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Book: Nanotechnology in gene delivery

Liu, Yarong / Wang, Pin

(The world scientific encyclopedia of nanomedicine and bioengineering I ; 3)

2017

Author's details	editors Yarong Liu, Pin Wang
Series title	The world scientific encyclopedia of nanomedicine and bioengineering I ; 3
Collection
Language	English
Size	ix, 328 Seiten, Illustrationen
Publisher	World Scientific
Publishing place	New Jersey
Publishing country	United States
Document type	Book
HBZ-ID	HT019189368
ISBN	978-981-4667-70-8 ; 9789813202528 ; 981-4667-70-6 ; 9813202521
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2016 A 2676	available for loan (reading room)	Lesesaal EG

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Article ; Online: The Opening of Pandora's Box: An Emerging Role of Long Noncoding RNA in Viral Infections.

Wang, Pin

Frontiers in immunology

2019 Volume 9, Page(s) 3138

Abstract: Emerging evidence has proved that long noncoding RNAs (lncRNAs) participate in various physiological and pathological processes. Recent evidence has demonstrated that lncRNAs are crucial regulators of virus infections and antiviral immune responses. Upon ...

Abstract	Emerging evidence has proved that long noncoding RNAs (lncRNAs) participate in various physiological and pathological processes. Recent evidence has demonstrated that lncRNAs are crucial regulators of virus infections and antiviral immune responses. Upon viral infections, significant changes take place at the transcriptional level and the majority of the expression modifications occur in lncRNAs from both the host and viral genomes with dynamic regulatory courses. These lncRNAs exert diverse effects. Some are antiviral either through directly inhibiting viral infections or through stimulating antiviral immune responses, while others are pro-viral through directly promoting virus replication or through influencing cellular status, such as suppressing antiviral mechanisms. Consequently, these dynamic regulations lead to disparate pathophysiological outcomes and clinical manifestations. This review will focus on the roles of lncRNAs in viral infection and antiviral responses, summarize expression patterns of both host- and virally derived lncRNAs, describe their acting stages and modes of action, discuss challenges and novel concepts, and propose solutions and perspectives. Research into lncRNA will help identify novel viral infection-related regulators and design preventative and therapeutic strategies against virus-related diseases and immune disorders.
MeSH term(s)	Adaptive Immunity ; Animals ; Biomarkers ; Cytokines/biosynthesis ; Disease Susceptibility/immunology ; Gene Expression Regulation ; Genetic Predisposition to Disease ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Innate ; RNA, Long Noncoding/genetics ; RNA, Viral ; Virus Diseases/etiology ; Virus Replication
Chemical Substances	Biomarkers ; Cytokines ; RNA, Long Noncoding ; RNA, Viral
Language	English
Publishing date	2019-01-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.03138
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Prognostic value of neutrophil extracellular trap signature in clear cell renal cell carcinoma.

Li, Rong / Jiang, Xuewen / Wang, Pin / Liu, Xiaoyan

Frontiers in oncology

2023 Volume 13, Page(s) 1205713

Abstract: Introduction: Clear cell renal cell carcinoma (ccRCC) is the most prevalent type of urological carcinoma. Although targeted therapy and immunotherapy are usually employed, they often result in primary and acquired resistance. There is currently a lack ... ...

Abstract	Introduction: Clear cell renal cell carcinoma (ccRCC) is the most prevalent type of urological carcinoma. Although targeted therapy and immunotherapy are usually employed, they often result in primary and acquired resistance. There is currently a lack of dependable biomarkers that can accurately anticipate the prognosis of ccRCC. Recent research has indicated the critical role of neutrophil extracellular traps (NETs) in the development, metastasis, and immune evasion of cancer. The aim of this study was to explore the value of NETs in the development and prognosis of ccRCC. Methods: Clinical features and genetic expression information of ccRCC patients were acquired from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC) and E-MTAB-1980 database. NETs-related gene set were obtained from previous studies. A NETs-related gene signature was constructed based on TCGA data and validated using ICGC and E-MTAB-1980 databases. Furthermore, the immune microenvironment and responsiveness to anticancer medications in ccRCC patients with varying levels of NETs risks were investigated. Results: A total of 31 NET-related genes were differently expressed between normal kidney and ccRCC tissues. 17 out of 31 were significantly associated with overall survival. After LASSO Cox regression analysis, nine NETs-related genes were enrolled to construct the NETs prognosis signature, and all the ccRCC patients from TCGA were divided into low and high risk group. This signature demonstrated excellent performance in predicting the overall survival of TCGA patients as well as the validation ICGC and E-MTAB-1980 patients. Additionally, the NETs signature was significantly correlated with immune infiltration and drug sensitivity. Conclusions: The NETs signature established by the current study has prognostic significance in ccRCC, and may serve as a useful biomarker for patient stratification and treatment decisions. Further validation and clinical studies are required to fully translate these findings into clinical practice.
Language	English
Publishing date	2023-07-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1205713
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Article ; Online: DYRK1A-mediated PLK2 phosphorylation regulates the proliferation and invasion of glioblastoma cells.

