recent studies suggest that ICB does not restore potency to terminally dysfunctional T cells, but instead drives proliferation and differentiation of self-renewing progenitor T cells into fresh, effector-like T cells. Antitumor immunity catalyzed by ICB is characterized by mobilization of antitumor T cells in systemic circulation and tumor. To address whether abundance of self-renewing T cells in blood is associated with immunotherapy response, we used flow cytometry of peripheral blood from a cohort of patients with metastatic non-small cell lung cancer (NSCLC) treated with ICB. At baseline, expression of T-cell factor 1 (TCF1), a marker of self-renewing T cells, was detected at higher frequency in effector-memory (CCR7-) CD8+ T cells from patients who experienced durable clinical benefit compared to those with primary resistance to ICB. On-treatment blood samples from patients benefiting from ICB also exhibited a greater frequency of TCF1+CCR7-CD8+ T cells and higher proportions of TCF1 expression in treatment-expanded PD-1+CCR7-CD8+ T cells. The observed correlation of TCF1 frequency in CCR7-CD8+ T cells and response to ICB suggests that broader examination of self-renewing T-cell abundance in blood will determine its potential as a noninvasive, predictive biomarker of response and resistance to immunotherapy.
    Mesh-Begriff(e) Humans ; Carcinoma, Non-Small-Cell Lung ; Lung Neoplasms ; Receptors, CCR7 ; CD8-Positive T-Lymphocytes ; Immunotherapy
    Chemische Substanzen Receptors, CCR7
    Sprache Englisch
    Erscheinungsdatum 2022-12-12
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2732489-8
    ISSN 2326-6074 ; 2326-6066
    ISSN (online) 2326-6074
    ISSN 2326-6066
    DOI 10.1158/2326-6066.CIR-22-0524
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Farmers and the Immigration Act of 1924

    Wang, Peter H

    Agricultural history : a publication of the Agricultural History Society Vol. 49, No. 4 , p. 647-652

    1975  Band 49, Heft 4, Seite(n) 647–652

    Verfasserangabe Peter H. Wang
    Schlagwörter Agrararbeiterwanderung ; Wanderungsrecht ; Vereinigte Staaten
    Verlag Univ. of California Pr.
    Erscheinungsort Berkeley, Calif.
    Dokumenttyp Artikel
    ZDB-ID 430278-3
    Datenquelle ECONomics Information System

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