Tan, Shichuan / Zhao, Juan / Wang, Pin

International journal of oncology

2023 Volume 63, Issue 2

Abstract: Polo-like kinases (PLKs) are a family of serine-threonine kinases that exert regulatory effects on diverse cellular processes. Dysregulation of PLKs has been implicated in multiple cancers, including glioblastoma (GBM). Notably, PLK2 expression in GBM ... ...

Abstract	Polo-like kinases (PLKs) are a family of serine-threonine kinases that exert regulatory effects on diverse cellular processes. Dysregulation of PLKs has been implicated in multiple cancers, including glioblastoma (GBM). Notably, PLK2 expression in GBM tumor tissue is lower than that in normal brains. Notably, high PLK2 expression is significantly correlated with poor prognosis. Thus, it can be inferred that PLK2 expression alone may not be sufficient for accurate prognosis evaluation, and there are unknown mechanisms underlying PLK2 regulation. In the present study, it was demonstrated that dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) interacts with and phosphorylates PLK2 at Ser358. DYRK1A-mediated phosphorylation of PLK2 increases its protein stability. Moreover, PLK2 kinase activity was markedly induced by DYRK1A, which was exemplified by the upregulation of alpha-synuclein S129 phosphorylation. Furthermore, it was found that phosphorylation of PLK2 by DYRK1A contributes to the proliferation, migration and invasion of GBM cells. DYRK1A further enhances the inhibition of the malignancy of GBM cells already induced by PLK2. The findings of the present study indicate that PLK2 may play a crucial role in GBM pathogenesis partially in a DYRK1A-dependent manner, suggesting that PLK2 Ser358 may serve as a therapeutic target for GBM.
MeSH term(s)	Humans ; Phosphorylation ; Glioblastoma/genetics ; Protein Serine-Threonine Kinases/genetics ; Brain ; Cell Proliferation
Chemical Substances	Protein Serine-Threonine Kinases (EC 2.7.11.1) ; PLK2 protein, human (EC 2.7.11.-)
Language	English
Publishing date	2023-06-30
Publishing country	Greece
Document type	Journal Article
ZDB-ID	1154403-x
ISSN	1791-2423 ; 1019-6439
ISSN (online)	1791-2423
ISSN	1019-6439
DOI	10.3892/ijo.2023.5542
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Article ; Online: Contributions of climate change and urbanization to urban flood hazard changes in China's 293 major cities since 1980.

Tang, Ziyi / Wang, Pin / Li, Yao / Sheng, Yue / Wang, Ben / Popovych, Nataliia / Hu, Tangao

Journal of environmental management

2024 Volume 353, Page(s) 120113

Abstract: The growing incidence of urban flood disasters poses a major challenge to urban sustainability in China. Previous studies have reported that climate change and urbanization exacerbate urban flood risk in some major cities of China. However, few ... ...

Abstract	The growing incidence of urban flood disasters poses a major challenge to urban sustainability in China. Previous studies have reported that climate change and urbanization exacerbate urban flood risk in some major cities of China. However, few assessments have quantified the contributions of these two factors to urban flood changes in recent decades at the nationwide scale. Here, surface runoff caused by precipitation extremes was used as the urban flood hazard to evaluate the impacts of climate change and urbanization in China's 293 major cities. This study assessed the contributions of these drivers to urban flood hazard changes and identified the hotspot cities with increased trends under both factors during the past four decades (1980-2019). The results showed that approximately 70% of the cities analyzed have seen an increase of urban flood hazard in the latest decade. Urbanization made a positive contribution to increased urban flood hazards in more than 90% of the cities. The contribution direction of climate change showed significant variations across China. Overall, the absolute contribution rate of climate change far outweighed that of urbanization. In half of the cities (mainly distributed in eastern China), both climate change and urbanization led to increased urban flood hazard over the past decade. Among them, 33 cities have suffered a consecutive increase in urban flood hazard driven by both factors.
MeSH term(s)	Urbanization ; Cities ; Floods ; Climate Change ; Sustainable Growth ; China
Language	English
Publishing date	2024-01-28
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2024.120113
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Article ; Online: Ultrasound combined with shear wave elastography to observe the pregnancy uterine wall and cervix for pre- and postnatal outcome comparison analysis.

Zhang, Chunye / Fu, Liman / Chen, Yu / Zhao, Wei / Geng, Xuna / Wang, Pin

Minerva medica

2024

Language	English
Publishing date	2024-04-17
Publishing country	Italy
Document type	Journal Article
ZDB-ID	123586-2
ISSN	1827-1669 ; 0026-4806
ISSN (online)	1827-1669
ISSN	0026-4806
DOI	10.23736/S0026-4806.24.09241-3
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Article ; Online: Improvement of actin dynamics and cognitive impairment in diabetes through troxerutin-mediated downregulation of TRPM7/CaN/cofilin.

Li, Hongyan / Li, Jie / Wang, Pin / Yuan, Fang / Zhang, Songyun

Neuropeptides

2023 Volume 102, Page(s) 102381

Abstract: Diabetic cognitive impairment is a central nervous complication of diabetes mellitus. Its specific pathogenesis is unknown, and no effective treatment strategy is currently available. An imbalance in actin dynamics is an important mechanism underlying ... ...

Abstract	Diabetic cognitive impairment is a central nervous complication of diabetes mellitus. Its specific pathogenesis is unknown, and no effective treatment strategy is currently available. An imbalance in actin dynamics is an important mechanism underlying cognitive impairment. Transient receptor potential channel 7 (TRPM7) mediates actin dynamics imbalance through calcineurin (CaN) and cofilin cascades involved in various neurodegenerative diseases. We previously demonstrated that TRPM7 expression is increased in diabetic cognitive impairment, and troxerutin has been shown to ameliorate diabetic cognitive impairment. However, the relationship between troxerutin and TRPM7 remains unclear. In this study, we hypothesize that troxerutin may improve diabetic cognitive impairment by enhancing actin dynamics through downregulation of the TRPM7/CaN/cofilin pathway. To test this hypothesis, we divided db/m and db/db mice into the following groups: normal control group (NC), normal + troxerutin group (NT), diabetic group (DM), diabetic + troxerutin group (DT) and diabetic + troxerutin + bradykinin group (DTB). The results showed that diabetic mice exhibited cognitive impairment at 17 weeks of age, TRPM7, CaN, cofilin and G-actin were highly expressed in the CA1 region of hippocampus, while p-cofilin and F-actin expression decreased. Furthermore, hippocampal neuronal cellsshowed varying degrees of damage. The length of synaptic active zone, the width of synaptic cleft, and the number of synapses per high-power field were decreased. Troxerutin intervention alleviated these manifestations in the DT group; however, the effect of troxerutin was weakened in the DTB group. In conclusion, our findings suggest that diabetes leads to cognitive impairment, activation of the TRPM7/CaN/cofilin pathway, actin dynamics imbalance, and destruction of hippocampal neuronal cells and synapses. Troxerutin can downregulate TRPM7/CaN/cofilin, improve actin dynamics imbalance, and ameliorate cognitive impairment in diabetic mice. This study provides a new avenue for exploring and treating cognitive impairment in diabetes.
MeSH term(s)	Mice ; Animals ; Actins/metabolism ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Calcineurin/metabolism ; Actin Depolymerizing Factors/metabolism ; Down-Regulation ; TRPM Cation Channels/metabolism ; Cognitive Dysfunction/drug therapy
Chemical Substances	Actins ; Calcineurin (EC 3.1.3.16) ; Actin Depolymerizing Factors ; troxerutin (7Y4N11PXO8) ; TRPM Cation Channels
Language	English
Publishing date	2023-09-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	9048-7
ISSN	1532-2785 ; 0143-4179
ISSN (online)	1532-2785
ISSN	0143-4179
DOI	10.1016/j.npep.2023.102381
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Article ; Online: Phospho-proteomics reveals that RSK signaling is required for proliferation of natural killer cells stimulated with IL-2 or IL-15.

MacMullan, Melanie A / Wang, Pin / Graham, Nicholas A

Cytokine

2022 Volume 157, Page(s) 155958

Abstract: Natural killer (NK) cells are cytotoxic lymphocytes that play a critical role in the innate immune system. Although cytokine signaling is crucial for the development, expansion, and cytotoxicity of NK cells, the signaling pathways stimulated by cytokines ...

Abstract	Natural killer (NK) cells are cytotoxic lymphocytes that play a critical role in the innate immune system. Although cytokine signaling is crucial for the development, expansion, and cytotoxicity of NK cells, the signaling pathways stimulated by cytokines are not well understood. Here, we sought to compare the early signaling dynamics induced by the cytokines interleukin (IL)-2 and IL-15 using liquid chromatography-mass spectrometry (LC-MS)-based phospho-proteomics. Following stimulation of the immortalized NK cell line NK-92 with IL-2 or IL-15 for 5, 10, 15, or 30 min, we identified 8,692 phospho-peptides from 3,023 proteins. Comparing the kinetic profiles of 3,619 fully quantified phospho-peptides, we found that IL-2 and IL-15 induced highly similar signaling in NK-92 cells. Among the IL-2/IL-15-regulated phospho-peptides were both well-known signaling events like the JAK/STAT pathway and novel signaling events with potential functional significance including LCP1 pSer5, STMN1 pSer25, CHEK1 pSer286, STIM1 pSer608, and VDAC1 pSer104. Using bioinformatic approaches, we sought to identify kinases regulated by IL-2/IL-15 stimulation and found that the p90 ribosomal S6 kinase (p90RSK) family was activated by both cytokines. Using pharmacological inhibitors, we then discovered that RSK signaling is required for IL-2 and IL-15-induced proliferation in NK-92 cells. Taken together, our analysis represents the first phospho-proteomic characterization of cytokine signaling in NK cells and increases our understanding of how cytokine signaling regulates NK cell function.
MeSH term(s)	Cell Proliferation ; Cytokines/metabolism ; Interleukin-15/metabolism ; Interleukin-15/pharmacology ; Interleukin-2/metabolism ; Interleukin-2/pharmacology ; Janus Kinases/metabolism ; Killer Cells, Natural ; Proteomics ; STAT Transcription Factors/metabolism ; Signal Transduction
Chemical Substances	Cytokines ; Interleukin-15 ; Interleukin-2 ; STAT Transcription Factors ; Janus Kinases (EC 2.7.10.2)
Language	English
Publishing date	2022-07-13
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2022.155958
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Article: The Lattice Distortion-Induced Ferromagnetism in the Chemical-Bonded MoSe

Huang, Shiu-Ming / Wang, Pin-Cing / Chen, Pin-Cyuan

Nanoscale research letters

2022 Volume 17, Issue 1, Page(s) 55

Abstract: Ferromagnetism to non-ferromagnetism transition is detected in a chemically bonded MoSe[Formula: see text]/WSe[Formula: see text] powder with different thermal annealing temperatures. All samples exhibit ferromagnetism and Raman redshift, except for the ... ...

Abstract	Ferromagnetism to non-ferromagnetism transition is detected in a chemically bonded MoSe[Formula: see text]/WSe[Formula: see text] powder with different thermal annealing temperatures. All samples exhibit ferromagnetism and Raman redshift, except for the 1100 °C thermally annealed sample in which the MoSe[Formula: see text] and WSe[Formula: see text] are thermally dissociated and geometrically separated. The element analysis reveals no significant element ratio difference and detectable magnetic elements in all samples. These results support that, in contrast to the widely reported structure defect or transition element dopant, the observed ferromagnetism originates from the structure distortion due to the chemical bonding at the interface between MoSe[Formula: see text] and WSe[Formula: see text].
Language	English
Publishing date	2022-05-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2253244-4
ISSN	1556-276X ; 1931-7573
ISSN (online)	1556-276X
ISSN	1931-7573
DOI	10.1186/s11671-022-03692-6
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Article ; Online: Prospective comparative analysis for application and selection of FIESTA sequence and SSFSE sequence in MRI for prenatal diagnosis of placenta previa accreta.

Tian, Gan / Liu, Zhaofa / Zhang, Dawei / Wang, Pin

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

2022 Volume 42, Issue 6, Page(s) 2051–2057

Abstract: Placenta previa accreta patients were examined using fast-imaging employing steady-state acquisition (FIESTA) and single-shot fast spin echo (SSFSE) sequence. The diagnostic value of the two sequences was compared. FIESTA was better than the SSFSE ... ...

Abstract	Placenta previa accreta patients were examined using fast-imaging employing steady-state acquisition (FIESTA) and single-shot fast spin echo (SSFSE) sequence. The diagnostic value of the two sequences was compared. FIESTA was better than the SSFSE sequence in displaying outline-boundary (excellent: 82
MeSH term(s)	Female ; Humans ; Magnetic Resonance Imaging/methods ; Placenta Accreta/diagnostic imaging ; Placenta Previa/diagnostic imaging ; Pregnancy ; Prenatal Diagnosis ; Prospective Studies ; Retrospective Studies
Language	English
Publishing date	2022-07-15
Publishing country	England
Document type	Journal Article
ZDB-ID	604639-3
ISSN	1364-6893 ; 0144-3615
ISSN (online)	1364-6893
ISSN	0144-3615
DOI	10.1080/01443615.2022.2081489
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